ES2166328B1 - Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos - Google Patents
Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativosInfo
- Publication number
- ES2166328B1 ES2166328B1 ES200001185A ES200001185A ES2166328B1 ES 2166328 B1 ES2166328 B1 ES 2166328B1 ES 200001185 A ES200001185 A ES 200001185A ES 200001185 A ES200001185 A ES 200001185A ES 2166328 B1 ES2166328 B1 ES 2166328B1
- Authority
- ES
- Spain
- Prior art keywords
- neurodegenerative
- treatment
- processes
- gsk
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 101150090422 gsk-3 gene Proteins 0.000 title abstract 3
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000000626 neurodegenerative effect Effects 0.000 title abstract 2
- YKFCOMVGLPKVBL-UHFFFAOYSA-N 1,2,4-thiadiazolidine-3,5-dione Chemical class O=C1NSC(=O)N1 YKFCOMVGLPKVBL-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000001267 GSK3 Human genes 0.000 abstract 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/597—Unsaturated compounds containing a keto groups being part of a ring of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200001185A ES2166328B1 (es) | 2000-05-11 | 2000-05-11 | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
| GB0030284A GB0030284D0 (en) | 2000-05-11 | 2000-12-12 | Enzyme inhibitors |
| MXPA02011079A MXPA02011079A (es) | 2000-05-11 | 2001-05-11 | Inhibidores heterociclicos de quinasa de sintasa de glucogeno gsk3. |
| PCT/GB2001/002100 WO2001085685A1 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase gsk-3 |
| JP2001582286A JP4897179B2 (ja) | 2000-05-11 | 2001-05-11 | グリコーゲンシンターゼキナーゼｇｓｋ−３の複素環インヒビター |
| EP01928117A EP1286964B1 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase gsk-3 |
| CN2007101010104A CN101045715B (zh) | 2000-05-11 | 2001-05-11 | 糖原合酶激酶gsk-3的杂环抑制剂 |
| PT01928117T PT1286964E (pt) | 2000-05-11 | 2001-05-11 | Inibidores heterocíclicos da glicogénio sintase cinase gsk-3 |
| DK01928117T DK1286964T3 (da) | 2000-05-11 | 2001-05-11 | Heterocykliske inhibitorer glycogensynthasekinase GSK-3 |
| AU54981/01A AU783615B2 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase GSK-3 |
| PL359671A PL209780B1 (pl) | 2000-05-11 | 2001-05-11 | Zastosowanie pochodnych tiadiazolidynodionu do wytwarzania leku |
| SI200130744T SI1286964T1 (sl) | 2000-05-11 | 2001-05-11 | Heterocikliäťni inhibitorji glikogenske sintaze kinaze gsk-3 |
| IL15272101A IL152721A0 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic compounds and pharmaceutical compositions for inhibition of glycogen synthase kinase containing the same |
| HU0302002A HUP0302002A3 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase gsk-3, their use and pharmaceutical compositions containing them |
| BR0110734-8A BR0110734A (pt) | 2000-05-11 | 2001-05-11 | Inibidores heterocìclicos de cinase de sintase de glicogênio gsk-3 |
| AT01928117T ATE366238T1 (de) | 2000-05-11 | 2001-05-11 | Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3 |
| KR1020027015132A KR100812407B1 (ko) | 2000-05-11 | 2001-05-11 | 글리코겐 신타제 키나제 ｇｓｋ-3의 헤테로사이클릭 억제제 |
| CZ20023692A CZ296087B6 (cs) | 2000-05-11 | 2001-05-11 | Farmaceutický prostredek pro lécbu nemoci, na nízse podílí heterocyklické inhibitory glykogensyntázakinázy GSK-3 |
| RU2002133222/04A RU2294931C2 (ru) | 2000-05-11 | 2001-05-11 | Гетероциклические ингибиторы гликоген-синтазы киназы gsk-3 |
| CA2408747A CA2408747C (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase gsk-3 |
| CNB01812738XA CN100358867C (zh) | 2000-05-11 | 2001-05-11 | 糖原合酶激酶gsk-3的杂环抑制剂 |
| ES01928117T ES2288948T3 (es) | 2000-05-11 | 2001-05-11 | Inhibidores heterociclicos del glicogeno sintasa quinasa gsk-3. |
| DE60129222T DE60129222T2 (de) | 2000-05-11 | 2001-05-11 | Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3 |
| US10/290,569 US6872737B2 (en) | 2000-05-11 | 2002-11-08 | Heterocyclic inhibitors of glycogen synthase kinase GSK-3 |
| US10/917,175 US7666885B2 (en) | 2000-05-11 | 2004-08-12 | Enzyme inhibitors |
| AU2006200668A AU2006200668B2 (en) | 2000-05-11 | 2006-02-17 | Heterocyclic inhibitors of glycogen synthase kinase GSK-3 |
| US11/788,755 US7781463B2 (en) | 2000-05-11 | 2007-04-20 | Enzyme inhibitors |
| CY20071101111T CY1106826T1 (el) | 2000-05-11 | 2007-08-30 | Ετεροκυκλικοι αναστολεις της κινασης συνθασης γλυκογονου gsk-3 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200001185A ES2166328B1 (es) | 2000-05-11 | 2000-05-11 | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2166328A1 ES2166328A1 (es) | 2002-04-01 |
| ES2166328B1 true ES2166328B1 (es) | 2003-09-16 |
Family
ID=8493477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200001185A Expired - Fee Related ES2166328B1 (es) | 2000-05-11 | 2000-05-11 | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP4897179B2 (enExample) |
| CN (1) | CN101045715B (enExample) |
| ES (1) | ES2166328B1 (enExample) |
| GB (1) | GB0030284D0 (enExample) |
| PT (1) | PT1286964E (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005024755A2 (en) * | 2002-12-31 | 2005-03-17 | Deciphera Pharmaceuticals, Llc. | Medicaments for the treatment of neurodegenerative disorders or diabetes |
| EP1586318A1 (en) * | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinones as GSK-3 inhibitors |
| AU2007275686B2 (en) * | 2006-07-18 | 2013-10-31 | University Of Rochester | Thiadiazolidinone derivatives |
| ES2567753T3 (es) * | 2009-07-08 | 2016-04-26 | Baltic Bio Ab | Derivados de 1,2,4-tiazolidin-3-ona y su uso en el tratamiento del cáncer |
| US9371299B2 (en) * | 2012-02-24 | 2016-06-21 | Asd Therapeutics Partners, Llc | Thiadiazolidinediones as GSK-3 inhibitors |
| CA2978182A1 (en) * | 2015-03-17 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Amino acid acylation reagents and methods of using the same |
| CN105330608B (zh) * | 2015-10-27 | 2018-06-26 | 南方科技大学 | 脲唑类轴手性化合物及其催化不对称合成方法 |
| CN107151235B (zh) * | 2016-03-04 | 2019-12-13 | 上海市计划生育科学研究所 | 噻二唑烷二酮基gsk3抑制剂在调节精子运动能力中的用途 |
| GB201915094D0 (en) * | 2019-10-18 | 2019-12-04 | Balticgruppen Bio Ab | New formulations |
| CN110698380B (zh) * | 2019-10-24 | 2021-01-15 | 华东理工大学 | 一种内酰胺衍生物及其制备方法与应用 |
| CN115197167B (zh) * | 2022-07-22 | 2023-07-28 | 中国药科大学 | 1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863803A (en) * | 1957-05-13 | 1958-12-09 | Stauffer Chemical Co | Protecting materials against fungi by applying substituted dithiono and thiono-oxo-thiadiazolidines |
| US3301894A (en) * | 1964-11-16 | 1967-01-31 | Olin Mathieson | S-[nu'-(chlorocarbonyl)-amino] isothiocarbamyl chlorides and their preparation |
| DE1670701A1 (de) * | 1966-05-23 | 1970-11-12 | Bayer Ag | Verfahren zur Darstellung von Thiaimidazolidinen |
| US3900485A (en) * | 1967-02-10 | 1975-08-19 | Velsicol Chemical Corp | New substituted 1,2,4-thiadiazolidine-3,5-diones |
| US3534057A (en) * | 1968-05-28 | 1970-10-13 | Velsicol Chemical Corp | Halogenation process for the production of certain oxadiazolidines and thiadiazolidines |
| DE2109755A1 (de) * | 1971-03-02 | 1972-09-07 | Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen | Substituierte Thiadiazolidindione |
| JPS58216177A (ja) * | 1982-06-10 | 1983-12-15 | Sumitomo Chem Co Ltd | フエニルチアジアゾリジンジオン誘導体、その製造法および該化合物を有効成分として含有する除草剤 |
| WO1995017182A1 (en) * | 1993-12-23 | 1995-06-29 | Eli Lilly And Company | Protein kinase c inhibitors |
| US5532256A (en) * | 1994-05-18 | 1996-07-02 | American Home Products Corporation | New azolidinediones and thiadiazolidinediones as antihyperglycemic agents |
| DE4420522A1 (de) * | 1994-06-13 | 1995-12-14 | Bayer Ag | Bakterizide Thiadiazolidinone |
| AU2381397A (en) * | 1996-04-19 | 1997-11-12 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| EP1119548B1 (en) * | 1998-10-08 | 2004-12-08 | SmithKline Beecham plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrole-2,5-dione as glycogen synthase kinase-3 inhibitor (gsk-3) |
| GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| GB9918180D0 (en) * | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
-
2000
- 2000-05-11 ES ES200001185A patent/ES2166328B1/es not_active Expired - Fee Related
- 2000-12-12 GB GB0030284A patent/GB0030284D0/en not_active Ceased
-
2001
- 2001-05-11 JP JP2001582286A patent/JP4897179B2/ja not_active Expired - Lifetime
- 2001-05-11 CN CN2007101010104A patent/CN101045715B/zh not_active Expired - Lifetime
- 2001-05-11 PT PT01928117T patent/PT1286964E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4897179B2 (ja) | 2012-03-14 |
| CN101045715B (zh) | 2010-11-24 |
| CN101045715A (zh) | 2007-10-03 |
| PT1286964E (pt) | 2007-08-08 |
| JP2003532708A (ja) | 2003-11-05 |
| GB0030284D0 (en) | 2001-01-24 |
| ES2166328A1 (es) | 2002-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2166328B1 Country of ref document: ES |
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| FD1A | Patent lapsed |
Effective date: 20101018 |