JP2004051592A5 - - Google Patents
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- JP2004051592A5 JP2004051592A5 JP2002214098A JP2002214098A JP2004051592A5 JP 2004051592 A5 JP2004051592 A5 JP 2004051592A5 JP 2002214098 A JP2002214098 A JP 2002214098A JP 2002214098 A JP2002214098 A JP 2002214098A JP 2004051592 A5 JP2004051592 A5 JP 2004051592A5
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- JP
- Japan
- Prior art keywords
- substituent
- formula
- atom
- group
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 10
- 150000002902 organometallic compounds Chemical class 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229910052744 lithium Inorganic materials 0.000 claims description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 150000002641 lithium Chemical group 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 230000000737 periodic effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- RWNISPVLLBWJBU-UHFFFAOYSA-N 2-sulfonyl-1h-pyridine Chemical class O=S(=O)=C1C=CC=CN1 RWNISPVLLBWJBU-UHFFFAOYSA-N 0.000 claims description 2
- NYPYPOZNGOXYSU-UHFFFAOYSA-N 3-bromopyridine Chemical class BrC1=CC=CN=C1 NYPYPOZNGOXYSU-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 125000004436 sodium atom Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical group [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 0 *c1c(*)c(C(C(*)=C2*)=C(*)NC2=O)nc(*)c1* Chemical compound *c1c(*)c(C(C(*)=C2*)=C(*)NC2=O)nc(*)c1* 0.000 description 1
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002214098A JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| US10/521,800 US7524967B2 (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2′-pyridyl)-2-pyridone derivative |
| AU2003252241A AU2003252241B2 (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2'-pyridyl)-2-pyridone derivative |
| CNB038176904A CN100393702C (zh) | 2002-07-23 | 2003-07-23 | 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 |
| KR1020057001229A KR101025528B1 (ko) | 2002-07-23 | 2003-07-23 | 5-(2'-피리딜)-2-피리돈 유도체의 제조 방법 |
| MXPA05000944A MXPA05000944A (es) | 2002-07-23 | 2003-07-23 | Procedimiento para producir un derivado de 5-(2'-piridil)-2-piridona. |
| PCT/JP2003/009316 WO2004009553A1 (ja) | 2002-07-23 | 2003-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| AT03765356T ATE444952T1 (de) | 2002-07-23 | 2003-07-23 | Verfahren zur herstellung eines 5-(2'-pyridyl)-2- pyridonderivats |
| HK05112103.4A HK1077578B (zh) | 2002-07-23 | 2003-07-23 | 用於制备5-(2'-吡啶基)-2-吡啶酮衍生物的方法 |
| DE60329615T DE60329615D1 (de) | 2002-07-23 | 2003-07-23 | Verfahren zur herstellung eines 5-(2'-pyridyl)-2-pyridonderivats |
| CA2493036A CA2493036C (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2'-pyridyl)-2-pyridone derivative |
| EP03765356A EP1553086B1 (en) | 2002-07-23 | 2003-07-23 | Process for producing 5-(2 '-pyridyl)-2-pyridone derivative |
| IL166451A IL166451A (en) | 2002-07-23 | 2005-01-23 | Processes for the preparation of ultrasound contrast agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002214098A JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004051592A JP2004051592A (ja) | 2004-02-19 |
| JP2004051592A5 true JP2004051592A5 (https=) | 2008-06-19 |
| JP4208512B2 JP4208512B2 (ja) | 2009-01-14 |
Family
ID=30767870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002214098A Expired - Fee Related JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7524967B2 (https=) |
| EP (1) | EP1553086B1 (https=) |
| JP (1) | JP4208512B2 (https=) |
| KR (1) | KR101025528B1 (https=) |
| CN (1) | CN100393702C (https=) |
| AT (1) | ATE444952T1 (https=) |
| AU (1) | AU2003252241B2 (https=) |
| CA (1) | CA2493036C (https=) |
| DE (1) | DE60329615D1 (https=) |
| HK (1) | HK1077578B (https=) |
| IL (1) | IL166451A (https=) |
| MX (1) | MXPA05000944A (https=) |
| WO (1) | WO2004009553A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| AU2006232517A1 (en) * | 2005-04-04 | 2006-10-12 | Eisai R&D Management Co., Ltd. | Dihydropyridine compounds and compositions for headaches |
| JP5112317B2 (ja) | 2005-08-29 | 2013-01-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン |
| ATE548363T1 (de) * | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| EP1919906B1 (en) | 2005-08-29 | 2011-10-12 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| JP4865337B2 (ja) * | 2006-01-24 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | ２，３’−ビピリジル−６’−オンの製造方法 |
| US20100016603A1 (en) * | 2007-01-29 | 2010-01-21 | Fujifilm Finechemicals Co., Ltd. | Production process of 2,3'-bipyridyl-6'-one |
| WO2008111590A2 (en) * | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | Ampa and nmda receptor antagonists for neurodegenerative diseases |
| WO2008139984A1 (en) * | 2007-04-26 | 2008-11-20 | Eisai R & D Management Co., Ltd. | Cinnamide compounds for dementia |
| JP5536458B2 (ja) * | 2007-12-21 | 2014-07-02 | 株式会社クラレ | ６−ハロゲノ−３−アリールピリジン誘導体の製造方法 |
| ITMI20111952A1 (it) | 2011-10-27 | 2013-04-28 | Italiana Sint Spa | Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel |
| US9096574B2 (en) | 2012-01-03 | 2015-08-04 | Mapi Pharma Ltd. | Polymorphs of perampanel |
| US9695147B2 (en) | 2013-07-25 | 2017-07-04 | Teva Pharmaceuticals International Gmbh | Process for the preparation of perampanel |
| CN104725301A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种1,2-二氢吡啶-2-酮衍生物的制备方法 |
| WO2016132343A1 (en) | 2015-02-17 | 2016-08-25 | Mapi Pharma Ltd. | Process and intermediates for the preparation of perampanel |
| EP3834167A4 (en) | 2018-08-06 | 2022-05-04 | Olive Seed Industries, LLC | PROCESSES AND SYSTEMS FOR PERSONALIZING VISITOR EXPERIENCES AT A VENUE |
| US20240247019A1 (en) * | 2021-05-24 | 2024-07-25 | Sumitomo Chemical Company, Limited | Method for producing bipyridine derivative, method for producing macrocyclic compound, method for producing metal complex containing macrocyclic compound as ligand, metal complex, electrode for air battery, and air battery |
| CN116930351A (zh) * | 2023-06-08 | 2023-10-24 | 上海现代制药股份有限公司 | 一种hplc测定吡仑帕奈关键起始物料有关物质的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693611A (en) | 1996-02-01 | 1997-12-02 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| DE19633746A1 (de) | 1996-08-22 | 1998-02-26 | Basf Ag | Substituierte 2-Phenylpyridine |
| DE19636995A1 (de) * | 1996-09-12 | 1998-03-19 | Basf Ag | Verfahren zur Herstellung substituierter Phenylpyridine |
| JP4176201B2 (ja) | 1998-09-02 | 2008-11-05 | 株式会社クラレ | ５−ハロゲノ−２−置換ピリジンの製造方法 |
| HK1049834A1 (zh) * | 1999-10-11 | 2003-05-30 | 辉瑞大药厂 | 用作磷酸二酯酶抑制剂的5-(2-取代的-5-杂环基磺酰基吡啶-3-基)-二氢吡唑并[4，3-d]嘧啶-7-酮类化合物 |
| US20020045613A1 (en) | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| ES2320973T3 (es) | 2000-06-12 | 2009-06-01 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos. |
-
2002
- 2002-07-23 JP JP2002214098A patent/JP4208512B2/ja not_active Expired - Fee Related
-
2003
- 2003-07-23 CN CNB038176904A patent/CN100393702C/zh not_active Expired - Fee Related
- 2003-07-23 AT AT03765356T patent/ATE444952T1/de not_active IP Right Cessation
- 2003-07-23 CA CA2493036A patent/CA2493036C/en not_active Expired - Fee Related
- 2003-07-23 KR KR1020057001229A patent/KR101025528B1/ko not_active Expired - Fee Related
- 2003-07-23 EP EP03765356A patent/EP1553086B1/en not_active Expired - Lifetime
- 2003-07-23 US US10/521,800 patent/US7524967B2/en not_active Expired - Fee Related
- 2003-07-23 DE DE60329615T patent/DE60329615D1/de not_active Expired - Lifetime
- 2003-07-23 HK HK05112103.4A patent/HK1077578B/zh not_active IP Right Cessation
- 2003-07-23 AU AU2003252241A patent/AU2003252241B2/en not_active Ceased
- 2003-07-23 WO PCT/JP2003/009316 patent/WO2004009553A1/ja not_active Ceased
- 2003-07-23 MX MXPA05000944A patent/MXPA05000944A/es active IP Right Grant
-
2005
- 2005-01-23 IL IL166451A patent/IL166451A/en not_active IP Right Cessation
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