JP2004509120A - カスパーゼ阻害剤およびそれらの用途 - Google Patents

カスパーゼ阻害剤およびそれらの用途 Download PDF

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Publication number
JP2004509120A
JP2004509120A JP2002526864A JP2002526864A JP2004509120A JP 2004509120 A JP2004509120 A JP 2004509120A JP 2002526864 A JP2002526864 A JP 2002526864A JP 2002526864 A JP2002526864 A JP 2002526864A JP 2004509120 A JP2004509120 A JP 2004509120A
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group
optionally substituted
disease
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ring
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JP2004509120A5 (OSRAM
Inventor
カリエール，　ジーン−ダミエン
ネテル，　ロナルド
モルティモア，　マイケル
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JP2004509120A publication Critical patent/JP2004509120A/ja
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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JP2002526864A 2000-09-13 2001-09-12 カスパーゼ阻害剤およびそれらの用途 Pending JP2004509120A (ja)

Applications Claiming Priority (2)

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US23257300P 2000-09-13 2000-09-13
PCT/US2001/028450 WO2002022611A2 (en) 2000-09-13 2001-09-12 Caspase inhibitors and uses thereof

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JP2008198860A Division JP2008297321A (ja) 2000-09-13 2008-07-31 カスパーゼ阻害剤およびそれらの用途

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JP2004509120A true JP2004509120A (ja) 2004-03-25
JP2004509120A5 JP2004509120A5 (OSRAM) 2008-09-25

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JP2008198860A Pending JP2008297321A (ja) 2000-09-13 2008-07-31 カスパーゼ阻害剤およびそれらの用途

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US (1) US6800619B2 (OSRAM)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527548A (ja) * 2001-04-19 2004-09-09 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤としての複素環ジカルバミド
JP2006502415A (ja) * 2002-10-10 2006-01-19 ベクトン・ディキンソン・アンド・カンパニー カスパーゼ阻害剤を有するサンプル収集システム
JP2008520620A (ja) * 2004-11-24 2008-06-19 テラプトシス エス アー カスパーゼ−２／−６二重阻害剤として有用な新規ペプチドおよびそれらの生物学的適用
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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020058636A1 (en) * 1994-09-21 2002-05-16 Geoffrey P. Symonds Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
FR2815541B1 (fr) * 2000-10-24 2008-02-29 Lipha Utilisation d'inhibiteurs de l'apoptose des pericytes pour le traitement et/ou la prevention de la retinopathie diabetique
EP1392289A2 (en) * 2001-05-23 2004-03-03 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
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AU2003211052A1 (en) 2002-02-11 2003-09-04 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
AU2003225088A1 (en) * 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
JP4675628B2 (ja) * 2002-12-20 2011-04-27 バーテックス ファーマシューティカルズ インコーポレイテッド ４−オキソ−３−（１−オキソ−１ｈ−イソキノリン−２−イルアセチルアミノ）−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用
ES2272911T3 (es) * 2003-04-25 2007-05-01 Neurofit Sas Uso de derivados de fenotiazina piperazina en la fabricacion de un medicamento con efectos neuroprotector y/o neurotroficos sobre cns y/o pns.
AU2003902704A0 (en) * 2003-05-29 2003-06-19 Crc For Waste Management And Pollution Control Limited Of Unsw Process for producing a nanoscale zero-valent metal
CN102161656B (zh) 2004-02-27 2013-02-20 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
CA2559303C (en) 2004-03-12 2013-09-10 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
CN102362867A (zh) 2004-05-15 2012-02-29 沃泰克斯药物股份有限公司 使用ice抑制剂治疗癫痫发作
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US8012751B2 (en) * 2005-03-31 2011-09-06 Wisconsin Alumni Research Foundation Differentiation of pluripotent embryonic stem cells
JP2009502922A (ja) * 2005-07-28 2009-01-29 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤プロドラッグ
AU2006349611A1 (en) 2005-11-30 2008-05-02 Massachusetts Institute Of Technology Pathogen-detecting cell preservation systems
WO2008008264A2 (en) * 2006-07-07 2008-01-17 The Board Of Trustees Of The Leland Stanford Junior University Selective caspase inhibitors
US8828950B2 (en) * 2007-05-01 2014-09-09 Cedars-Sinai Medical Center Caspase inhibitors in the treatment of infection-associated preterm delivery
EP2288615B1 (en) * 2008-05-21 2017-06-21 Genesis Technologies Limited Selective caspase inhibitors and uses thereof
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
WO2011094426A1 (en) * 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
CN102241627B (zh) * 2010-05-14 2014-07-02 中国人民解放军总医院 脲类化合物及其医药用途
EP2635906A4 (en) 2010-11-05 2014-04-02 Univ Brandeis Ice inhibiting compounds and uses thereof
DK2697246T3 (en) 2011-04-15 2018-05-28 Genesis Tech Limited SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
WO2015175381A1 (en) 2014-05-12 2015-11-19 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitors
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
JP2019500397A (ja) 2015-12-31 2019-01-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤を肝疾患の治療に使用する方法
JP7471818B2 (ja) 2016-08-18 2024-04-22 ヴィダック ファーマ リミテッド ピペラジン誘導体、医薬組成物、及びその使用方法
RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients
IT202300000834A1 (it) 2023-01-20 2024-07-20 Scylla Biotech Srl Inibitori selettivi della caspasi-8 ed usi degli stessi per potenziare le difese innate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500828A (ja) * 1991-11-04 1995-01-26 サンド・リミテッド ＩＬ−１β遊離を阻害するペプチド類
WO1995023222A1 (en) * 1994-02-25 1995-08-31 Khepri Pharmaceuticals, Inc. Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
WO1998016502A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1999047545A2 (en) * 1998-03-19 1999-09-23 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789951A (ja) * 1993-06-03 1995-04-04 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
WO1999018781A1 (en) 1997-10-10 1999-04-22 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
US6153591A (en) 1998-03-16 2000-11-28 Cytovia, Inc. Dipeptide caspase inhibitors and the use thereof
WO2000061542A1 (en) * 1999-04-09 2000-10-19 Cytovia, Inc. Caspase inhibitors and the use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500828A (ja) * 1991-11-04 1995-01-26 サンド・リミテッド ＩＬ−１β遊離を阻害するペプチド類
WO1995023222A1 (en) * 1994-02-25 1995-08-31 Khepri Pharmaceuticals, Inc. Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
WO1998016502A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1999047545A2 (en) * 1998-03-19 1999-09-23 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途
JP2004527548A (ja) * 2001-04-19 2004-09-09 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤としての複素環ジカルバミド
JP2006502415A (ja) * 2002-10-10 2006-01-19 ベクトン・ディキンソン・アンド・カンパニー カスパーゼ阻害剤を有するサンプル収集システム
JP2008520620A (ja) * 2004-11-24 2008-06-19 テラプトシス エス アー カスパーゼ−２／−６二重阻害剤として有用な新規ペプチドおよびそれらの生物学的適用
US8324173B2 (en) 2004-11-24 2012-12-04 Chiesi Farmaceutici S.P.A. Peptides useful as dual caspase-2/-6 inhibitors and their biological applications

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