AU2001240890B2 - Treatment of fungal infections with polyene or beta glucan synthase inhibitor antifungals combined with anti hsp90 antibodies - Google Patents
Treatment of fungal infections with polyene or beta glucan synthase inhibitor antifungals combined with anti hsp90 antibodies Download PDFInfo
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- AU2001240890B2 AU2001240890B2 AU2001240890A AU2001240890A AU2001240890B2 AU 2001240890 B2 AU2001240890 B2 AU 2001240890B2 AU 2001240890 A AU2001240890 A AU 2001240890A AU 2001240890 A AU2001240890 A AU 2001240890A AU 2001240890 B2 AU2001240890 B2 AU 2001240890B2
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- antifungal agent
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- 238000011282 treatment Methods 0.000 title claims abstract description 47
- 229940121375 antifungal agent Drugs 0.000 title claims description 58
- 206010017533 Fungal infection Diseases 0.000 title claims description 42
- 208000031888 Mycoses Diseases 0.000 title claims description 41
- 150000004291 polyenes Chemical class 0.000 title claims description 10
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 title description 13
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 title description 13
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 title description 13
- 229920002498 Beta-glucan Polymers 0.000 title description 2
- 108010052221 glucan synthase Proteins 0.000 title description 2
- 239000003112 inhibitor Substances 0.000 title description 2
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39575—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from other living beings excluding bacteria and viruses, e.g. protozoa, fungi, plants
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Biophysics (AREA)
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- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0008305.5 | 2000-04-06 | ||
| GBGB0008305.5A GB0008305D0 (en) | 2000-04-06 | 2000-04-06 | Treatment of fungal infections |
| PCT/GB2001/001195 WO2001076627A1 (en) | 2000-04-06 | 2001-03-20 | Treatment of fungal infections with polyene or beta glucan synthase inhibitor antifungals combined with anti hsp90 antibodies |
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| AU2001240890A1 AU2001240890A1 (en) | 2002-01-10 |
| AU2001240890B2 true AU2001240890B2 (en) | 2005-06-16 |
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| AU4089001A Pending AU4089001A (en) | 2000-04-06 | 2001-03-20 | Treatment of fungal infections with polyene or beta glucan synthase inhibitor antifungals combined with anti hsp90 antibodies |
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| AU4089001A Pending AU4089001A (en) | 2000-04-06 | 2001-03-20 | Treatment of fungal infections with polyene or beta glucan synthase inhibitor antifungals combined with anti hsp90 antibodies |
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| AU (2) | AU2001240890B2 (enExample) |
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| CA (1) | CA2401836A1 (enExample) |
| CY (1) | CY1106794T1 (enExample) |
| DE (1) | DE60128893T2 (enExample) |
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| RU (1) | RU2262952C2 (enExample) |
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| US20050129665A1 (en) * | 2002-07-25 | 2005-06-16 | Martin Friedlander | Isolated lineage negative hematopoietic stem cells and methods of treatment therewith |
| US7651689B2 (en) * | 2002-11-15 | 2010-01-26 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of applying ionization radiation for therapy of infections |
| EP1457499A1 (en) * | 2003-03-12 | 2004-09-15 | Tufts University School Of Medicine | Inhibitors of extracellular Hsp90 |
| US7959915B2 (en) | 2003-03-12 | 2011-06-14 | Tufts University | Inhibitors of extracellular Hsp90 |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| GB0409077D0 (en) | 2004-04-23 | 2004-05-26 | Neutec Pharma Plc | Treatment of fungal infections |
| SG153877A1 (en) * | 2004-07-02 | 2009-07-29 | Neutec Pharma Plc | Treatment of cancer |
| CN101010100A (zh) | 2004-07-02 | 2007-08-01 | 纽泰克医药有限公司 | 癌症的治疗方法 |
| EP1858542A4 (en) * | 2005-02-24 | 2009-08-19 | Joslin Diabetes Center Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF VASPEREPERMABILITY |
| PT2332909E (pt) * | 2005-04-13 | 2014-12-17 | Astex Therapeutics Ltd | Derivados de hidroxibenzamida e sua utilização como inibidores de hsp90 |
| GB0600168D0 (en) * | 2006-01-05 | 2006-02-15 | Neutec Pharma Plc | A therapeutic composition |
| GB0620259D0 (en) * | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| US20100119512A1 (en) * | 2007-01-25 | 2010-05-13 | Joslin Diabetes Center | Methods of diagnosing, treating, and preventing increased vascular permeability |
| US20100111943A1 (en) * | 2007-03-22 | 2010-05-06 | Medical College Of Georgia Research Institute, Inc | Compositions and methods for inhibiting cancer metastasis |
| US20100113355A1 (en) * | 2007-04-27 | 2010-05-06 | Naresh Chennamsetty | Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90 |
| WO2008132174A1 (en) * | 2007-04-27 | 2008-11-06 | Novartis Ag | An immunoglobulin composition |
| US10457726B2 (en) | 2016-06-30 | 2019-10-29 | University Of Connecticut | Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof |
| CN111116743B (zh) * | 2018-10-30 | 2022-01-28 | 迈威(上海)生物科技股份有限公司 | Hsp90抗体及其在抗真菌感染中的应用 |
| CN111679069A (zh) * | 2019-12-31 | 2020-09-18 | 安徽中医药大学 | 一种通过耳道念珠菌细胞壁重构来评价中药单体抗真菌作用的方法 |
Citations (1)
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|---|---|---|---|---|
| WO1994004676A1 (en) * | 1992-08-18 | 1994-03-03 | The Victoria University Of Manchester | Stress protein epitopes |
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| GB8915019D0 (en) * | 1989-06-30 | 1989-08-23 | Matthews Ruth C | Medicaments |
| US6365165B1 (en) * | 1995-09-22 | 2002-04-02 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
| US5834592A (en) * | 1995-09-22 | 1998-11-10 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
| US6375955B1 (en) * | 1995-09-22 | 2002-04-23 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
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2000
- 2000-04-06 GB GBGB0008305.5A patent/GB0008305D0/en not_active Ceased
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2001
- 2001-03-20 AU AU2001240890A patent/AU2001240890B2/en not_active Ceased
- 2001-03-20 EP EP07075462A patent/EP1852128A1/en not_active Withdrawn
- 2001-03-20 WO PCT/GB2001/001195 patent/WO2001076627A1/en not_active Ceased
- 2001-03-20 AU AU4089001A patent/AU4089001A/xx active Pending
- 2001-03-20 AT AT01911971T patent/ATE364396T1/de active
- 2001-03-20 JP JP2001574143A patent/JP2003530357A/ja active Pending
- 2001-03-20 CN CN200910167220A patent/CN101683525A/zh active Pending
- 2001-03-20 CN CNA2007101126651A patent/CN101095952A/zh active Pending
- 2001-03-20 ES ES01911971T patent/ES2287105T3/es not_active Expired - Lifetime
- 2001-03-20 DK DK01911971T patent/DK1267925T3/da active
- 2001-03-20 US US10/240,819 patent/US20030180285A1/en not_active Abandoned
- 2001-03-20 EP EP07075857A patent/EP2011512A1/en not_active Withdrawn
- 2001-03-20 RU RU2002129510/15A patent/RU2262952C2/ru not_active IP Right Cessation
- 2001-03-20 DE DE60128893T patent/DE60128893T2/de not_active Expired - Lifetime
- 2001-03-20 CA CA002401836A patent/CA2401836A1/en not_active Abandoned
- 2001-03-20 EP EP07075188A patent/EP1818062A3/en not_active Withdrawn
- 2001-03-20 CN CN01807383A patent/CN1420786A/zh active Pending
- 2001-03-20 BR BR0109846-2A patent/BR0109846A/pt not_active IP Right Cessation
- 2001-03-20 PL PL01358394A patent/PL358394A1/xx not_active Application Discontinuation
- 2001-03-20 PT PT01911971T patent/PT1267925E/pt unknown
- 2001-03-20 NZ NZ520899A patent/NZ520899A/en not_active IP Right Cessation
- 2001-03-20 EP EP01911971A patent/EP1267925B8/en not_active Expired - Lifetime
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2002
- 2002-10-04 NO NO20024815A patent/NO20024815L/no not_active Application Discontinuation
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2007
- 2007-08-07 CY CY20071101053T patent/CY1106794T1/el unknown
- 2007-11-14 US US11/984,177 patent/US20100285029A1/en not_active Abandoned
-
2008
- 2008-03-20 US US12/076,643 patent/US20080193459A1/en not_active Abandoned
- 2008-03-21 US US12/076,705 patent/US20080181884A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004676A1 (en) * | 1992-08-18 | 1994-03-03 | The Victoria University Of Manchester | Stress protein epitopes |
| EP0861892A1 (en) * | 1992-08-18 | 1998-09-02 | Neutec Pharma Plc | Stress protein epitopes |
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Legal Events
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| FGA | Letters patent sealed or granted (standard patent) | ||
| TC | Change of applicant's name (sec. 104) |
Owner name: NEUTEC PHARMA LTD Free format text: FORMER NAME: NEUTEC PHARMA PLC |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |