AU2001250912B2 - VEGF-modulated genes and methods employing them - Google Patents
VEGF-modulated genes and methods employing them Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61P35/00—Antineoplastic agents
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| PCT/US2001/009043 WO2001070174A2 (en) | 2000-03-21 | 2001-03-21 | Vegf-modulated genes and methods employing them |
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| ES2353490T3 (es) * | 2001-03-20 | 2011-03-02 | Cns Protein Therapeutics, Inc. | Factores de estimulación de la supervivencia neuronal dopaminérgica y sus utilizaciones. |
| US7452969B2 (en) | 2002-08-30 | 2008-11-18 | Licentia Ltd | Neurotrophic factor protein and uses thereof |
| WO2007068784A1 (en) | 2005-12-14 | 2007-06-21 | Licentia Ltd | Novel neurotrophic factor protein and uses thereof |
| EP1644406B1 (en) | 2003-07-11 | 2012-08-15 | DeveloGen Aktiengesellschaft | Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome |
| JPWO2005082412A1 (ja) * | 2004-02-26 | 2007-10-25 | 株式会社ペルセウスプロテオミクス | 癌の治療および予防薬 |
| WO2005094888A1 (ja) * | 2004-03-31 | 2005-10-13 | Two Cells Co. Ltd. | 損傷組織の治療剤と治療方法 |
| EP1869076A2 (en) * | 2005-03-10 | 2007-12-26 | Genentech, Inc. | Methods and compositions for modulating vascular integrity |
| EP2271358B1 (en) * | 2008-03-25 | 2018-11-21 | Amarantus Therapeutics, Inc. | use of mesencephalic astrocyte-derived neurotrophic factor for treating Parkinson's disease |
| EP2280988B1 (en) * | 2008-04-23 | 2017-05-24 | Novacell Technology Inc. | Angiogenic peptide |
| FI20080326A0 (fi) | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
| US9447152B2 (en) | 2008-07-07 | 2016-09-20 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20110229877A1 (en) | 2008-07-07 | 2011-09-22 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| US9132168B2 (en) | 2008-08-05 | 2015-09-15 | University Of South Florida | Methods of treating cognitive impairment |
| WO2010017224A2 (en) | 2008-08-05 | 2010-02-11 | University Of South Florida | Methods of treating cognitive impairment |
| CN102113396B (zh) | 2008-08-06 | 2013-10-16 | 夏普株式会社 | 通信系统、移动站装置以及通信方法 |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| CA2750874A1 (en) * | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Hybridization linkers |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| WO2012094600A1 (en) * | 2011-01-06 | 2012-07-12 | William Marsh Rice University | Methods for treating lysosomal storage diseases using l-type ca2+ channel blockers with a 1,4 dihydropyridine structure and inhibitors of er-associated degradation |
| KR101939420B1 (ko) | 2011-02-11 | 2019-01-16 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 세공 |
| EA201400002A1 (ru) * | 2011-06-09 | 2014-08-29 | Юниверсити Оф Майами | Способы лечения заболеваний сетчатки |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| EP2875154B1 (en) | 2012-07-19 | 2017-08-23 | Oxford Nanopore Technologies Limited | SSB method for characterising a nucleic acid |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| AU2014224432B2 (en) | 2013-03-08 | 2019-10-24 | Oxford Nanopore Technologies Limited | Enzyme stalling method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| CA3077518C (en) * | 2016-09-07 | 2021-10-19 | Frederic Fellouse | Synthetic antibodies against vegf and their uses |
| JP2021519578A (ja) * | 2018-03-29 | 2021-08-12 | ヘルシンギン ユリオピストＨｅｌｓｉｎｇｉｎ Ｙｌｉｏｐｉｓｔｏ | Ｃ末端ｃｄｎｆ断片、それらを含む医薬組成物、並びにそれらの使用 |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| AU2019296451B2 (en) | 2018-06-29 | 2021-04-29 | Wuhan Neurophth Biotechnology Limited Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| SG11202101032VA (en) * | 2018-08-20 | 2021-02-25 | Wuhan Neurophth Biotechnology Ltd Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| CN113025633B (zh) | 2019-12-09 | 2024-08-27 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT374041B (de) * | 1982-03-25 | 1984-03-12 | Naimer H L | Stern-dreieck-schalter mit nullspannungsausloesung |
| US4758195A (en) * | 1986-09-08 | 1988-07-19 | 3 W Designers, Inc. | Elastomeric foam building units |
| FR2626254B1 (fr) * | 1988-01-27 | 1990-07-06 | Valois Sa | Poussoir-etui avec systeme de garantie |
| US5174392A (en) * | 1991-11-21 | 1992-12-29 | Reinhardt Paul A | Mechanically actuated fluid control device for downhole fluid motor |
| US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| DE4340891A1 (de) * | 1993-12-01 | 1995-06-08 | Mahle Gmbh | Hubkolben für Verbrennungsmotoren aus insbesondere Leichtmetall |
| US5856103A (en) * | 1994-10-07 | 1999-01-05 | Board Of Regents The University Of Texas | Method for selectively ranking sequences for antisense targeting |
| US6410046B1 (en) * | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
| MXPA02002765A (es) * | 1999-09-16 | 2005-09-08 | Prescient Neuropharma Inc | Factores promotores de supervivencia neuronal, opaminergicos y sus usos. |
| WO2001025427A1 (fr) * | 1999-10-01 | 2001-04-12 | Kyowa Hakko Kogyo Co., Ltd. | Adn reagissant a la contrainte de cisaillement |
| EP1869076A2 (en) * | 2005-03-10 | 2007-12-26 | Genentech, Inc. | Methods and compositions for modulating vascular integrity |
-
2001
- 2001-03-21 WO PCT/US2001/009043 patent/WO2001070174A2/en not_active Ceased
- 2001-03-21 US US09/815,153 patent/US20020132978A1/en not_active Abandoned
- 2001-03-21 AU AU2001250912A patent/AU2001250912B2/en not_active Expired
- 2001-03-21 EP EP01924240A patent/EP1290005A4/en not_active Withdrawn
- 2001-03-21 AU AU5091201A patent/AU5091201A/xx active Pending
- 2001-03-21 CA CA002403804A patent/CA2403804A1/en not_active Abandoned
- 2001-03-21 JP JP2001568372A patent/JP2004501608A/ja active Pending
-
2003
- 2003-05-02 US US10/428,487 patent/US20040006780A1/en not_active Abandoned
-
2007
- 2007-10-31 US US11/932,133 patent/US20080166724A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| Arkonac BM et al, J Biol Chem 273(8) pp.4400-4405 * |
| Ushiro S et al, Jpn J Cancer Res 87, 1996, pp. 68-77 * |
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| US20020132978A1 (en) | 2002-09-19 |
| WO2001070174A2 (en) | 2001-09-27 |
| US20080166724A1 (en) | 2008-07-10 |
| AU2001250912C1 (en) | 2001-10-03 |
| EP1290005A2 (en) | 2003-03-12 |
| AU5091201A (en) | 2001-10-03 |
| JP2004501608A (ja) | 2004-01-22 |
| US20040006780A1 (en) | 2004-01-08 |
| EP1290005A4 (en) | 2005-04-20 |
| WO2001070174A8 (en) | 2003-01-16 |
| WO2001070174A3 (en) | 2002-04-11 |
| CA2403804A1 (en) | 2001-09-27 |
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