JP2003530357A5 - - Google Patents

Info

Publication number

JP2003530357A5

JP2003530357A5 JP2001574143A JP2001574143A JP2003530357A5 JP 2003530357 A5 JP2003530357 A5 JP 2003530357A5 JP 2001574143 A JP2001574143 A JP 2001574143A JP 2001574143 A JP2001574143 A JP 2001574143A JP 2003530357 A5 JP2003530357 A5 JP 2003530357A5

Authority

JP

Japan

Prior art keywords

antibody

composition according

antigen

antifungal agent

binding fragment

Prior art date

2001-03-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229940121375 antifungal agent Drugs 0.000 claims description 27
• 239000003429 antifungal agent Substances 0.000 claims description 22
• 206010017533 Fungal infection Diseases 0.000 claims description 19
• 208000031888 Mycoses Diseases 0.000 claims description 19
• 239000000427 antigen Substances 0.000 claims description 18
• 102000036639 antigens Human genes 0.000 claims description 18
• 108091007433 antigens Proteins 0.000 claims description 18
• 239000012634 fragment Substances 0.000 claims description 18
• 108010049047 Echinocandins Proteins 0.000 claims description 9
• 150000004291 polyenes Chemical class 0.000 claims description 9
• 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 8
• 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 8
• 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 7
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 6
• 230000002538 fungal effect Effects 0.000 claims description 5
• 241000233866 Fungi Species 0.000 claims description 4
• 230000000843 anti-fungal effect Effects 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 3
• 206010005098 Blastomycosis Diseases 0.000 claims description 3
• 206010061418 Zygomycosis Diseases 0.000 claims description 3
• 229960003942 amphotericin b Drugs 0.000 claims description 3
• JHVAMHSQVVQIOT-MFAJLEFUSA-N anidulafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@@H](C)O)[C@H](O)[C@@H](O)C=2C=CC(O)=CC=2)[C@@H](C)O)=O)C=C1 JHVAMHSQVVQIOT-MFAJLEFUSA-N 0.000 claims description 3
• 239000012636 effector Substances 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 201000007524 mucormycosis Diseases 0.000 claims description 3
• 241000222122 Candida albicans Species 0.000 claims description 2
• 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 claims description 2
• 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 claims description 2
• 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 claims description 2
• 229940095731 candida albicans Drugs 0.000 claims description 2
• 229940079593 drug Drugs 0.000 claims description 2
• 241001465754 Metazoa Species 0.000 description 2
• 239000000032 diagnostic agent Substances 0.000 description 2
• 229940039227 diagnostic agent Drugs 0.000 description 2
• 108010064760 Anidulafungin Proteins 0.000 description 1
• 241000228212 Aspergillus Species 0.000 description 1
• 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
• 238000009007 Diagnostic Kit Methods 0.000 description 1
• 241000228402 Histoplasma Species 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 238000000034 method Methods 0.000 description 1