JP2004508299A - 治療薬としてのマグネシウム結合異常のアンタゴニストと、異常な生理的状態の治療方法 - Google Patents
治療薬としてのマグネシウム結合異常のアンタゴニストと、異常な生理的状態の治療方法 Download PDFInfo
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- JP2004508299A JP2004508299A JP2002517051A JP2002517051A JP2004508299A JP 2004508299 A JP2004508299 A JP 2004508299A JP 2002517051 A JP2002517051 A JP 2002517051A JP 2002517051 A JP2002517051 A JP 2002517051A JP 2004508299 A JP2004508299 A JP 2004508299A
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- G01N2800/00—Detection or diagnosis of diseases
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- G—PHYSICS
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/321—Arterial hypertension
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/635,266 US6455734B1 (en) | 2000-08-09 | 2000-08-09 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| PCT/US2001/024909 WO2002011714A2 (en) | 2000-08-09 | 2001-08-09 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
Publications (2)
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| JP2004508299A true JP2004508299A (ja) | 2004-03-18 |
| JP2004508299A5 JP2004508299A5 (US07982048-20110719-C00001.png) | 2008-09-25 |
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| JP2002517051A Pending JP2004508299A (ja) | 2000-08-09 | 2001-08-09 | 治療薬としてのマグネシウム結合異常のアンタゴニストと、異常な生理的状態の治療方法 |
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| US6372440B2 (en) * | 1999-03-10 | 2002-04-16 | Magnesium Diagnostics, Inc. | Method for detecting deficient cellular membrane tightly bound magnesium for disease diagnoses |
| US20040171093A1 (en) * | 1999-03-10 | 2004-09-02 | Wells Ibert C. | Methods for detecting deficient cellular membrane tightly bound magnesium for disease diagnoses |
| US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| EP1981497A2 (en) | 2006-01-27 | 2008-10-22 | F.Hoffmann-La Roche Ag | Use of substituted 2-imidazole of imidazoline derivatives |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6419053A (en) * | 1987-01-21 | 1989-01-23 | Sandoz Ag | Novel peptide derivative, manufacture and use |
| JPH0225417A (ja) * | 1988-07-12 | 1990-01-26 | Asahi Chem Ind Co Ltd | 抗潰瘍剤 |
| FR2640970A1 (en) * | 1988-12-28 | 1990-06-29 | Pf Medicament | "Z"-1-Phenyl-2-(aminomethyl)cyclopropanecarboxamide derivatives and their therapeutic application |
| JPH02300200A (ja) * | 1989-03-03 | 1990-12-12 | Merck & Co Inc | レニン阻害性ジー、トリ―及びテトラペプチド |
| JPH05230095A (ja) * | 1991-09-12 | 1993-09-07 | Ciba Geigy Ag | 治療薬としての新規５−アミノ−４−ヒドロキシヘキサン酸誘導体 |
| WO1997016188A1 (en) * | 1995-10-30 | 1997-05-09 | Merck & Co., Inc. | Novel inhibitors of peptide binding to mhc class ii proteins |
| JPH09169713A (ja) * | 1995-12-05 | 1997-06-30 | Bristol Myers Squibb Co | β−アミロイド蛋白生成の阻害剤としての５−アミノ−６−シクロヘキシル−４−ヒドロキシ−ヘキサンアミド誘導体 |
| US6011066A (en) * | 1998-02-02 | 2000-01-04 | Veterans General Hospital-Taipei | Method for treating septic shock |
Family Cites Families (116)
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| NL142416B (nl) * | 1969-04-30 | 1974-06-17 | Univ Osaka | Werkwijze voor het bereiden van 6-amino-acylaminopenicillanzuren, alsmede werkwijze voor de bereiding van farmaceutische preparaten. |
| US4097472A (en) | 1974-11-08 | 1978-06-27 | Mitsubishi Chemical Industries Limited | N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof |
| US4073913A (en) | 1974-11-08 | 1978-02-14 | Mitsubishi Chemical Industries Limited | N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| FR2166316A1 (en) * | 1972-01-07 | 1973-08-17 | Toyama Chemical Co Ltd | 7-acylcephalosporins - prepd via a silylated inter |
| IL42124A (en) | 1972-05-02 | 1977-02-28 | Kabi Ab | Substrate for the determination of proteolytic enzymes |
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- 2001-08-09 NZ NZ523915A patent/NZ523915A/en unknown
- 2001-08-09 DE DE60119385T patent/DE60119385D1/de not_active Expired - Lifetime
- 2001-08-09 AT AT01961984T patent/ATE324881T1/de not_active IP Right Cessation
- 2001-08-09 JP JP2002517051A patent/JP2004508299A/ja active Pending
- 2001-08-09 CA CA002418951A patent/CA2418951A1/en not_active Abandoned
- 2001-08-09 EP EP01961984A patent/EP1355638B1/en not_active Expired - Lifetime
- 2001-08-09 WO PCT/US2001/024909 patent/WO2002011714A2/en active IP Right Grant
-
2002
- 2002-08-29 US US10/230,133 patent/US6664420B2/en not_active Expired - Fee Related
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2003
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2004
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2005
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2006
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2007
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2008
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2009
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-
2010
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2011
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2012
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Also Published As
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| US7132537B2 (en) | 2006-11-07 |
| WO2002011714A2 (en) | 2002-02-14 |
| US6855826B2 (en) | 2005-02-15 |
| US20070010535A1 (en) | 2007-01-11 |
| US20070197659A1 (en) | 2007-08-23 |
| US20100048711A1 (en) | 2010-02-25 |
| AU2001283203A1 (en) | 2002-02-18 |
| US6455734B1 (en) | 2002-09-24 |
| US6664420B2 (en) | 2003-12-16 |
| US20030040625A1 (en) | 2003-02-27 |
| US20120142781A1 (en) | 2012-06-07 |
| CA2418951A1 (en) | 2002-02-14 |
| US7211667B2 (en) | 2007-05-01 |
| NZ523915A (en) | 2005-05-27 |
| US7795450B2 (en) | 2010-09-14 |
| US7405311B2 (en) | 2008-07-29 |
| US8129545B2 (en) | 2012-03-06 |
| US20060069259A1 (en) | 2006-03-30 |
| US20110281923A1 (en) | 2011-11-17 |
| US7982048B2 (en) | 2011-07-19 |
| US7619097B2 (en) | 2009-11-17 |
| US20090030080A1 (en) | 2009-01-29 |
| EP1355638B1 (en) | 2006-05-03 |
| US20050096279A1 (en) | 2005-05-05 |
| US7041829B2 (en) | 2006-05-09 |
| US20110021633A1 (en) | 2011-01-27 |
| ATE324881T1 (de) | 2006-06-15 |
| US20040110692A1 (en) | 2004-06-10 |
| DE60119385D1 (de) | 2006-06-08 |
| WO2002011714A3 (en) | 2003-08-14 |
| EP1355638A2 (en) | 2003-10-29 |
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