JP2004244382A - Cosmetic composition or food or beverage - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safe elastase activity inhibitor, collagenase activity inhibitor and hyaluronidase activity inhibitor and further a cosmetic composition or a food or a beverage. <P>SOLUTION: The elastase activity inhibitor, collagenase activity inhibitor and hyaluronidase activity inhibitor and further a cosmetic composition or a food or a beverage each comprises extracts of one or more plants selected from Agave americana L., Agave sisalana Perrine and Adenophora triphylla. According to the present invention, they each has elastase activity-inhibiting action, collagenase activity-inhibiting action and hyaluronidase activity-inhibiting action and further imparts firmness and gloss to the skin and can reduce wrinkle and fine wrinkles. As a result, they are effective for preventing aging of the skin and the scalp and are safe to human or animals when they are internally or externally taken and can be applied to preparations in various shape (medicines, quasi-drugs, cosmetics and foods). <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

【００８６】
（試験結果）
表１の通り、本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンの各種植物抽出物は、エラスターゼ活性を有意に抑える作用を有することが確認でき、エラスターゼ活性阻害剤として使用できる。
【００８７】
（試験２）コラゲナーゼ活性阻害試験
「試験方法及び評価方法」
本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンの各種植物抽出物のコラゲナーゼ活性阻害作用は、放線菌由来コラゲナーゼ及び合成基質ＰＺ−ｐｅｐｔｉｄｅを用いて評価した。緩衝液は０．１Ｍトリス（塩酸）緩衝液（ｐＨ７．１，２０ｍＭＣａＣｌ２含有）を用いた。酵素は緩衝液にて０．１ｍｇ／ｍＬに調製し、基質は緩衝液にて０．５ｍｇ／ｍＬに調製した。試料、酵素、及び基質を混合し３７℃で３０分間反応させた後、２５ｍＭクエン酸溶液を添加し反応を停止した。次に酢酸エチルを添加し酢酸エチル層を抽出した。遠心分離（３０００ｒｐｍ，５ｍｉｎ）後、波長３２０ｎｍにおける酢酸エチル層の吸光度を測定し、以下の数２により阻害率を算出した。尚、対照は各種植物抽出物の溶媒とし、反応停止後に基質を添加する盲検を設け、検体と盲検の吸光度の差から以下の数２で阻害率を算出し、結果を表２に示した。
ａ．試料
尚、コラゲナーゼ活性阻害試験の試料は、本発明の製造例２で得られた各種の植物抽出液（固形分濃度：０．５％に調整）を用い試験に供した。
【００８８】
〈数２〉
コラゲナーゼ活性阻害率（％）＝１００−｛（阻害物質存在下の検体−盲検）／（阻害物質非存在下の検体−盲検）｝×１００
【００８９】
【表２】

【００９０】
（試験結果）
表２の通り、本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンの各種植物抽出物は、コラゲナーゼ活性を有意に阻害する作用を有することが確認でき、コラゲナーゼ活性阻害剤として使用できる。
【００９１】
（試験３）ヒアルロニダーゼ活性阻害試験
「試験方法及び評価方法」
試料０．１ｍＬに、ヒアルロニダーゼ溶液（最終濃度０．４ｍｇ／ｍＬ）０．０５ｍＬを加え、３７℃で２０分間放置した後、Ｃｏｍｐｏｕｎｄ４８／８０溶液（最終濃度０．１ｍｇ／ｍＬ）を加え、更に３７℃で２０分間放置した後、ヒアルロン酸溶液（最終濃度０．４ｍｇ／ｍＬ）０．２５ｍＬを加え、３７℃で４０分間放置した。次に０．４Ｎ水酸化ナトリウム溶液０．１ｍＬを加え反応を停止させた後、０．８Ｍホウ酸カリウム溶液０．１ｍＬを加え、沸水中で３分間加熱した。室温まで冷却後、１％ｐ−ジメチルアミノベンズアルデヒド酢酸溶液３ｍＬを加え、３７℃で２０分間放置した後、５８５ｎｍにおける吸光度を測定した。尚、試料の代わりに精製水を入れたものを対照とし、各試料、対照について酵素を入れないブランクを設定し、次式（数３）によりヒアルロニダーゼ活性阻害率を求めた。
ａ．試料
尚、ヒアルロニダーゼ活性阻害試験の試料は、本発明の製造例２で得られた各種の植物抽出液（固形分濃度：０．５％に調整）を用い試験に供した。
【００９２】
〈数３〉
ヒアルロニダーゼ活性阻害率（％）＝１００−（阻害物質存在下／阻害物質なし）×１００
【００９３】
【表３】

【００９４】
（試験結果）
表３の通り、本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンの各種植物抽出物は、ヒアルロニダーゼ活性阻害作用を有することが確認でき、ヒアルロニダーゼ活性阻害剤として使用できる。
【００９５】
（試験４）安全性試験
（１）皮膚一次刺激性試験
製造例１〜４で得られた各種植物抽出物を固形分濃度が約１．０％になるように調製し、これを背部を剪毛したハートレー系モルモット（雌性，１群３匹，体重３００〜３５０ｇ）の皮膚の２×２ｃｍ^２の四角当たり０．０３ｍＬずつ塗布した。判定は、適用後２４，４８，７２時間に一次刺激性の評点法により紅斑及び浮腫を指標として行った。その結果、全ての動物において、何等、紅斑及び浮腫を認めず陰性と判定された。
【００９６】
（試験５）安全性試験
（２）皮膚累積刺激性試験
製造例１〜４で得られた各種植物抽出物を固形分濃度が約１．０％となるように調製し、これを側腹部を剪毛（２×４ｃｍ^２）したハートレー系モルモット（雌性，１群３匹，体重３２０ｇ前後）の皮膚に１日１回、週５回、０．５ｍＬ／動物当りを塗布した。塗布は２週にわたって、又、剪毛は各週の最終塗布日に行った。判定は、各塗布日及び最終塗布日の翌日に一次刺激性の評点法により紅斑及び浮腫を指標として行った。その結果、全ての動物において、塗布後２週間にわたって、何等、紅斑及び浮腫を認めず陰性と判断された。
【００９７】
（試験６）安全性試験
（３）単回投与毒性試験
製造例１〜４で得られた各種植物抽出物を１２．５％濃度になるよう精製水にて調整し、一匹につき１６ｍＬ／ｋｇ量を、試験前、１６時間絶食させたｄｄｙ系マウス（雄性及び雌性、１群５匹、５週齢）に経口にてゾンデを以て投与し、毒性症状の発現、程度等を経時的に観察した。その結果、全てのマウスにおいて１４日間、何等異常を認めず、解剖の結果も異常がなかった。よって、ＬＤ_５０は２，０００ｍｇ／ｋｇ以上であり、安全な物質と判断した。
【００９８】
（処方例）エラスターゼ活性阻害剤、コラゲナーゼ活性阻害剤、ヒアルロニダーゼ活性阻害剤、化粧料組成物又は飲食品の製造
上記の評価結果に従い、以下にその処方例を示すが、各処方例は各製品の製造における常法により製造したもので良く、配合量のみを示した。又、本発明はこれらに限定されるわけではない。
【００９９】

【０１００】

【０１０１】

【０１０２】

【０１０３】

【０１０４】

【０１０５】

【０１０６】

【０１０７】

【０１０８】

【０１０９】

【０１１０】

【０１１１】

【０１１２】

【０１１３】

【０１１４】

【０１１５】

【０１１６】

【０１１７】

【０１１８】

【０１１９】

【０１２０】

【０１２１】

【０１２２】

【０１２３】

【０１２４】

【０１２５】

【０１２６】

【０１２７】

【０１２８】

【０１２９】
（処方例３１）被覆保護剤
ガーゼ又はリニメント布にアオノリュウゼツラン全草又はサイザルアサ全草又はツリガネニンジン根茎熱水抽出液、抗生物質、抗炎症剤等、適量を混合した処方液を含浸させ、外傷部に添付する。又、アオノリュウゼツラン全草又はサイザルアサ全草又はツリガネニンジン根茎熱水抽出液を直接、局所に散布し、ガーゼ等で被覆しても良い。
【０１３０】

【０１３１】

【０１３２】

【０１３３】

【０１３４】

【０１３５】

【０１３６】

【０１３７】

【０１３８】

【０１３９】

【０１４０】

【０１４１】
（試験７）使用効果試験
本発明の化粧料組成物を実際に使用した場合の効果について検討を行った。使用テストは肌の張り・ツヤのない肌で悩む成人女性３０〜５０歳及びシワ・小ジワ悩む成人女性３０〜５０歳の各２０名をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液の適量を顔面に３ヶ月に渡って塗布することにより行った。尚、対照には、乳液から本発明の各種植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表４の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
【０１４２】
「肌の張り・ツヤ改善効果」
有 効：肌の張り・ツヤが増した。
やや有効：肌の張り・ツヤがやや増した。
無 効：使用前と変化なし。
【０１４３】
「肌のシワ・小ジワ改善効果」
有 効：肌のシワ・小ジワが目立たなくなった。
やや有効：肌のシワ・小ジワがやや目立たなくなった。
無 効：使用前と変化なし。
【０１４４】
【表４】

【０１４５】
（試験結果）
表４の通り、本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンの各種植物抽出物を含有した化粧料組成物は、有意に肌の張り・ツヤを与え、又、肌のシワ・小ジワも軽減することが確認できた。
【０１４６】
（試験８）使用効果試験
本発明の飲食品を実際に使用した場合の効果について検討を行った。使用テストは肌の張り・ツヤのない肌で悩む成人女性３０〜５０歳及びシワ・小ジワ悩む成人女性３０〜５０歳の各２０名をパネラーとし、毎日、朝と夜の２回、処方例４１のみそ汁を必ず一杯（約１５０ｃｃ）、３ヶ月に渡って飲用してもらった。尚、対照には、みそ汁から本発明の各種植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表５の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
【０１４７】
「肌の張り・ツヤ改善効果」
有 効：肌の張り・ツヤが増した。
やや有効：肌の張り・ツヤがやや増した。
無 効：使用前と変化なし。
【０１４８】
「肌のシワ・小ジワ改善効果」
有 効：肌のシワ・小ジワが目立たなくなった。
やや有効：肌のシワ・小ジワがやや目立たなくなった。
無 効：使用前と変化なし。
【０１４９】
【表５】

【０１５０】
（試験結果）
表５の通り、本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンの各種植物抽出物を含有した飲食品は、有意に肌の張り・ツヤを与え、又、肌のシワ・小ジワも軽減することが確認できた。
【０１５１】
【発明の効果】
本発明のアオノリュウゼツラン、サイザルアサ、ツリガネニンジンから選ばれる１種以上の植物抽出物を含有したエラスターゼ活性阻害剤、コラゲナーゼ活性阻害剤、ヒアルロニダーゼ活性阻害剤、更に化粧料組成物又は飲食品は、エラスターゼ活性阻害作用、コラゲナーゼ活性阻害作用、ヒアルロニダーゼ活性阻害作用を有すること。更に肌に対して、張りやツヤを与え、シワや小ジワを軽減することができる。よって、皮膚・頭皮の老化防止に有効である。又、人又は動物に対して内用又は外用しても安全であり、あらゆる形態の製剤（医薬品類、医薬部外品類、化粧品類、食品類）に応用することができる。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an elastase activity inhibitor, a collagenase activity inhibitor, a hyaluronidase activity inhibitor, and a cosmetic composition or an application to a food or drink containing at least one plant extract selected from Aonoave agave, sisal ginseng, and Trichoderma ginseng. It is.
[0002]
[Prior art]
The typical changes in human skin aging are wrinkles and lumps, which are one of the major concerns for older people and women. However, at present, there are few effective treatments for skin wrinkles and tarmi, and various studies on aging have been conducted in an aging society. At present, it is thought that the formation of wrinkles and lumps on human skin is caused by a decrease in the elasticity of the skin. Specific histological phenomena include changes in fibrous proteins such as elastin and collagen in the dermis, and extracellular matrix components such as glucosaminoglycan represented by hyaluronic acid.
[0003]
In other words, the decrease in skin elasticity that occurs during the formation of wrinkles and tarmi is caused by elastase, collagenase, and hyaluronidase, which are produced and secreted by dermal fibroblasts and immune system cells that have infiltrated by the inflammatory reaction, and degrade elastin, collagen, and hyaluronic acid. It is considered that the three-dimensional structure of the dermis is denatured. Therefore, the activity of these elastases, collagenases, and hyaluronidases is suppressed, and the elasticity and firmness of the skin are suppressed. Is important for preventing aging.
[0004]
In addition, as an elastase activity inhibitor, a seprix extract (for example, see Patent Document 1) and a Clara extract (for example, see Patent Document 2) are known, and chitintofil and α-carotene are used in the oral cavity due to the collagenase activity inhibitory effect. Use as a composition (for example, see Patent Document 3). In addition, as a collagenase activity inhibitor, a thorn extract and a lightly loaded extract (for example, see Patent Document 4). It is known that an extract of chestnut or biwa (see, for example, Patent Document 5) is used as a hyaluronidase activity inhibitor.
[Patent Document 1] Japanese Patent Application Laid-Open No. 9-87137
[Patent Document 2] Japanese Patent Application Laid-Open No. 10-17460
[Patent Document 3] JP-A-6-65033
[Patent Document 4] JP-A-6-183990
[Patent Document 5] JP-A-8-217688
[0005]
[Problems to be solved by the invention]
Therefore, the present invention suppresses the activity of three enzymes, elastase, collagenase, and hyaluronidase, prevents skin aging by restoring and maintaining skin firmness and elasticity, and keeps youthful skin free of wrinkles and lumps. Although an anti-aging agent having an effect has been sought, it has not been found at present.
[0006]
In view of these circumstances, the present inventors have developed a useful plant having an elastase activity inhibitory activity, a collagenase activity inhibitory activity, a hyaluronidase activity inhibitory activity, and as a result, Aono agave plant, It was confirmed that an extract containing at least one selected from sisal and ginseng significantly suppressed the activities of three enzymes, elastase, collagenase, and hyaluronidase. And a safe elastase activity inhibitor, a collagenase activity inhibitor, a hyaluronidase activity inhibitor, and a cosmetic composition that can give the skin firmness and luster and maintain young skin without wrinkles and wrinkles The present invention has been completed by providing the product or food or drink.
[0007]
BEST MODE FOR CARRYING OUT THE INVENTION
In the present invention, “Aon agave (also called Ryu tongue orchid)” is a plant of the family Agave (Agavaceae) or the genus Agave (Agave): flowers, spikes, pericarps, fruits, and flowers of Agave americana L. Cones, buds, stems, leaves, branches, foliage, stems, bark, rhizomes, bark, roots, seeds or whole plants are used, but other congeners of the species A. americana L. var marginata HORT. , Sasanoyuki (A. victoriae-reginae T. Moore), lysin (A. potatorum Zucc.), Or a variety or hybrid of these can also be used.
[0008]
In addition, the term “sisalasa (also known as swordfish)” used in the present invention refers to a plant of the family Agaveaceae (Agavaceae) or the genus Agave (Agave): a flower of sisalasa “Agave sisalana Perr. (= A. Rigida Mill.)”. , Cotyledons, fruits, cones, buds, stems, leaves, branches, leaves, stems, bark, rhizomes, root bark, roots, seeds, or whole plants, but other species of the same species, A. cantala (A. cantala) Haw.) Roxb. ", Heneken (A. fourcroides Lem.), Or their variants and hybrids.
[0009]
In the present invention, “Tuligan ginseng (alias: bell ginseng, shajin, and ginseng)” refers to a plant of the family Amarantidae (Campanulaceae), a genus of the genus Adenophora: Adenophora triphylla (Thumbb. A. DC. Japonica (Regel) Hara (= A. Triphylla A.DC. var. Tetraphylla Makino; = A. Buds, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but other species of the genus Toushadin "A. axilliflora Borb. = A. stricta.Miq.) ", Miyayama Shajin" Adenophora lamarckii Fisch. (A. remotiflora Miq.), Ginseng (A. tetraphylla Fisch.), Or a variety or hybrid thereof can also be used.
[0010]
The extracts of Aurora agave, sisal, carrot ginseng used in the present invention are various parts of each plant (flower, spike, pericarp, fruit, cone, bud, stem, leaf, branch, branch leaf, stem, bark, Rhizome, root bark, root, seed or whole plant) as it is or after crushing and then squeezed. Alternatively, it is extracted with a solvent as it is or after pulverization.
[0011]
The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol Isopropyl alcohol, butanol, isobutanol, lower alcohols such as pentanediol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and various organics such as ethyl acetate It is desirable to use one kind or a mixture of two or more kinds selected from solvents. However, when the content of the organic solvent is not preferable due to the purpose of use, water alone may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in any mixed solution with water. It may be extracted and exploited. Furthermore, it can be used in a state where each solvent extract is combined.
[0012]
In addition to the above-mentioned various plants, those obtained by hydrolysis with acids and alkalis in addition to hydrolysis and extraction by enzymatic decomposition can also be used.
[0013]
In addition, the production method is not particularly limited, but usually, it may be in the range of the boiling point of the solvent at normal temperature and normal pressure, and after extraction, using filtration or ion exchange resin, adsorption, decolorization, and purification. It may be in the form of a solution, paste, gel, or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to an extracted substance may be arbitrarily selected. Further, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol, pentanediol, or an arbitrary mixture thereof can be added to the extract after the extraction. The obtained extract can be used as it is, but it can also be concentrated and dried to be used as a paste or powder.
[0014]
Various plant extracts of A. agave, sisal, ginseng of the present invention can be contained in elastase activity inhibitors, collagenase activity inhibitors, hyaluronidase activity inhibitors, and further in cosmetic compositions or foods and drinks, and the content is particularly defined. Rather, the elastase activity inhibitor, collagenase activity inhibitor, hyaluronidase activity inhibitor, the type of cosmetic composition or food and drink, the quality, slightly different depending on the expected effect, usually in the total amount of the formulation, solid It is 0.0001% by mass or more (hereinafter expressed as%), preferably 0.01 to 50.0% in terms of minute. In the case of a bath agent, it may be poured into 200 to 300 L of bath water and the formulation may be considered so that the concentration becomes almost the same.
[0015]
In addition, the elastase activity inhibitor, collagenase activity inhibitor, hyaluronidase activity inhibitor of the present invention, the cosmetic composition or food and drink may be in any form, capsule, powder, granule, solid, liquid, gel, It can be blended and used in the form of air bubbles, emulsion, cream, ointment, sheet and the like.
[0016]
The field of application can be used, for example, in all kinds of internal / external preparations (including preparations used for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, cosmetics) in suitable forms for use as liquids, gels, air bubbles, emulsions, sheets, mist, sprays, etc. Basic cosmetics such as water, emulsion, cream, ointment, lotion, oil, and pack, facial cleanser and skin cleanser, massage agent, cleansing agent, depilatory, depilatory, shaving treatment, after-shave lotion, pre-show Makeup cosmetics such as lotions, shaving creams, foundations, lipsticks, blushers, eye shadows, eyeliners, mascaras, perfumes, nail polish, and nail enamel Beauty nail enamel removers, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.) 4) Medicinal and / or cosmetic preparations for scalp and hair (eg, shampoos, rinses) Agents, hair treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair tonics, hair restoration / hair restoration, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 5 ) Bath agents to be poured into bath water, 6) Others, axillary deodorant, deodorant, deodorant, antiperspirant, sanitary goods, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, 7) Foods and drinks.
[0017]
Further, as foods and drinks, oral compositions (gum, candy, etc.), processed fishery products such as kamaboko, chikuwa, livestock products such as sausage, ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat, etc. Noodles, sauces, soy sauce, sauces, sugar, honey, seasonings such as powdered candy, starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce, sprinkles, or Processed vegetables and fruits such as canned and bottled vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drinks, soft drinks, beverages such as alcoholic beverages, health foods And the like for general foods and drinks.
[0018]
Incidentally, the elastase activity inhibitor, the collagenase activity inhibitor, the hyaluronidase activity inhibitor, and further the cosmetic composition or the food and drink of the present invention, if necessary, in addition to the above-mentioned essential components, within a range that does not impair the effects of the present invention. The components and additives exemplified below can be arbitrarily selected and used in combination. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.
[0019]
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard , Squalene, squalane, pristane, hydrogenated products of these oils and fats (hardened oils, etc.) and the like.
[0020]
(2) waxes
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.
[0021]
(3) Mineral oil
Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.
[0022]
(4) Fatty acids
Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acids, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid.
[0023]
(5) Alcohols
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.
[0024]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0025]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.
[0026]
(8) Metal soaps
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
[0027]
(9) Gum, sugar or water-soluble polymer compound
Gum arabic, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan, alkylene (C2-C4) oxide, such as ethylene oxide, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, potassium Boxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or a crosslinked polymer thereof, a carboxyvinyl polymer, polyethyleneimine and the like.
[0028]
(10) Surfactant
Anionic surfactants (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactants (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing nonionic surfactant), other surfactants (natural surfactant, protein) Derivatives of hydrolysates, polymeric surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0029]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0030]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And their amino acids such as sulfates, phosphates, nitrates, citrates, and pyrrolidone carboxylic acids.
[0031]
(13) Various additives derived from plant or animal raw materials
These are processed in a conventional manner according to the type and form of the product to be added (eg, pulverization, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization). , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., are arbitrarily selected and combined), and arbitrarily selected from various materials.
[0032]
The solvent used for the extraction may be selected in consideration of the purpose of use, the type of the product to be provided, or the processing to be performed later, but is usually water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol. Selected from lower alcohols such as isobutanol and pentanediol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, and various organic solvents such as acetone and ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.
[0033]
In addition, when an additive derived from a plant or animal-based material is applied to a systemic or topical external preparation or cosmetics, the skin and hair are protected, the moisturizer is improved, the feel / feel is improved, flexibility is imparted, and stimulation is provided. Mitigation, alleviation of stress by aroma, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin and hair quality, prevention and improvement of rough skin, hair growth, hair growth, hair loss prevention, gloss imparting, cleaning effect, In addition to cosmetic effects such as alleviation of fatigue, promotion of blood flow, and warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.
[0034]
In foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and other health and cosmetic effects, improvement of taste, color and aroma, gloss imparting, stabilization, thickening, It can be used for antiseptic purposes. Furthermore, in addition to the above, various cosmetic and pharmacological effects of each raw material known so far are expected, and by combining these, the intended effect can be enhanced or multifunctional. It is also possible to make a product that expects an effect.
[0035]
Specific plants (herbal medicines) as raw materials include, for example, almonds (herring peach), eyes (blue leaves), blue moss (Seifu wisteria), blue oysters (Aoki), blue oysters, or kenashiogiri (Otogi), and blue oysters (Komi) , Aotema, acacia, red ginger (red maize), red crocodile "fruit", red clover, red grape, red akaminoki (logwood), red akameshiwa (red bud), red akamane or rape or madder (akane grass root), red pheasant or pheasant (land yellow), Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Omiten palm), Akebi (Kidori), Asa (Jinji), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Ashitaba (morning leaves), Azuki (red azuki bean), Asunaro, Acerola, Acene Ku (Asenyaku), Achilla (Shokuyoukanna), Anise, Abiu, Abiurana, Brassica, Abemaki "fruit", Avocado, Ama, Amacha (sweet tea), Amacadul, Amadokoro (Tamatake), Amana (Kojingi), Amaranth (Amaranthus, Balsam pear, Hymenoptera, Senninkoku, Sugimorigeito, Hosoaoigato, Aogaito, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Yurizisen), Arcana (Alcanabo), Alcana , Althea, Arnica, Alpinia or Katsumadai (Sou-zuku), Aloe (lux), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azuka), Yellow sapote, Igakouzolina , Epimedium or Epimedium (Indian kaku), Igusa (Water heart grass), Itadori (Tiger root), Yew (No. 1), Strawberry, Fig (Figurine "fruit, leaf"), Ichihatsu (Primary), Ichibi (Winter Aiko) ), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo "seed, leaves"), Itohimemegi (Enshi), Carob, Inosumanus (Teilexi), Inuyuyu (Honaguinubiyu), Rice "seed, seed coat", Inondo "seed", Ibukijakosou, Nettle, ylang-ylang, iwa tobacco (Iwagashi chi), iwahiba or iwamatsu (makikashi), kidney bean, oolong tea, fennel (feng scent), wheat (chibusanoki), ukiyagara (sanraku), squid "fruit", hime uikyo, turmeric Ukukushi), duckweed (floating), usubasaishin or keirinsaishin or cattle Hyacinthus (spicy), Usbania oyster, Usbenitachiaoi, Uchouran, Utsubogusa (summer hay), Udo or Shisiudo (Qanggai, Independent, Tang Dungyo), Unyadegato (Unkaria, Cat's Claw), Uba tea, Ume (Ume (seed, flesh) )), Vladimir, Elephant's walnut (Kusakomomo), Unshurikan (Chen skin), Eunboku, Estragon, Ezocogi (Ezo Goka), Ezo lily of the valley, Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enotake mushroom), Ebisugusa or Mise ), Elcampre, Elderberry "fruit", Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gossip flowers, Sophora oleracea), Pea, Ogi or Kibana-ohagi (Ascot radix), Narco lily or Kagikuru mabanaruko lily (Yellow), Ouren (Yellow) Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Civil engineering incense), Ootsu-la-Fuji (self-defense), Oobako (car front child, car front grass), Obanana thistle (Keju Leak reed, Baekshio), Oohashibami (Haruko), Oohashira cactus, Obanana Okera or Okera (white jujube), Obananasasuberi (banaba), Obanayashabushi "fruit", Oohiratake, Oohoshigusa (grain sperm), Oumia Katetsu, Oumihasashi or Hawthorn (Mounter), Oomiyashi, Barley (barley), Oka, Okaze Flooring), okra "fruit", oguruma (turning over), okururihigotai (Ushu sashimi, indigo head), panax ginseng or horseshoe ginseng (carrot), hypericum or kogomebayotogirisui or hypericum perforatum (brother's cut grass), odorisou (continuation) ), Onami fir (blue ear child), Niguru, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Halibut (Hisashiyu), Ominaeshi (defeated), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch beetle, Dutch honeysuckle, olive "fruit, seed, leaf", oregano, orange "fruit, peel", calyxio (ripe yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf") , Kagikazura (Hook of Choto), Kakidooshi or Kantosou (Rensenso), Kakiran, Gaku hydrangea, Cassia, Cassiaki (Kozomi "fruit"), Kajutsu (Gagajutsu), Kashiwa (Kazuki tree, Kazalea), Kascarilla, Ka Scala sagrada, gypsophila, gypsophila, kanikusa (kinsato), kaniwa, carnation, kano Saw (Kikusone), Hippopotamus, Hippopotamus, Birch or Weeping Birch (Birch), Gerbera, Pumpkin, Kapokinoki "Seeds", Kahokoku Sansho (Shupper), Gama (Kabou), Chamomile or Roman Chamomile, Kamiyatsude (Commonweed), Kamcam (Duck), Karaguwa or Yamaguwa (mushroom), color, karaksakeman, crow squirrel or cinnamon cucurbite (roasted melon), crow sabisaku (midsummer), mussels, guarana "seed", karahoo (thick), karaya, galyu, karin ), Garcinia, Kawamidori, Kawara Psycho (Kelyo greens, white-leaved grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranginjin (blue croak), Kawamuragi (in ??) Ko), Kansui (sweet), Licorice (licorice), Candelilla, Canto, Canna, Kanran, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi "fruit, leaf", Kikarasuuri Ryone), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kangiku, Daffodilium), Chrysanthemum, Catalpa (Azusa), Giant crow (Yotei), Pheasant (Komimi), Kizuta, Kidachiaroe, Kidachiha, Kinna, Chinese quince (Shincona, red linden), quinoa (quinoa), yellowfin (yellow), pigeonpea, gymnema sylvestre, kimmenkaku, cabbage, cabbage "immature fruit", caraway, cucumber, gyoryu (Nishikawayanagi, teruyanagi), Kiraja saponaria, Kiraya, Kiran-so (golden pea), Nkan "fruits", Kinkiju, Ginsekai, Kimbusen, betel, Kinmizukiki (Sengaku grass), Kinran, Ginran, Kinryohen, Guapeva Vermelha, Guava "fruits", Guayule, Quercus Infectria (gallicate), Kukuinuts, Kugenumaran, Cuco ( Gugi, gugi, gugi leaf, ground bone bark), cedar oak (Tenmen winter), kudzu (kuzukon), camphor tree, gooseberry "fruit", xining ginseng (yellow flower), cutiti river, gardenia (sunflower), kunugi Bokusou), Kupuas, Kubeba, Kumazasa, Kumatsuzura (horse whip grass), Clara (bitter carrot), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaf", Buckthorn, black mound (rescue rescue), kamebahikio Shii or Kurobana Hikiokoshi or Hikiokoshi (extended lifegrass), clove (clove, clove), gumbinazu (sekimei, sekimeishi), kaygai (infestation, thorny spikelet), celosia (cow flower, cinnamon), gekkavidin, bay laurel, kenashi Sartorii rose (Tokubukuryo, mountain return), gentian, genoshoko (Oirou grass), Kemponashi (Kigushi), Koukisekikoku, Kishumican (Koji, Tachibana, Obeninican, Fucremican, Sagamikouji, Ponkan, Santara (tachibana)), Koshinbara (Tachibana) Monthly flower), Kosui mentha, Kozo "fruit", Kocha (tea), Kouhone (river bone), Kouhon (straw and kara straw), Kouriang, Kourikyo (Korajang), Cilantro "fruit", Kouren (huohren), Scutellaria (Yellow Gon), Cowberry (Koshibachi) ), Coconut palm "fruit", goshuyu (goshuyu), goshoichigo (covered bunko), pepper (pepper), cosmos, copaiba balsam, coffee "seed, leaf", kofukisarunokokake (ume parasitic), kobushi or magnolia (spicy), Burdock (burdock, burdock), coconut wool, sesame (sesame), sesame seeds (ginseng), garnish (gomiko), Sanekazura or Binankazura or Matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, Cola Acuminata "seed", Cola Bella "seed", Coleus Forskoli, Colony Lya, Fenugreek "fruit", Colombo, Kondulango, Kombu, Konjac, Comfrey (Finbari grass), Saihailan, Sakanelan (Ezosakaneran), Saxima button Or syrup button or sycamore Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "Leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabaginran Sadomodaka (Sawaka), Sweet potato, Sugarcane, Sugar beet, Satsuma jujube (Satsuma jujube), Saffron (Bamboo safflower, West safflower), Sapodilla, Sapotea marillo, Pomelo "Fruit", Sabonsou, Salmonberry "Fruit", Sarasin-shama (Masahima) , Saranshito (sand sashimi), salvia (sage), Sawagyoukyo (Yamakosai), Sawagurumi (Yamakowa), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (Sanjin ginseng), Sanshuyu (Mountain Yuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shiitake), Shion (Shion), Deer bean, Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenjiso or Kamenjiso (purple leaves, perilla), rosewood, linden, Chinese pine, Chinese beetle (ream of forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, ossiloishimeji, bunashimeji, honjimesi, shirotamoge mushroom) , Peonies (shakuyaku), jasmine (matsurika), scabbard (wheat stalks), ginger beetle, sycamore, sycamore (sand vines, sand compaction), gyuzdama, palm "fruit", shunlan, jowashi, ginger (ginger) ), Giant hydrangea ( Tsuneyama), Shobu (irises, iris roots), Shozuku "fruits", Shirakashi "seed", Silane (byakkyu), Shirogou butterfly "seed", White clover (clover), White adzuki (chicken bone grass), White iris (Small iris), White banana "Flowers", Shirobanana Lupine, Shirominanten (Minami Tenmi), Cinchona Saksilbra, Jinkoge (Mizuka, Mizuka, Shencho), Cinnamon, Cinnammum Cassia (Guirin), Watermelon (Watermelon), Honeysuckle (Golden Ginka, Shinobi) , Sorrel (acidic), swimberry "fruit", star apple, stevia, strawberry "fruit", suzu psycho (Xu Chang Lord), horsetail (question thorn), purslane (horse dent, horse tooth kenko), plum "fruit", Surugaran (Oran), Pinus sylvestris "cone", Larch, L. T., walnuts, walnuts, hawthorn, eucalypt, dandelion, horse chestnut (malonie), pear "fruits", eucalypt, euphorbia japonica (elder), eucalyptus (juniper, juniper), euphoric atum Roses, cornflowers, mistletoe, mint or mint, horseradish, rosewood (iris iris), seaweed (seaweed, seaweed, seaweed, seaweed, seaweed, seaweed) (Dendrobium, Ishimura), Cedron (Bowshokuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Senkyu (River Kyu), Senshinren ( Shinren, sendan, sennin cactus, senna "fruit, leaf", senninso (great tate), senburi (drug), senboku, souka (grass), elephant, shinshinbai, buckwheat "seed", soybean potato, fava bean, rhubarb (Daihuang), radish, soybean, daidai (orange peel, kikomi), takasagorurihigotai (southeast indigo plant), takasaburo (dry lotus grass), takatodai (daidai), takawarabi (inu), dark sweet cherry "fruit" , Tachiaoi, Tachijakosou (thyme, Hyoka), Tachidokoro (Hikari), Tachiyanagi, Tamarind "seed", onion, tamshiba (spicy), Tara tree "fruit, leaf, root bark", Tarayou (large leaf winter blue, one leaf tea, bitter) Dingcha, bitter tea), dahlia (tenjikubotan), tarui, tanuki bean, tanshiuchiwa, tanjin (dansan), ta Danpopo (Gakukoei) or White dandelion or Moko dandelion, Danmar, Cherry "fruit", Chigaya "fruit, root, bud", Chixetsu carrot (Bamboo ginseng), Chicory, Chancapiedra (Kidachikomikansou), Tulip, Chocolate stay, Artichoke (Artichoke), Artichoke (Ohta), Artichoke (Wuyi), Artemisia (Aoba), Choreimaitake (Irei), Japanese cricket, Tsukimisou, Tsukushisakaneran, Tsukutake (mushroom), Tsuchiakebi, Camellia, Camellia Tsumekusa (lacquer lacustrine), Tsuyukusa (duckling grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (Hanshukara), Tsuruna (Banju), Tsurujin (four-leaf ginseng), Tsuruame, Tsuwabuki, Deiko, Teuchigurumi, Duberry "fruit"", Ten Sa, Tencha (Tencha), Tendai-Yaku (Wakayaku), Pepper (Winter Gourd), Toukagi Kazura, Pepper (Bansho), Touki (Tokyo), Tokinsenka (Marigold), Tousakaika, Tounabena (River Cut), Corn Or corn hair (Southern barb hair), horned rice mochi (female child), eucalyptus or Korean gentian (dragon bile), horsetail (wood pirates), dokudami (jujutsu), konkon (spit root), sashimi or beetle or beetle or sardine, eucommia (tochu) "Bark, leaves, roots"), ash (qin bark), tomato, tragacanth, triacanthus "seed", truffle (Germania edulis), eustoma, tormentilla, dronoki, trollo aoi, tongue bean, Niseria berry "fruit", potato or Yamanoimo (Yamayaku), Nagi-kida (Butcherable) ), Naginata Kouju, Nazuna, Rape, Natsume or Manbuki (Sword Beans), Natsumikan, Jujube (Daijutsu), Naniwaibara (Kanekurako), Navena (intermittent), Nameko, Peanut (Peanut), Nanten (Namitenmi) , Namban karamushi (ramie), scented violet, bitter oyster (bitter tree), bitter mugwort (bitter mite), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or keiseki (keishi), nymphalidae, leek (niriko), Elderberry (bone-bearing tree "fruit, flower, stem, leaf"), garlic (garlic), nurde (fivefold), leek, nemoki or nebu or nebi or nemlinoki or zigokubana (healing), nozami (Oji), nobara (business) , Nozuka Kazura (Liao Xiaohua), Nogatei, Yarrow, Nodake (Maehu), Nobara, Nomomo, Pineapple "fruit" Fruit ", hibiscus (Bussouge, fusulin bussouge, Roselle), Hiyindow, Hauchowa, Pau Dosse, Hakamauraboshi (Bone Crushing), Hakuka Yumatou, Hakusanchidori, Hakusen (Rinosaur), Hakuruberry" Fruit ", Hakobi Hazel (Haruko), Hashidokoro (Roth Root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland Jelly), Naked Wheat, Batata, Hachikku or Madake (Bamboo Boiled), Patchouli, Mint (Light Weight, Light Weight Leaves) , Hashime bean, Adlay (Yokuinin), Hanasuge (Girl's mother), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanilla bins, Papaya, Japonica (Rabbit malt), Pahalobobo, Hub "whole plant, stem, leaf", paprika, Hamakakiran, Hamago or Mitsuba Hamago (vine thorns), Hamasuge (Katsuki ), Hamabishi (Situriko), Hamanas (Maikai flower), Hamabofu (Beach storm), Hamamelis, Palm, Rose (Roses), Ballata, Balata gum tree, Haratake (Haratake, White-faced Oharatake, Uchimorinocasa), Haran, Pariurus , Parietaria, Harkanran, Balsamina (Tsurureishi, Nigari), Harnile (Yellow, Yuhakuhide, Yuba), Barbasco, Harindou, Handaikai (Matsudaikai), Breadfruit, Hiougi (Radiated sunflower), Hikagetsuru carrot (Party), Pecan Nuts, Amaryllidaceae (garlic, garlic sprout), Higulmadaria, Higotai, Hishi (Hisami), Pistachio, Beet, Hitotsuba (Stone reed), Hipotsubani, Ferris, Daisies (Daisy), Hinata Kozuchi (cow knees), Hinomizu , Cypress, hiba, castor, Mawari, Bell Pepper, Himeuzu (Tamaoi), Himegama (Incense Bulb), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta "Fruit", Juniper, Bjakuyu, Hiyu "Fruit", Chickpea, Flounder, Beloudooi, Hirohokunagu Shirato), loquat "fruits, leaves, stems", betel nut (large clothing skin, betel nut), Puer tea (pu? Tea), spruce buds (southern rattan), butterflies, butterbur poppies (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans), fujimodoki (butterfly clover, pine flowers), grapes "fruit, peel, seeds, leaves", beech , Fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry, Branjen, Plum "fruit", Flucellaria, Blueberry (Prunus avium), Prune , Floral Blanca, Blond Psyllium, Bundo (Mung Bean), Hazelnut, Loofah, Hetkaran, Safflower (Safflower), Belladonna, Berry "Fruit", Persair, Perbianberg, Pereschia Grandifolia, Benqueisou or Ikusa (Keiten), Boysenberry Fruits ", Butterflies or Elderweed or Nendowe or Haeukigi Kokia (skinskin), Hosairan, Balsam pear (Fengseng, acute child, osteophyte), potteria sapota, potteria lukuma, spinach, spinach, physalis (Torone), Japanese cypress (Japanese magnolia, magnolia), bokeh (gourd), hosoba aburagiku (bitter gourd), hosobaoguruma, hosobananaokera (sojutsu), hosobanokirinsou (Kageten Sanshichi), hosoobabarengiku, bodaiju (bodaiju), button (peony) Flowers, leaves, stems, bark "), crocodile (peony bark), hops, jojoba, borage (ruriticha), bordeaux, white berries" fruits ", hon-oniku (meat porcelain, daigei), hon-sekko (iron bark stones, Sparrow mountain stones), Myzuruten Nansha (Tennan star), Maitake (Maitake), Ephedra (Maoh), Maca, Macadamia Zu, Margaret (Mokshungiku), Makuri (Seaweed), Magwa (Mulberry white bark "bark, leaves"), Magnolia splengeri, Masarambaba, Masaranzuba do Ceara, Masaira de Boi, Masahua (Tamanow) Senharen, Kyukonkinrenka, Matatabi (Kiten Tate), Matsukasa, Pine “leaves, bark, roots”, Matta Oryo, Matsutake (Matsutake), Matsuhod (Bukuryo), Matico (Cordoncillo), Mayolam (Hanahakka), Malvanojazine (Bitterfruit), Mulberry "Fruit", Quince, Malein (Birudomozu), Mango, Mangosteen, Mansagna (Andesca Mitsure), Mansugurumi, Mandarin "Fruit", Mannentake (Lingzhi), Pheasant (Fruit "Fruit") ), Mishima saiko (Saiko), Psyllium or Mizua Sagao (dragon tongue grass), mizokokushi (half-side lotus), misohagi (senkakuna), michinagi or elderwood (renzoku), mitsugashiwa, honeywort, midori sapote, green peppermint, mimosa, mioga, miracle fruit "fruit", myrrh, mirobaran , Wheat ragwort, mukuge (wood geese), mukunoki, mukuroji (extended skin), munya, murasaki (purple root), murasakisikibu or womurasakishikibu (purple pearl), murasaki maize, murasakinatsuji (Kunming chicken blood Fuji), megakansa opuntika, mesimashima (Mulberry yellow), swordfish (mother grass), scallop, primrose (primrose primrose), melaleuca, melissa, melilloto, melon "fruit", sagebrush, sagebrush, mokukirin, moss (koshouboku), suzuki, mokobuki Rhubarb, peach (peach "leaf" Seeds, flowers, fruits "), sprouts, morello cherries" fruits ", moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), yakyougarega, cornflower (cornflower), cornflowerhakka, yacon, yabasanta, yashabushi (arrow wheel) Or Himeyashabushi or Obayashishabushi "fruit, peel, ears", yachiyanagi, yatsude (octagonal gold plate), mistletoe (parasitic willow), willow (kawayanagi, tachinyanagi, weeping willow, akameyanagi, pussy willow, inuyanagi, konoyaginagi, kinoyanagi, kinoyanagi, kinoyanagi, konoyaginagi, kinoyaginagi, kinoyanagi, kuniyanagi, konoyaginagi, ryukosanagi , Palm, willow, willow willow, foxtail willow, fox willow, drone tree), willow leaf “leaves, stems”, yaba santa, yabugarashi, yabukouji (purple gold beef), yabu cigarette (tsuruisui, tenmeisei), yamagobo (land) Boletus edulis (porcini, cep, steinpilz), alder (Yamaharu), yamamomo (Yangmei), yamamogi, eucalyptus, yukinoshita (tiger eargrass), yucca or flevifolia, yuzu "fruit", lily, yorugusa, mugwort , Rigan (Raimaru), lime "fruit", rye, lakanka "fruit", raspberry "leaf, fruit", latania (clameria), rakkyo or shallot (scallop), lavender, longan (longan meat), ryocha (green tea), Apple "fruits, seeds, leaves, roots", gentian, rubus or suavisimus (sweeten), lullfish thistle (Urajirohigotai, Xinjiang indigo sashimi), litchi (Lichi, Lichi nucleus), lettuce (Chisha), red currant " Fruit ", Red Pitaya, Lemon" Fruit ", Lemongrass, Forsythia or Chinese Forsythia, astragalus, astragalus, waxy plum, coconut palm, locust (reed, azuki), loganberry "fruit", rosemary (mannenrow), rosehip (nobara), wasabi, cotton wisteria Waremokou (chiyu) and the like.
[0036]
Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usbaaonori, Sujiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), Anaausa (Aosa) and seaweed [Brown algae] (Macomb, Resiliconbu, Hosomebu, Mitsuikonbu), Wakame, Hirome, Aookame, Giant Kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys Luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa, Kiribano Sea Prickly Pear, Akabumi Prickly Pear, Konau Prickly Pear, Okinawa Prickly Pear, Usuki Prickly Pear, Ecchi Prickly Pear], Seaweed [Red Algae: Hijirimen, Maxa (Tengusa), Hiracusa, Onixa, Obaku ) Kainori, Yaleus Banori, Kagius Banori, Sujius Banori, Hyus Banori, Akamomininori] and the like.
[0037]
In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Genus kuwanomimo, Volvox: Ohigemawari, Volvox, Palmera, Yotsumemo, Aomidro: Hizaori, Spirogyra, Papilio spp., Hibimidro spp .: Hibimidro spp. Echinacea spp .: Echinacea spp., Iwata spp .: Husaiwata, Sricogulata, Helaiwata, Crocita, Janemo, Mir spp .: Mill, Cromil, Sakibuchimil, Nagamil, Hira Le, Casanori: Casanoli, Jusmo: Futozuzumo, Tamazuzumo, Mizojusmo, Mikazukimo, Korekaete, Tsuzumimo, Kikkogusa: Kikkougusa, Hitoexa Genus: Hitougusa, Hirohanohitengusa, Utsutoegumo, Genus Sumiremo: Sumiremo, Hoshimidoro, Fushinashimidoro etc.).
[0038]
Blue-green algae (Genus L .: L., L., L .: Kawatake, Ishikurage, Hassai, Juremo, L. (spirulina): Spirulina, Trichodesmium (Aiakashio), etc.).
[0039]
Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami spp., Isogrape spp .: Isogrape, Isogawara spp .: Isogawara spp. , Genus Sanadagusa: Sanadagusa, Fukurinamiji, common genus: common rush, terrestrial genus: Ezoyahazu, Yahuzugusa, Uraboshiyahazu, genus Genus: jigamigususa, Umiuchiwa genus: Genus genus, genus genus, genus Genus : Nabarimo, Chasoumen: Motsucha-chasomen, Matsumo: Matsumo, Nagamatsumo: Nagamatsumo, Okinawamozuku: Okinawamozuku, fake Genus Tomozuku: Niseftomozuku, Genus Futomozuku: Genus Futomozuku, Genus Genus: Ishimozuku, Genus Cromo: Chromo, Genus Nisemozuku: Nisemozuku, Genus Mozuku: Mozuku, Genus Ishige: Ishige, Genus Genus: Ichimegasa, Callarial spp. Umibos, Urushigusa genus: Urushigusa, Keulushigusa, Tobacco moss, Kombmodoki: Kombudoki, Hambamodoki genus: Havamodoki, Habanori genus: Habanori, Hiranohabanori genus: Habanori, Commonbukuro genus: Commonbukuro, Ezobukurono, Ezobukurono, Ezobukuronozo, genus Genus genus: genus genus: genus kagomenori: genus kagomenori, muralidori: murachidori, sharksugusa genus: sharksugusa, iwahige genus: iwahige, yokojimanori genus: yokojimanori, Genus: Cyperus, Fennel: Fennel, Turmo: Turmo, Anana: Aname, Sujime: Sujime, Miss kelp: Miss kelp, Atsuba Miss kelp, kelp: Gatsugara kelp, Kakisima kelp, Oni kelp, Gohei sorghum, Gohei kelp, Gohei sorghum Genus Oleoptera, Trolocomb: Trolocomb, Antokume: Antokume, Swordfish: Swordfish, Tsurarame, Kurome, Asterina: Asterine, Nesulecomb: Nesirecomb, Kuroshiome: Kuroshiome, Nekoashikame: Acerium, Araumenu Genus: Ainu-Wakame, Chigaiso, Oniwakamezo-Ezoishige: Ezoishige, Yabanemoku: Yabanmoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jo Lomoku, Hiemoku, Hondawara: Tamanamoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Hashimomoku, Haikumokugi, Hawk Mokumoku , Genus genus: genus oleum, genus bulumium: genus bulumium, genus kayamoris: kayamoris, etc.).
[0040]
Red algae (Coleoptera genus: genus oxenori, fenori no moss, Amanori genus: Asakusanori, Susabinori, Uppulinori, Oniamanori, Tasa, Filitasa, Benitasa, Rhodocorton genus: Milnoveni, Akebonomozuku, Agenidae, Genus: Sea elephant, Tsukumonori, Kamogashiranori, Benimozuku: Benimozuku, Hosobenimozuku, Kasamatsu: Casamatsu, Fusanori: Fusanori, Nisefusanori: Nisefusanori, Sodegarami: Sodegaramiragara, Gallaghera Genus: Tamaitadaki, genus genus: genus kaginori, genus chinensis, proboscis genus: scrophularus, scrophium, oobusa, nambugu , Kohira, Yohira, Kinukusa, Hibiroudo: Hibiroudo, Himehibiroudo, Isomemudoki: Isomemudoki, Michigaesou: Michigaesu, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekisuba, Nisekareqaba, Nisekarekubasa Genus Naminohana: Hosobanaminohana, Naminohana, Coralthrum Genus: Garagaramodoki, Shiogosagoromo Genus: Shiogosagoromo, Iwanokawa Genus: Etsukiiwanokawa, Kainokawa Genus: Kainokawa, Kaninote Genus: Kaninote, Kanonomi, Genus, Sagomo, Dessertica Cyanophora, Sakuranori, Nikumukade, Tambanori, Smooth, Fudarak, Malbahudarak, Isonohana: Nuracusa, Ronulaxa, Giant Coleoptera, Hirakintoki: Hirakintoki, Pleurotus genus: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aimatsumatsu, Fushikintoki, Tsunomukade, Nagakinotoki, Suzumekito, Kakutoitto, Kakutoto Genus Nagaobane: Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Kalexigusa: Kalexigusa, Tosakamokuki: Hosobanotosakamodo, Hirohanotosakamoki, Yatsudegatatosakamoki, Kurotosakanotoka, Japanese moss Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, genus genus: hornworm, lycaenoid genus: lycopodium, cypress, genus genus: nikhonoo, venicenago genus: venicenago, sukakebeni genus: sukakebeni, okamurasa genus: yamadagusa, mirin genus: mirin, saucaminae spp. , Isomocca: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Rhinoceros, Tachiibara, Kagiibaranori, Kizinoo: Kijinoo, Isosanthus: Isodantsuu, Atsubanori: Atsubanori, Ogononori, Ogonotori, Ogonotori, Mizo-Okonori, Kabanori, Beniogonori, Fukuroshinori, Murasaki Kabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogono Li, Sorbus americana, Cyperus sylvestris, Ligustrum serrata, Lily of the valley, Genus sylvestris, L. Genus: crocodile, saimi, crocodile, lotus spp .: lotus spp. Genus genus goats: genus goatsou, hanasakura, fukuronagi genus: fukurotsunagi, sujikonori, hananoeda genus: hananoeda, hiratagoata genus: hiratagoat, darsu : Darus, masagoshibari, anadarus, webagsa genus: webugsa, Benifukuronori: Benifukuronori, Fushitsunagi: Fushitsunagi, Himefushinagi, Hirohafushinagi, Watsunagisou: Hirawagnagisou, Utsuwagisuigi, Iriomota, Iriomota , Genus Egonori: Egonori, Futogigis, Saeda genus: Saeda, Chrysanthemum genus: Chirimomiji, Konohanoriaceae: Habutaenori, Konohanori, Suzurononori, Usveni genus: Usveni, Genus: Hasuziginu, Nagakonosuginonu Genus: Kagiusbanori, Yaleusbanori, Siusiusbanori, Hyusbanori, Usubanorimodoki Genus: Usubanolimodoki, Ayanishiki genus: Ayani Ki, Ayaginu: Ayaginu, Dadia: Enashidazia, Shimadada: Isohagi, Shimadada, Dazimodoki: Dazimomodoki, Itogusa: Moletogusa, Futigusa, Makri: Makuri, Sanaginori: Hanayanagi, Yuna, Yanaginaginamo, Yanaginaginamomori, Yanaginaginomibe, Yanaginaginomibe, and Yanaginaginomibe, Yanaginaginomibe, Yanaginarinamoyana, Yanaginaginoyamo, Yanaginarinamoyana, Yanaginayori, Yanaginayorimo, Yanaginayori, and Yanaginayori-namo-na-yagi-namo-nagi-na-gori , Sasabayanaginori, Sozogenus: Kurosozo, Kobusozo, Hanesozo, Sozonohana, Hanegusa: Hanegusa, Kehanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Genus: Himegoke, Kurohoshigoshi, Hioudoogoshigu Isomegusa, Aspergillus: Aspera, Aspera, Aspera, Aspergillus: Aspera, Aspergillus: Aspergillus, Aspergillus : Kawamozuku, Aokawamozuku, Himekamozuku, Ideyukogome spp .: Ideyukogome, Okichimozuku: Ochichimozuku, Itogusa, Chinorimo: Chinorimo, Chisinori: etc.).
[0041]
Axle algae (Erythra spp., Echinacea spp., Hoshiturimo genus: Hoshiturimo, Lichnotamus genus, Phalaenopsis genus: Himejirabamo, Chaboflavidium, Tripella genus, etc.), yellow algae (Hikarimo genus: Hikarimo etc.) and the like.
[0042]
In addition, as a material derived from animal-based raw materials, a cockscomb extract, a cow or pig, a human placenta extract, a cow or pig stomach, a duodenum, an intestine, an extract of a spleen or a decomposition product thereof, a cow or pig brain tissue Extract, collagen hydrolyzate (acid, alkali, enzyme, etc.) hydrolyzate of bovine / pork or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin or elastin hydrolyzate of bovine / pork / fish (acid, Alkali or enzyme) or water-soluble elastin derivative, keratin and its degradation product or their derivative, silk protein and its degradation product or their derivative, pig or bovine blood cell protein degradation product (globin peptide), cow or pig hemoglobin Decomposition products (hemin, hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or derivatives thereof, skim milk powder and its decomposition products or it Derivatives, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0043]
In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, or the like derived from a genetically modified product or a cell fusion can be used. Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.
[0044]
(14) Marine components
Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salt obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fungo), for example , Italian fango, German fango, Eifelfango, Freiburgfango, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide , Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintokushi, black pearl stone, etc.
[0045]
(15) Microbial culture metabolite
Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red bran, white bran) ) Fermented extract, Euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation product of raw milk or skim milk powder, lactic acid fermentation product of leguminous plant, lactic acid fermentation product of coconut genus plant, and the like.
[0046]
(16) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0047]
(17) Inorganic pigment
Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0048]
(18) UV absorber / blocker
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Sodium acid, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, paramethoxycinnamate 2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, etc., salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, Myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives , Dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative , Vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, Talc, kaolin, etc.
[0049]
(19) Whitening agent
Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives , Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol, etc.
[0050]
(20) Tyrosinase activity inhibitor
Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or its derivative, N-acetyltyrosine or its derivative , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, Admiral, bolet, hops, hawthorn, eucalyptus, yarrow, Altea, calyx, mankei, hammeris, caragua or yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, mahuang, senkyu, dokkatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0051]
(21) Melanin pigment reduction / decomposition substance
Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether) and the like.
[0052]
(22) Turnover promoting action / cell activator
Hydroquinone, lactic acid bacterium extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, ogon, horsetail, gentian, burdock, sicon, carrot, Hamamelis, hops, okinin, edulis, assembly, touki, balsam, amacha, hypericum, cucumber, scotch, mannenrou, parsley) and the like.
[0053]
(23) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) and the like.
[0054]
(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.
[0055]
(25) Antioxidant
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaseletenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamolin, gossypol, propolis etc.
[0056]
(26) Lipid peroxide production inhibitor
β-carotene, plant extracts (sesame cultured cells, amacha, Hypericum perforatum, hamamelis, clove, melissa, emisoso, birch, salvia, mannenrou, Nantenmi, Eijitsu, Ginkgo, green tea) and the like.
[0057]
(27) Anti-inflammatory agent
Icutamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof Salt, licorice extract, sicon extract, age extract, propolis and the like.
[0058]
(28) Antibacterial, disinfectant, disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine compound, iodoform, sorbin Acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidi , Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benza chloride) Ruconium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, Star Le violet, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.
[0059]
(29) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative , Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or a derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, Acid, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats such as avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, Cucumber oil, beef tallow fatty acid, quince seed oil, kukuinut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, coconut oil, eucalyptus oil, tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened) Oil) ", waxes (bee wax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin) , Hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax), natto metabolite, natto extract, silk fiber extract, plant extract (Akamatsu sap, aloe, kakkon, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assemblage, mulberry bark, biwa leaf, loofah, peony, penguin) and the like.
[0060]
(30) Hair agent
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0061]
(31) Antiandrogen agent
Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.
[0062]
(32) Peripheral blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.
[0063]
(33) Stimulant
Pepper tincture, nonyl acid vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
[0064]
(34) Metabolic activator
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate, and the like.
[0065]
(35) Antiseborrheic
Pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.
[0066]
(36) Keratolytic agent
Resorcinol, salicylic acid, lactic acid, urea, etc.
[0067]
(37) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.
[0068]
(38) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide and calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0069]
(39) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0070]
(40) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol P-nitroorthophenylenediamine, p-phenylenediamine, p-methylaminophenol, picramic acid, sodium piclamate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- ( 2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, sulfuric acid Orthochloroparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrophenol sulfate Tophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcinol , Tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.
[0071]
(41) Fragrance
Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black character Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, large fragrance essential oil, Tuberose essential oil, T-shaped essential oil, orange flower essential oil, winter green essential oil, Truval sam essential oil, baturi essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil, sandalwood essential oil, petitgren essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, perl Vegetable flavors such as balsam essential oil, boad rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannen wax) essential oil, Japanese mint essential oil, etc. Synthetic fragrances, etc.
[0072]
(42) Dyes / colorants
Red cabbage pigment, red rice pigment, Akane pigment, anato pigment, squid pigment, turmeric pigment, endju pigment, krill pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, Buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.
[0073]
(43) Sweetener
Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.
[0074]
(44) Nutrition enhancer
Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.
[0075]
(45) Dairy products
Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk, etc.
[0076]
(46) Other
Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / antibacterial agents, fresheners, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products , Animal and plant glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters) Etc.), oral preparations, deodorants / deodorants, bitters, seasonings, etc., and when used in combination therewith, an additive or synergistic improvement in the effects of the present invention or other cosmetic effects is expected. it can.
[0077]
Incidentally, the elastase activity inhibitor, collagenase activity inhibitor, hyaluronidase activity inhibitor of the present invention, the method of addition to cosmetic compositions or foods and beverages, may be added in advance, even during the production What is necessary is just to select suitably considering workability.
[0078]
【Example】
Hereinafter, production examples, test examples, and prescription examples will be described, but the present invention is not limited thereto.
[0079]
(Production Example 1)
100 g of various dried plants of Aon agave, sisal, and carrot are extracted with warm water in purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solid content: about 0.1 to 2.0% by mass). About 1.0 kg.
[0080]
(Production Example 2)
100 g of various dried plants of Aono agave, sisal and carrot are immersed in a 50% 1,3-butylene glycol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: about 0.1 to 2). 1.0% by weight).
[0081]
(Production Example 3)
100 g of various dried plants of Aono agave, sisal, and ginseng are immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: about 0.1 to 2.0% by weight). About 1.0 kg.
[0082]
(Production Example 4)
100 g of various dried plants of Aono agave, sisal, and ginseng are immersed in 70% ethanol solution or 70% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified water (about 30 ° C.), and are immersed at room temperature for 5 hours. After extraction day and night, the mixture is filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.5% by weight).
[0083]
(Test 1) Elastase activity inhibition test
"Test method and evaluation method"
The elastase activity inhibitory activity of various plant extracts was evaluated using pancreatic elastase and a synthetic substrate N-succinyl-ala-ala-ala-p-nitroanilde. The substrate was adjusted to 0.1 M with Dimethyl sulfoxide, and a 1 mM solution diluted 100-fold with a buffer at the time of use was used. The enzyme was adjusted to 0.05 unit / mL with a buffer. 100 μL of the substrate was reacted with 50 μL of the enzyme and 50 μL of the inhibitor (sample) at 37 ° C. for 30 minutes. Thereafter, the absorbance was measured at 405 nm, and the inhibition rate was calculated by the following equation (1). The buffer used was 0.2 M Tris-HCl buffer (pH 8.8). The results are shown in Table 1.
a. sample
In addition, the sample of the elastase activity inhibition test was used for the test using various plant extracts (adjusted to a solid content of 0.5%) obtained in Production Example 2 of the present invention.
[0084]
<Equation 1>
Elastase activity inhibition rate (%) = 100− (presence of harmful substance / no inhibitor) × 100
[0085]
[Table 1]

[0086]
(Test results)
As shown in Table 1, it can be confirmed that various plant extracts of A. agave, sisal and carrot ginseng of the present invention have an effect of significantly suppressing elastase activity, and can be used as an elastase activity inhibitor.
[0087]
(Test 2) Collagenase activity inhibition test
"Test method and evaluation method"
Collagenase activity inhibitory effects of various plant extracts of A. agave, sisal and ginseng of the present invention were evaluated using actinomycete-derived collagenase and synthetic substrate PZ-peptide. As a buffer, a 0.1 M Tris (hydrochloric acid) buffer (pH 7.1, containing 20 mM CaCl 2) was used. The enzyme was adjusted to 0.1 mg / mL with a buffer, and the substrate was adjusted to 0.5 mg / mL with a buffer. After mixing the sample, the enzyme, and the substrate and reacting at 37 ° C. for 30 minutes, the reaction was stopped by adding a 25 mM citric acid solution. Next, ethyl acetate was added to extract an ethyl acetate layer. After centrifugation (3000 rpm, 5 min), the absorbance of the ethyl acetate layer at a wavelength of 320 nm was measured, and the inhibition rate was calculated by the following equation (2). In addition, a control was used as a solvent for various plant extracts, and a blind test in which a substrate was added after the reaction was stopped was provided. From the difference in absorbance between the sample and the blind test, the inhibition rate was calculated by the following equation 2, and the results are shown in Table 2. Was.
a. sample
In addition, the sample of the collagenase activity inhibition test was used for the test using various plant extracts (adjusted to a solid content of 0.5%) obtained in Production Example 2 of the present invention.
[0088]
<Equation 2>
Collagenase activity inhibition rate (%) = 100-{(sample in the presence of inhibitor—blind) / (sample in the absence of inhibitor—blind)} × 100
[0089]
[Table 2]

[0090]
(Test results)
As shown in Table 2, it was confirmed that the various plant extracts of A. aeruginosa, sisal, and ginseng of the present invention have an activity of significantly inhibiting collagenase activity, and can be used as a collagenase activity inhibitor.
[0091]
(Test 3) Hyaluronidase activity inhibition test
"Test method and evaluation method"
0.05 mL of a hyaluronidase solution (final concentration 0.4 mg / mL) was added to 0.1 mL of the sample, left at 37 ° C. for 20 minutes, and then a Compound 48/80 solution (final concentration 0.1 mg / mL) was added. After leaving at 20 ° C. for 20 minutes, 0.25 mL of a hyaluronic acid solution (final concentration 0.4 mg / mL) was added, and the mixture was allowed to stand at 37 ° C. for 40 minutes. Next, 0.1 mL of a 0.4N sodium hydroxide solution was added to stop the reaction, and then 0.1 mL of a 0.8 M potassium borate solution was added, followed by heating in boiling water for 3 minutes. After cooling to room temperature, 3 mL of a 1% p-dimethylaminobenzaldehyde acetic acid solution was added, and the mixture was allowed to stand at 37 ° C for 20 minutes, and then the absorbance at 585 nm was measured. A sample containing purified water instead of a sample was used as a control, and a blank containing no enzyme was set for each sample and control, and the hyaluronidase activity inhibition rate was determined by the following equation (Equation 3).
a. sample
In addition, the sample of the hyaluronidase activity inhibition test was used for the test using various plant extracts (adjusted to a solid content of 0.5%) obtained in Production Example 2 of the present invention.
[0092]
<Equation 3>
Hyaluronidase activity inhibition rate (%) = 100− (presence of inhibitor / no inhibitor) × 100
[0093]
[Table 3]

[0094]
(Test results)
As shown in Table 3, it can be confirmed that various plant extracts of A. agave, sisal and ginseng of the present invention have a hyaluronidase activity inhibitory activity and can be used as a hyaluronidase activity inhibitor.
[0095]
(Test 4) Safety test
(1) Skin primary irritation test
Various plant extracts obtained in Production Examples 1 to 4 were prepared so that the solid content concentration was about 1.0%, and this was used for Hartley-type guinea pigs whose female back was shaved (female, 3 per group, body weight 300 to 100%). 2 x 2 cm of 350 g) skin ² 0.03 mL per square of was applied. The evaluation was performed using erythema and edema as indices by the primary irritation scoring method at 24, 48 and 72 hours after application. As a result, in all animals, no erythema and edema were observed, and the animals were determined to be negative.
[0096]
(Test 5) Safety test
(2) Skin irritation test
Various plant extracts obtained in Production Examples 1 to 4 were prepared so that the solid content concentration was about 1.0%, and the flank was shaved (2 × 4 cm). ² ) Was applied to the skin of Hartley-type guinea pigs (female, 3 animals per group, body weight of about 320 g) once a day, 5 times a week, 0.5 mL / animal. Application was over two weeks and shaving was performed on the last application day of each week. The judgment was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method with erythema and edema as indices. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged to be negative.
[0097]
(Test 6) Safety test
(3) Single dose toxicity test
Various plant extracts obtained in Production Examples 1 to 4 were adjusted with purified water so as to have a concentration of 12.5%, and the amount of 16 mL / kg per animal was fasted for 16 hours before the test, and ddy mice ( Male and female females, 5 animals per group, 5 weeks old) were orally administered with a sonde, and the appearance and extent of toxic symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD ₅₀ Is 2,000 mg / kg or more, which was judged to be a safe substance.
[0098]
(Formulation example) Production of elastase activity inhibitor, collagenase activity inhibitor, hyaluronidase activity inhibitor, cosmetic composition or food and drink
In accordance with the above evaluation results, formulation examples are shown below. Each formulation example may be one manufactured by a usual method for manufacturing each product, and only the compounding amount is shown. Further, the present invention is not limited to these.
[0099]

[0100]

[0101]

[0102]

[0103]

[0104]

[0105]

[0106]

[0107]

[0108]

[0109]

[0110]

[0111]

[0112]

[0113]

[0114]

[0115]

[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127]

[0128]

[0129]
(Formulation Example 31) Coating protective agent
A gauze or liniment cloth is impregnated with a prescription solution containing an appropriate amount of a green agave whole plant or sisal whole plant or turmeric ginseng rhizome hot water extract, an antibiotic, an anti-inflammatory agent, etc., and attached to the wound. Alternatively, the hot water extract of Aono agave whole plant, sisal whole plant or Triganella ginseng may be directly applied locally and covered with gauze or the like.
[0130]

[0131]

[0132]

[0133]

[0134]

[0135]

[0136]

[0137]

[0138]

[0139]

[0140]

[0141]
(Test 7) Use effect test
The effect when the cosmetic composition of the present invention was actually used was examined. The use test is a panel of 20 adult women aged 30-50 years old who are worried about the skin with no skin tension and gloss and 30-50 years old worried about wrinkles and small wrinkles. The test was carried out by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over 3 months. Incidentally, a control prepared by the same method except that the various plant extracts of the present invention were removed from the emulsion was used as a control. The evaluation was performed according to the following criteria. The results are as shown in Table 4 and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.
[0142]
"Effect of improving skin tension and gloss"
Effective: Skin tension and gloss increased.
Slightly effective: Skin tension and gloss increased slightly.
Ineffective: No change from before use.
[0143]
"Effect of skin wrinkles and fine wrinkles"
Effective: Wrinkles and wrinkles on the skin are less noticeable.
Slightly effective: wrinkles and wrinkles on the skin are slightly less noticeable.
Ineffective: No change from before use.
[0144]
[Table 4]

[0145]
(Test results)
As shown in Table 4, the cosmetic composition containing various plant extracts of Aono-agave, sisal, and carrot ginseng of the present invention significantly imparts skin firmness and luster, and also reduces skin wrinkles and fine wrinkles. Was confirmed.
[0146]
(Test 8) Use effect test
The effect when the food or drink of the present invention was actually used was examined. The usage test was conducted with a panel of 20 adult women aged 30-50 years and worried about wrinkles and small wrinkles, 30 to 50 years old, twice daily in the morning and evening, twice a day. I always had one cup (about 150 cc) of miso soup for three months. A control prepared by removing the various plant extracts of the present invention from miso soup in the same manner was used as a control. The evaluation was performed according to the following criteria. The results are as shown in Table 5, and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.
[0147]
"Effect of improving skin tension and gloss"
Effective: Skin tension and gloss increased.
Slightly effective: Skin tension and gloss increased slightly.
Ineffective: No change from before use.
[0148]
"Effect of skin wrinkles and fine wrinkles"
Effective: Wrinkles and wrinkles on the skin are less noticeable.
Slightly effective: wrinkles and wrinkles on the skin are slightly less noticeable.
Ineffective: No change from before use.
[0149]
[Table 5]

[0150]
(Test results)
As shown in Table 5, it was confirmed that the food and drink containing various plant extracts of Aono-agave, sisal and carrot ginseng of the present invention significantly imparted skin firmness and luster, and also reduced skin wrinkles and fine wrinkles. did it.
[0151]
【The invention's effect】
Aeon agave of the present invention, sisal asa, elastase activity inhibitor, collagenase activity inhibitor, hyaluronidase activity inhibitor containing at least one plant extract selected from carrot ginseng, further cosmetic composition or food and drink, elastase activity inhibition Have an action, a collagenase activity inhibitory action, and a hyaluronidase activity inhibitory action. Further, the skin is given tension and gloss, and wrinkles and wrinkles can be reduced. Therefore, it is effective in preventing skin and scalp aging. Moreover, it is safe to use internally or externally for humans or animals and can be applied to all forms of pharmaceuticals (medicines, quasi-drugs, cosmetics, foods).

Claims (5)

An elastase activity inhibitor, comprising at least one plant extract selected from Aono-agave, sisal, and ginseng. A collagenase activity inhibitor comprising one or more plant extracts selected from Aono-agave, sisal, and carrot ginseng. A hyaluronidase activity inhibitor comprising one or more plant extracts selected from Aono-agave, sisal, and carrot. A cosmetic composition comprising any one or more of the elastase activity inhibitor, the collagenase activity inhibitor, and the hyaluronidase activity inhibitor according to claims 1 to 3. A food or drink comprising any one or more of the elastase activity inhibitor, collagenase activity inhibitor and hyaluronidase activity inhibitor according to claims 1 to 3.