JP2003529632A - 親水性シアニン染料 - Google Patents
親水性シアニン染料Info
- Publication number
- JP2003529632A JP2003529632A JP2001552799A JP2001552799A JP2003529632A JP 2003529632 A JP2003529632 A JP 2003529632A JP 2001552799 A JP2001552799 A JP 2001552799A JP 2001552799 A JP2001552799 A JP 2001552799A JP 2003529632 A JP2003529632 A JP 2003529632A
- Authority
- JP
- Japan
- Prior art keywords
- och
- conh
- nhco
- independently
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 title claims abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 13
- 150000001875 compounds Chemical class 0.000 claims abstract 12
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 10
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 7
- 239000003814 drug Substances 0.000 claims abstract 7
- 229940079593 drug Drugs 0.000 claims abstract 7
- 230000000975 bioactive effect Effects 0.000 claims abstract 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000005556 hormone Substances 0.000 claims abstract 4
- 229940088597 hormone Drugs 0.000 claims abstract 4
- 238000003384 imaging method Methods 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 230000002285 radioactive effect Effects 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 11
- 229910052751 metal Inorganic materials 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 102000002068 Glycopeptides Human genes 0.000 claims 6
- 108010015899 Glycopeptides Proteins 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004103 aminoalkyl group Chemical group 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 6
- 239000002738 chelating agent Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 150000002772 monosaccharides Chemical class 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229920001542 oligosaccharide Polymers 0.000 claims 6
- 150000002482 oligosaccharides Chemical class 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 238000002405 diagnostic procedure Methods 0.000 claims 3
- 229930182830 galactose Natural products 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- CFODQUSMSYDHBS-UHFFFAOYSA-N octreotate Chemical group O=C1NC(CC=2C=CC=CC=2)C(=O)NC(CC=2[C]3C=CC=CC3=NC=2)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(C(=O)NC(C(O)C)C(O)=O)CSSCC1NC(=O)C(N)CC1=CC=CC=C1 CFODQUSMSYDHBS-UHFFFAOYSA-N 0.000 claims 3
- 239000000816 peptidomimetic Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- VZGJNCHEUPMLPM-DGKZTOLNSA-N C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C1=CN=CN1 Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C1=CN=CN1 VZGJNCHEUPMLPM-DGKZTOLNSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000000149 argon plasma sintering Methods 0.000 claims 2
- 108010062050 bombesin (7-14) Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
- 108010051479 Bombesin Proteins 0.000 claims 1
- 102000013585 Bombesin Human genes 0.000 claims 1
- 208000003788 Neoplasm Micrometastasis Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 238000002594 fluoroscopy Methods 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000000171 quenching effect Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000003325 tomography Methods 0.000 claims 1
- 239000000975 dye Substances 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 3
- 238000002059 diagnostic imaging Methods 0.000 abstract 2
- 230000005856 abnormality Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/484,319 US6180086B1 (en) | 2000-01-18 | 2000-01-18 | Hydrophilic cyanine dyes |
| US09/484,319 | 2000-01-18 | ||
| US09/757,332 | 2001-01-09 | ||
| US09/757,332 US7011817B2 (en) | 2000-01-18 | 2001-01-09 | Hydrophilic cyanine dyes |
| PCT/US2001/001468 WO2001052744A1 (en) | 2000-01-18 | 2001-01-17 | Hydrophilic cyanine dyes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011047019A Division JP2011116773A (ja) | 2000-01-18 | 2011-03-03 | 親水性シアニン染料 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003529632A true JP2003529632A (ja) | 2003-10-07 |
| JP2003529632A5 JP2003529632A5 (enExample) | 2008-08-21 |
Family
ID=27047953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001552799A Pending JP2003529632A (ja) | 2000-01-18 | 2001-01-17 | 親水性シアニン染料 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1250091B1 (enExample) |
| JP (1) | JP2003529632A (enExample) |
| AT (1) | ATE392183T1 (enExample) |
| AU (1) | AU2001232818A1 (enExample) |
| WO (1) | WO2001052744A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004526669A (ja) * | 2000-10-16 | 2004-09-02 | マリンクロッド・インコーポレイテッド | 最小の生理機能モニタリング物質としてのインドール化合物 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US6663847B1 (en) * | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
| US7556797B2 (en) | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| US20030105299A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications |
| US20030105300A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Tumor targeted photodiagnostic-phototherapeutic agents |
| US20030152577A1 (en) * | 2002-02-07 | 2003-08-14 | Mallinckrodt Inc. | Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications |
| US6919333B2 (en) * | 2002-11-12 | 2005-07-19 | Rutgers, The State University Of New Jersey | Bis-transition-metal-chelate probes |
| WO2003091689A2 (en) * | 2002-03-28 | 2003-11-06 | Rutgers, The State Of University Of New Jersey | Bis-transition-metal-chelate-probes |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3721580A1 (de) * | 1986-07-01 | 1988-01-14 | Glaxo Group Ltd | Veterinaerzubereitungen |
| WO1996000902A1 (en) * | 1994-06-30 | 1996-01-11 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| WO1997013810A1 (en) * | 1995-10-09 | 1997-04-17 | Sorin Biomedica Cardio S.P.A. | SULFO BENZ[e]INDOCYANINE FLUORESCENT DYES |
| US5631364A (en) * | 1994-03-31 | 1997-05-20 | Axis Biochemicals Asa | Labelled boronic acid derivatives |
| WO2000016806A1 (en) * | 1998-09-17 | 2000-03-30 | Nippon Kayaku Kabushiki Kaisha | Remedies for photochemotherapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3721850A1 (de) * | 1987-07-02 | 1989-01-12 | Bayer Ag | Indolin-carbocyaninfarbstoffe |
| JP3354975B2 (ja) * | 1992-10-06 | 2002-12-09 | イビデン株式会社 | 蛍光標識試薬および蛍光免疫測定法 |
| JP4041613B2 (ja) * | 1999-03-12 | 2008-01-30 | 富士フイルム株式会社 | 画像形成材料 |
| DE19911102A1 (de) * | 1999-03-12 | 2000-09-14 | Few Chemicals Gmbh Wolfen | Cyanin-Farbstoffe |
| US6180086B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
-
2001
- 2001-01-17 WO PCT/US2001/001468 patent/WO2001052744A1/en not_active Ceased
- 2001-01-17 JP JP2001552799A patent/JP2003529632A/ja active Pending
- 2001-01-17 AT AT01904882T patent/ATE392183T1/de not_active IP Right Cessation
- 2001-01-17 AU AU2001232818A patent/AU2001232818A1/en not_active Abandoned
- 2001-01-17 EP EP01904882A patent/EP1250091B1/en not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3721580A1 (de) * | 1986-07-01 | 1988-01-14 | Glaxo Group Ltd | Veterinaerzubereitungen |
| US5631364A (en) * | 1994-03-31 | 1997-05-20 | Axis Biochemicals Asa | Labelled boronic acid derivatives |
| WO1996000902A1 (en) * | 1994-06-30 | 1996-01-11 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| WO1997013810A1 (en) * | 1995-10-09 | 1997-04-17 | Sorin Biomedica Cardio S.P.A. | SULFO BENZ[e]INDOCYANINE FLUORESCENT DYES |
| WO2000016806A1 (en) * | 1998-09-17 | 2000-03-30 | Nippon Kayaku Kabushiki Kaisha | Remedies for photochemotherapy |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004526669A (ja) * | 2000-10-16 | 2004-09-02 | マリンクロッド・インコーポレイテッド | 最小の生理機能モニタリング物質としてのインドール化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE392183T1 (de) | 2008-05-15 |
| WO2001052744A1 (en) | 2001-07-26 |
| EP1250091B1 (en) | 2008-04-16 |
| EP1250091A4 (en) | 2003-05-07 |
| AU2001232818A1 (en) | 2001-07-31 |
| EP1250091A1 (en) | 2002-10-23 |
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