JP2004089204A5 - - Google Patents

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Publication number
JP2004089204A5
JP2004089204A5 JP2003398813A JP2003398813A JP2004089204A5 JP 2004089204 A5 JP2004089204 A5 JP 2004089204A5 JP 2003398813 A JP2003398813 A JP 2003398813A JP 2003398813 A JP2003398813 A JP 2003398813A JP 2004089204 A5 JP2004089204 A5 JP 2004089204A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003398813A
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Japanese (ja)
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JP2004089204A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2004089204A publication Critical patent/JP2004089204A/ja
Publication of JP2004089204A5 publication Critical patent/JP2004089204A5/ja
Pending legal-status Critical Current

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JP2003398813A 1990-05-03 2003-11-28 遺伝病を検出するための熱安定リガーゼによるdna増幅系 Pending JP2004089204A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51844790A 1990-05-03 1990-05-03

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP50889191A Division JP3889807B2 (ja) 1990-05-03 1991-04-29 遺伝病を検出するための熱安定リガーゼによるdna増幅系

Publications (2)

Publication Number Publication Date
JP2004089204A JP2004089204A (ja) 2004-03-25
JP2004089204A5 true JP2004089204A5 (https=) 2005-05-26

Family

ID=24063976

Family Applications (3)

Application Number Title Priority Date Filing Date
JP50889191A Expired - Lifetime JP3889807B2 (ja) 1990-05-03 1991-04-29 遺伝病を検出するための熱安定リガーゼによるdna増幅系
JP2001060432A Pending JP2001269187A (ja) 1990-05-03 2001-03-05 遺伝病を検出するための熱安定リガーゼによるdna増幅系
JP2003398813A Pending JP2004089204A (ja) 1990-05-03 2003-11-28 遺伝病を検出するための熱安定リガーゼによるdna増幅系

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP50889191A Expired - Lifetime JP3889807B2 (ja) 1990-05-03 1991-04-29 遺伝病を検出するための熱安定リガーゼによるdna増幅系
JP2001060432A Pending JP2001269187A (ja) 1990-05-03 2001-03-05 遺伝病を検出するための熱安定リガーゼによるdna増幅系

Country Status (7)

Country Link
EP (2) EP1507000B1 (https=)
JP (3) JP3889807B2 (https=)
AT (2) ATE375392T1 (https=)
DE (2) DE69133629D1 (https=)
DK (1) DK0528882T3 (https=)
ES (1) ES2294777T3 (https=)
WO (1) WO1991017239A1 (https=)

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DE4217134A1 (de) * 1992-05-23 1993-11-25 Boehringer Mannheim Gmbh Thermostabile Ligase aus Archaebakterien
US5700672A (en) 1992-07-23 1997-12-23 Stratagene Purified thermostable pyrococcus furiousus DNA ligase
EP0654093B1 (en) * 1992-08-03 2001-01-03 Abbott Laboratories Detecting and amplifying target nucleic acids using exonucleolytic activity
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
US5462854A (en) * 1993-04-19 1995-10-31 Beckman Instruments, Inc. Inverse linkage oligonucleotides for chemical and enzymatic processes
DE69506393T2 (de) * 1994-04-04 1999-07-01 Ciba Corning Diagnostics Corp., Medfield, Mass. Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen
CA2202990A1 (en) * 1994-10-21 1996-05-02 Alan H. Davis Use of spermidine to relieve inhibition of ligase chain reaction in a clinical test sample
AU3943095A (en) * 1994-11-04 1996-05-31 Genis Hf. A gene from the bacterium rhodothermus marinus, coding for the amino acid sequence of dna-ligase, produced in escherichia coli or some other suitable host organism
EP2332957B1 (en) 1996-02-09 2015-04-08 Cornell Research Foundation, Inc. Detection of nucleic and acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
AU776810B2 (en) * 1996-07-19 2004-09-23 Cornell Research Foundation Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US6949370B1 (en) 1998-10-30 2005-09-27 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
EP1127135B1 (en) * 1998-10-30 2007-05-23 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
DE50001774D1 (de) 1999-09-29 2003-05-22 Tecan Trading Ag Maennedorf Thermocycler sowie Hebeelement für Mikrotiterplatte
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
WO2001079548A2 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US6719949B1 (en) 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US6942836B2 (en) 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US7309575B2 (en) * 2002-01-16 2007-12-18 The University Of North Carolina At Chapel Hill Protein purification and detection methods
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
WO2005108618A2 (en) 2004-04-30 2005-11-17 Applera Corporation Methods and kits for methylation detection
WO2006076017A2 (en) 2004-04-30 2006-07-20 Applera Corporation Methods and kits for identifying target nucleotides in mixed populations
DE602005024987D1 (de) 2004-08-24 2011-01-05 Cornell Res Foundation Inc Detektion von nucleinsäureunterschieden mit hilfe von endonucleasespaltungs-/ligaseabgabereaktionen und kapillarelektrophoresen oder mikroarrays
AU2006279420B2 (en) 2005-08-16 2010-12-16 Merlogen, Llc Methods for identification of merle gene
US7285388B1 (en) 2006-04-07 2007-10-23 Merlogen, Llc Methods for identification of alport syndrome
WO2009087687A1 (en) * 2008-01-04 2009-07-16 Premas Biotech Pvt.Ltd Nucleic acid based detection process and uses thereof
WO2009087686A2 (en) * 2008-01-04 2009-07-16 Premas Biotech Pvt.Ltd Nucleic acid based detection methods
PT3204520T (pt) 2014-10-08 2020-04-16 Univ Cornell Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação
CN118984874A (zh) * 2022-03-25 2024-11-19 马里兰大学巴尔的摩县 用于产生具有单链粘端的双链dna片段的异源双链体热稳定性连接组装(htla)和/或环状异源双链体热稳定性连接组装(chtla)
WO2025197400A1 (ja) * 2024-03-19 2025-09-25 デンカ株式会社 高い正確性で、ミスマッチ塩基対を有さない配列を接合するリガーゼ
JP2026007482A (ja) * 2024-07-03 2026-01-16 デンカ株式会社 キメラリガーゼ

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US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
AU3539089A (en) * 1988-04-08 1989-11-03 Salk Institute For Biological Studies, The Ligase-based amplification method
US4879214A (en) * 1988-11-15 1989-11-07 E. I. Du Pont De Nemours And Company Differentiation of nucleic acid segments on the basis of nucleotide differences
AU627809B2 (en) * 1988-12-16 1992-09-03 Abbott Laboratories Isolating thermostable enzymes from engineered mesophiles

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