JP2004504032A - 性的機能不全の処置用の新規なヒト可溶性分泌エンドペプチダーゼ（ｓｅｐ） - Google Patents

性的機能不全の処置用の新規なヒト可溶性分泌エンドペプチダーゼ（ｓｅｐ） Download PDF

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JP2004504032A
JP2004504032A JP2002512384A JP2002512384A JP2004504032A JP 2004504032 A JP2004504032 A JP 2004504032A JP 2002512384 A JP2002512384 A JP 2002512384A JP 2002512384 A JP2002512384 A JP 2002512384A JP 2004504032 A JP2004504032 A JP 2004504032A
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polypeptide
sep
human sep
sequence
human
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JP2004504032A5 (enExample
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ハロー，イアン・デニス
ステイシー，ピーター
ウォルシュ，ロデリック・トーマス
ウェイマン，クリストファー・ピーター
フィリップス，スティーヴン・チャールズ
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ファイザー・インク
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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    • G01N2800/344—Disorders of the penis and the scrotum and erectile dysfuncrion

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JP2002512384A 2000-07-14 2001-07-16 性的機能不全の処置用の新規なヒト可溶性分泌エンドペプチダーゼ（ｓｅｐ） Pending JP2004504032A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0017387.2A GB0017387D0 (en) 2000-07-14 2000-07-14 Novel enzyme
PCT/IB2001/001263 WO2002006492A1 (en) 2000-07-14 2001-07-16 A novel human soluble secreted endopeptidase (sep) for the treatment of sexual dysunfction

Publications (2)

Publication Number Publication Date
JP2004504032A true JP2004504032A (ja) 2004-02-12
JP2004504032A5 JP2004504032A5 (enExample) 2005-02-24

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ID=9895717

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JP2002512384A Pending JP2004504032A (ja) 2000-07-14 2001-07-16 性的機能不全の処置用の新規なヒト可溶性分泌エンドペプチダーゼ（ｓｅｐ）

Country Status (8)

Country Link
US (1) US6878529B2 (enExample)
EP (1) EP1303619A1 (enExample)
JP (1) JP2004504032A (enExample)
AU (1) AU2001269371A1 (enExample)
CA (1) CA2415557A1 (enExample)
GB (1) GB0017387D0 (enExample)
MX (1) MXPA03000426A (enExample)
WO (1) WO2002006492A1 (enExample)

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US6650943B1 (en) 2000-04-07 2003-11-18 Advanced Bionics Corporation Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction
GB0017387D0 (en) * 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme
US6991916B2 (en) * 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
US6885895B1 (en) * 2001-04-26 2005-04-26 Advanced Bionics Corporation Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction
AR039352A1 (es) * 2001-05-18 2005-02-16 Solvay Pharm Gmbh Uso de un compuesto que tiene actividad inhibitoria combinada y concurrente con endopeptidasa neutra y metaloproteasa igs5.
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
EP1753433A1 (en) * 2004-05-14 2007-02-21 Solvay Pharmaceuticals GmbH Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and pde v inhibitors
JP4940135B2 (ja) * 2004-05-17 2012-05-30 ギブン イメージング リミテッド 生体内生検のための方法、システムおよびデバイス
EP2131900B1 (en) 2007-03-19 2018-05-30 Insuline Medical Ltd. Drug delivery device
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
RU2532893C2 (ru) 2008-11-07 2014-11-10 Инсьюлин Медикал Лтд. Устройство и способ доставки лекарственных средств
PT3192500T (pt) 2009-05-19 2021-01-05 Neuroderm Ltd Composições para a administração contínua de inibidores da dopa decarboxilase
DK2640358T3 (en) 2010-11-15 2018-04-16 Neuroderm Ltd CONTINUOUS ADMINISTRATION OF L-DOPA, DOPA-DECARBOXYLASE INHIBITORS, CATECHOL-O-METHYL TRANSFERASE INHIBITORS AND COMPOSITIONS THEREOF
WO2013025261A2 (en) * 2011-04-06 2013-02-21 Georgia Tech Research Corporation Fluorogenic peptide probes and assays
US9375202B2 (en) 2012-05-04 2016-06-28 Given Imaging Ltd. Device and method for in vivo cytology acquisition
EP2854764B1 (en) 2012-06-05 2018-12-12 Neuroderm Ltd Compositions comprising apomorphine and organic acids and uses thereof
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
PL3777833T3 (pl) 2014-03-13 2024-03-25 Neuroderm Ltd. Kompozycje inhibitorów dekarboksylazy dopa
CN112546453B (zh) * 2020-10-15 2022-11-29 西安蓝极医疗电子科技有限公司 基于激光照射治疗男性勃起功能障碍的发光体组件及装置
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

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FR2777291B1 (fr) 1998-04-08 2000-07-07 Inst Nat Sante Rech Med Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
CA2260376A1 (en) 1999-02-11 2000-08-11 Universite De Montreal New metalloproteases of the neprilysin family
EP1069188A1 (en) 1999-07-15 2001-01-17 Sanofi-Synthelabo Three neprilysin-like membrane metallopeptidases
GB0017387D0 (en) * 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme

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US6878529B2 (en) 2005-04-12
MXPA03000426A (es) 2003-06-24
WO2002006492A1 (en) 2002-01-24
EP1303619A1 (en) 2003-04-23
CA2415557A1 (en) 2002-01-24
GB0017387D0 (en) 2000-08-30
US20020102707A1 (en) 2002-08-01
AU2001269371A1 (en) 2002-01-30

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