JP2004002290A - 直接圧縮用β−マンニトールの製造方法 - Google Patents

直接圧縮用β−マンニトールの製造方法 Download PDF

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Publication number
JP2004002290A
JP2004002290A JP2002362318A JP2002362318A JP2004002290A JP 2004002290 A JP2004002290 A JP 2004002290A JP 2002362318 A JP2002362318 A JP 2002362318A JP 2002362318 A JP2002362318 A JP 2002362318A JP 2004002290 A JP2004002290 A JP 2004002290A
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JP
Japan
Prior art keywords
mannitol
spray
powder
product
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002362318A
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English (en)
Japanese (ja)
Inventor
Martin Erdmann
マルティン・エルドマン
Walter Hamm
ウォルター・ハム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7709161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2004002290(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2004002290A publication Critical patent/JP2004002290A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Glanulating (AREA)
JP2002362318A 2001-12-13 2002-12-13 直接圧縮用β−マンニトールの製造方法 Pending JP2004002290A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10161402A DE10161402A1 (de) 2001-12-13 2001-12-13 Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit

Publications (1)

Publication Number Publication Date
JP2004002290A true JP2004002290A (ja) 2004-01-08

Family

ID=7709161

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002362318A Pending JP2004002290A (ja) 2001-12-13 2002-12-13 直接圧縮用β−マンニトールの製造方法
JP2003556370A Expired - Lifetime JP5537755B2 (ja) 2001-12-13 2002-12-13 直接圧縮可能なα型マンニトールの製造方法
JP2013026628A Pending JP2013139455A (ja) 2001-12-13 2013-02-14 直接圧縮可能なα−マンニトールの製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2003556370A Expired - Lifetime JP5537755B2 (ja) 2001-12-13 2002-12-13 直接圧縮可能なα型マンニトールの製造方法
JP2013026628A Pending JP2013139455A (ja) 2001-12-13 2013-02-14 直接圧縮可能なα−マンニトールの製造方法

Country Status (7)

Country Link
US (2) US6998481B2 (https=)
EP (2) EP1319644B2 (https=)
JP (3) JP2004002290A (https=)
AT (1) ATE296791T1 (https=)
AU (2) AU2002360958A1 (https=)
DE (3) DE10161402A1 (https=)
WO (2) WO2003053896A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010021300A1 (ja) 2008-08-18 2010-02-25 三菱商事フードテック株式会社 新規マンニトール打錠用賦形剤
JP2013507499A (ja) * 2009-10-12 2013-03-04 ビーエーエスエフ ソシエタス・ヨーロピア １種以上の錯化剤の塩を含む粉末の製造方法
JP2014501226A (ja) * 2010-12-17 2014-01-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 直接圧縮可能なδ−マンニトールの調製方法
JP2018520192A (ja) * 2015-07-17 2018-07-26 ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ 直接圧縮用マンニトール顆粒
JP2025505542A (ja) * 2022-02-08 2025-02-28 ロケット フレール 直接圧縮可能なマンニトール顆粒

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10161402A1 (de) † 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
DE10240778A1 (de) * 2002-08-30 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem a-Mannit
US8186265B2 (en) * 2005-08-08 2012-05-29 Ron's Enterprises, Inc. Device to efficiently cook food
CN101460150B (zh) * 2006-03-31 2014-02-12 鲁比康研究私人有限公司 用于口腔崩解片剂的可直接压片复合物
WO2008079342A2 (en) * 2006-12-21 2008-07-03 Mallinckrodt Inc. Composition of and method for preparing orally disintegrating tablets
EP2264042B1 (en) * 2007-07-27 2012-07-18 Cargill, Incorporated Micronization of polyols
BRPI0914164B1 (pt) 2008-06-20 2019-04-30 Merck Patent Gmbh Comistura para produção de comprimidos de desintegração rápida em um processo de formação de comprimido direto, seus usos, e formulações de comprimido
FR2933299B1 (fr) 2008-07-04 2012-02-03 Roquette Freres Mannitol orodispersible
FR2944971B1 (fr) * 2009-04-30 2012-09-07 Roquette Freres Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre
ES2467141T3 (es) 2009-07-10 2014-06-12 Merck Patent Gmbh Composición para la fabricación de comprimidos y procedimiento para su preparación
EP2451447B1 (de) 2009-07-10 2017-10-11 Merck Patent GmbH Wasserarmes tablettierhilfsmittel und verfahren zu seiner herstellung
AR086505A1 (es) 2012-05-21 2013-12-18 Consejo Nac Invest Cient Tec Un excipiente co-procesado, obtenido mediante secado por atomizacion, utilizable como excipiente farmaceutico o aditivo alimenticio
TW201516023A (zh) * 2013-09-30 2015-05-01 Daiichi Sankyo Co Ltd 使用噴霧乾燥法之Ｄ－甘露醇α型結晶之選擇性製造方法
CN110172012A (zh) * 2019-07-06 2019-08-27 浙江华康药业股份有限公司 直接压片甘露醇的制备方法
CN110787722A (zh) * 2019-12-01 2020-02-14 浙江华康药业股份有限公司 一种结晶甘露醇干法造粒装置及工艺
FR3132522B1 (fr) 2022-02-08 2025-04-04 Roquette Freres Granules de mannitol directement comprimable
CN115671053A (zh) * 2022-11-09 2023-02-03 江西中医药大学 一种含有多孔甘露醇的载药粉末的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145146A (en) * 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
FR2571045B1 (fr) * 1984-10-03 1987-12-11 Roquette Freres Mannitol granulaire directement compressible et son procede de fabrication
FR2571046B1 (fr) * 1984-10-03 1987-10-16 Roquette Freres Procede de preparation de mannitol granulaire directement compressible
JPS6185330A (ja) * 1984-10-04 1986-04-30 Fuji Kagaku Kogyo Kk 直打用賦形薬の製造法
DK160809C (da) * 1989-01-09 1995-10-02 Niro Holding As Fremgangsmåde og forstøvningstørringsapparat til fremstilling af stabile partikelagglomerater
ATE128959T1 (de) * 1989-01-24 1995-10-15 Spi Polyols Inc Kryoschützende kristalline sorbitolkügelchen.
FR2710637B1 (fr) * 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
JP3126683B2 (ja) * 1996-04-16 2001-01-22 武田薬品工業株式会社 Ｄ−マンニトールおよびその製造法
AU718658B2 (en) * 1996-04-16 2000-04-20 Bayer Aktiengesellschaft D-mannitol and its preparation
DE19615418A1 (de) † 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
DE19927537A1 (de) † 1999-06-16 2000-12-21 Merck Patent Gmbh Sprühtrocknungsanlage und Verfahren zu ihrer Verwendung
DE10161402A1 (de) * 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010021300A1 (ja) 2008-08-18 2010-02-25 三菱商事フードテック株式会社 新規マンニトール打錠用賦形剤
JP2013507499A (ja) * 2009-10-12 2013-03-04 ビーエーエスエフ ソシエタス・ヨーロピア １種以上の錯化剤の塩を含む粉末の製造方法
US9540597B2 (en) 2009-10-12 2017-01-10 Basf Se Process for the preparation of a powder comprising one or more complexing agent salts
JP2014501226A (ja) * 2010-12-17 2014-01-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 直接圧縮可能なδ−マンニトールの調製方法
JP2017036280A (ja) * 2010-12-17 2017-02-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 直接圧縮可能なδ−マンニトールの調製方法
JP2018520192A (ja) * 2015-07-17 2018-07-26 ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ 直接圧縮用マンニトール顆粒
JP2021105035A (ja) * 2015-07-17 2021-07-26 ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ 直接圧縮用マンニトール顆粒
JP7198860B2 (ja) 2015-07-17 2023-01-04 ロケット フレール 直接圧縮用マンニトール顆粒
JP2025505542A (ja) * 2022-02-08 2025-02-28 ロケット フレール 直接圧縮可能なマンニトール顆粒

Also Published As

Publication number Publication date
DE50203302D1 (de) 2005-07-07
JP5537755B2 (ja) 2014-07-02
EP1319644B1 (de) 2006-01-11
DE10161402A1 (de) 2003-06-18
EP1453781B2 (de) 2014-03-05
WO2003055834A3 (de) 2003-10-16
WO2003053896A1 (de) 2003-07-03
US6998481B2 (en) 2006-02-14
ATE296791T1 (de) 2005-06-15
US20050008693A1 (en) 2005-01-13
EP1319644A1 (de) 2003-06-18
EP1453781A2 (de) 2004-09-08
AU2002360972A1 (en) 2003-07-15
EP1453781B1 (de) 2005-06-01
DE50205571D1 (de) 2006-04-06
AU2002360958A1 (en) 2003-07-09
WO2003055834A2 (de) 2003-07-10
JP2013139455A (ja) 2013-07-18
JP2005513151A (ja) 2005-05-12
US6998482B2 (en) 2006-02-14
US20030114717A1 (en) 2003-06-19
EP1319644B2 (de) 2009-04-01

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