MXPA03002446A - Imidazoles substituidos como agonistas o antagonistas duales h1 y h3 de histamina. - Google Patents
Imidazoles substituidos como agonistas o antagonistas duales h1 y h3 de histamina.Info
- Publication number
- MXPA03002446A MXPA03002446A MXPA03002446A MXPA03002446A MXPA03002446A MX PA03002446 A MXPA03002446 A MX PA03002446A MX PA03002446 A MXPA03002446 A MX PA03002446A MX PA03002446 A MXPA03002446 A MX PA03002446A MX PA03002446 A MXPA03002446 A MX PA03002446A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted imidazoles
- dual histamine
- histamine
- dual
- imidazoles
- Prior art date
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
- 230000009977 dual effect Effects 0.000 title 1
- 229960001340 histamine Drugs 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23403900P | 2000-09-20 | 2000-09-20 | |
| PCT/US2001/029062 WO2002044141A2 (en) | 2000-09-20 | 2001-09-18 | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03002446A true MXPA03002446A (es) | 2003-06-19 |
Family
ID=22879625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03002446A MXPA03002446A (es) | 2000-09-20 | 2001-09-18 | Imidazoles substituidos como agonistas o antagonistas duales h1 y h3 de histamina. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6762186B2 (https=) |
| EP (1) | EP1318996B1 (https=) |
| JP (1) | JP2004514709A (https=) |
| CN (1) | CN1461304A (https=) |
| AR (1) | AR032894A1 (https=) |
| AT (1) | ATE283853T1 (https=) |
| AU (1) | AU2002241459A1 (https=) |
| CA (1) | CA2422729A1 (https=) |
| DE (1) | DE60107586T2 (https=) |
| ES (1) | ES2233708T3 (https=) |
| HK (1) | HK1052182B (https=) |
| MX (1) | MXPA03002446A (https=) |
| TW (1) | TWI228127B (https=) |
| WO (1) | WO2002044141A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003268117A1 (en) * | 2002-09-18 | 2004-04-08 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparaton and therapeutic uses |
| US8063650B2 (en) | 2002-11-27 | 2011-11-22 | Rambus Inc. | Testing fuse configurations in semiconductor devices |
| WO2004066960A2 (en) * | 2003-01-28 | 2004-08-12 | Schering Corporation | Combination of h1, h3 and h4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
| EP1667955A2 (en) | 2003-07-28 | 2006-06-14 | SmithKline Beecham Corporation | Cycloalkylidene compounds as modulators of the estrogen receptor |
| TWI290140B (en) * | 2003-08-25 | 2007-11-21 | Schering Corp | 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders |
| US20080306087A1 (en) * | 2005-08-08 | 2008-12-11 | Astrazeneca Ab | Therapeutic Agents |
| US20100029681A1 (en) * | 2006-05-26 | 2010-02-04 | Hassan Pajouhesh | Heterocyclic compounds as calcium channel blockers |
| JP5208962B2 (ja) | 2006-12-22 | 2013-06-12 | アベキサ・リミテッド | 二環式ピリミジノンおよびその使用 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| CN110878069A (zh) * | 2019-12-09 | 2020-03-13 | 南京杰运医药科技有限公司 | 一种4-吗琳基-2-乙基哌嗪的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586562B1 (fr) | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| US4829065A (en) * | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| DK0437645T3 (da) * | 1990-01-15 | 1995-05-01 | Heumann Pharma Gmbh & Co | Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse |
| DE59006842D1 (de) | 1990-03-30 | 1994-09-22 | Heumann Pharma Gmbh & Co | Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung. |
| FR2665160A1 (fr) * | 1990-07-26 | 1992-01-31 | Esteve Labor Dr | Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments. |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| DK0618905T3 (da) | 1991-12-18 | 1995-12-04 | Schering Corp | Imidazolyl-alkyl-piperazin- og -diazepinderivater som histamin H3-agonister/antagonister |
| US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| HU213104B (en) * | 1992-06-17 | 1997-02-28 | Richter Gedeon Vegyeszet | Process for producing 4-methyl-2-imidazolinone derivatives and pharmaceutical compositions containing them |
| JPH09505298A (ja) | 1993-11-15 | 1997-05-27 | シェーリング コーポレイション | Ｈ▲下３▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| EP1019050B1 (en) | 1997-06-24 | 2002-03-20 | Novo Nordisk A/S | Use of somatostatin agonists and antagonists for treating diseases related to the eye |
| US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
-
2001
- 2001-09-18 CA CA002422729A patent/CA2422729A1/en not_active Abandoned
- 2001-09-18 AT AT01988119T patent/ATE283853T1/de not_active IP Right Cessation
- 2001-09-18 WO PCT/US2001/029062 patent/WO2002044141A2/en not_active Ceased
- 2001-09-18 US US09/955,383 patent/US6762186B2/en not_active Expired - Fee Related
- 2001-09-18 ES ES01988119T patent/ES2233708T3/es not_active Expired - Lifetime
- 2001-09-18 MX MXPA03002446A patent/MXPA03002446A/es active IP Right Grant
- 2001-09-18 DE DE60107586T patent/DE60107586T2/de not_active Expired - Lifetime
- 2001-09-18 JP JP2002546511A patent/JP2004514709A/ja active Pending
- 2001-09-18 HK HK03104439.8A patent/HK1052182B/en not_active IP Right Cessation
- 2001-09-18 EP EP01988119A patent/EP1318996B1/en not_active Expired - Lifetime
- 2001-09-18 AR ARP010104401A patent/AR032894A1/es unknown
- 2001-09-18 AU AU2002241459A patent/AU2002241459A1/en not_active Abandoned
- 2001-09-18 CN CN01815990A patent/CN1461304A/zh active Pending
- 2001-09-19 TW TW090123022A patent/TWI228127B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI228127B (en) | 2005-02-21 |
| EP1318996B1 (en) | 2004-12-01 |
| DE60107586T2 (de) | 2005-10-06 |
| AR032894A1 (es) | 2003-12-03 |
| ATE283853T1 (de) | 2004-12-15 |
| US6762186B2 (en) | 2004-07-13 |
| HK1052182A1 (en) | 2003-09-05 |
| AU2002241459A1 (en) | 2002-06-11 |
| HK1052182B (en) | 2005-04-01 |
| EP1318996A2 (en) | 2003-06-18 |
| WO2002044141A3 (en) | 2002-11-07 |
| CN1461304A (zh) | 2003-12-10 |
| DE60107586D1 (de) | 2005-01-05 |
| ES2233708T3 (es) | 2005-06-16 |
| WO2002044141A2 (en) | 2002-06-06 |
| CA2422729A1 (en) | 2002-06-06 |
| US20020082278A1 (en) | 2002-06-27 |
| JP2004514709A (ja) | 2004-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |