JP2003532708A5 - - Google Patents
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- Publication number
- JP2003532708A5 JP2003532708A5 JP2001582286A JP2001582286A JP2003532708A5 JP 2003532708 A5 JP2003532708 A5 JP 2003532708A5 JP 2001582286 A JP2001582286 A JP 2001582286A JP 2001582286 A JP2001582286 A JP 2001582286A JP 2003532708 A5 JP2003532708 A5 JP 2003532708A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- aryl
- compound
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 14
- 125000003118 aryl group Chemical group 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 9
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000005843 halogen group Chemical group 0.000 description 7
- 150000002431 hydrogen Chemical group 0.000 description 7
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 0 *N(C(N1I)=*)SC1=* Chemical compound *N(C(N1I)=*)SC1=* 0.000 description 1
- -1 - (Z) n - aryl Chemical group 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 description 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200001185A ES2166328B1 (es) | 2000-05-11 | 2000-05-11 | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
| ESP200001185ES | 2000-05-11 | ||
| ES200001185ES | 2000-05-11 | ||
| GB0030284.4 | 2000-12-12 | ||
| GB0030284A GB0030284D0 (en) | 2000-05-11 | 2000-12-12 | Enzyme inhibitors |
| PCT/GB2001/002100 WO2001085685A1 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase gsk-3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003532708A JP2003532708A (ja) | 2003-11-05 |
| JP2003532708A5 true JP2003532708A5 (enExample) | 2006-01-05 |
| JP4897179B2 JP4897179B2 (ja) | 2012-03-14 |
Family
ID=8493477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001582286A Expired - Lifetime JP4897179B2 (ja) | 2000-05-11 | 2001-05-11 | グリコーゲンシンターゼキナーゼｇｓｋ−３の複素環インヒビター |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP4897179B2 (enExample) |
| CN (1) | CN101045715B (enExample) |
| ES (1) | ES2166328B1 (enExample) |
| GB (1) | GB0030284D0 (enExample) |
| PT (1) | PT1286964E (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005024755A2 (en) * | 2002-12-31 | 2005-03-17 | Deciphera Pharmaceuticals, Llc. | Medicaments for the treatment of neurodegenerative disorders or diabetes |
| EP1586318A1 (en) * | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinones as GSK-3 inhibitors |
| AU2007275686B2 (en) * | 2006-07-18 | 2013-10-31 | University Of Rochester | Thiadiazolidinone derivatives |
| ES2567753T3 (es) * | 2009-07-08 | 2016-04-26 | Baltic Bio Ab | Derivados de 1,2,4-tiazolidin-3-ona y su uso en el tratamiento del cáncer |
| US9371299B2 (en) * | 2012-02-24 | 2016-06-21 | Asd Therapeutics Partners, Llc | Thiadiazolidinediones as GSK-3 inhibitors |
| CA2978182A1 (en) * | 2015-03-17 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Amino acid acylation reagents and methods of using the same |
| CN105330608B (zh) * | 2015-10-27 | 2018-06-26 | 南方科技大学 | 脲唑类轴手性化合物及其催化不对称合成方法 |
| CN107151235B (zh) * | 2016-03-04 | 2019-12-13 | 上海市计划生育科学研究所 | 噻二唑烷二酮基gsk3抑制剂在调节精子运动能力中的用途 |
| GB201915094D0 (en) * | 2019-10-18 | 2019-12-04 | Balticgruppen Bio Ab | New formulations |
| CN110698380B (zh) * | 2019-10-24 | 2021-01-15 | 华东理工大学 | 一种内酰胺衍生物及其制备方法与应用 |
| CN115197167B (zh) * | 2022-07-22 | 2023-07-28 | 中国药科大学 | 1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863803A (en) * | 1957-05-13 | 1958-12-09 | Stauffer Chemical Co | Protecting materials against fungi by applying substituted dithiono and thiono-oxo-thiadiazolidines |
| US3301894A (en) * | 1964-11-16 | 1967-01-31 | Olin Mathieson | S-[nu'-(chlorocarbonyl)-amino] isothiocarbamyl chlorides and their preparation |
| DE1670701A1 (de) * | 1966-05-23 | 1970-11-12 | Bayer Ag | Verfahren zur Darstellung von Thiaimidazolidinen |
| US3900485A (en) * | 1967-02-10 | 1975-08-19 | Velsicol Chemical Corp | New substituted 1,2,4-thiadiazolidine-3,5-diones |
| US3534057A (en) * | 1968-05-28 | 1970-10-13 | Velsicol Chemical Corp | Halogenation process for the production of certain oxadiazolidines and thiadiazolidines |
| DE2109755A1 (de) * | 1971-03-02 | 1972-09-07 | Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen | Substituierte Thiadiazolidindione |
| JPS58216177A (ja) * | 1982-06-10 | 1983-12-15 | Sumitomo Chem Co Ltd | フエニルチアジアゾリジンジオン誘導体、その製造法および該化合物を有効成分として含有する除草剤 |
| WO1995017182A1 (en) * | 1993-12-23 | 1995-06-29 | Eli Lilly And Company | Protein kinase c inhibitors |
| US5532256A (en) * | 1994-05-18 | 1996-07-02 | American Home Products Corporation | New azolidinediones and thiadiazolidinediones as antihyperglycemic agents |
| DE4420522A1 (de) * | 1994-06-13 | 1995-12-14 | Bayer Ag | Bakterizide Thiadiazolidinone |
| AU2381397A (en) * | 1996-04-19 | 1997-11-12 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| EP1119548B1 (en) * | 1998-10-08 | 2004-12-08 | SmithKline Beecham plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrole-2,5-dione as glycogen synthase kinase-3 inhibitor (gsk-3) |
| GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| GB9918180D0 (en) * | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
-
2000
- 2000-05-11 ES ES200001185A patent/ES2166328B1/es not_active Expired - Fee Related
- 2000-12-12 GB GB0030284A patent/GB0030284D0/en not_active Ceased
-
2001
- 2001-05-11 JP JP2001582286A patent/JP4897179B2/ja not_active Expired - Lifetime
- 2001-05-11 CN CN2007101010104A patent/CN101045715B/zh not_active Expired - Lifetime
- 2001-05-11 PT PT01928117T patent/PT1286964E/pt unknown
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