JP2004509131A5 - - Google Patents
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- Publication number
- JP2004509131A5 JP2004509131A5 JP2002526897A JP2002526897A JP2004509131A5 JP 2004509131 A5 JP2004509131 A5 JP 2004509131A5 JP 2002526897 A JP2002526897 A JP 2002526897A JP 2002526897 A JP2002526897 A JP 2002526897A JP 2004509131 A5 JP2004509131 A5 JP 2004509131A5
- Authority
- JP
- Japan
- Prior art keywords
- carried out
- hydroxy
- molecule
- process according
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 229960003387 progesterone Drugs 0.000 claims 5
- 239000000186 progesterone Substances 0.000 claims 5
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 4
- 230000007062 hydrolysis Effects 0.000 claims 4
- 238000006460 hydrolysis reaction Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 claims 4
- MDJRZSNPHZEMJH-MTMZYOSNSA-N artisone acetate Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 MDJRZSNPHZEMJH-MTMZYOSNSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000007363 ring formation reaction Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- MOIPGXQKZSZOQX-UHFFFAOYSA-N carbonyl bromide Chemical compound BrC(Br)=O MOIPGXQKZSZOQX-UHFFFAOYSA-N 0.000 claims 2
- 230000032050 esterification Effects 0.000 claims 2
- 238000005886 esterification reaction Methods 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 230000000865 phosphorylative effect Effects 0.000 claims 2
- UFDULEKOJAEIRI-UHFFFAOYSA-N (2-acetyloxy-3-iodophenyl) acetate Chemical compound CC(=O)OC1=CC=CC(I)=C1OC(C)=O UFDULEKOJAEIRI-UHFFFAOYSA-N 0.000 claims 1
- LOVNYFVWYTXDRE-WMSSUOLPSA-N 16-Hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(O)[C@H](C(=O)C)[C@@]1(C)CC2 LOVNYFVWYTXDRE-WMSSUOLPSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001263 acyl chlorides Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 238000006552 photochemical reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00119494 | 2000-09-18 | ||
| PCT/EP2001/010734 WO2002022646A2 (en) | 2000-09-18 | 2001-09-17 | Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509131A JP2004509131A (ja) | 2004-03-25 |
| JP2004509131A5 true JP2004509131A5 (https=) | 2005-04-07 |
Family
ID=8169774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526897A Pending JP2004509131A (ja) | 2000-09-18 | 2001-09-17 | ２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7071328B2 (https=) |
| EP (1) | EP1325022B1 (https=) |
| JP (1) | JP2004509131A (https=) |
| AT (1) | ATE344273T1 (https=) |
| AU (2) | AU1817902A (https=) |
| CA (1) | CA2419960A1 (https=) |
| DE (1) | DE60124289T2 (https=) |
| DK (1) | DK1325022T3 (https=) |
| ES (1) | ES2271090T3 (https=) |
| IL (2) | IL154776A0 (https=) |
| PT (1) | PT1325022E (https=) |
| SI (1) | SI1325022T1 (https=) |
| WO (1) | WO2002022646A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1325022T1 (sl) * | 2000-09-18 | 2007-04-30 | Applied Research Systems | Metoda za pripravo 21-hidroksi-6,19-oksidoprogesterona (21oh-6op) |
| SI1330468T1 (sl) * | 2000-09-18 | 2007-10-31 | Serono Lab | Ĺ˝veplovi analogi 21-hidroksi-6,19-oksido-progesterona (21oh-6op) za zdravljenje preseĺ˝ka glukokortikoidov |
| WO2007106385A2 (en) * | 2006-03-10 | 2007-09-20 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment |
| EP1862468A1 (de) * | 2006-06-02 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on |
| DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
| DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
| MX2015004606A (es) | 2012-10-09 | 2017-04-04 | Avery Dennison Corp | Adhesivos y metodos relacionados. |
| US20210355154A1 (en) * | 2018-09-28 | 2021-11-18 | The Regents Of The University Of Michigan | Halogenated Cholesterol Analogues and Methods of Making and Using Same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3036068A (en) * | 1960-01-06 | 1962-05-22 | Syntex Sa | C-6, 19-steroidal lactones |
| LU77457A1 (https=) * | 1977-05-31 | 1979-01-19 | ||
| US4814333A (en) * | 1987-07-28 | 1989-03-21 | The Trustees Of Dartmouth College | Method for treatment of hypercortisolemic, depressed patients |
| GB9606016D0 (en) * | 1996-03-22 | 1996-05-22 | Smithkline Beecham Plc | Novel use |
| EP0903146A1 (en) * | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid |
| ATE332696T1 (de) * | 1997-10-06 | 2006-08-15 | Univ Leland Stanford Junior | Methode zur behandlung von durch glycocorticoidstörungen verursachten psychosen |
| SI1330468T1 (sl) * | 2000-09-18 | 2007-10-31 | Serono Lab | Ĺ˝veplovi analogi 21-hidroksi-6,19-oksido-progesterona (21oh-6op) za zdravljenje preseĺ˝ka glukokortikoidov |
| SI1325022T1 (sl) * | 2000-09-18 | 2007-04-30 | Applied Research Systems | Metoda za pripravo 21-hidroksi-6,19-oksidoprogesterona (21oh-6op) |
-
2001
- 2001-09-17 SI SI200130675T patent/SI1325022T1/sl unknown
- 2001-09-17 DE DE60124289T patent/DE60124289T2/de not_active Expired - Fee Related
- 2001-09-17 AU AU1817902A patent/AU1817902A/xx active Pending
- 2001-09-17 CA CA002419960A patent/CA2419960A1/en not_active Abandoned
- 2001-09-17 US US10/380,167 patent/US7071328B2/en not_active Expired - Fee Related
- 2001-09-17 AU AU2002218179A patent/AU2002218179B2/en not_active Ceased
- 2001-09-17 ES ES01984642T patent/ES2271090T3/es not_active Expired - Lifetime
- 2001-09-17 EP EP01984642A patent/EP1325022B1/en not_active Expired - Lifetime
- 2001-09-17 IL IL15477601A patent/IL154776A0/xx active IP Right Grant
- 2001-09-17 DK DK01984642T patent/DK1325022T3/da active
- 2001-09-17 WO PCT/EP2001/010734 patent/WO2002022646A2/en not_active Ceased
- 2001-09-17 JP JP2002526897A patent/JP2004509131A/ja active Pending
- 2001-09-17 AT AT01984642T patent/ATE344273T1/de not_active IP Right Cessation
- 2001-09-17 PT PT01984642T patent/PT1325022E/pt unknown
-
2003
- 2003-03-05 IL IL154776A patent/IL154776A/en not_active IP Right Cessation
-
2005
- 2005-06-01 US US11/141,029 patent/US20050277769A1/en not_active Abandoned
-
2007
- 2007-04-12 US US11/734,628 patent/US20070249826A1/en not_active Abandoned
-
2009
- 2009-02-09 US US12/367,859 patent/US20090216008A1/en not_active Abandoned
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