JP2004500390A5 - - Google Patents
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- Publication number
- JP2004500390A5 JP2004500390A5 JP2001564775A JP2001564775A JP2004500390A5 JP 2004500390 A5 JP2004500390 A5 JP 2004500390A5 JP 2001564775 A JP2001564775 A JP 2001564775A JP 2001564775 A JP2001564775 A JP 2001564775A JP 2004500390 A5 JP2004500390 A5 JP 2004500390A5
- Authority
- JP
- Japan
- Prior art keywords
- chemotherapeutic
- administered
- herbal preparation
- combination according
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000973 chemotherapeutic effect Effects 0.000 description 14
- 238000009472 formulation Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000890 drug combination Substances 0.000 description 5
- 241000202807 Glycyrrhiza Species 0.000 description 3
- 241000736199 Paeonia Species 0.000 description 3
- 241000207929 Scutellaria Species 0.000 description 3
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 3
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- 229960002949 fluorouracil Drugs 0.000 description 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 2
- 235000008191 folinic acid Nutrition 0.000 description 2
- 239000011672 folinic acid Substances 0.000 description 2
- 229960001691 leucovorin Drugs 0.000 description 2
- RXRGZNYSEHTMHC-NKWVEPMBSA-N 4-amino-1-[(2r,4s)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@H](CO)OC1 RXRGZNYSEHTMHC-NKWVEPMBSA-N 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52205500A | 2000-03-09 | 2000-03-09 | |
| US09/522,055 | 2000-03-09 | ||
| PCT/US2001/007353 WO2001066123A2 (en) | 2000-03-09 | 2001-03-08 | Composition consisting of phy906 and chemotherapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012095816A Division JP2012167101A (ja) | 2000-03-09 | 2012-04-19 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500390A JP2004500390A (ja) | 2004-01-08 |
| JP2004500390A5 true JP2004500390A5 (cg-RX-API-DMAC7.html) | 2010-05-27 |
| JP5064630B2 JP5064630B2 (ja) | 2012-10-31 |
Family
ID=24079273
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001564775A Expired - Lifetime JP5064630B2 (ja) | 2000-03-09 | 2001-03-08 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
| JP2012095816A Pending JP2012167101A (ja) | 2000-03-09 | 2012-04-19 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
| JP2014136932A Pending JP2014208684A (ja) | 2000-03-09 | 2014-07-02 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012095816A Pending JP2012167101A (ja) | 2000-03-09 | 2012-04-19 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
| JP2014136932A Pending JP2014208684A (ja) | 2000-03-09 | 2014-07-02 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7025993B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1401458B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5064630B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100840213B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN100490845C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE494899T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU4550801A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2402466C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60143857D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1401458T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2358639T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI324069B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001066123A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8871279B2 (en) | 2000-03-09 | 2014-10-28 | Yale University | Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen |
| US7534455B2 (en) * | 2000-03-09 | 2009-05-19 | Yale University | Herbal composition PHY906 and its use in chemotherapy |
| EP1487434B1 (en) * | 2002-03-06 | 2007-05-09 | The Medical Research and Education Trust | Botanical extract compositions with anti-cancer activity comprising isoliquiritigenin |
| RU2209062C1 (ru) * | 2002-03-19 | 2003-07-27 | Институт физиологии им. И.П.Павлова РАН | Вещество, обладающее седативным действием |
| CA2556254A1 (en) * | 2004-02-13 | 2005-08-25 | Kabushiki Kaisha Yakult Honsha | Aqueous solution preparation containing camptothecins |
| CN101730535A (zh) | 2007-02-15 | 2010-06-09 | 耶鲁大学 | 草药组合物phy906及其在化疗中的用途 |
| US20110111070A1 (en) | 2007-10-25 | 2011-05-12 | Yung-Chi Cheng | Use of phy906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome |
| US9778276B2 (en) * | 2007-11-20 | 2017-10-03 | Hewlett-Packard Development Company, L.P. | Liquid handling device |
| KR100915457B1 (ko) * | 2008-01-31 | 2009-09-04 | 세종대학교산학협력단 | 한국산 겨우살이 추출물이 함유된 미세캡슐을 유효성분으로포함하는 기능성 식품 |
| TWI366466B (en) * | 2008-05-08 | 2012-06-21 | Ind Tech Res Inst | Herbal extracts capable of inducing immune cells to produce interferon and activating toll-like receptors and the preparation thereof |
| WO2010035262A2 (en) * | 2008-09-25 | 2010-04-01 | Life Biotech Medical Research Ltd | Herbal formulations |
| KR101138461B1 (ko) * | 2010-02-12 | 2012-04-26 | 한국생명공학연구원 | 감초 추출물을 포함하는 로타바이러스 감염의 예방 또는 치료용 조성물 |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8734859B1 (en) | 2010-11-13 | 2014-05-27 | Sirbal Ltd. | Molecular combinations for cancer or other disease treatment |
| US20170049835A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Scalp Conditions |
| CN102716421A (zh) * | 2012-06-21 | 2012-10-10 | 中国人民解放军第三军医大学第一附属医院 | 治疗扁平疣的中药口服液及其制备方法 |
| CN102698068B (zh) * | 2012-07-02 | 2013-07-24 | 张秀香 | 一种预防化疗所致口腔黏膜炎的口腔护理液制备方法 |
| KR101350143B1 (ko) * | 2013-05-30 | 2014-01-16 | 재단법인 통합의료진흥원 | 반하 및 황금 생약 추출물을 포함하는 항암제로 인한 부작용의 경감용 조성물 |
| EP3498288A1 (en) | 2013-12-02 | 2019-06-19 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| CN107921282A (zh) * | 2015-08-21 | 2018-04-17 | 卫理公会医院研究所 | 选择性抑制肠羧酸酯酶2酶活性的组合物及方法 |
| CN109414422A (zh) * | 2016-05-23 | 2019-03-01 | 耶鲁大学 | 使用包含phy906提取物、黄芩提取物或来自这些提取物的化合物的联合疗法改善抗免疫检查点抑制剂的治疗指数 |
| AU2017281065B2 (en) | 2016-06-22 | 2022-10-27 | Yale University | Mechanism based quality control for botanical medicine |
| JP7132344B2 (ja) | 2018-02-28 | 2022-09-06 | チュンアン・ユニヴァーシティ・インダストリー・アカデミック・コーペレーション・ファウンデーション | 悪液質および筋損失の予防、改善または治療用組成物 |
| WO2019204471A1 (en) * | 2018-04-20 | 2019-10-24 | Yale University | Treatment of hepatitis c |
| WO2020255133A1 (en) * | 2019-06-18 | 2020-12-24 | The Cures Ltd. | Novel therapeutic preparations comprising scutellaria barbata |
| CN111011136B (zh) * | 2019-11-13 | 2021-11-02 | 云南中烟新材料科技有限公司 | 一种假秦艽的人工种植方法 |
| JP2023504202A (ja) * | 2019-12-09 | 2023-02-01 | イエール ユニバーシティ | がんの再発を予防するための組成物および方法 |
| US20240226214A1 (en) * | 2020-03-30 | 2024-07-11 | Yale University | Methods for treating inflammatory and fibrotic diseases and disorders |
| CN114642732A (zh) * | 2020-12-21 | 2022-06-21 | 苏州普瑞森生物科技有限公司 | 一种组合物及其在制备治疗肿瘤的药物中的应用 |
| CN116712507B (zh) * | 2023-08-10 | 2023-10-20 | 中国人民解放军总医院第六医学中心 | 一种辅助乳腺癌化疗的中药组合物及其制备方法、应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5936619A (ja) | 1982-08-23 | 1984-02-28 | Tsumura Juntendo Inc | 制癌補助剤 |
| JPS5936621A (ja) | 1982-08-25 | 1984-02-28 | Tsumura Juntendo Inc | 脂肪分解促進作用阻害剤 |
| AU655160B2 (en) | 1989-11-03 | 1994-12-08 | Alexander S. Sun | Herbal treatment of malignancy |
| US5665393A (en) | 1996-09-03 | 1997-09-09 | International Medical Research, Inc. | Herbal composition for treating prostate carcinoma |
| US6048847A (en) | 1997-09-30 | 2000-04-11 | Dabur Research Foundation | Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this |
-
2001
- 2001-03-08 JP JP2001564775A patent/JP5064630B2/ja not_active Expired - Lifetime
- 2001-03-08 DE DE60143857T patent/DE60143857D1/de not_active Expired - Lifetime
- 2001-03-08 AT AT01918429T patent/ATE494899T1/de not_active IP Right Cessation
- 2001-03-08 ES ES01918429T patent/ES2358639T3/es not_active Expired - Lifetime
- 2001-03-08 AU AU4550801A patent/AU4550801A/xx active Pending
- 2001-03-08 KR KR1020027011817A patent/KR100840213B1/ko not_active Expired - Lifetime
- 2001-03-08 DK DK01918429.0T patent/DK1401458T3/da active
- 2001-03-08 CA CA2402466A patent/CA2402466C/en not_active Expired - Lifetime
- 2001-03-08 US US10/220,876 patent/US7025993B2/en not_active Expired - Lifetime
- 2001-03-08 CN CNB018081975A patent/CN100490845C/zh not_active Expired - Lifetime
- 2001-03-08 TW TW090105449A patent/TWI324069B/zh not_active IP Right Cessation
- 2001-03-08 WO PCT/US2001/007353 patent/WO2001066123A2/en not_active Ceased
- 2001-03-08 EP EP01918429A patent/EP1401458B1/en not_active Expired - Lifetime
-
2012
- 2012-04-19 JP JP2012095816A patent/JP2012167101A/ja active Pending
-
2014
- 2014-07-02 JP JP2014136932A patent/JP2014208684A/ja active Pending
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