JP2004501181A5 - - Google Patents
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- Publication number
- JP2004501181A5 JP2004501181A5 JP2002504977A JP2002504977A JP2004501181A5 JP 2004501181 A5 JP2004501181 A5 JP 2004501181A5 JP 2002504977 A JP2002504977 A JP 2002504977A JP 2002504977 A JP2002504977 A JP 2002504977A JP 2004501181 A5 JP2004501181 A5 JP 2004501181A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mucoadhesive
- pharmaceutically acceptable
- acceptable salt
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 17
- 230000003232 mucoadhesive effect Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000003589 local anesthetic agent Substances 0.000 description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- 229960003150 bupivacaine Drugs 0.000 description 1
- 229960002023 chloroprocaine Drugs 0.000 description 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
- 229960001747 cinchocaine Drugs 0.000 description 1
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 description 1
- 229960003976 etidocaine Drugs 0.000 description 1
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
- 229960001571 loperamide Drugs 0.000 description 1
- 229960002409 mepivacaine Drugs 0.000 description 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960001549 ropivacaine Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22216400P | 2000-06-26 | 2000-06-26 | |
| PCT/US2001/020322 WO2002000195A2 (en) | 2000-06-26 | 2001-06-26 | Methods and compositions for treating pain of the mucous membrane |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008163375A Division JP2009001574A (ja) | 2000-06-26 | 2008-06-23 | 粘膜の痛みを治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004501181A JP2004501181A (ja) | 2004-01-15 |
| JP2004501181A5 true JP2004501181A5 (https=) | 2008-08-14 |
Family
ID=22831130
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002504977A Pending JP2004501181A (ja) | 2000-06-26 | 2001-06-26 | 粘膜の痛みを治療するための方法および組成物 |
| JP2008163375A Pending JP2009001574A (ja) | 2000-06-26 | 2008-06-23 | 粘膜の痛みを治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008163375A Pending JP2009001574A (ja) | 2000-06-26 | 2008-06-23 | 粘膜の痛みを治療するための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20020013331A1 (https=) |
| EP (1) | EP1296650B1 (https=) |
| JP (2) | JP2004501181A (https=) |
| AT (1) | ATE289802T1 (https=) |
| AU (1) | AU2001270177A1 (https=) |
| CA (1) | CA2413545A1 (https=) |
| DE (1) | DE60109164T2 (https=) |
| ES (1) | ES2239144T3 (https=) |
| IL (2) | IL153656A0 (https=) |
| PT (1) | PT1296650E (https=) |
| WO (1) | WO2002000195A2 (https=) |
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2001
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- 2001-06-26 AU AU2001270177A patent/AU2001270177A1/en not_active Abandoned
- 2001-06-26 WO PCT/US2001/020322 patent/WO2002000195A2/en not_active Ceased
- 2001-06-26 IL IL15365601A patent/IL153656A0/xx unknown
- 2001-06-26 DE DE60109164T patent/DE60109164T2/de not_active Expired - Fee Related
- 2001-06-26 PT PT01948733T patent/PT1296650E/pt unknown
- 2001-06-26 EP EP01948733A patent/EP1296650B1/en not_active Expired - Lifetime
- 2001-06-26 JP JP2002504977A patent/JP2004501181A/ja active Pending
- 2001-06-26 ES ES01948733T patent/ES2239144T3/es not_active Expired - Lifetime
- 2001-06-26 CA CA002413545A patent/CA2413545A1/en not_active Abandoned
-
2002
- 2002-06-17 US US10/172,455 patent/US6509028B2/en not_active Expired - Lifetime
- 2002-12-25 IL IL153656A patent/IL153656A/en not_active IP Right Cessation
-
2003
- 2003-01-21 US US10/347,385 patent/US20030124190A1/en not_active Abandoned
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2008
- 2008-06-23 JP JP2008163375A patent/JP2009001574A/ja active Pending
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