JP2004502756A5 - - Google Patents
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- Publication number
- JP2004502756A5 JP2004502756A5 JP2002509087A JP2002509087A JP2004502756A5 JP 2004502756 A5 JP2004502756 A5 JP 2004502756A5 JP 2002509087 A JP2002509087 A JP 2002509087A JP 2002509087 A JP2002509087 A JP 2002509087A JP 2004502756 A5 JP2004502756 A5 JP 2004502756A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- halogen
- substituted
- alkoxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0017174A GB0017174D0 (en) | 2000-07-12 | 2000-07-12 | Organic compounds |
| GB0023326A GB0023326D0 (en) | 2000-09-22 | 2000-09-22 | Organic compounds |
| PCT/EP2001/007941 WO2002004420A1 (en) | 2000-07-12 | 2001-07-10 | Piperidine coumpounds for use as ccr-3 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502756A JP2004502756A (ja) | 2004-01-29 |
| JP2004502756A5 true JP2004502756A5 (https=) | 2005-02-03 |
Family
ID=26244644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509087A Pending JP2004502756A (ja) | 2000-07-12 | 2001-07-10 | Ｃｃｒ−３インヒビターとして使用するためのピペリジン化合物 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6670379B2 (https=) |
| EP (1) | EP1303488B1 (https=) |
| JP (1) | JP2004502756A (https=) |
| KR (1) | KR20030036603A (https=) |
| CN (1) | CN1184204C (https=) |
| AR (1) | AR031597A1 (https=) |
| AT (1) | ATE447553T1 (https=) |
| AU (2) | AU8197201A (https=) |
| BR (1) | BR0112456A (https=) |
| CA (1) | CA2412941C (https=) |
| CZ (1) | CZ200375A3 (https=) |
| DE (1) | DE60140366D1 (https=) |
| ES (1) | ES2334886T3 (https=) |
| HU (1) | HUP0301341A2 (https=) |
| IL (1) | IL153661A0 (https=) |
| MX (1) | MXPA02012848A (https=) |
| MY (1) | MY126139A (https=) |
| NO (1) | NO324760B1 (https=) |
| NZ (1) | NZ523414A (https=) |
| PE (1) | PE20020616A1 (https=) |
| PL (1) | PL358673A1 (https=) |
| PT (1) | PT1303488E (https=) |
| SK (1) | SK272003A3 (https=) |
| TW (1) | TWI227231B (https=) |
| WO (1) | WO2002004420A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19952147A1 (de) * | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| EP1330436B1 (en) * | 2000-10-09 | 2010-06-30 | Novartis AG | N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr3-3 receptor antagonists |
| GB0114699D0 (en) | 2001-06-15 | 2001-08-08 | Novartis Ag | Organic compounds |
| AU2004271744B2 (en) | 2003-09-16 | 2010-07-29 | Covis Pharma B.V. | Use of ciclesonide for the treatment of respiratory diseases |
| JP6473133B2 (ja) * | 2013-03-15 | 2019-02-20 | アラクセス ファーマ エルエルシー | Ｋｒａｓｇ１２ｃの共有結合性阻害剤 |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| JP2018513853A (ja) | 2015-04-10 | 2018-05-31 | アラクセス ファーマ エルエルシー | 置換キナゾリン化合物およびその使用方法 |
| JP6789239B2 (ja) | 2015-04-15 | 2020-11-25 | アラクセス ファーマ エルエルシー | Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法 |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3356353A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058902A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| KR20180081596A (ko) | 2015-11-16 | 2018-07-16 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| US10280172B2 (en) | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3523289A1 (en) | 2016-10-07 | 2019-08-14 | Araxes Pharma LLC | Heterocyclic compounds as inhibitors of ras and methods of use thereof |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| CN110382482A (zh) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | 稠合的杂-杂二环化合物及其使用方法 |
| JP2020521741A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | がんの処置のための化合物およびその使用の方法 |
| US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
| AU2018271990A1 (en) | 2017-05-25 | 2019-12-12 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| MX2021000887A (es) | 2018-08-01 | 2021-03-31 | Araxes Pharma Llc | Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999004794A1 (en) | 1997-07-25 | 1999-02-04 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| DE69921351T2 (de) | 1998-11-17 | 2006-03-09 | F. Hoffmann-La Roche Ag | 4-Aroyl-Piperidin-CCR-3 Rezeptorantagonisten III |
| EP1140087A4 (en) | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
| US6518286B1 (en) * | 1999-03-26 | 2003-02-11 | Astrazeneca Ab | Compounds |
-
2001
- 2001-07-09 TW TW090116691A patent/TWI227231B/zh not_active IP Right Cessation
- 2001-07-10 MX MXPA02012848A patent/MXPA02012848A/es active IP Right Grant
- 2001-07-10 PT PT01960488T patent/PT1303488E/pt unknown
- 2001-07-10 AU AU8197201A patent/AU8197201A/xx active Pending
- 2001-07-10 KR KR10-2003-7000445A patent/KR20030036603A/ko not_active Withdrawn
- 2001-07-10 EP EP01960488A patent/EP1303488B1/en not_active Expired - Lifetime
- 2001-07-10 CZ CZ200375A patent/CZ200375A3/cs unknown
- 2001-07-10 IL IL15366101A patent/IL153661A0/xx unknown
- 2001-07-10 SK SK27-2003A patent/SK272003A3/sk not_active Application Discontinuation
- 2001-07-10 CN CNB018126111A patent/CN1184204C/zh not_active Expired - Fee Related
- 2001-07-10 DE DE60140366T patent/DE60140366D1/de not_active Expired - Lifetime
- 2001-07-10 JP JP2002509087A patent/JP2004502756A/ja active Pending
- 2001-07-10 BR BR0112456-0A patent/BR0112456A/pt not_active IP Right Cessation
- 2001-07-10 ES ES01960488T patent/ES2334886T3/es not_active Expired - Lifetime
- 2001-07-10 CA CA2412941A patent/CA2412941C/en not_active Expired - Fee Related
- 2001-07-10 WO PCT/EP2001/007941 patent/WO2002004420A1/en not_active Ceased
- 2001-07-10 PE PE2001000683A patent/PE20020616A1/es not_active Application Discontinuation
- 2001-07-10 HU HU0301341A patent/HUP0301341A2/hu unknown
- 2001-07-10 AT AT01960488T patent/ATE447553T1/de not_active IP Right Cessation
- 2001-07-10 AR ARP010103261A patent/AR031597A1/es unknown
- 2001-07-10 MY MYPI20013274A patent/MY126139A/en unknown
- 2001-07-10 NZ NZ523414A patent/NZ523414A/en unknown
- 2001-07-10 US US10/332,642 patent/US6670379B2/en not_active Expired - Fee Related
- 2001-07-10 PL PL01358673A patent/PL358673A1/xx not_active Application Discontinuation
- 2001-07-10 AU AU2001281972A patent/AU2001281972B2/en not_active Ceased
-
2003
- 2003-01-10 NO NO20030135A patent/NO324760B1/no unknown
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