JP2004051592A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004051592A5 JP2004051592A5 JP2002214098A JP2002214098A JP2004051592A5 JP 2004051592 A5 JP2004051592 A5 JP 2004051592A5 JP 2002214098 A JP2002214098 A JP 2002214098A JP 2002214098 A JP2002214098 A JP 2002214098A JP 2004051592 A5 JP2004051592 A5 JP 2004051592A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- formula
- atom
- group
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 10
- 150000002902 organometallic compounds Chemical class 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229910052744 lithium Inorganic materials 0.000 claims description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 150000002641 lithium Chemical group 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 230000000737 periodic effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- RWNISPVLLBWJBU-UHFFFAOYSA-N 2-sulfonyl-1h-pyridine Chemical class O=S(=O)=C1C=CC=CN1 RWNISPVLLBWJBU-UHFFFAOYSA-N 0.000 claims description 2
- NYPYPOZNGOXYSU-UHFFFAOYSA-N 3-bromopyridine Chemical class BrC1=CC=CN=C1 NYPYPOZNGOXYSU-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 125000004436 sodium atom Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical group [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 0 *c1c(*)c(C(C(*)=C2*)=C(*)NC2=O)nc(*)c1* Chemical compound *c1c(*)c(C(C(*)=C2*)=C(*)NC2=O)nc(*)c1* 0.000 description 1
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002214098A JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| EP03765356A EP1553086B1 (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2 '-pyridyl)-2-pyridone derivative |
| US10/521,800 US7524967B2 (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2′-pyridyl)-2-pyridone derivative |
| KR1020057001229A KR101025528B1 (ko) | 2002-07-23 | 2003-07-23 | 5-(2'-피리딜)-2-피리돈 유도체의 제조 방법 |
| AU2003252241A AU2003252241B2 (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2'-pyridyl)-2-pyridone derivative |
| DE60329615T DE60329615D1 (de) | 2002-07-23 | 2003-07-23 | Verfahren zur herstellung eines 5-(2'-pyridyl)-2-pyridonderivats |
| PCT/JP2003/009316 WO2004009553A1 (ja) | 2002-07-23 | 2003-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| CA2493036A CA2493036C (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2'-pyridyl)-2-pyridone derivative |
| HK05112103.4A HK1077578B (zh) | 2002-07-23 | 2003-07-23 | 用於制备5-(2'-吡啶基)-2-吡啶酮衍生物的方法 |
| MXPA05000944A MXPA05000944A (es) | 2002-07-23 | 2003-07-23 | Procedimiento para producir un derivado de 5-(2'-piridil)-2-piridona. |
| CNB038176904A CN100393702C (zh) | 2002-07-23 | 2003-07-23 | 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 |
| AT03765356T ATE444952T1 (de) | 2002-07-23 | 2003-07-23 | Verfahren zur herstellung eines 5-(2'-pyridyl)-2- pyridonderivats |
| IL166451A IL166451A (en) | 2002-07-23 | 2005-01-23 | Processes for the preparation of ultrasound contrast agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002214098A JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004051592A JP2004051592A (ja) | 2004-02-19 |
| JP2004051592A5 true JP2004051592A5 (https=) | 2008-06-19 |
| JP4208512B2 JP4208512B2 (ja) | 2009-01-14 |
Family
ID=30767870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002214098A Expired - Fee Related JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7524967B2 (https=) |
| EP (1) | EP1553086B1 (https=) |
| JP (1) | JP4208512B2 (https=) |
| KR (1) | KR101025528B1 (https=) |
| CN (1) | CN100393702C (https=) |
| AT (1) | ATE444952T1 (https=) |
| AU (1) | AU2003252241B2 (https=) |
| CA (1) | CA2493036C (https=) |
| DE (1) | DE60329615D1 (https=) |
| HK (1) | HK1077578B (https=) |
| IL (1) | IL166451A (https=) |
| MX (1) | MXPA05000944A (https=) |
| WO (1) | WO2004009553A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| US20060270709A1 (en) * | 2005-04-04 | 2006-11-30 | Eisai Co. Ltd. | Dihydropyridine compounds and compositions for headaches |
| JP2009506123A (ja) | 2005-08-29 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン |
| EP1919905B1 (en) | 2005-08-29 | 2011-02-23 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-recptor tyrosine kinases |
| WO2007027594A1 (en) * | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| JP4865337B2 (ja) * | 2006-01-24 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | ２，３’−ビピリジル−６’−オンの製造方法 |
| WO2008093392A1 (ja) * | 2007-01-29 | 2008-08-07 | Fujifilm Finechemicals Co., Ltd. | ２，３'－ビピリジル－６'－オンの製造方法 |
| US20100099714A1 (en) * | 2007-03-05 | 2010-04-22 | Eisai R&D Management Co., Ltd. | AMPA and NMDA Receptor Antagonists for Neurodegenerative Diseases |
| EP2148673A1 (en) * | 2007-04-26 | 2010-02-03 | Eisai R&D Management Co., Ltd. | Cinnamide compounds for dementia |
| WO2009081872A1 (ja) * | 2007-12-21 | 2009-07-02 | Kuraray Co., Ltd. | ６－ハロゲノ－３－アリールピリジン誘導体の製造方法 |
| ITMI20111952A1 (it) * | 2011-10-27 | 2013-04-28 | Italiana Sint Spa | Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel |
| EP2800747A4 (en) | 2012-01-03 | 2015-12-09 | Mapi Pharma Ltd | POLYMORPHY OF PERAMPANEL |
| US9695147B2 (en) | 2013-07-25 | 2017-07-04 | Teva Pharmaceuticals International Gmbh | Process for the preparation of perampanel |
| CN104725301A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种1,2-二氢吡啶-2-酮衍生物的制备方法 |
| EP3259262A4 (en) | 2015-02-17 | 2018-08-01 | Mapi Pharma Limited | Process and intermediates for the preparation of perampanel |
| AU2019317366A1 (en) | 2018-08-06 | 2021-03-04 | Olive Seed Industries, Llc | Methods and systems for personalizing visitor experience at a venue |
| CN117425653A (zh) * | 2021-05-24 | 2024-01-19 | 住友化学株式会社 | 联吡啶衍生物的制造方法、大环状化合物的制造方法、包含大环状化合物作为配体的金属络合物的制造方法、金属络合物、空气电池用电极和空气电池 |
| CN116930351A (zh) * | 2023-06-08 | 2023-10-24 | 上海现代制药股份有限公司 | 一种hplc测定吡仑帕奈关键起始物料有关物质的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693611A (en) | 1996-02-01 | 1997-12-02 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| DE19633746A1 (de) * | 1996-08-22 | 1998-02-26 | Basf Ag | Substituierte 2-Phenylpyridine |
| DE19636995A1 (de) * | 1996-09-12 | 1998-03-19 | Basf Ag | Verfahren zur Herstellung substituierter Phenylpyridine |
| JP4176201B2 (ja) * | 1998-09-02 | 2008-11-05 | 株式会社クラレ | ５−ハロゲノ−２−置換ピリジンの製造方法 |
| AP2002002455A0 (en) | 1999-10-11 | 2002-06-30 | Pfizer | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors. |
| US20020045613A1 (en) | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| IL152848A0 (en) * | 2000-06-12 | 2003-06-24 | Eisai Co Ltd | 1,2-dihydropyridine derivatives, pharmaceutical compositions containing the same and methods for the production thereof |
-
2002
- 2002-07-23 JP JP2002214098A patent/JP4208512B2/ja not_active Expired - Fee Related
-
2003
- 2003-07-23 US US10/521,800 patent/US7524967B2/en not_active Expired - Fee Related
- 2003-07-23 KR KR1020057001229A patent/KR101025528B1/ko not_active Expired - Fee Related
- 2003-07-23 AT AT03765356T patent/ATE444952T1/de not_active IP Right Cessation
- 2003-07-23 CA CA2493036A patent/CA2493036C/en not_active Expired - Fee Related
- 2003-07-23 AU AU2003252241A patent/AU2003252241B2/en not_active Ceased
- 2003-07-23 CN CNB038176904A patent/CN100393702C/zh not_active Expired - Fee Related
- 2003-07-23 MX MXPA05000944A patent/MXPA05000944A/es active IP Right Grant
- 2003-07-23 DE DE60329615T patent/DE60329615D1/de not_active Expired - Lifetime
- 2003-07-23 HK HK05112103.4A patent/HK1077578B/zh not_active IP Right Cessation
- 2003-07-23 EP EP03765356A patent/EP1553086B1/en not_active Expired - Lifetime
- 2003-07-23 WO PCT/JP2003/009316 patent/WO2004009553A1/ja not_active Ceased
-
2005
- 2005-01-23 IL IL166451A patent/IL166451A/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004051592A5 (https=) | ||
| JP2010531876A5 (https=) | ||
| JP2001515084A5 (https=) | ||
| JP2009523146A5 (https=) | ||
| JP2008530102A5 (https=) | ||
| CA2493036A1 (en) | Process for producing 5-(2'-pyridyl)-2-pyridone derivative | |
| JP2012526168A5 (https=) | ||
| JP2009167162A5 (https=) | ||
| JP2012528811A5 (https=) | ||
| JP2021504440A5 (https=) | ||
| JP2013527840A5 (https=) | ||
| JP2003313184A5 (https=) | ||
| JP2004536153A5 (https=) | ||
| CA2399089A1 (en) | Process for exchanging functional groups by halogen-metal exchange reaction | |
| JP2006528215A5 (https=) | ||
| JP2004517891A5 (https=) | ||
| JP2003528098A5 (https=) | ||
| JP2007048462A5 (https=) | ||
| JP2004018389A5 (https=) | ||
| JP2006160643A5 (https=) | ||
| JP2006316032A5 (https=) | ||
| JP2009221187A5 (https=) | ||
| JP2003226682A5 (https=) | ||
| JP2003113163A (ja) | フッ素置換イリジウム錯体、その中間体及びその製造方法 | |
| JP2005255556A5 (https=) |