JP2004504032A5 - - Google Patents

Info

Publication number

JP2004504032A5

JP2004504032A5 JP2002512384A JP2002512384A JP2004504032A5 JP 2004504032 A5 JP2004504032 A5 JP 2004504032A5 JP 2002512384 A JP2002512384 A JP 2002512384A JP 2002512384 A JP2002512384 A JP 2002512384A JP 2004504032 A5 JP2004504032 A5 JP 2004504032A5

Authority

JP

Japan

Prior art keywords

polypeptide

pharmaceutical composition

sep

activity

seq

Prior art date

2001-07-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 19
• 102000004196 processed proteins & peptides Human genes 0.000 claims 18
• 229920001184 polypeptide Polymers 0.000 claims 17
• 230000000694 effects Effects 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 5
• 206010057671 Female sexual dysfunction Diseases 0.000 claims 3
• 201000001880 Sexual dysfunction Diseases 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 231100000872 sexual dysfunction Toxicity 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102000005593 Endopeptidases Human genes 0.000 claims 2
• 108010059378 Endopeptidases Proteins 0.000 claims 2
• 102000048186 Endothelin-converting enzyme 1 Human genes 0.000 claims 2
• 108030001679 Endothelin-converting enzyme 1 Proteins 0.000 claims 2
• 208000021663 Female sexual arousal disease Diseases 0.000 claims 2
• 206010057672 Male sexual dysfunction Diseases 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000002299 complementary DNA Substances 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 230000003248 secreting effect Effects 0.000 claims 2
• 102000015427 Angiotensins Human genes 0.000 claims 1
• 108010064733 Angiotensins Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
• 102000003729 Neprilysin Human genes 0.000 claims 1
• 108090000028 Neprilysin Proteins 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 201000001881 impotence Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1