JP2003531129A5 - - Google Patents

Download PDF

Info

Publication number
JP2003531129A5
JP2003531129A5 JP2001576078A JP2001576078A JP2003531129A5 JP 2003531129 A5 JP2003531129 A5 JP 2003531129A5 JP 2001576078 A JP2001576078 A JP 2001576078A JP 2001576078 A JP2001576078 A JP 2001576078A JP 2003531129 A5 JP2003531129 A5 JP 2003531129A5
Authority
JP
Japan
Prior art keywords
seq
pharmaceutical composition
immunoglobulin
antigen
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001576078A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003531129A (ja
Filing date
Publication date
Priority claimed from US09/748,960 external-priority patent/US20010046496A1/en
Application filed filed Critical
Publication of JP2003531129A publication Critical patent/JP2003531129A/ja
Publication of JP2003531129A5 publication Critical patent/JP2003531129A5/ja
Withdrawn legal-status Critical Current

Links

JP2001576078A 2000-04-14 2001-04-13 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 Withdrawn JP2003531129A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55008200A 2000-04-14 2000-04-14
US09/550,082 2000-04-14
US09/748,960 US20010046496A1 (en) 2000-04-14 2000-12-27 Method of administering an antibody
US09/748,960 2000-12-27
PCT/US2001/012234 WO2001078779A2 (en) 2000-04-14 2001-04-13 Antibody alpha4beta7 integrin and its use to treat inflammatory bowel disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012105379A Division JP5764524B2 (ja) 2000-04-14 2012-05-02 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用

Publications (2)

Publication Number Publication Date
JP2003531129A JP2003531129A (ja) 2003-10-21
JP2003531129A5 true JP2003531129A5 (https=) 2011-02-17

Family

ID=27069332

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2001576078A Withdrawn JP2003531129A (ja) 2000-04-14 2001-04-13 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用
JP2012105379A Expired - Lifetime JP5764524B2 (ja) 2000-04-14 2012-05-02 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用
JP2015007655A Expired - Lifetime JP6021959B2 (ja) 2000-04-14 2015-01-19 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012105379A Expired - Lifetime JP5764524B2 (ja) 2000-04-14 2012-05-02 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用
JP2015007655A Expired - Lifetime JP6021959B2 (ja) 2000-04-14 2015-01-19 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用

Country Status (15)

Country Link
US (5) US20010046496A1 (https=)
EP (3) EP2298348B9 (https=)
JP (3) JP2003531129A (https=)
AU (1) AU2001251629A1 (https=)
BE (1) BE2017C009I2 (https=)
CA (1) CA2406220C (https=)
CY (3) CY1113489T1 (https=)
DK (2) DK1278543T3 (https=)
ES (2) ES2609689T3 (https=)
FR (1) FR14C0080I2 (https=)
LU (1) LUC00014I2 (https=)
MX (1) MXPA02010059A (https=)
NL (1) NL300702I2 (https=)
PT (1) PT2298348T (https=)
WO (1) WO2001078779A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030025B2 (en) 2008-02-20 2011-10-04 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
DK1485127T3 (da) * 2002-02-25 2011-10-03 Elan Pharm Inc Anvendelse af midler til behandling af inflammation
SG187991A1 (en) 2002-05-02 2013-03-28 Wyeth Corp Calicheamicin derivative-carrier conjugates
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
MX370489B (es) * 2004-01-09 2019-12-16 Pfizer Anticuerpos contra madcam.
WO2006026759A2 (en) 2004-09-03 2006-03-09 Genentech, Inc. Humanized anti-beta7 antagonists and uses therefor
EP1904531B1 (en) * 2005-07-08 2010-10-06 Pfizer Limited Madcam antibodies
WO2007007152A2 (en) * 2005-07-11 2007-01-18 Pfizer Limited Anti-madcam antibodies to treat metastatic cancers and chloroma
MX2008000659A (es) * 2005-07-11 2008-03-13 Pfizer Ltd Nueva combinacion de anticuerpo contra madcam y de inhibidor de caspasa antifibrotico.
CN105037549B (zh) 2007-01-11 2018-09-28 诺和诺德公司 抗-kir抗体、制剂及其应用
US20100297699A1 (en) * 2007-03-20 2010-11-25 Millennium Pharmaceuticals, Inc. Nucleic Acids Encoding Humanized Immunoglobulin That Binds Alpha4Beta7 Integrin
US20110105724A1 (en) * 2007-08-16 2011-05-05 Stephanie Jane Clegg Novel compounds
KR101361905B1 (ko) * 2008-05-16 2014-02-21 제넨테크, 인크. 베타7 인테그린 길항제를 이용한 위장관 염증 장애의 치료를 평가하기 위한 바이오마커의 용도
CN103382222B (zh) 2009-03-20 2016-12-28 安姆根有限公司 α-4-β-7异二聚体特异性拮抗剂抗体
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2625189B1 (en) 2010-10-01 2018-06-27 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
MX367097B (es) * 2011-05-02 2019-08-05 Millennium Pharm Inc FORMULACION PARA ANTICUERPO ANTI-A4ß7.
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
WO2013078375A2 (en) * 2011-11-23 2013-05-30 Amgen Inc. Administration of alpha4beta7 hetero-dimer-specific antibody
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
EA034583B1 (ru) * 2012-01-12 2020-02-21 Милленниум Фармасьютикалз, Инк. ПРИМЕНЕНИЯ АНТИ-α4β7 АНТИТЕЛА
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2016086147A1 (en) 2014-11-26 2016-06-02 Millennium Pharmaceuticals, Inc. Vedolizumab for the treatment of fistulizing crohn's disease
WO2016105572A1 (en) 2014-12-24 2016-06-30 Millennium Pharmaceuticals, Inc. PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-α4β7 INTEGRIN ANTIBODY
CA3017743A1 (en) 2016-03-14 2017-09-21 Millennium Pharmaceuticals, Inc. Method of preventing graft versus host disease
AU2017234010B2 (en) 2016-03-14 2024-06-13 Millennium Pharmaceuticals, Inc. Methods of treating or preventing graft versus host disease
WO2017165742A1 (en) 2016-03-24 2017-09-28 Millennium Pharmaceuticals, Inc. Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments
JP7069032B2 (ja) 2016-03-24 2022-05-17 ミレニアム ファーマシューティカルズ， インコーポレイテッド がん免疫治療における胃腸の免疫関連有害事象の治療方法
US10918716B2 (en) 2016-05-04 2021-02-16 Millennium Pharmaceuticals, Inc. Triple combination therapy for treating Crohn's disease
EP3468597A1 (en) 2016-06-12 2019-04-17 Millennium Pharmaceuticals, Inc. Method of treating inflammatory bowel disease
EP3652211A1 (en) 2017-07-14 2020-05-20 Pfizer Inc. Antibodies to madcam
US12492245B2 (en) * 2021-09-21 2025-12-09 University Of South Carolina Anti-CCL8 antibodies and treatment of lung injury by CCL8 inhibition
WO2024249568A1 (en) 2023-05-30 2024-12-05 Paragon Therapeutics, Inc. Alpha4beta7 integrin antibody compositions and methods of use
WO2024252368A2 (en) 2023-06-09 2024-12-12 Takeda Pharmaceutical Company Limited Methods and compositions for treating ulcerative colitis
CN121889424A (zh) 2023-08-14 2026-04-17 派拉冈医疗公司 α4β7整联蛋白结合蛋白及使用方法
WO2025149974A1 (en) 2024-01-11 2025-07-17 Takeda Pharmaceutical Company Limited Combination therapy with an anti-alpha4beta7 antibody
WO2025177214A1 (en) 2024-02-20 2025-08-28 Takeda Pharmaceutical Company Limited Therapeutic methods
WO2026058045A1 (en) 2024-09-12 2026-03-19 Takeda Pharmaceutical Company Limited Alpha4beta7 inhibitor and il-23 inhibitor combination therapy

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP3101690B2 (ja) * 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
ATE243754T1 (de) 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
US5403919A (en) * 1987-08-11 1995-04-04 Board Of Trustees Of The Leland Stanford Junior University Stanford University Method to control leukocyte extravasation
US5538724A (en) * 1987-08-11 1996-07-23 The Board Of Trustees For The Leland Stanford Junior Univ. Method of control leukocyte extravasation
WO1989007142A1 (en) 1988-02-05 1989-08-10 Morrison Sherie L Domain-modified constant region antibodies
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
EP1400536A1 (en) * 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
US5871734A (en) * 1992-01-13 1999-02-16 Biogen, Inc. Treatment for asthma with VLA-4 blocking agents
US5932214A (en) * 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
ATE161730T1 (de) * 1993-02-09 1998-01-15 Biogen Inc Antikörper zur behandlung von insulinabhängigen diabetes
CA2115811A1 (en) 1993-02-17 1994-08-18 Claus Krebber A method for in vivo selection of ligand-binding proteins
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5840299A (en) 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
GB2292079B (en) * 1994-08-12 1998-07-15 Flexpharm Ltd Coated prednisolone preparation for the treatment of inflamatory bowel disease
US6551593B1 (en) * 1995-02-10 2003-04-22 Millennium Pharmaceuticals, Inc. Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
US6015662A (en) * 1996-01-23 2000-01-18 Abbott Laboratories Reagents for use as calibrators and controls
US7147851B1 (en) * 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
JP2002524529A (ja) * 1998-09-14 2002-08-06 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム インテグリンアンタゴニストを用いて多発性骨髄腫および骨髄腫誘導骨吸収を治療する方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030025B2 (en) 2008-02-20 2011-10-04 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
US8221749B2 (en) 2008-02-20 2012-07-17 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof

Similar Documents

Publication Publication Date Title
JP2003531129A5 (https=)
CN105517570B (zh) 通过施用il-4r拮抗剂治疗鼻息肉症的方法
CN104684552B (zh) 组合及其用途
JP2022543612A5 (https=)
JP2025172841A5 (https=)
JP2022033868A5 (https=)
US11591406B2 (en) Treatment for multiple myeloma (MM)
JP2024129139A (ja) ベンラリツマブを使用して喘息の増悪率を低減する方法
JP2013166765A5 (https=)
JP2009519257A5 (https=)
JP2017537105A5 (https=)
JP2022531408A5 (https=)
JP2002524529A5 (https=)
JP2023546503A5 (https=)
CN114729054A (zh) 使用免疫检查点抑制剂抗体治疗癌症的方法和组合
Lolis et al. Effect of intravenous immunoglobulin with or without cytotoxic drugs on pemphigus intercellular antibodies
JP2022514561A5 (https=)
JP2024521105A5 (https=)
Gobel Hypersensitivity reactions to biological drugs
JP2022534494A5 (https=)
WO2021213523A1 (zh) 抗pd-1抗体和抗ctla-4抗体的组合在预防或治疗癌症中的用途
CN114423455A (zh) 用于治疗系统性硬化症的药物组合物
JP2025526402A5 (https=)
JP2024526742A5 (https=)
JP2024522620A5 (https=)