JP2004501608A - Ｖｅｇｆ調節遺伝子及びそれらを利用する方法 - Google Patents

Ｖｅｇｆ調節遺伝子及びそれらを利用する方法 Download PDF

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Publication number
JP2004501608A
JP2004501608A JP2001568372A JP2001568372A JP2004501608A JP 2004501608 A JP2004501608 A JP 2004501608A JP 2001568372 A JP2001568372 A JP 2001568372A JP 2001568372 A JP2001568372 A JP 2001568372A JP 2004501608 A JP2004501608 A JP 2004501608A
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Japan
Prior art keywords
vegf
polypeptide
activity
expression
cell
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English (en)
Japanese (ja)
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JP2004501608A5 (enExample
Inventor
ラステッリ，ルカ，ケー．
ガーバー，ハンス−ピーター
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Genentech Inc
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Genentech Inc
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Publication of JP2004501608A publication Critical patent/JP2004501608A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2001568372A 2000-03-21 2001-03-21 Ｖｅｇｆ調節遺伝子及びそれらを利用する方法 Pending JP2004501608A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19120100P 2000-03-21 2000-03-21
PCT/US2001/009043 WO2001070174A2 (en) 2000-03-21 2001-03-21 Vegf-modulated genes and methods employing them

Publications (2)

Publication Number Publication Date
JP2004501608A true JP2004501608A (ja) 2004-01-22
JP2004501608A5 JP2004501608A5 (enExample) 2008-05-08

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JP2001568372A Pending JP2004501608A (ja) 2000-03-21 2001-03-21 Ｖｅｇｆ調節遺伝子及びそれらを利用する方法

Country Status (6)

Country Link
US (3) US20020132978A1 (enExample)
EP (1) EP1290005A4 (enExample)
JP (1) JP2004501608A (enExample)
AU (2) AU2001250912B2 (enExample)
CA (1) CA2403804A1 (enExample)
WO (1) WO2001070174A2 (enExample)

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WO2005082412A1 (ja) * 2004-02-26 2005-09-09 Perseus Proteomics Inc. 癌の治療および予防薬
JPWO2005094888A1 (ja) * 2004-03-31 2008-02-14 株式会社ツーセル 損傷組織の治療剤と治療方法

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AU2001278746A1 (en) * 2000-08-16 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Seamless soft capsule preparations containing dihydrobenzofuran derivatives
DE60238038D1 (de) * 2001-03-20 2010-12-02 Cns Protein Therapeutics Inc Das Überleben dopaminerger Neuronen fördernde Faktoren und deren Verwendungen
US7452969B2 (en) 2002-08-30 2008-11-18 Licentia Ltd Neurotrophic factor protein and uses thereof
EP1644406B1 (en) 2003-07-11 2012-08-15 DeveloGen Aktiengesellschaft Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
MX2007010922A (es) * 2005-03-10 2007-10-12 Genentech Inc Metodos y composiciones para modular la integridad vascular.
PL1969003T3 (pl) 2005-12-14 2011-05-31 Herantis Pharma Plc Zastosowanie białka czynnika neurotroficznego
WO2009120810A2 (en) * 2008-03-25 2009-10-01 Cns Protein Therapeutics, Inc. Neurodegenerative disorders
JP5337868B2 (ja) 2008-04-23 2013-11-06 ノヴァセル テクノロジー インコーポレイテッド． 血管新生ペプチド
FI20080326A0 (fi) 2008-04-30 2008-04-30 Licentia Oy Neurotroofinen tekijä MANF ja sen käytöt
CA2730068A1 (en) 2008-07-07 2010-01-14 Oxford Nanopore Technologies Limited Base-detecting pore
US20110229877A1 (en) 2008-07-07 2011-09-22 Oxford Nanopore Technologies Limited Enzyme-pore constructs
US9132168B2 (en) 2008-08-05 2015-09-15 University Of South Florida Methods of treating cognitive impairment
CN102215860A (zh) * 2008-08-05 2011-10-12 南佛罗里达大学 治疗认知损害的方法
EP2312896B1 (en) 2008-08-06 2018-01-10 Sharp Kabushiki Kaisha Base station device, mobile station device and corresponding communication methods using carrier aggregation
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
EP2391732B1 (en) 2009-01-30 2015-05-27 Oxford Nanopore Technologies Limited Methods using adaptors for nucleic acid constructs in transmembrane sequencing
CN102482330A (zh) * 2009-01-30 2012-05-30 牛津纳米孔技术有限公司 酶突变体
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
WO2012094600A1 (en) * 2011-01-06 2012-07-12 William Marsh Rice University Methods for treating lysosomal storage diseases using l-type ca2+ channel blockers with a 1,4 dihydropyridine structure and inhibitors of er-associated degradation
BR112013020411B1 (pt) 2011-02-11 2021-09-08 Oxford Nanopore Technologies Limited Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo
CA2838818A1 (en) * 2011-06-09 2012-12-13 University Of Miami Methods of treatment for retinal diseases
KR20140050067A (ko) 2011-07-25 2014-04-28 옥스포드 나노포어 테크놀로지즈 리미티드 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
US11155860B2 (en) 2012-07-19 2021-10-26 Oxford Nanopore Technologies Ltd. SSB method
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
CA2901545C (en) 2013-03-08 2019-10-08 Oxford Nanopore Technologies Limited Use of spacer elements in a nucleic acid to control movement of a helicase
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
US10443097B2 (en) 2014-05-02 2019-10-15 Oxford Nanopore Technologies Ltd. Method of improving the movement of a target polynucleotide with respect to a transmembrane pore
CN119899249A (zh) 2014-09-01 2025-04-29 弗拉芒区生物技术研究所 突变csgg孔
US10266885B2 (en) 2014-10-07 2019-04-23 Oxford Nanopore Technologies Ltd. Mutant pores
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
US11254738B2 (en) * 2016-09-07 2022-02-22 The Governing Council Of The University Of Toronto Banting Institute Synthetic antibodies against VEGF and their uses
EP3774858B1 (en) * 2018-03-29 2025-07-30 MyNeuroCure Oy C-terminal cdnf fragments having neuroprotective effect
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
EP3814492A4 (en) 2018-06-29 2022-02-23 Wuhan Neurophth Biotechnology Limited Company Compositions and methods for treating leber's hereditary optic neuropathy
KR20210068014A (ko) * 2018-08-20 2021-06-08 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법
CN113025633B (zh) 2019-12-09 2024-08-27 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用

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DE4340891A1 (de) * 1993-12-01 1995-06-08 Mahle Gmbh Hubkolben für Verbrennungsmotoren aus insbesondere Leichtmetall
US5856103A (en) * 1994-10-07 1999-01-05 Board Of Regents The University Of Texas Method for selectively ranking sequences for antisense targeting
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WO2001019851A2 (en) * 1999-09-16 2001-03-22 Neurotrophic Bioscience Inc. Opaminergic neuronal survival-promoting factors and uses thereof
EP1225224A4 (en) * 1999-10-01 2004-03-24 Kyowa Hakko Kogyo Kk DNA THE SHEAR RESPONSE
MX2007010922A (es) * 2005-03-10 2007-10-12 Genentech Inc Metodos y composiciones para modular la integridad vascular.

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JPN6010075537, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1998, ｖｏｌ．２７３， ｎｏ．８, ｐｐ．４４００−４４０５ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005082412A1 (ja) * 2004-02-26 2005-09-09 Perseus Proteomics Inc. 癌の治療および予防薬
JPWO2005094888A1 (ja) * 2004-03-31 2008-02-14 株式会社ツーセル 損傷組織の治療剤と治療方法
US8119397B2 (en) 2004-03-31 2012-02-21 Two Cells Co., Ltd. Therapeutic agents and therapeutic methods for treating injured tissue

Also Published As

Publication number Publication date
WO2001070174A2 (en) 2001-09-27
CA2403804A1 (en) 2001-09-27
AU2001250912C1 (en) 2001-10-03
US20040006780A1 (en) 2004-01-08
US20080166724A1 (en) 2008-07-10
AU5091201A (en) 2001-10-03
WO2001070174A3 (en) 2002-04-11
EP1290005A2 (en) 2003-03-12
EP1290005A4 (en) 2005-04-20
AU2001250912B2 (en) 2007-01-04
WO2001070174A8 (en) 2003-01-16
US20020132978A1 (en) 2002-09-19

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