JP2004509131A - ２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の製造方法 - Google Patents

２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の製造方法 Download PDF

Info

Publication number
JP2004509131A
JP2004509131A JP2002526897A JP2002526897A JP2004509131A JP 2004509131 A JP2004509131 A JP 2004509131A JP 2002526897 A JP2002526897 A JP 2002526897A JP 2002526897 A JP2002526897 A JP 2002526897A JP 2004509131 A JP2004509131 A JP 2004509131A
Authority
JP
Japan
Prior art keywords
hydroxy
oxideprogesterone
dichloromethane
acid
cyclization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002526897A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004509131A5 (https=
Inventor
ブルトン，ヘラルド
ラントス，カルロス　ペー．
ベレイロ　アドリアナ　シルビア
Original Assignee
アプライド　リサーチ　システムズ　エーアールエス　ホールディング　ナームロゼ　フェンノートシャップ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アプライド　リサーチ　システムズ　エーアールエス　ホールディング　ナームロゼ　フェンノートシャップ filed Critical アプライド　リサーチ　システムズ　エーアールエス　ホールディング　ナームロゼ　フェンノートシャップ
Publication of JP2004509131A publication Critical patent/JP2004509131A/ja
Publication of JP2004509131A5 publication Critical patent/JP2004509131A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2002526897A 2000-09-18 2001-09-17 ２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の製造方法 Pending JP2004509131A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00119494 2000-09-18
PCT/EP2001/010734 WO2002022646A2 (en) 2000-09-18 2001-09-17 Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)

Publications (2)

Publication Number Publication Date
JP2004509131A true JP2004509131A (ja) 2004-03-25
JP2004509131A5 JP2004509131A5 (https=) 2005-04-07

Family

ID=8169774

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002526897A Pending JP2004509131A (ja) 2000-09-18 2001-09-17 ２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の製造方法

Country Status (13)

Country Link
US (4) US7071328B2 (https=)
EP (1) EP1325022B1 (https=)
JP (1) JP2004509131A (https=)
AT (1) ATE344273T1 (https=)
AU (2) AU1817902A (https=)
CA (1) CA2419960A1 (https=)
DE (1) DE60124289T2 (https=)
DK (1) DK1325022T3 (https=)
ES (1) ES2271090T3 (https=)
IL (2) IL154776A0 (https=)
PT (1) PT1325022E (https=)
SI (1) SI1325022T1 (https=)
WO (1) WO2002022646A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1325022T1 (sl) * 2000-09-18 2007-04-30 Applied Research Systems Metoda za pripravo 21-hidroksi-6,19-oksidoprogesterona (21oh-6op)
SI1330468T1 (sl) * 2000-09-18 2007-10-31 Serono Lab Ĺ˝veplovi analogi 21-hidroksi-6,19-oksido-progesterona (21oh-6op) za zdravljenje preseĺ˝ka glukokortikoidov
WO2007106385A2 (en) * 2006-03-10 2007-09-20 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment
EP1862468A1 (de) * 2006-06-02 2007-12-05 Bayer Schering Pharma Aktiengesellschaft Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
MX2015004606A (es) 2012-10-09 2017-04-04 Avery Dennison Corp Adhesivos y metodos relacionados.
US20210355154A1 (en) * 2018-09-28 2021-11-18 The Regents Of The University Of Michigan Halogenated Cholesterol Analogues and Methods of Making and Using Same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3036068A (en) * 1960-01-06 1962-05-22 Syntex Sa C-6, 19-steroidal lactones
LU77457A1 (https=) * 1977-05-31 1979-01-19
US4814333A (en) * 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
GB9606016D0 (en) * 1996-03-22 1996-05-22 Smithkline Beecham Plc Novel use
EP0903146A1 (en) * 1997-09-23 1999-03-24 Applied Research Systems ARS Holdings N.V. 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid
ATE332696T1 (de) * 1997-10-06 2006-08-15 Univ Leland Stanford Junior Methode zur behandlung von durch glycocorticoidstörungen verursachten psychosen
SI1330468T1 (sl) * 2000-09-18 2007-10-31 Serono Lab Ĺ˝veplovi analogi 21-hidroksi-6,19-oksido-progesterona (21oh-6op) za zdravljenje preseĺ˝ka glukokortikoidov
SI1325022T1 (sl) * 2000-09-18 2007-04-30 Applied Research Systems Metoda za pripravo 21-hidroksi-6,19-oksidoprogesterona (21oh-6op)

Also Published As

Publication number Publication date
ATE344273T1 (de) 2006-11-15
ES2271090T3 (es) 2007-04-16
AU2002218179B2 (en) 2006-11-16
AU1817902A (en) 2002-03-26
SI1325022T1 (sl) 2007-04-30
EP1325022B1 (en) 2006-11-02
PT1325022E (pt) 2006-12-29
CA2419960A1 (en) 2002-03-21
WO2002022646A2 (en) 2002-03-21
IL154776A (en) 2007-07-04
WO2002022646A3 (en) 2002-06-06
DE60124289T2 (de) 2007-09-06
US20050277769A1 (en) 2005-12-15
US20040092733A1 (en) 2004-05-13
US20090216008A1 (en) 2009-08-27
DK1325022T3 (da) 2007-02-19
EP1325022A2 (en) 2003-07-09
IL154776A0 (en) 2003-10-31
US7071328B2 (en) 2006-07-04
WO2002022646A9 (en) 2002-09-19
DE60124289D1 (de) 2006-12-14
US20070249826A1 (en) 2007-10-25

Similar Documents

Publication Publication Date Title
US20090216008A1 (en) Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
JP3977462B2 (ja) １１−（置換フェニル）−エストラ−４，９−ジエン誘導体
JPS6354391A (ja) ステロイドの製法
JP2001524487A (ja) アンドロゲンステロイド化合物並びにその調製法及び使用法
AU2002218179A1 (en) Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
JP2643943B2 (ja) 新規な６−もしくは７−メチレンアンドロスタ−１，４−ジエン−３，１７−ジオン誘導体およびその製造方法
JP2677626B2 (ja) １７−置換アンドロスタ−１，４−ジエン−３−オン誘導体
JPH08504806A (ja) 親規ステロイド
US4910191A (en) 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
US7479486B2 (en) Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
AU610413B2 (en) 19-fluoro-or cyano-21-hydroxy-progesterone derivatives useful as 19-hydroxylase inhibitors
JPS60252494A (ja) エストロゲン合成阻害剤
WO1993014105A1 (en) Difluoromethylenandrostenone derivatives and process for their preparation
JPS6411039B2 (https=)
JPS604200A (ja) プレグナン系ステロイド化合物
JPH06145193A (ja) 新規なアンドロステンジオン誘導体

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20080625

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080916

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120131

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120703