JP2004514709A5 - - Google Patents
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- Publication number
- JP2004514709A5 JP2004514709A5 JP2002546511A JP2002546511A JP2004514709A5 JP 2004514709 A5 JP2004514709 A5 JP 2004514709A5 JP 2002546511 A JP2002546511 A JP 2002546511A JP 2002546511 A JP2002546511 A JP 2002546511A JP 2004514709 A5 JP2004514709 A5 JP 2004514709A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- allergy
- lower alkyl
- compound according
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 29
- 125000000217 alkyl group Chemical group 0.000 description 11
- 206010020751 Hypersensitivity Diseases 0.000 description 10
- 230000007815 allergy Effects 0.000 description 10
- 208000024172 Cardiovascular disease Diseases 0.000 description 8
- 208000026935 allergic disease Diseases 0.000 description 8
- 206010028735 Nasal congestion Diseases 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 208000008589 Obesity Diseases 0.000 description 5
- 230000008369 airway response Effects 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 235000020824 obesity Nutrition 0.000 description 5
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 208000015114 central nervous system disease Diseases 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000938 histamine H1 antagonist Substances 0.000 description 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23403900P | 2000-09-20 | 2000-09-20 | |
| PCT/US2001/029062 WO2002044141A2 (en) | 2000-09-20 | 2001-09-18 | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004514709A JP2004514709A (ja) | 2004-05-20 |
| JP2004514709A5 true JP2004514709A5 (https=) | 2008-09-11 |
Family
ID=22879625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546511A Pending JP2004514709A (ja) | 2000-09-20 | 2001-09-18 | ヒスタミンｈ１およびｈ３の二重アゴニストまたは二重アンタゴニストとしての置換イミダゾール |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6762186B2 (https=) |
| EP (1) | EP1318996B1 (https=) |
| JP (1) | JP2004514709A (https=) |
| CN (1) | CN1461304A (https=) |
| AR (1) | AR032894A1 (https=) |
| AT (1) | ATE283853T1 (https=) |
| AU (1) | AU2002241459A1 (https=) |
| CA (1) | CA2422729A1 (https=) |
| DE (1) | DE60107586T2 (https=) |
| ES (1) | ES2233708T3 (https=) |
| HK (1) | HK1052182B (https=) |
| MX (1) | MXPA03002446A (https=) |
| TW (1) | TWI228127B (https=) |
| WO (1) | WO2002044141A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003268117A1 (en) * | 2002-09-18 | 2004-04-08 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparaton and therapeutic uses |
| US8063650B2 (en) | 2002-11-27 | 2011-11-22 | Rambus Inc. | Testing fuse configurations in semiconductor devices |
| US20050090527A1 (en) * | 2003-01-28 | 2005-04-28 | Schering Corporation | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
| BRPI0413013A (pt) | 2003-07-28 | 2006-10-03 | Smithkline Beecham Corp | composto, seus sais, solvatos, e derivados farmaceuticamente funcionais, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou profilaxia de condições ou distúrbios, e de doenças |
| TWI290140B (en) * | 2003-08-25 | 2007-11-21 | Schering Corp | 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders |
| JP2009504637A (ja) * | 2005-08-08 | 2009-02-05 | アストラゼネカ・アクチエボラーグ | 治療薬 |
| US20100029681A1 (en) * | 2006-05-26 | 2010-02-04 | Hassan Pajouhesh | Heterocyclic compounds as calcium channel blockers |
| KR20090097194A (ko) | 2006-12-22 | 2009-09-15 | 아벡사 리미티드 | 바이사이클 피리미디논 및 그 용도 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| CN110878069A (zh) * | 2019-12-09 | 2020-03-13 | 南京杰运医药科技有限公司 | 一种4-吗琳基-2-乙基哌嗪的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586562B1 (fr) | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| US4829065A (en) * | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| EP0437645B1 (de) * | 1990-01-15 | 1995-03-29 | HEUMANN PHARMA GMBH & CO | Imidazolylpropylguanidinderivat, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel |
| ES2058651T3 (es) | 1990-03-30 | 1994-11-01 | Heumann Pharma Gmbh & Co | Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy. |
| FR2665160A1 (fr) * | 1990-07-26 | 1992-01-31 | Esteve Labor Dr | Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments. |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| WO1993012093A1 (en) | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists |
| US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| HU213104B (en) * | 1992-06-17 | 1997-02-28 | Richter Gedeon Vegyeszet | Process for producing 4-methyl-2-imidazolinone derivatives and pharmaceutical compositions containing them |
| ATE234290T1 (de) | 1993-11-15 | 2003-03-15 | Schering Corp | Phenylalkyl-imidazole als h3-rezeptor- antagonisten |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| WO1998058646A1 (en) | 1997-06-24 | 1998-12-30 | Novo Nordisk A/S | Use of somatostatin agonists and antagonists for treating diseases related to the eye |
| US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
-
2001
- 2001-09-18 AT AT01988119T patent/ATE283853T1/de not_active IP Right Cessation
- 2001-09-18 EP EP01988119A patent/EP1318996B1/en not_active Expired - Lifetime
- 2001-09-18 CN CN01815990A patent/CN1461304A/zh active Pending
- 2001-09-18 CA CA002422729A patent/CA2422729A1/en not_active Abandoned
- 2001-09-18 ES ES01988119T patent/ES2233708T3/es not_active Expired - Lifetime
- 2001-09-18 MX MXPA03002446A patent/MXPA03002446A/es active IP Right Grant
- 2001-09-18 AU AU2002241459A patent/AU2002241459A1/en not_active Abandoned
- 2001-09-18 DE DE60107586T patent/DE60107586T2/de not_active Expired - Lifetime
- 2001-09-18 HK HK03104439.8A patent/HK1052182B/en not_active IP Right Cessation
- 2001-09-18 WO PCT/US2001/029062 patent/WO2002044141A2/en not_active Ceased
- 2001-09-18 JP JP2002546511A patent/JP2004514709A/ja active Pending
- 2001-09-18 AR ARP010104401A patent/AR032894A1/es unknown
- 2001-09-18 US US09/955,383 patent/US6762186B2/en not_active Expired - Fee Related
- 2001-09-19 TW TW090123022A patent/TWI228127B/zh not_active IP Right Cessation
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