JP2004503525A5 - - Google Patents
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- Publication number
- JP2004503525A5 JP2004503525A5 JP2002510429A JP2002510429A JP2004503525A5 JP 2004503525 A5 JP2004503525 A5 JP 2004503525A5 JP 2002510429 A JP2002510429 A JP 2002510429A JP 2002510429 A JP2002510429 A JP 2002510429A JP 2004503525 A5 JP2004503525 A5 JP 2004503525A5
- Authority
- JP
- Japan
- Prior art keywords
- chem
- trans
- chiral
- cispentacin
- pharm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 2
- JWYOAMOZLZXDER-UHNVWZDZSA-N (1r,2s)-2-azaniumylcyclopentane-1-carboxylate Chemical compound N[C@H]1CCC[C@H]1C(O)=O JWYOAMOZLZXDER-UHNVWZDZSA-N 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000011914 asymmetric synthesis Methods 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical class OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00112577 | 2000-06-14 | ||
| PCT/EP2001/006541 WO2001096285A1 (en) | 2000-06-14 | 2001-06-08 | Beta-amino acid nitrile derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004503525A JP2004503525A (ja) | 2004-02-05 |
| JP2004503525A5 true JP2004503525A5 (https=) | 2005-02-03 |
| JP3872427B2 JP3872427B2 (ja) | 2007-01-24 |
Family
ID=8168969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510429A Expired - Fee Related JP3872427B2 (ja) | 2000-06-14 | 2001-06-08 | β−アミノ酸ニトリル誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6462076B2 (https=) |
| EP (1) | EP1294679B1 (https=) |
| JP (1) | JP3872427B2 (https=) |
| KR (1) | KR20030029057A (https=) |
| CN (1) | CN1324006C (https=) |
| AR (1) | AR031594A1 (https=) |
| AT (1) | ATE304997T1 (https=) |
| AU (2) | AU2001266056B2 (https=) |
| BR (1) | BR0111733A (https=) |
| CA (1) | CA2410303C (https=) |
| DE (1) | DE60113533T2 (https=) |
| EC (1) | ECSP024383A (https=) |
| ES (1) | ES2248346T3 (https=) |
| HR (1) | HRP20020963A2 (https=) |
| HU (1) | HUP0300896A3 (https=) |
| IL (1) | IL153166A0 (https=) |
| JO (1) | JO2234B1 (https=) |
| MA (1) | MA26913A1 (https=) |
| MX (1) | MXPA02012253A (https=) |
| NO (1) | NO20025823D0 (https=) |
| NZ (1) | NZ522587A (https=) |
| PE (1) | PE20020064A1 (https=) |
| PL (1) | PL359811A1 (https=) |
| RU (1) | RU2245871C2 (https=) |
| UY (1) | UY26769A1 (https=) |
| WO (1) | WO2001096285A1 (https=) |
| YU (1) | YU90802A (https=) |
| ZA (1) | ZA200209415B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9916575D0 (en) * | 1999-07-15 | 1999-09-15 | Cambridge Combinatorial Ltd | Solid phase nitrile synthesis |
| CA2439415C (en) * | 2001-03-02 | 2011-09-20 | Merck Frosst Canada & Co. | Cathepsin cysteine protease inhibitors |
| JP2005502700A (ja) * | 2001-09-13 | 2005-01-27 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｃｒ−３受容体アンタゴニストｖ |
| HUP0402344A2 (hu) * | 2001-12-04 | 2005-02-28 | F. Hoffmann-La Roche Ag | Helyettesített 2-amino-cikloalkán-karboxamidok, felhasználásuk cisztein-proteáz-inhibitorként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| US6759428B2 (en) * | 2001-12-04 | 2004-07-06 | Roche Palo Alto Llc | Indole nitriles |
| ATE469645T1 (de) * | 2002-10-23 | 2010-06-15 | Bristol Myers Squibb Co | Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv |
| RU2005141533A (ru) * | 2003-06-02 | 2006-08-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Бензамиднитрильные производные |
| WO2005000793A1 (ja) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | ２位置換シクロアルキルカルボン酸誘導体 |
| JP4690319B2 (ja) | 2003-06-30 | 2011-06-01 | メルク フロスト カナダ リミテツド | カテプシンシステインプロテアーゼ阻害剤 |
| EP1841730A4 (en) * | 2005-01-19 | 2010-10-27 | Merck Frosst Canada Ltd | CATHEPSIN K INHIBITORS AND ATHEROSCLEROSIS |
| CN103172568A (zh) * | 2005-07-06 | 2013-06-26 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
| US7893099B2 (en) * | 2009-06-11 | 2011-02-22 | Hoffman-La Roche Inc. | Cyclopentane derivatives |
| MY169319A (en) * | 2011-07-26 | 2019-03-21 | Sanofi Sa | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
| CN103086923B (zh) * | 2013-01-21 | 2014-04-23 | 吉林大学 | 肼腈类组织蛋白酶k抑制剂及其在治疗骨质疏松症方面的应用 |
| CN105593230B (zh) * | 2013-10-08 | 2018-07-06 | 默沙东公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| NO2699580T3 (https=) | 2014-01-24 | 2018-02-24 | ||
| CN105837479B (zh) * | 2016-04-05 | 2017-10-27 | 吉林大学 | 肼腈类组织蛋白酶k抑制剂及其在制备治疗骨关节炎药物中的应用 |
| HUE070049T2 (hu) | 2018-03-01 | 2025-05-28 | Astrazeneca Ab | (2S)-{(1S)-1-ciano-2-[4-(3-metil-2-oxo-2,3-dihidro-1,3-benzoxazol-5-il)fenil]etil} -1,4-oxazepán-2-karboxamidot tartalmazó gyógyászati készítmények |
| WO2020018547A1 (en) | 2018-07-17 | 2020-01-23 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis |
| CN113045491B (zh) * | 2019-12-26 | 2024-09-06 | 罗欣药业(上海)有限公司 | 一种仑伐替尼及中间体的制备方法 |
| CN115996923B (zh) | 2020-08-26 | 2025-07-18 | 海思科医药集团股份有限公司 | 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途 |
| KR20230117738A (ko) | 2020-12-04 | 2023-08-09 | 레이스톤 바이오파마 컴퍼니 리미티드 | 카텝신 c의 소분자 억제제 및 이의 의약적 용도 |
| EP4538271A4 (en) | 2022-06-07 | 2025-10-08 | Reistone Biopharma Company Ltd | POLYMORPH OF BENZO[C]CHROMANE COMPOUND, ITS PREPARATION METHOD AND ITS USE |
| TW202404961A (zh) | 2022-06-07 | 2024-02-01 | 大陸商瑞石生物醫藥有限公司 | 苯并［ｃ］色滿化合物的可藥用鹽、其多晶型及用途 |
| JP2026503035A (ja) | 2023-01-06 | 2026-01-27 | インスメッド インコーポレイテッド | 新規な可逆性ｄｐｐ１阻害剤及びその用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177576B (en) | 1975-06-02 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 2-amino-cyclohexane carboxylic acid,its amides and similar compounds |
| HU185876B (en) * | 1980-02-29 | 1985-04-28 | Egyt Gyogyszervegyeszeti Gyar | Composition for controlling growth of plants and process for producing the active agent |
| TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| IT1283467B1 (it) | 1996-07-19 | 1998-04-21 | Menarini Farma Ind | Derivati di cicloalcani 1,2 sostituiti come inibitori della trombina, procedimento per la loro preparazione e loro impiego in formulazioni |
| EP1024134A4 (en) * | 1997-10-09 | 2003-05-14 | Ono Pharmaceutical Co | DERIVATIVES OF AMINOBUTANIC ACID |
| SK6572000A3 (en) | 1997-11-05 | 2000-10-09 | Novartis Ag | Dipeptide nitriles, process for the preparation thereof, their use as medicaments and pharmaceutical composition comprising them |
-
2001
- 2001-06-01 US US09/872,927 patent/US6462076B2/en not_active Expired - Fee Related
- 2001-06-07 JO JO200188A patent/JO2234B1/en active
- 2001-06-08 YU YU90802A patent/YU90802A/sh unknown
- 2001-06-08 PE PE2001000541A patent/PE20020064A1/es not_active Application Discontinuation
- 2001-06-08 DE DE60113533T patent/DE60113533T2/de not_active Expired - Fee Related
- 2001-06-08 RU RU2002135634/04A patent/RU2245871C2/ru not_active IP Right Cessation
- 2001-06-08 ES ES01943489T patent/ES2248346T3/es not_active Expired - Lifetime
- 2001-06-08 KR KR1020027017073A patent/KR20030029057A/ko not_active Abandoned
- 2001-06-08 IL IL15316601A patent/IL153166A0/xx unknown
- 2001-06-08 EP EP01943489A patent/EP1294679B1/en not_active Expired - Lifetime
- 2001-06-08 AU AU2001266056A patent/AU2001266056B2/en not_active Ceased
- 2001-06-08 BR BR0111733-5A patent/BR0111733A/pt not_active IP Right Cessation
- 2001-06-08 NZ NZ522587A patent/NZ522587A/en unknown
- 2001-06-08 JP JP2002510429A patent/JP3872427B2/ja not_active Expired - Fee Related
- 2001-06-08 AT AT01943489T patent/ATE304997T1/de not_active IP Right Cessation
- 2001-06-08 CA CA002410303A patent/CA2410303C/en not_active Expired - Fee Related
- 2001-06-08 CN CNB018110819A patent/CN1324006C/zh not_active Expired - Fee Related
- 2001-06-08 MX MXPA02012253A patent/MXPA02012253A/es active IP Right Grant
- 2001-06-08 AU AU6605601A patent/AU6605601A/xx active Pending
- 2001-06-08 WO PCT/EP2001/006541 patent/WO2001096285A1/en not_active Ceased
- 2001-06-08 HU HU0300896A patent/HUP0300896A3/hu unknown
- 2001-06-08 HR HR20020963A patent/HRP20020963A2/xx not_active Application Discontinuation
- 2001-06-08 PL PL35981101A patent/PL359811A1/xx not_active Application Discontinuation
- 2001-06-12 AR ARP010102783A patent/AR031594A1/es not_active Application Discontinuation
- 2001-06-13 UY UY26769A patent/UY26769A1/es not_active Application Discontinuation
-
2002
- 2002-11-19 ZA ZA200209415A patent/ZA200209415B/en unknown
- 2002-12-04 NO NO20025823A patent/NO20025823D0/no not_active Application Discontinuation
- 2002-12-13 MA MA26950A patent/MA26913A1/fr unknown
- 2002-12-13 EC EC2002004383A patent/ECSP024383A/es unknown
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