CY1106794T1 - Θεραπεια μολυνσης απο μυκητα με πολυενιο ή με αντιμυκητιασικα αναστολεα της συνθασης της βητα γλουκανης σε συνδυασμο με αντισωματα αντι hsp90 - Google Patents

Θεραπεια μολυνσης απο μυκητα με πολυενιο ή με αντιμυκητιασικα αναστολεα της συνθασης της βητα γλουκανης σε συνδυασμο με αντισωματα αντι hsp90

Info

Publication number
CY1106794T1
CY1106794T1 CY20071101053T CY071101053T CY1106794T1 CY 1106794 T1 CY1106794 T1 CY 1106794T1 CY 20071101053 T CY20071101053 T CY 20071101053T CY 071101053 T CY071101053 T CY 071101053T CY 1106794 T1 CY1106794 T1 CY 1106794T1
Authority
CY
Cyprus
Prior art keywords
fungal
polyene
treatment
combination
synthesis inhibitors
Prior art date
Application number
CY20071101053T
Other languages
English (en)
Inventor
James Peter Burnie
Original Assignee
Neutec Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neutec Pharma Limited filed Critical Neutec Pharma Limited
Publication of CY1106794T1 publication Critical patent/CY1106794T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39575—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from other living beings excluding bacteria and viruses, e.g. protozoa, fungi, plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η παρούσα εφεύρεση συνδέεται με καινοτόμες συνθέσεις και παρασκευάσματα που είναι αποτελεσματικοί αντιμυκητιασικοί παράγοντες και ένα καινοτόμο αντίσωμα που μπορεί να ενσωματωθεί στις συνθέσεις και στα παρασκευάσματα.
CY20071101053T 2000-04-06 2007-08-07 Θεραπεια μολυνσης απο μυκητα με πολυενιο ή με αντιμυκητιασικα αναστολεα της συνθασης της βητα γλουκανης σε συνδυασμο με αντισωματα αντι hsp90 CY1106794T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0008305.5A GB0008305D0 (en) 2000-04-06 2000-04-06 Treatment of fungal infections
PCT/GB2001/001195 WO2001076627A1 (en) 2000-04-06 2001-03-20 Treatment of fungal infections with polyene or beta glucan synthase inhibitor antifungals combined with anti hsp90 antibodies

Publications (1)

Publication Number Publication Date
CY1106794T1 true CY1106794T1 (el) 2012-05-23

Family

ID=9889204

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101053T CY1106794T1 (el) 2000-04-06 2007-08-07 Θεραπεια μολυνσης απο μυκητα με πολυενιο ή με αντιμυκητιασικα αναστολεα της συνθασης της βητα γλουκανης σε συνδυασμο με αντισωματα αντι hsp90

Country Status (19)

Country Link
US (4) US20030180285A1 (el)
EP (4) EP1852128A1 (el)
JP (1) JP2003530357A (el)
CN (3) CN1420786A (el)
AT (1) ATE364396T1 (el)
AU (2) AU2001240890B2 (el)
BR (1) BR0109846A (el)
CA (1) CA2401836A1 (el)
CY (1) CY1106794T1 (el)
DE (1) DE60128893T2 (el)
DK (1) DK1267925T3 (el)
ES (1) ES2287105T3 (el)
GB (1) GB0008305D0 (el)
NO (1) NO20024815L (el)
NZ (1) NZ520899A (el)
PL (1) PL358394A1 (el)
PT (1) PT1267925E (el)
RU (1) RU2262952C2 (el)
WO (1) WO2001076627A1 (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050129665A1 (en) * 2002-07-25 2005-06-16 Martin Friedlander Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
US7651689B2 (en) * 2002-11-15 2010-01-26 Albert Einstein College Of Medicine Of Yeshiva University Methods of applying ionization radiation for therapy of infections
US7959915B2 (en) 2003-03-12 2011-06-14 Tufts University Inhibitors of extracellular Hsp90
EP1457499A1 (en) * 2003-03-12 2004-09-15 Tufts University School Of Medicine Inhibitors of extracellular Hsp90
GB0309126D0 (en) 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
GB0409077D0 (en) * 2004-04-23 2004-05-26 Neutec Pharma Plc Treatment of fungal infections
CA2572318A1 (en) 2004-07-02 2006-01-12 Neutec Pharma Plc Treatment of cancer
SG153877A1 (en) * 2004-07-02 2009-07-29 Neutec Pharma Plc Treatment of cancer
WO2006091459A2 (en) * 2005-02-24 2006-08-31 Joslin Diabetes Center, Inc. Compositions and methods for treating vascular permeability
JP5154406B2 (ja) * 2005-04-13 2013-02-27 アステックス、セラピューティックス、リミテッド 医薬化合物
GB0600168D0 (en) * 2006-01-05 2006-02-15 Neutec Pharma Plc A therapeutic composition
GB0620259D0 (en) * 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
WO2008091692A2 (en) * 2007-01-25 2008-07-31 Joslin Diabetes Center, Inc. Methods of diagnosing, treating, and preventing increased vascular permeability
WO2008116216A1 (en) * 2007-03-22 2008-09-25 Medical College Of Georgia Research Institute, Inc. Compositions and methods for inhibiting cancer metastasis
US20100113355A1 (en) * 2007-04-27 2010-05-06 Naresh Chennamsetty Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90
WO2008132174A1 (en) * 2007-04-27 2008-11-06 Novartis Ag An immunoglobulin composition
US10457726B2 (en) 2016-06-30 2019-10-29 University Of Connecticut Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof
CN113845591B (zh) * 2018-10-30 2023-10-31 迈威(上海)生物科技股份有限公司 Hsp90抗体及其在抗真菌感染中的应用
CN111679069A (zh) * 2019-12-31 2020-09-18 安徽中医药大学 一种通过耳道念珠菌细胞壁重构来评价中药单体抗真菌作用的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915019D0 (en) * 1989-06-30 1989-08-23 Matthews Ruth C Medicaments
GB2270076A (en) * 1992-08-18 1994-03-02 Univ Manchester Human HSP 90 Epitopes
US6375955B1 (en) * 1995-09-22 2002-04-23 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
US6365165B1 (en) * 1995-09-22 2002-04-02 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis
US5834592A (en) * 1995-09-22 1998-11-10 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides

Also Published As

Publication number Publication date
NO20024815D0 (no) 2002-10-04
EP1267925A1 (en) 2003-01-02
BR0109846A (pt) 2003-06-03
EP1852128A1 (en) 2007-11-07
EP1818062A3 (en) 2007-10-24
EP1267925B1 (en) 2007-06-13
PL358394A1 (en) 2004-08-09
EP1267925B8 (en) 2007-08-29
CA2401836A1 (en) 2001-10-18
EP2011512A1 (en) 2009-01-07
CN101095952A (zh) 2008-01-02
JP2003530357A (ja) 2003-10-14
ATE364396T1 (de) 2007-07-15
NO20024815L (no) 2002-12-02
RU2262952C2 (ru) 2005-10-27
ES2287105T3 (es) 2007-12-16
PT1267925E (pt) 2007-09-04
DE60128893D1 (de) 2007-07-26
DK1267925T3 (da) 2007-10-15
US20030180285A1 (en) 2003-09-25
WO2001076627A8 (en) 2001-11-15
DE60128893T2 (de) 2007-12-06
US20080181884A1 (en) 2008-07-31
US20100285029A1 (en) 2010-11-11
AU4089001A (en) 2001-10-23
CN101683525A (zh) 2010-03-31
AU2001240890B2 (en) 2005-06-16
CN1420786A (zh) 2003-05-28
GB0008305D0 (en) 2000-05-24
WO2001076627A1 (en) 2001-10-18
EP1818062A1 (en) 2007-08-15
RU2002129510A (ru) 2004-03-27
NZ520899A (en) 2005-03-24
US20080193459A1 (en) 2008-08-14

Similar Documents

Publication Publication Date Title
CY1106794T1 (el) Θεραπεια μολυνσης απο μυκητα με πολυενιο ή με αντιμυκητιασικα αναστολεα της συνθασης της βητα γλουκανης σε συνδυασμο με αντισωματα αντι hsp90
CY2015057I2 (el) Μονοκλωνικα αντισωματα ανθρωπου εναντι της πρωτεϊνης προγραμματισμενου θανατου (pd-1) και μεθοδοι αγωγης εναντι του καρκινου χρησιμοποιωντας αντισωματα αντι-pd-1 μεμονωμενα 'h σε συνδυασμο με αλλους ανοσοθεραπευτικους παραγοντες
CY1121162T1 (el) M-csf-ειδικο μονοκλωνικο αντισωμα και χρησεις αυτου
CY1105078T1 (el) Ανταγωνιστες τεκ
CY1109730T1 (el) Μιμητικα θρομβοποιητινης
CY1115730T1 (el) Θεραπευτικοι επιτοποι και χρησεις αυτων
BR0312692A (pt) anticorpos selecionados e peptìdeos de duramicina que se ligam a fosfolipìdios aniÈnicos e aminofosfolipìdios e seus usos no tratamento de infecções virais e cáncer
CY1119106T1 (el) Αντισωματα εναντι masp-2
CR7786A (es) Anticuerpos neutralizantes contra gdf-8 y el uso de los mismos
CY1107503T1 (el) Αντιβιοτικα διπλης δρασης
BR0114646A (pt) anticorpos anti-lt-beta-r humanizados
CY1106532T1 (el) Ετερολογος εκφραση των πρωτεϊνων της neisseria
ECSP066294A (es) Un conjugado citotóxico ca6 antígeno-específico y métodos para utilizar el mismo
CY1111872T1 (el) Συνθεσεις υποτασικου λιπιδιου (προσταγλανδινης) και τιμολολης - σχετικες μεθοδοι χρησης
CY1108211T1 (el) Προφυλακτικη και θεραπευτικη αγωγη των μολυσματικων, αυτοανοσων και αλλεργικων νοσων με ενωσεις βασης μονοσακχαριτη
UY26807A1 (es) Anticuerpos de especificidad doble y métodos para la elaboración y el uso de los mismos
NO20025302D0 (no) Aromatase-inhibitorer og monoklonale anti-HER2-antistoffer som antitumormidler
CY1110669T1 (el) Χρησιμοποιηση βενζο-συγχωνευμενων ετεροκυκλικων παραγωγων σουλφαμιδιου για τη θεραπευτικη αγωγη της καταθλιψης
CY1105892T1 (el) Θepαπεια του ξανθωματος με παραγωγα αζετιδινονης ως αναστολεις απορροφησης στepολης
CY1106074T1 (el) Πεπτιδια με αντιαγγειογονο δραση
CY1105008T1 (el) Αντιμικροβιακη ενεργοτητα του πρωτου κατιονικου συγκροτηματος της ανθρωπινης λακτοφερρινης
DE60042369D1 (de) Chemisch programmierbare immunität
DK1572087T3 (da) Antistoffer med cancerantigen TMEFF2 og anvendelser deraf
CY1107485T1 (el) 3-θειομεθυλπυραζoλες ως παρασιτοκτoνα
CY1111567T1 (el) Ενδιαμεσα διβενζο (b,f) αζεπινης