JP2003534368A - ラゾフォキシフェンの経皮送達 - Google Patents
ラゾフォキシフェンの経皮送達Info
- Publication number
- JP2003534368A JP2003534368A JP2001587740A JP2001587740A JP2003534368A JP 2003534368 A JP2003534368 A JP 2003534368A JP 2001587740 A JP2001587740 A JP 2001587740A JP 2001587740 A JP2001587740 A JP 2001587740A JP 2003534368 A JP2003534368 A JP 2003534368A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- effective amount
- transdermal
- formulation
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 230000007170 pathology Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 239000013047 polymeric layer Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 229940077150 progesterone and estrogen Drugs 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 description 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
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- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20878900P | 2000-06-01 | 2000-06-01 | |
| US60/208,789 | 2000-06-01 | ||
| PCT/US2001/017567 WO2001091724A2 (en) | 2000-06-01 | 2001-05-31 | Transdermal delivery of lasofoxifene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003534368A true JP2003534368A (ja) | 2003-11-18 |
| JP2003534368A5 JP2003534368A5 (enExample) | 2008-07-17 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001587740A Pending JP2003534368A (ja) | 2000-06-01 | 2001-05-31 | ラゾフォキシフェンの経皮送達 |
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| Country | Link |
|---|---|
| US (1) | US20020037311A1 (enExample) |
| EP (1) | EP1229909B1 (enExample) |
| JP (1) | JP2003534368A (enExample) |
| KR (1) | KR100795870B1 (enExample) |
| CN (1) | CN1400897A (enExample) |
| AT (1) | ATE253910T1 (enExample) |
| AU (2) | AU785199B2 (enExample) |
| BR (1) | BR0106680A (enExample) |
| CA (1) | CA2380769A1 (enExample) |
| CZ (1) | CZ2002488A3 (enExample) |
| DE (1) | DE60101206T2 (enExample) |
| DK (1) | DK1229909T3 (enExample) |
| ES (1) | ES2210168T3 (enExample) |
| HK (1) | HK1052472A1 (enExample) |
| HU (1) | HUP0202592A3 (enExample) |
| IL (2) | IL147640A0 (enExample) |
| MX (1) | MXPA02001152A (enExample) |
| NZ (1) | NZ516582A (enExample) |
| PL (1) | PL201222B1 (enExample) |
| PT (1) | PT1229909E (enExample) |
| RU (1) | RU2328276C2 (enExample) |
| TR (1) | TR200400241T4 (enExample) |
| WO (1) | WO2001091724A2 (enExample) |
| ZA (1) | ZA200200519B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7804912B2 (en) * | 2004-09-23 | 2010-09-28 | Motorola, Inc. | Method and apparatus for encryption of over-the-air communications in a wireless communication system |
| US7564908B2 (en) * | 2004-09-23 | 2009-07-21 | Motorola, Inc. | Method and apparatus for encryption of over-the-air communications in a wireless communication system |
| GT200600411A (es) * | 2005-09-13 | 2007-05-21 | Novartis Ag | Combinaciones que comprenden un inhibidor del receptor del factor de crecimiento endotelial vascular |
| FR2905601A1 (fr) * | 2006-09-11 | 2008-03-14 | Innoderm Sarl | Utilisation de derives oleiques comme methode et composition favorisant la penetration cutanee des actifs contenus dans les compositions cosmetiques, pharmaceutiques ou dermatologiques. |
| US20100292660A1 (en) * | 2007-07-10 | 2010-11-18 | Agis Kydonieus | Dermal delivery device with ultrasonic weld |
| BRPI0814697B8 (pt) * | 2007-07-10 | 2021-05-25 | Agile Therapeutics Inc | dispositivo de liberação de fármacos |
| US20140378424A1 (en) * | 2011-12-30 | 2014-12-25 | Rosscreening, Inc. | Estrogen receptor modulators for reducing body weight |
| CN103751138A (zh) * | 2013-12-31 | 2014-04-30 | 北京万全德众医药生物技术有限公司 | 一种含酒石酸拉索昔芬的口腔崩解片及其制备方法 |
| CN103830196A (zh) * | 2014-03-14 | 2014-06-04 | 王志刚 | 一种酒石酸拉索昔芬分散片及其制备方法 |
| CN103830207A (zh) * | 2014-03-14 | 2014-06-04 | 崔书豪 | 一种酒石酸拉索昔芬贴膏剂 |
| PL3325080T3 (pl) * | 2015-07-24 | 2022-01-24 | Sorrento Therapeutics, Inc. | Sposoby lepszego dostarczania środków czynnych do guzów |
| CN107949418B (zh) * | 2015-07-24 | 2024-07-02 | 索伦托治疗有限公司 | 用于活性剂的淋巴递送的方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH107562A (ja) * | 1996-02-28 | 1998-01-13 | Pfizer Inc | 骨粗鬆症を治療する併用療法−ポリホスホネートまたはプロゲスチンおよびエストロゲンアゴニスト |
| JP2001002588A (ja) * | 1999-06-01 | 2001-01-09 | Pfizer Prod Inc | 経皮エストロゲンアゴニスト・アンタゴニスト療法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5122383A (en) * | 1991-05-17 | 1992-06-16 | Theratech, Inc. | Sorbitan esters as skin permeation enhancers |
| CN1170360A (zh) * | 1994-12-21 | 1998-01-14 | 瑟垃技术有限公司 | 具有粘性贴面和剥离密封圆片的经皮输送系统 |
| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| HN1996000101A (es) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
| US6007837A (en) * | 1996-07-03 | 1999-12-28 | Alza Corporation | Drug delivery devices and process of manufacture |
| US6034102A (en) * | 1996-11-15 | 2000-03-07 | Pfizer Inc | Atherosclerosis treatment |
| US6203817B1 (en) * | 1997-02-19 | 2001-03-20 | Alza Corporation | Reduction of skin reactions caused by transdermal drug delivery |
-
2001
- 2001-05-31 PL PL354628A patent/PL201222B1/pl not_active IP Right Cessation
- 2001-05-31 TR TR2004/00241T patent/TR200400241T4/xx unknown
- 2001-05-31 NZ NZ516582A patent/NZ516582A/en active IP Right Revival
- 2001-05-31 CZ CZ2002488A patent/CZ2002488A3/cs unknown
- 2001-05-31 US US09/871,318 patent/US20020037311A1/en not_active Abandoned
- 2001-05-31 AT AT01939751T patent/ATE253910T1/de not_active IP Right Cessation
- 2001-05-31 HK HK03104920.4A patent/HK1052472A1/zh unknown
- 2001-05-31 IL IL14764001A patent/IL147640A0/xx active IP Right Grant
- 2001-05-31 PT PT01939751T patent/PT1229909E/pt unknown
- 2001-05-31 BR BR0106680-3A patent/BR0106680A/pt not_active Application Discontinuation
- 2001-05-31 ES ES01939751T patent/ES2210168T3/es not_active Expired - Lifetime
- 2001-05-31 HU HU0202592A patent/HUP0202592A3/hu unknown
- 2001-05-31 WO PCT/US2001/017567 patent/WO2001091724A2/en not_active Ceased
- 2001-05-31 AU AU65235/01A patent/AU785199B2/en not_active Ceased
- 2001-05-31 DE DE60101206T patent/DE60101206T2/de not_active Expired - Fee Related
- 2001-05-31 EP EP01939751A patent/EP1229909B1/en not_active Expired - Lifetime
- 2001-05-31 RU RU2002105378/15A patent/RU2328276C2/ru not_active IP Right Cessation
- 2001-05-31 MX MXPA02001152A patent/MXPA02001152A/es unknown
- 2001-05-31 CN CN01801561A patent/CN1400897A/zh active Pending
- 2001-05-31 KR KR1020027001424A patent/KR100795870B1/ko not_active Expired - Fee Related
- 2001-05-31 JP JP2001587740A patent/JP2003534368A/ja active Pending
- 2001-05-31 DK DK01939751T patent/DK1229909T3/da active
- 2001-05-31 CA CA002380769A patent/CA2380769A1/en not_active Abandoned
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2002
- 2002-01-15 IL IL147640A patent/IL147640A/en not_active IP Right Cessation
- 2002-01-21 ZA ZA200200519A patent/ZA200200519B/en unknown
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2007
- 2007-02-01 AU AU2007200426A patent/AU2007200426A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH107562A (ja) * | 1996-02-28 | 1998-01-13 | Pfizer Inc | 骨粗鬆症を治療する併用療法−ポリホスホネートまたはプロゲスチンおよびエストロゲンアゴニスト |
| JP2001002588A (ja) * | 1999-06-01 | 2001-01-09 | Pfizer Prod Inc | 経皮エストロゲンアゴニスト・アンタゴニスト療法 |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0202592A2 (hu) | 2002-12-28 |
| KR20030025219A (ko) | 2003-03-28 |
| HK1052472A1 (zh) | 2003-09-19 |
| TR200400241T4 (tr) | 2004-04-21 |
| AU2007200426A1 (en) | 2007-02-22 |
| PL201222B1 (pl) | 2009-03-31 |
| DK1229909T3 (da) | 2004-03-15 |
| EP1229909A2 (en) | 2002-08-14 |
| DE60101206D1 (de) | 2003-12-18 |
| US20020037311A1 (en) | 2002-03-28 |
| MXPA02001152A (es) | 2002-08-20 |
| ES2210168T3 (es) | 2004-07-01 |
| CA2380769A1 (en) | 2001-12-06 |
| WO2001091724A2 (en) | 2001-12-06 |
| RU2328276C2 (ru) | 2008-07-10 |
| EP1229909B1 (en) | 2003-11-12 |
| KR100795870B1 (ko) | 2008-01-21 |
| BR0106680A (pt) | 2002-04-30 |
| AU785199B2 (en) | 2006-11-02 |
| HUP0202592A3 (en) | 2003-07-28 |
| DE60101206T2 (de) | 2004-09-02 |
| IL147640A (en) | 2007-03-08 |
| CZ2002488A3 (cs) | 2002-06-12 |
| PT1229909E (pt) | 2004-04-30 |
| CN1400897A (zh) | 2003-03-05 |
| ZA200200519B (en) | 2003-04-22 |
| NZ516582A (en) | 2004-08-27 |
| IL147640A0 (en) | 2002-08-14 |
| WO2001091724A3 (en) | 2002-05-30 |
| AU6523501A (en) | 2001-12-11 |
| ATE253910T1 (de) | 2003-11-15 |
| PL354628A1 (en) | 2004-02-09 |
| RU2002105378A (ru) | 2003-11-10 |
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