JP2003528144A - 頭痛治療のためのプロスタノイドｅｐ４受容体アンタゴニストの使用およびそのアンタゴニストについてのアッセイ - Google Patents
頭痛治療のためのプロスタノイドｅｐ４受容体アンタゴニストの使用およびそのアンタゴニストについてのアッセイInfo
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- JP2003528144A JP2003528144A JP2001570263A JP2001570263A JP2003528144A JP 2003528144 A JP2003528144 A JP 2003528144A JP 2001570263 A JP2001570263 A JP 2001570263A JP 2001570263 A JP2001570263 A JP 2001570263A JP 2003528144 A JP2003528144 A JP 2003528144A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/001138 WO2001072302A1 (en) | 2000-03-24 | 2000-03-24 | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003528144A true JP2003528144A (ja) | 2003-09-24 |
| JP2003528144A5 JP2003528144A5 (enExample) | 2007-05-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570263A Pending JP2003528144A (ja) | 2000-03-24 | 2000-03-24 | 頭痛治療のためのプロスタノイドｅｐ４受容体アンタゴニストの使用およびそのアンタゴニストについてのアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1267867B1 (enExample) |
| JP (1) | JP2003528144A (enExample) |
| AT (1) | ATE395058T1 (enExample) |
| AU (2) | AU2000234451B2 (enExample) |
| CA (1) | CA2402099C (enExample) |
| DE (1) | DE60038902D1 (enExample) |
| DK (1) | DK1267867T3 (enExample) |
| WO (1) | WO2001072302A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010519260A (ja) * | 2007-02-26 | 2010-06-03 | メルク フロスト カナダ リミテツド | Ｅｐ４受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1450813B1 (en) * | 2001-10-31 | 2007-08-29 | Medical Research Council | Antagonists of prostaglandin receptors ep2 and/or ep4 for the treatment of menorrhagia |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2013167582A1 (en) | 2012-05-09 | 2013-11-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
| LT3625224T (lt) | 2017-05-18 | 2021-10-25 | Idorsia Pharmaceuticals Ltd | N-pakeistieji indolo dariniai |
| TW201900180A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 嘧啶衍生物 |
| LT3625222T (lt) | 2017-05-18 | 2021-11-10 | Idorsia Pharmaceuticals Ltd | Fenilo dariniai, kaip pge2 receptoriaus moduliatoriai |
| PT3625228T (pt) | 2017-05-18 | 2021-09-16 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores dos recetores de pge2 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09506894A (ja) * | 1993-12-20 | 1997-07-08 | 藤沢薬品工業株式会社 | ４，５−ジアリールオキサゾール誘導体 |
| WO1998055468A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds useful as pge2 agonists and antagonists |
| WO2001010426A2 (en) * | 1999-08-10 | 2001-02-15 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of neuropathic pain and colon cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720270D0 (en) * | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
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2000
- 2000-03-24 JP JP2001570263A patent/JP2003528144A/ja active Pending
- 2000-03-24 DK DK00912807T patent/DK1267867T3/da active
- 2000-03-24 WO PCT/GB2000/001138 patent/WO2001072302A1/en not_active Ceased
- 2000-03-24 AU AU2000234451A patent/AU2000234451B2/en not_active Ceased
- 2000-03-24 AT AT00912807T patent/ATE395058T1/de not_active IP Right Cessation
- 2000-03-24 DE DE60038902T patent/DE60038902D1/de not_active Expired - Lifetime
- 2000-03-24 CA CA2402099A patent/CA2402099C/en not_active Expired - Fee Related
- 2000-03-24 AU AU3445100A patent/AU3445100A/xx active Pending
- 2000-03-24 EP EP00912807A patent/EP1267867B1/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09506894A (ja) * | 1993-12-20 | 1997-07-08 | 藤沢薬品工業株式会社 | ４，５−ジアリールオキサゾール誘導体 |
| WO1998055468A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds useful as pge2 agonists and antagonists |
| WO2001010426A2 (en) * | 1999-08-10 | 2001-02-15 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of neuropathic pain and colon cancer |
Non-Patent Citations (5)
| Title |
|---|
| JPN6010021460; Ｐｒａｄａｌｉｅｒ Ａ．: 'ＮＳＡＩＤｓ' Ｃｅｐｈａｌａｌｇｉａ １９巻, 1999, ｐｐ．１９９-２００ * |
| JPN6010021461; Ｃｏｌｅｍａｎ Ｒ．Ａ． ｅｔ ａｌ．: 'Ａ ｎｏｖｅｌ ｉｎｈｉｂｉｔｏｒｙ ｐｒｏｓｔａｎｏｉｄ ｒｅｃｅｐｔｏｒ ｉｎ ｐｉｇｌｅｔ ｓａｐｈｅｎｏｕｓ ｖｅｉｎ' Ｐｒｏｓｔａｇｌａｎｄｉｎｓ ４７巻, 1994, ｐｐ．１５１-１６８ * |
| JPN6010021463; Ｍａｒｉｎ Ｐ．Ａ．: 'Ｐｈａｒｍａｃｏｌｏｇｙ Ｕｐｄａｔｅ：Ｐｈａｒｍａｃｏｌｏｇｉｃ Ｍａｎａｇｅｍｅｎｔ ｏｆ Ｍｉｇｒａｉｎｅ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ａｃａｄｅｍｙ ｏｆ Ｎｕｒｓｅ Ｐｒａｃｔｉｔｉｏｎｅｒｓ １０巻９号, 199809, ｐｐ．４０７-４１２ * |
| JPN6010021468; Ｂｈａｔｔａｃｈａｒｙａ Ｍ． ｅｔ ａｌ．: 'Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｆｕｎｃｔｉｏｎａｌ Ｐｒｏｓｔａｇｌａｎｄｉｎ Ｅ２ Ｒｅｃｅｐｔｏｒｓ ＥＰ３ ａｎｄ ＥＰ４ ｉｎ ｔｈｅ Ｎｕｃｌｅａｒ Ｅｎｖｅｌｏｐｅ' Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ ２７４巻２２号, 1999, ｐｐ．１５７１９-１５７２４ * |
| JPN6013046174; Ａｎｄｒｅｗ Ａ Ｐａｒｓｏｎｓ ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｆ ｐｒｏｓｔａｎｏｉｄｓ ｏｎ ｈｕｍａｎ ａｎｄ ｒａｂｂｉｔ ｂａｓｉｌａｒ ａｒｔｅｒｉｅｓ ｐｒｅｃｏｎｔｒａｃｔｅｄ ｉｎ ｖｉｔｒｏ' Ｃｅｐｈａｌａｌｇｉａ ｖｏｌ． ９， ｎｏ． ３, 1989, ｐｐ． １６５-１７２ |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010519260A (ja) * | 2007-02-26 | 2010-06-03 | メルク フロスト カナダ リミテツド | Ｅｐ４受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2000234451B2 (en) | 2005-09-29 |
| EP1267867A1 (en) | 2003-01-02 |
| WO2001072302A1 (en) | 2001-10-04 |
| EP1267867B1 (en) | 2008-05-14 |
| DE60038902D1 (de) | 2008-06-26 |
| ATE395058T1 (de) | 2008-05-15 |
| DK1267867T3 (da) | 2008-08-25 |
| CA2402099A1 (en) | 2001-10-04 |
| AU3445100A (en) | 2001-10-08 |
| CA2402099C (en) | 2011-04-26 |
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