|
US6685941B1
(en)
*
|
1988-11-23 |
2004-02-03 |
The Regents Of The University Of Michigan |
Methods of treating autoimmune disease via CTLA-4Ig
|
|
US5637481A
(en)
*
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
US6887471B1
(en)
|
1991-06-27 |
2005-05-03 |
Bristol-Myers Squibb Company |
Method to inhibit T cell interactions with soluble B7
|
|
US5773253A
(en)
|
1993-01-22 |
1998-06-30 |
Bristol-Myers Squibb Company |
MYPPPY variants of CTL A4 and uses thereof
|
|
US6824779B1
(en)
*
|
1993-07-26 |
2004-11-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for inhibiting the interaction of B7-2 with its natural ligand
|
|
US6084067A
(en)
*
|
1993-07-26 |
2000-07-04 |
Dana-Farber Cancer Institute |
CTLA4/CD28 ligands and uses therefor
|
|
US5855887A
(en)
*
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
*
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
SE9601245D0
(sv)
*
|
1996-03-29 |
1996-03-29 |
Pharmacia Ab |
Chimeric superantigens and their use
|
|
IL125928A
(en)
*
|
1996-03-20 |
2002-11-10 |
Bristol Myers Squibb Co |
The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparations
|
|
TW517061B
(en)
*
|
1996-03-29 |
2003-01-11 |
Pharmacia & Amp Upjohn Ab |
Modified/chimeric superantigens and their use
|
|
US20060034844A1
(en)
*
|
1996-12-04 |
2006-02-16 |
The Regents Of The University Of California |
Stimulation of T cells against self antigens using CTLA-4 blocking agents
|
|
KR19980066046A
(ko)
*
|
1997-01-18 |
1998-10-15 |
정용훈 |
고역가의 CTLA4-Ig 융합단백질
|
|
US20030219863A1
(en)
*
|
1997-01-31 |
2003-11-27 |
Bristol-Myers Squibb Company |
Soluble CTLA4 mutant molecules and uses thereof
|
|
AU9095498A
(en)
*
|
1997-09-19 |
1999-04-12 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Oligopeptide compounds
|
|
EP0947582A1
(en)
*
|
1998-03-31 |
1999-10-06 |
Innogenetics N.V. |
A polypeptide structure for use as a scaffold
|
|
US6613327B1
(en)
*
|
1999-07-28 |
2003-09-02 |
Genetics Institute, Inc. |
Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
EP1165752A4
(en)
*
|
1999-10-22 |
2003-02-05 |
Alexion Pharma Inc |
MODIFIED RECOMBINATION MOLECULE REGULATING HUMOR AND CELLULAR EFFECTOR FUNCTIONS OF THE IMMUNE SYSTEM
|
|
US7094874B2
(en)
*
|
2000-05-26 |
2006-08-22 |
Bristol-Myers Squibb Co. |
Soluble CTLA4 mutant molecules
|
|
MXPA02012157A
(es)
|
2000-06-09 |
2003-06-06 |
Bristol Myers Squibb Co |
Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos.
|
|
US20040022787A1
(en)
|
2000-07-03 |
2004-02-05 |
Robert Cohen |
Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
|
|
ATE401909T1
(de)
*
|
2000-07-03 |
2008-08-15 |
Bristol Myers Squibb Co |
Verwendung von löslichen ctla4-mutanten zur behandlung von rheumatoider arthritis
|
|
US7829084B2
(en)
*
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US20030133939A1
(en)
*
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7754208B2
(en)
*
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
AU2008200400B2
(en)
*
|
2001-01-17 |
2012-06-07 |
Aptevo Research And Development Llc |
Binding domain-immunoglobulin fusion proteins
|
|
HUP0303930A3
(en)
*
|
2001-01-26 |
2012-09-28 |
Univ Emory |
Methods of inducing organ transplant tolerance and correcting hemoglobinopathies
|
|
US20040058445A1
(en)
*
|
2001-04-26 |
2004-03-25 |
Ledbetter Jeffrey Alan |
Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
|
|
ATE390931T1
(de)
*
|
2001-05-23 |
2008-04-15 |
Bristol Myers Squibb Co |
Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4- mutationsmolekülen
|
|
KR100453877B1
(ko)
*
|
2001-07-26 |
2004-10-20 |
메덱스젠 주식회사 |
연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
|
|
AU2002357427A1
(en)
*
|
2001-12-04 |
2003-06-17 |
Tegenero Ag |
Peptide or protein containing a c'-d loop of the cd28 receptor family
|
|
US20030219436A1
(en)
*
|
2002-03-15 |
2003-11-27 |
Ledbetter Jeffrey A. |
Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein
|
|
BR0309254A
(pt)
|
2002-04-12 |
2005-03-01 |
Medarex Inc |
Uso de um anticorpo anti-ctla-4
|
|
AU2003234469A1
(en)
*
|
2002-05-02 |
2003-11-17 |
University Of Connecticut Health Center |
Use of heat shock proteins to enhance efficacy of antibody therapeutics
|
|
WO2004029069A2
(en)
*
|
2002-09-30 |
2004-04-08 |
Pfizer Products Inc. |
Hybridomas producing high levels of human sequence antibody
|
|
JP4541157B2
(ja)
*
|
2002-12-23 |
2010-09-08 |
ブリストル−マイヤーズ スクイブ カンパニー |
タンパク質を製造するための哺乳類細胞培養法
|
|
ES2354610T5
(es)
*
|
2002-12-23 |
2020-09-14 |
Bristol Myers Squibb Co |
Mejora de la calidad del producto en procedimientos de cultivo de células de mamífero para la producción de proteína
|
|
US7754209B2
(en)
|
2003-07-26 |
2010-07-13 |
Trubion Pharmaceuticals |
Binding constructs and methods for use thereof
|
|
JP2007501243A
(ja)
*
|
2003-08-04 |
2007-01-25 |
ブリストル−マイヤーズ スクイブ カンパニー |
可溶性ctla4分子を用いる心臓血管疾患の治療方法
|
|
KR100545720B1
(ko)
*
|
2004-05-31 |
2006-01-24 |
메덱스젠 주식회사 |
당화된 면역글로불린 및 이를 포함하는 면역접합체
|
|
US7453291B2
(en)
*
|
2004-09-09 |
2008-11-18 |
The Regents Of The University Of California |
Switch linearized track and hold circuit for switch linearization
|
|
WO2006108035A1
(en)
*
|
2005-04-06 |
2006-10-12 |
Bristol-Myers Squibb Company |
Methods for treating immune disorders associated with graft transplantation with soluble ctla4 mutant molecules
|
|
SI1912675T1
(sl)
*
|
2005-07-25 |
2014-07-31 |
Emergent Product Development Seattle, Llc |
zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20
|
|
WO2007067959A2
(en)
|
2005-12-07 |
2007-06-14 |
Medarex, Inc. |
Ctla-4 antibody dosage escalation regimens
|
|
AR058568A1
(es)
|
2005-12-20 |
2008-02-13 |
Bristol Myers Squibb Co |
Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
|
|
JP5096369B2
(ja)
|
2005-12-20 |
2012-12-12 |
ブリストル−マイヤーズ スクイブ カンパニー |
組成物および組成物の製造方法
|
|
ES2363891T3
(es)
|
2006-03-20 |
2011-08-18 |
The Regents Of The University Of California |
Anticuerpos contra el antígeno de células troncales de la próstata (psca) modificados genéticamente para el direccionamiento al cáncer.
|
|
US7528111B2
(en)
*
|
2006-05-12 |
2009-05-05 |
Bristol-Myers Squibb Company |
Method of vaccinating subjects receiving immune modulating therapy
|
|
EP2418223A3
(en)
|
2006-06-12 |
2013-01-16 |
Emergent Product Development Seattle, LLC |
Single-chain multivalent binding proteins with effector function
|
|
GB0620934D0
(en)
*
|
2006-10-20 |
2006-11-29 |
Cambridge Antibody Tech |
Protein variants
|
|
US8940298B2
(en)
|
2007-09-04 |
2015-01-27 |
The Regents Of The University Of California |
High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection
|
|
EP2612867A1
(en)
*
|
2007-11-01 |
2013-07-10 |
Perseid Therapeutics LLC |
Immunosuppressive polypeptides and nucleic acids
|
|
SG189772A1
(en)
*
|
2008-04-11 |
2013-05-31 |
Trubion Pharmaceuticals Inc |
Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
|
|
US7915222B2
(en)
|
2008-05-05 |
2011-03-29 |
Bristol-Myers Squibb Company |
Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis
|
|
EA024877B1
(ru)
|
2008-10-02 |
2016-10-31 |
Эмерджент Продакт Дивелопмент Сиэтл, Ллс |
Связывающие множество мишеней белки, обладающие антагонистическими свойствами по отношению к cd86
|
|
US9540426B2
(en)
*
|
2009-10-06 |
2017-01-10 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
|
TW201134481A
(en)
|
2010-03-12 |
2011-10-16 |
Abbott Biotherapeutics Corp |
CTLA4 proteins and their uses
|
|
WO2012042480A1
(en)
|
2010-09-28 |
2012-04-05 |
Kahr Medical Ltd. |
Compositions and methods for treatment of hematological malignancies
|
|
JP6074435B2
(ja)
*
|
2011-10-26 |
2017-02-01 |
ナショナル キャンサー センター |
変異ctla4遺伝子移入t細胞及びこれを含む抗がん免疫治療用組成物
|
|
WO2013062365A2
(ko)
*
|
2011-10-26 |
2013-05-02 |
국립암센터 |
변이 ctla4 유전자 이입 t 세포 및 이를 포함하는 항암 면역치료용 조성물
|
|
UA126278C2
(uk)
|
2015-09-21 |
2022-09-14 |
Аптево Рісьорч Енд Девелопмент Ллс |
Поліпептиди, які зв'язують cd3
|
|
JP2020517259A
(ja)
|
2017-04-19 |
2020-06-18 |
ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム |
操作された抗原受容体を発現する免疫細胞
|
|
JP7273421B2
(ja)
|
2018-02-21 |
2023-05-15 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
|
|
CN120548323A
(zh)
*
|
2022-11-18 |
2025-08-26 |
首尔国立大学校产学协力团 |
利用ctla-4变体及嵌合抗原受体的双基因转导免疫细胞及其用途
|