JP2004503546A5 - - Google Patents
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- Publication number
- JP2004503546A5 JP2004503546A5 JP2002510461A JP2002510461A JP2004503546A5 JP 2004503546 A5 JP2004503546 A5 JP 2004503546A5 JP 2002510461 A JP2002510461 A JP 2002510461A JP 2002510461 A JP2002510461 A JP 2002510461A JP 2004503546 A5 JP2004503546 A5 JP 2004503546A5
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- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- independently
- configuration
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 description 9
- -1 benzyloxymethyl Chemical group 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 4
- ZMGMDXCADSRNCX-UHFFFAOYSA-N 5,6-dihydroxy-1,3-diazepan-2-one Chemical class OC1CNC(=O)NCC1O ZMGMDXCADSRNCX-UHFFFAOYSA-N 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000000320 amidine group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR00/07507 | 2000-06-13 | ||
| FR0007507A FR2810039B1 (fr) | 2000-06-13 | 2000-06-13 | Composes urees cycliques et leur procede de preparation |
| PCT/FR2001/001837 WO2001096318A1 (fr) | 2000-06-13 | 2001-06-13 | Composes urees cycliques et leur procede de preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004503546A JP2004503546A (ja) | 2004-02-05 |
| JP2004503546A5 true JP2004503546A5 (enExample) | 2008-07-17 |
| JP5054877B2 JP5054877B2 (ja) | 2012-10-24 |
Family
ID=8851208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510461A Expired - Fee Related JP5054877B2 (ja) | 2000-06-13 | 2001-06-13 | 環式尿素化合物及びその調製方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7186828B2 (enExample) |
| EP (2) | EP1640368A3 (enExample) |
| JP (1) | JP5054877B2 (enExample) |
| KR (1) | KR20030031001A (enExample) |
| AT (1) | ATE386728T1 (enExample) |
| AU (2) | AU6764501A (enExample) |
| CA (2) | CA2412782C (enExample) |
| DE (1) | DE60132891T2 (enExample) |
| DK (1) | DK1289968T3 (enExample) |
| ES (1) | ES2301554T3 (enExample) |
| FR (1) | FR2810039B1 (enExample) |
| IL (1) | IL153408A0 (enExample) |
| WO (1) | WO2001096318A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006016168D1 (de) * | 2005-12-29 | 2010-09-23 | Immupharma France Sa | 1,3,5-triazepin-dionen zur Behandlung von Malaria |
| AU2006331355B2 (en) * | 2005-12-29 | 2011-09-29 | Immupharma France Sa | Compositions and methods for the inhibition of phospholipase A2 |
| US7777030B2 (en) | 2005-12-29 | 2010-08-17 | Centre National de la Recherge Scientifique (CNRS) | Compositions and methods for the treatment and prevention of disease |
| AU2006331357B2 (en) * | 2005-12-29 | 2012-05-17 | Immupharma France Sa | Compositions and methods for synthesizing novel heterocyclic therapeutics |
| JP2009522236A (ja) * | 2005-12-29 | 2009-06-11 | イミュファルマ・フランス・エスアー | マラリアまたはエイズの処置のためのアザ複素環化合物 |
| US8563115B2 (en) | 2008-08-12 | 2013-10-22 | Xerox Corporation | Protective coatings for solid inkjet applications |
| US8191992B2 (en) * | 2008-12-15 | 2012-06-05 | Xerox Corporation | Protective coatings for solid inkjet applications |
| EP2548869A1 (en) * | 2011-07-20 | 2013-01-23 | Cytec Technology Corp. | Process for the Synthesis of N-substituted Cyclic Alkylene Ureas |
| CN102911130B (zh) * | 2011-08-03 | 2015-05-20 | 北京师范大学 | 一种一锅法合成脲四元环化合物的方法、合成的脲四元环化合物 |
| EP3640263A1 (en) | 2013-08-21 | 2020-04-22 | UREKA Sarl | Peptide-oligourea chimeric compounds and methods of their use |
| WO2016207726A1 (en) | 2015-06-22 | 2016-12-29 | Ureka Sarl | Bioinspired catalysis using oligourea helical foldamers |
| WO2017037142A1 (en) | 2015-08-31 | 2017-03-09 | Centre National De La Recherche Scientifique (Cnrs) | Foldamer helix bundle-based molecular encapsulation |
| AU2017252015A1 (en) | 2016-04-19 | 2018-11-08 | Ureka Sarl | Peptide-oligourea foldamer compounds and methods of their use |
| US12434075B2 (en) * | 2021-05-11 | 2025-10-07 | Celestial Oncology Inc. | Coupled robotic radiation therapy system |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2847760A1 (de) * | 1978-11-03 | 1980-05-14 | Hoechst Ag | Verfahren zur herstellung von 1,3,5-triaza-2,4,6-triketo-cycloheptan- 3,5-di-essigsaeureestern |
| US4918186A (en) * | 1986-05-06 | 1990-04-17 | Mitsui Toatsu Chemicals, Inc. | Process for producing cyclic ureas |
| KR100268694B1 (ko) * | 1991-10-11 | 2000-10-16 | 미리암 디. 메코너헤이, 블레어큐. 퍼거슨 | 레트로바이러스 프로테아제 억제제로 유용한 시클릭 우레아 및 유사체 |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| US5637780A (en) | 1993-03-30 | 1997-06-10 | The Dupont Merck Pharmaceutical Company | Method for preparing alkylating agents and their use for alkylating cyclic ureas |
| US5508400A (en) * | 1994-04-20 | 1996-04-16 | The Du Pont Merck Pharmaceutical Company | Preparation of cyclic urea compounds |
| AU5310096A (en) * | 1995-03-17 | 1996-10-08 | Du Pont Merck Pharmaceutical Company, The | Cyclic urea hiv protease inhibitors |
| US5532356A (en) * | 1995-06-06 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N,N'-disubstituted cyclic ureas |
| US5532357A (en) * | 1995-06-07 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
| WO1997008150A1 (en) | 1995-08-22 | 1997-03-06 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors |
| NZ335919A (en) | 1996-11-08 | 2000-09-29 | Du Pont Pharm Co | (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
-
2000
- 2000-06-13 FR FR0007507A patent/FR2810039B1/fr not_active Expired - Lifetime
-
2001
- 2001-06-13 CA CA2412782A patent/CA2412782C/en not_active Expired - Lifetime
- 2001-06-13 KR KR1020027016995A patent/KR20030031001A/ko not_active Withdrawn
- 2001-06-13 EP EP05015015A patent/EP1640368A3/fr not_active Withdrawn
- 2001-06-13 JP JP2002510461A patent/JP5054877B2/ja not_active Expired - Fee Related
- 2001-06-13 AU AU6764501A patent/AU6764501A/xx active Pending
- 2001-06-13 DK DK01945420T patent/DK1289968T3/da active
- 2001-06-13 CA CA2778314A patent/CA2778314C/en not_active Expired - Lifetime
- 2001-06-13 EP EP01945420A patent/EP1289968B1/fr not_active Expired - Lifetime
- 2001-06-13 US US10/311,178 patent/US7186828B2/en not_active Expired - Lifetime
- 2001-06-13 IL IL15340801A patent/IL153408A0/xx unknown
- 2001-06-13 AU AU2001267645A patent/AU2001267645B2/en not_active Ceased
- 2001-06-13 DE DE60132891T patent/DE60132891T2/de not_active Expired - Lifetime
- 2001-06-13 ES ES01945420T patent/ES2301554T3/es not_active Expired - Lifetime
- 2001-06-13 WO PCT/FR2001/001837 patent/WO2001096318A1/fr not_active Ceased
- 2001-06-13 AT AT01945420T patent/ATE386728T1/de not_active IP Right Cessation
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