JP2004508066A5 - - Google Patents

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Publication number
JP2004508066A5
JP2004508066A5 JP2002527274A JP2002527274A JP2004508066A5 JP 2004508066 A5 JP2004508066 A5 JP 2004508066A5 JP 2002527274 A JP2002527274 A JP 2002527274A JP 2002527274 A JP2002527274 A JP 2002527274A JP 2004508066 A5 JP2004508066 A5 JP 2004508066A5
Authority
JP
Japan
Prior art keywords
tnk
tpa
cell line
vector
plasminogen activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002527274A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004508066A (ja
Filing date
Publication date
Priority claimed from PCT/CN2000/000260 external-priority patent/WO2002020802A1/zh
Application filed filed Critical
Publication of JP2004508066A publication Critical patent/JP2004508066A/ja
Publication of JP2004508066A5 publication Critical patent/JP2004508066A5/ja
Pending legal-status Critical Current

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JP2002527274A 2000-09-04 2001-02-16 一種の突然変異型のヒト組織型プラスミノゲン活性剤を発現する細胞株、構築方法及び発現蛋白の調剤方法 Pending JP2004508066A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2000/000260 WO2002020802A1 (en) 2000-09-04 2000-09-04 A cell line expressing mutant human tissue-type plasminogen activator, constructing strategy and method of expressed protein preparation
PCT/CN2001/000127 WO2002022832A1 (en) 2000-09-04 2001-02-16 A cell line expressing mutated human tissue - type plasminogen activator, the constructing strategy thereof and method of preparing expressed protein

Publications (2)

Publication Number Publication Date
JP2004508066A JP2004508066A (ja) 2004-03-18
JP2004508066A5 true JP2004508066A5 (enExample) 2005-02-24

Family

ID=4574691

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002527274A Pending JP2004508066A (ja) 2000-09-04 2001-02-16 一種の突然変異型のヒト組織型プラスミノゲン活性剤を発現する細胞株、構築方法及び発現蛋白の調剤方法

Country Status (6)

Country Link
US (1) US7632677B2 (enExample)
EP (1) EP1323826A4 (enExample)
JP (1) JP2004508066A (enExample)
CN (1) CN1216149C (enExample)
AU (2) AU2000268170A1 (enExample)
WO (2) WO2002020802A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112111475B (zh) * 2020-09-24 2021-07-20 江苏丰华生物制药有限公司 一种经上皮细胞转运能力增强的TNK-tPA融合蛋白及其应用
CN112490602B (zh) * 2020-10-19 2021-09-24 电子科技大学 一种基于多层结构的THz导波调控装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3613390C2 (de) 1985-04-22 2001-10-11 Genentech Inc Einkettige Human-Gewebeplasminogen-Aktivator (t-PA)-Mutanten, kodierende DNA, Expressionsvektor, Mikroorganismus, Zellkultur und pharmazeutische Zusammensetzung
DE3684680D1 (de) * 1985-12-23 1992-05-07 Chiron Corp Peptidplasminogenaktivatoren.
PT86162B (pt) * 1986-11-21 1990-11-20 Smithkline Beecham Corp Expressao de proteina recombinante
EP0340573A3 (de) * 1988-04-30 1990-05-30 BASF Aktiengesellschaft Neue Proteine, ihre Herstellung und Verwendung
DE3927865A1 (de) * 1989-08-23 1991-02-28 Boehringer Mannheim Gmbh T-pa-mutante gk1l
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
US5795737A (en) * 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
CN1113099C (zh) * 1996-10-26 2003-07-02 湖南医科大学 用于基因治疗的新的载体
AU2000258017A1 (en) * 2000-07-17 2002-02-13 Jiahui Xia Human source gene leading sequence, gene vector and gene expression strategy
CN1148228C (zh) * 2000-08-30 2004-05-05 夏家辉 治疗血友病b的基因药物及其制备方法

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