AU2000234451B2 - Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists - Google Patents
Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists Download PDFInfo
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- AU2000234451B2 AU2000234451B2 AU2000234451A AU2000234451A AU2000234451B2 AU 2000234451 B2 AU2000234451 B2 AU 2000234451B2 AU 2000234451 A AU2000234451 A AU 2000234451A AU 2000234451 A AU2000234451 A AU 2000234451A AU 2000234451 B2 AU2000234451 B2 AU 2000234451B2
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- receptor
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- hydroxyl
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
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- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
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- Pain & Pain Management (AREA)
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- Neurosurgery (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/001138 WO2001072302A1 (en) | 2000-03-24 | 2000-03-24 | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
Publications (2)
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|---|---|
| AU2000234451A1 AU2000234451A1 (en) | 2001-12-20 |
| AU2000234451B2 true AU2000234451B2 (en) | 2005-09-29 |
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| AU2000234451A Ceased AU2000234451B2 (en) | 2000-03-24 | 2000-03-24 | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
| AU3445100A Pending AU3445100A (en) | 2000-03-24 | 2000-03-24 | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
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| AU3445100A Pending AU3445100A (en) | 2000-03-24 | 2000-03-24 | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
Country Status (8)
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| EP (1) | EP1267867B1 (enExample) |
| JP (1) | JP2003528144A (enExample) |
| AT (1) | ATE395058T1 (enExample) |
| AU (2) | AU2000234451B2 (enExample) |
| CA (1) | CA2402099C (enExample) |
| DE (1) | DE60038902D1 (enExample) |
| DK (1) | DK1267867T3 (enExample) |
| WO (1) | WO2001072302A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20050059742A1 (en) * | 2001-10-31 | 2005-03-17 | Jabbour Henry Nicolas | Antagonists of prostaglandin receptors ep2 and/or ep4 for the treatment of dysmenorrhea and menorphagia |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| JP5301469B2 (ja) * | 2007-02-26 | 2013-09-25 | メルク カナダ インコーポレイテッド | Ｅｐ４受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体 |
| WO2013167582A1 (en) | 2012-05-09 | 2013-11-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| SI3625224T1 (sl) | 2017-05-18 | 2021-11-30 | Idorsia Pharmaceuticals Ltd | N-substituirani indolni derivati |
| AR111807A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de benzofurano y benzotiofeno como moduladores del receptor pge2 |
| HRP20211380T1 (hr) | 2017-05-18 | 2021-11-26 | Idorsia Pharmaceuticals Ltd | Derivati pirimidina kao modulatori receptora pge2 |
| TW201900180A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 嘧啶衍生物 |
| AR111941A1 (es) | 2017-05-18 | 2019-09-04 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998055468A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds useful as pge2 agonists and antagonists |
| AU9177698A (en) * | 1997-09-25 | 2000-04-17 | Asterand Uk Acquisition Limited | Medicaments for the treatment of primary headache disorders and drug-induced headaches |
| AU6836200A (en) * | 1999-08-10 | 2001-03-05 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer |
Family Cites Families (1)
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| JPH09506894A (ja) * | 1993-12-20 | 1997-07-08 | 藤沢薬品工業株式会社 | ４，５−ジアリールオキサゾール誘導体 |
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2000
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- 2000-03-24 DE DE60038902T patent/DE60038902D1/de not_active Expired - Lifetime
- 2000-03-24 AT AT00912807T patent/ATE395058T1/de not_active IP Right Cessation
- 2000-03-24 AU AU2000234451A patent/AU2000234451B2/en not_active Ceased
- 2000-03-24 WO PCT/GB2000/001138 patent/WO2001072302A1/en not_active Ceased
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- 2000-03-24 EP EP00912807A patent/EP1267867B1/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998055468A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds useful as pge2 agonists and antagonists |
| AU9177698A (en) * | 1997-09-25 | 2000-04-17 | Asterand Uk Acquisition Limited | Medicaments for the treatment of primary headache disorders and drug-induced headaches |
| AU6836200A (en) * | 1999-08-10 | 2001-03-05 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2402099C (en) | 2011-04-26 |
| JP2003528144A (ja) | 2003-09-24 |
| DK1267867T3 (da) | 2008-08-25 |
| AU3445100A (en) | 2001-10-08 |
| WO2001072302A1 (en) | 2001-10-04 |
| CA2402099A1 (en) | 2001-10-04 |
| ATE395058T1 (de) | 2008-05-15 |
| EP1267867B1 (en) | 2008-05-14 |
| DE60038902D1 (de) | 2008-06-26 |
| EP1267867A1 (en) | 2003-01-02 |
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