JP2003529543A5 - - Google Patents
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- Publication number
- JP2003529543A5 JP2003529543A5 JP2001518407A JP2001518407A JP2003529543A5 JP 2003529543 A5 JP2003529543 A5 JP 2003529543A5 JP 2001518407 A JP2001518407 A JP 2001518407A JP 2001518407 A JP2001518407 A JP 2001518407A JP 2003529543 A5 JP2003529543 A5 JP 2003529543A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- membered
- group
- alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 28
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 28
- 150000001875 compounds Chemical class 0.000 description 26
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 125000003545 alkoxy group Chemical group 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 11
- 229910052799 carbon Inorganic materials 0.000 description 11
- 125000005842 heteroatom Chemical group 0.000 description 11
- 239000001257 hydrogen Substances 0.000 description 10
- 150000002431 hydrogen Chemical class 0.000 description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 8
- 229910052736 halogen Inorganic materials 0.000 description 8
- 150000002367 halogens Chemical class 0.000 description 8
- 125000001054 5 membered carbocyclic group Chemical group 0.000 description 7
- 125000004122 cyclic group Chemical group 0.000 description 7
- -1 ammonium cations Chemical class 0.000 description 5
- 150000001767 cationic compounds Chemical class 0.000 description 5
- 150000001768 cations Chemical class 0.000 description 5
- 229910001411 inorganic cation Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 150000002892 organic cations Chemical class 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 125000002837 carbocyclic group Chemical group 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 0 *C(C1*)C(*)=C(*)C(CC(Nc2c(*)c(*)*(*)c(*)c2*)=O)=C1O* Chemical compound *C(C1*)C(*)=C(*)C(CC(Nc2c(*)c(*)*(*)c(*)c2*)=O)=C1O* 0.000 description 2
- 125000004008 6 membered carbocyclic group Chemical group 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 101100386054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CYS3 gene Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 101150035983 str1 gene Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15035199P | 1999-08-24 | 1999-08-24 | |
| US60/150,351 | 1999-08-24 | ||
| US17663500P | 2000-01-19 | 2000-01-19 | |
| US60/176,635 | 2000-01-19 | ||
| PCT/US2000/023029 WO2001014316A1 (en) | 1999-08-24 | 2000-08-23 | Substituted chiral allosteric hemoglobin modifiers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003529543A JP2003529543A (ja) | 2003-10-07 |
| JP2003529543A5 true JP2003529543A5 (enExample) | 2007-11-22 |
Family
ID=26847566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518407A Withdrawn JP2003529543A (ja) | 1999-08-24 | 2000-08-23 | 置換キラル・アロステリック・ヘモグロビン調節剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6486342B1 (enExample) |
| EP (1) | EP1206442A4 (enExample) |
| JP (1) | JP2003529543A (enExample) |
| AU (1) | AU782881B2 (enExample) |
| CA (1) | CA2384511A1 (enExample) |
| WO (1) | WO2001014316A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2384511A1 (en) * | 1999-08-24 | 2001-03-01 | Virginia Commonwealth University | Substituted chiral allosteric hemoglobin modifiers |
| AU2002238132A1 (en) * | 2001-02-23 | 2002-09-12 | Allos Therapeutics, Inc. | Methods and reagents to acquire mri signals and images |
| US20030232887A1 (en) * | 2002-04-10 | 2003-12-18 | Johnson Douglas Giles | Preparation and use of a stable formulation of allosteric effector compounds |
| CA2563749A1 (en) * | 2004-04-22 | 2005-11-03 | Allos Therapeutics, Inc. | Coadministration of radiation, efaproxiral sodium, and supplemental oxygen for the treatment of cancer |
| AU2005234796A1 (en) * | 2004-04-22 | 2005-11-03 | Allos Therapeutics, Inc. | Compositions of allosteric hemoglobin modifiers and methods of making the same |
| US20070259966A1 (en) * | 2004-04-22 | 2007-11-08 | Allos Therapeutics, Inc. | Coadministration of Radiation, Efaproxiral Sodium, and Supplemental Oxygen for the Treatment of Cancer |
| WO2007123126A1 (ja) * | 2006-04-17 | 2007-11-01 | Juridical Foundation Osaka Industrial Promotion Organization | 慢性心不全における運動耐容能低下の改善剤 |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| EP3092213B1 (en) * | 2013-12-27 | 2019-10-23 | Virginia Commonwealth University | Allosteric hemoglobin modifiers with nitric oxide releasing moiety |
| US10836729B1 (en) | 2020-05-04 | 2020-11-17 | King Abdulaziz University | Metabolically stable 5-HMF derivatives for the treatment of hypoxia |
| US11104632B1 (en) | 2020-05-12 | 2021-08-31 | King Abdulaziz University | Metabolically stable vanillin derivatives for the treatment of hypoxia |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049695A (en) * | 1990-02-12 | 1991-09-17 | Center For Innovative Technology | Allosteric hemoglobin modifiers |
| US5382680A (en) * | 1990-12-07 | 1995-01-17 | The Center For Innovative Technology | Allosteric hemoglobin modifier compounds |
| US5248785A (en) * | 1990-02-12 | 1993-09-28 | Virginia Commonwealth University | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
| US5591892A (en) * | 1990-02-12 | 1997-01-07 | Center For Innovative Technology | Allosteric modifiers of hemoglobin |
| US5122539A (en) * | 1990-02-12 | 1992-06-16 | Center For Innovative Technology | Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood |
| US5648375A (en) * | 1990-02-12 | 1997-07-15 | Virginia Commonwealth University | Use of hydrophobic compounds and anesthetics in combination with allosteric hemoglobin modifiers |
| US5677330A (en) * | 1990-02-12 | 1997-10-14 | The Center For Innovative Technology | Medical uses of allosteric hemoglobin modifier compounds in patient care |
| US5250701A (en) * | 1990-02-12 | 1993-10-05 | Center For Innovative Technology | Allosteric hemoglobin modifiers which decrease oxygen affinity in blood |
| US5731454A (en) * | 1990-02-12 | 1998-03-24 | Virginia Commonwealth University | Allosteric modifiers of hemoglobin useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood |
| US5290803A (en) * | 1990-02-12 | 1994-03-01 | The Center Of Innovative Technology | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
| US5661182A (en) * | 1990-02-12 | 1997-08-26 | Virginia Commonwealth University | Method for lowering oxygen affinity of hemoglobin in redcell suspensions, in whole blood and in vivo |
| US5432191A (en) * | 1990-02-12 | 1995-07-11 | The Center For Innovative Technology | Allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
| US5705521A (en) * | 1990-02-12 | 1998-01-06 | The Center For Innovative Technology | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors |
| DE4327365A1 (de) * | 1993-08-14 | 1995-02-16 | Boehringer Mannheim Gmbh | Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung |
| JP3394596B2 (ja) * | 1994-05-23 | 2003-04-07 | 日本テトラパック株式会社 | 包装容器 |
| FR2733685B1 (fr) * | 1995-05-05 | 1997-05-30 | Adir | Utilisation des derives du benzopyrane pour l'obtention de compositions pharmaceutiques destinees au traitement des pathologies liees a l'echangeur c1-/hc03-, na+ independant |
| US5525630A (en) * | 1995-06-01 | 1996-06-11 | Allos Therapeutics, Inc. | Treatment for carbon monoxide poisoning |
| US5827888A (en) * | 1996-10-29 | 1998-10-27 | The Center For Innovative Technology | Perinatal treatment of a fetus to avoid oxygen deprivation |
| CA2384511A1 (en) * | 1999-08-24 | 2001-03-01 | Virginia Commonwealth University | Substituted chiral allosteric hemoglobin modifiers |
| US20030232887A1 (en) * | 2002-04-10 | 2003-12-18 | Johnson Douglas Giles | Preparation and use of a stable formulation of allosteric effector compounds |
-
2000
- 2000-08-23 CA CA002384511A patent/CA2384511A1/en not_active Abandoned
- 2000-08-23 JP JP2001518407A patent/JP2003529543A/ja not_active Withdrawn
- 2000-08-23 US US09/643,874 patent/US6486342B1/en not_active Expired - Fee Related
- 2000-08-23 AU AU67967/00A patent/AU782881B2/en not_active Ceased
- 2000-08-23 WO PCT/US2000/023029 patent/WO2001014316A1/en not_active Ceased
- 2000-08-23 EP EP00955827A patent/EP1206442A4/en not_active Withdrawn
-
2002
- 2002-09-10 US US10/237,664 patent/US6894185B2/en not_active Expired - Fee Related
-
2004
- 2004-11-17 US US10/991,071 patent/US20050154062A1/en not_active Abandoned
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