JP2004507472A5 - - Google Patents
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- Publication number
- JP2004507472A5 JP2004507472A5 JP2002522698A JP2002522698A JP2004507472A5 JP 2004507472 A5 JP2004507472 A5 JP 2004507472A5 JP 2002522698 A JP2002522698 A JP 2002522698A JP 2002522698 A JP2002522698 A JP 2002522698A JP 2004507472 A5 JP2004507472 A5 JP 2004507472A5
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- sulfate
- linked
- collagen
- polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000011159 matrix material Substances 0.000 description 34
- 108090000623 proteins and genes Proteins 0.000 description 17
- 150000004676 glycans Chemical class 0.000 description 16
- 229920001282 polysaccharide Polymers 0.000 description 16
- 239000005017 polysaccharide Substances 0.000 description 16
- 229920000642 polymer Polymers 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 14
- 108010035532 Collagen Proteins 0.000 description 13
- 102000008186 Collagen Human genes 0.000 description 13
- 229920001436 collagen Polymers 0.000 description 13
- 238000000034 method Methods 0.000 description 9
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 8
- 229920002674 hyaluronan Polymers 0.000 description 8
- 229960003160 hyaluronic acid Drugs 0.000 description 8
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 6
- 108010088751 Albumins Proteins 0.000 description 6
- 229920002101 Chitin Polymers 0.000 description 6
- 229920001661 Chitosan Polymers 0.000 description 6
- 229920001287 Chondroitin sulfate Polymers 0.000 description 6
- 229920000045 Dermatan sulfate Polymers 0.000 description 6
- 229920002307 Dextran Polymers 0.000 description 6
- 102000008946 Fibrinogen Human genes 0.000 description 6
- 108010049003 Fibrinogen Proteins 0.000 description 6
- 108010067306 Fibronectins Proteins 0.000 description 6
- 102000016359 Fibronectins Human genes 0.000 description 6
- 229920002971 Heparan sulfate Polymers 0.000 description 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 6
- 229920000288 Keratan sulfate Polymers 0.000 description 6
- 108010085895 Laminin Proteins 0.000 description 6
- 102000007547 Laminin Human genes 0.000 description 6
- 108010031318 Vitronectin Proteins 0.000 description 6
- 102100035140 Vitronectin Human genes 0.000 description 6
- 229920000615 alginic acid Polymers 0.000 description 6
- 235000010443 alginic acid Nutrition 0.000 description 6
- 229940059329 chondroitin sulfate Drugs 0.000 description 6
- 229940051593 dermatan sulfate Drugs 0.000 description 6
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 6
- 229960002086 dextran Drugs 0.000 description 6
- -1 dextran sulfate Polymers 0.000 description 6
- 229960000633 dextran sulfate Drugs 0.000 description 6
- 229940012952 fibrinogen Drugs 0.000 description 6
- 229920000669 heparin Polymers 0.000 description 6
- 229960002897 heparin Drugs 0.000 description 6
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 6
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 5
- 229940072056 alginate Drugs 0.000 description 5
- 239000002299 complementary DNA Substances 0.000 description 5
- 239000003102 growth factor Substances 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 4
- 229940014041 hyaluronate Drugs 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 229940088623 biologically active substance Drugs 0.000 description 3
- 229920006037 cross link polymer Polymers 0.000 description 3
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 3
- 230000017423 tissue regeneration Effects 0.000 description 3
- 229920001744 Polyaldehyde Polymers 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000561734 Celosia cristata Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/652,604 US6773723B1 (en) | 2000-08-30 | 2000-08-30 | Collagen/polysaccharide bilayer matrix |
| PCT/US2001/025017 WO2002017713A1 (en) | 2000-08-30 | 2001-08-10 | Collagen/polysaccharide bilayer matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004507472A JP2004507472A (ja) | 2004-03-11 |
| JP2004507472A5 true JP2004507472A5 (https=) | 2008-11-06 |
Family
ID=24617433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522698A Ceased JP2004507472A (ja) | 2000-08-30 | 2001-08-10 | コラーゲン／多糖類二層性マトリックス |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6773723B1 (https=) |
| EP (1) | EP1320295A4 (https=) |
| JP (1) | JP2004507472A (https=) |
| AU (2) | AU2001283239B2 (https=) |
| CA (1) | CA2419935A1 (https=) |
| NZ (1) | NZ524500A (https=) |
| WO (1) | WO2002017713A1 (https=) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115557B2 (en) * | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
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| US20030118560A1 (en) * | 2001-12-20 | 2003-06-26 | Kelly Sheila J. | Composite biocompatible matrices |
| US20050069572A1 (en) * | 2002-10-09 | 2005-03-31 | Jennifer Elisseeff | Multi-layered polymerizing hydrogels for tissue regeneration |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| US20050136112A1 (en) * | 2003-12-19 | 2005-06-23 | Pediamed Pharmaceuticals, Inc. | Oral medicament delivery system |
| US20050283256A1 (en) * | 2004-02-09 | 2005-12-22 | Codman & Shurtleff, Inc. | Collagen device and method of preparing the same |
| EP1731180B1 (en) * | 2004-03-31 | 2017-10-11 | Nipro Corporation | Antiadhesive kit, process for producing the same and method of adhesion prevention |
| KR20070057932A (ko) * | 2004-09-15 | 2007-06-07 | 오츠카 세이야쿠 가부시키가이샤 | 경점막용 조성물, 및 경점막 흡수의 향상 방법 |
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| EP2816964B1 (en) | 2012-02-21 | 2023-12-27 | Ben-Gurion University of The Negev Research and Development Authority | Hydrogel system comprising spatially separated bioactive polypeptides |
| MX368000B (es) | 2012-03-22 | 2019-09-13 | Trb Chemedica Int S A | Composición de colágeno y ácido hialurónico para la reparación de ligamento o tendón. |
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-
2000
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2001
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- 2001-08-10 AU AU2001283239A patent/AU2001283239B2/en not_active Ceased
- 2001-08-10 CA CA002419935A patent/CA2419935A1/en not_active Abandoned
- 2001-08-10 AU AU8323901A patent/AU8323901A/xx active Pending
- 2001-08-10 EP EP01962023A patent/EP1320295A4/en not_active Withdrawn
- 2001-08-10 JP JP2002522698A patent/JP2004507472A/ja not_active Ceased
- 2001-08-10 WO PCT/US2001/025017 patent/WO2002017713A1/en not_active Ceased
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2004
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- 2004-06-14 US US10/868,046 patent/US6936276B2/en not_active Expired - Fee Related
- 2004-06-14 US US10/868,043 patent/US6939562B2/en not_active Expired - Fee Related
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