JP2003528133A5 - - Google Patents
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- Publication number
- JP2003528133A5 JP2003528133A5 JP2001570249A JP2001570249A JP2003528133A5 JP 2003528133 A5 JP2003528133 A5 JP 2003528133A5 JP 2001570249 A JP2001570249 A JP 2001570249A JP 2001570249 A JP2001570249 A JP 2001570249A JP 2003528133 A5 JP2003528133 A5 JP 2003528133A5
- Authority
- JP
- Japan
- Prior art keywords
- patients
- choline
- days
- cdp
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YWAFNFGRBBBSPD-OCMLZEEQSA-M sodium;[[(2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound [Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 YWAFNFGRBBBSPD-OCMLZEEQSA-M 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical compound CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 description 2
- 208000029650 alcohol withdrawal Diseases 0.000 description 2
- 229960004414 clomethiazole Drugs 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- WQNHWIYLCRZRLR-UHFFFAOYSA-N 2-(3-hydroxy-2,5-dioxooxolan-3-yl)acetic acid Chemical compound OC(=O)CC1(O)CC(=O)OC1=O WQNHWIYLCRZRLR-UHFFFAOYSA-N 0.000 description 1
- 206010054196 Affect lability Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 244000307700 Fragaria vesca Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 206010041243 Social avoidant behaviour Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- 235000019262 disodium citrate Nutrition 0.000 description 1
- 239000002526 disodium citrate Substances 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200000765 | 2000-03-29 | ||
| ES200000765A ES2170649B1 (es) | 2000-03-29 | 2000-03-29 | Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica. |
| ESP200000765 | 2000-03-29 | ||
| PCT/EP2001/003536 WO2001072288A2 (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528133A JP2003528133A (ja) | 2003-09-24 |
| JP2003528133A5 true JP2003528133A5 (enExample) | 2007-08-09 |
| JP4724348B2 JP4724348B2 (ja) | 2011-07-13 |
Family
ID=8492914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570249A Expired - Fee Related JP4724348B2 (ja) | 2000-03-29 | 2001-03-28 | アルコール禁断症状を治療するためのｃｄｐ−コリンの使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6894032B2 (enExample) |
| EP (1) | EP1267892B1 (enExample) |
| JP (1) | JP4724348B2 (enExample) |
| KR (1) | KR100794891B1 (enExample) |
| AT (1) | ATE281172T1 (enExample) |
| AU (2) | AU6214101A (enExample) |
| BR (1) | BR0109477A (enExample) |
| CA (1) | CA2402707C (enExample) |
| CZ (1) | CZ298933B6 (enExample) |
| DE (1) | DE60106890T2 (enExample) |
| DK (1) | DK1267892T3 (enExample) |
| ES (1) | ES2170649B1 (enExample) |
| IL (2) | IL151163A0 (enExample) |
| MX (1) | MXPA02009442A (enExample) |
| NO (1) | NO329766B1 (enExample) |
| NZ (1) | NZ520825A (enExample) |
| PL (1) | PL199291B1 (enExample) |
| PT (1) | PT1267892E (enExample) |
| RU (1) | RU2251422C2 (enExample) |
| WO (1) | WO2001072288A2 (enExample) |
| ZA (1) | ZA200206349B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001068104A1 (en) | 2000-03-16 | 2001-09-20 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
| CA2492725A1 (en) * | 2002-07-11 | 2004-01-22 | Yamasa Corporation | Medicinal composition for drug-induced neuropathy |
| PT1565055E (pt) | 2002-11-08 | 2013-09-16 | Mclean Hospital Corp | Compostos para o tratamento da dependência e da privação de tabaco |
| WO2004058160A2 (en) * | 2002-12-20 | 2004-07-15 | The Mclean Hospital Corporation | Compounds for the normalization of the sleep/wake cycle |
| JP2007508315A (ja) * | 2003-10-08 | 2007-04-05 | ザ マクレーン ホスピタル コーポレーション | ω−３脂肪酸を含む組み合わせを用いて、精神障害、物質乱用障害、および他の障害を治療する方法 |
| WO2005122767A1 (en) | 2004-06-10 | 2005-12-29 | Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
| US7947661B2 (en) | 2004-08-11 | 2011-05-24 | The Mclean Hospital Corporation | Compounds for the treatment of marihuana dependence, withdrawal, and usage |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308627A (en) * | 1990-08-07 | 1994-05-03 | Umbdenstock Jr Anthony J | Nutritional supplement for optimizing cellular health |
| RU2072239C1 (ru) * | 1991-01-11 | 1997-01-27 | Институт биохимии СО РАМН | Способ коррекции метаболической зависимости от алкоголя и средство л.е.панина для его осуществления |
| DE4342173A1 (de) * | 1993-12-10 | 1995-06-14 | Lohmann Therapie Syst Lts | Pharmazeutische Formulierung zur Prophylaxe bzw. Vorbehandlung einer Vergiftung durch phosphororganische Cholinesterasehemmer |
| CN101066276A (zh) * | 1994-07-01 | 2007-11-07 | 威尔斯塔特医疗公司 | 用于治疗全身性炎症和炎性肝炎的嘧啶核苷酸前体 |
| RU2127589C1 (ru) * | 1997-06-03 | 1999-03-20 | Порембский Ярослав Олегович | Способ лечения стрессорных поражений нервной системы |
| KR100217488B1 (ko) * | 1997-06-03 | 1999-09-01 | 맹섭 | 골프채의 헤드커버 |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| WO2001068104A1 (en) * | 2000-03-16 | 2001-09-20 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
-
2000
- 2000-03-29 ES ES200000765A patent/ES2170649B1/es not_active Expired - Fee Related
-
2001
- 2001-03-28 AU AU6214101A patent/AU6214101A/xx active Pending
- 2001-03-28 DK DK01936147T patent/DK1267892T3/da active
- 2001-03-28 CZ CZ20023245A patent/CZ298933B6/cs not_active IP Right Cessation
- 2001-03-28 NZ NZ520825A patent/NZ520825A/en not_active IP Right Cessation
- 2001-03-28 EP EP01936147A patent/EP1267892B1/en not_active Expired - Lifetime
- 2001-03-28 MX MXPA02009442A patent/MXPA02009442A/es active IP Right Grant
- 2001-03-28 PT PT01936147T patent/PT1267892E/pt unknown
- 2001-03-28 PL PL363177A patent/PL199291B1/pl unknown
- 2001-03-28 AU AU2001262141A patent/AU2001262141B2/en not_active Ceased
- 2001-03-28 JP JP2001570249A patent/JP4724348B2/ja not_active Expired - Fee Related
- 2001-03-28 AT AT01936147T patent/ATE281172T1/de active
- 2001-03-28 KR KR1020027012966A patent/KR100794891B1/ko not_active Expired - Fee Related
- 2001-03-28 IL IL15116301A patent/IL151163A0/xx active IP Right Grant
- 2001-03-28 BR BR0109477-7A patent/BR0109477A/pt not_active Application Discontinuation
- 2001-03-28 DE DE60106890T patent/DE60106890T2/de not_active Expired - Lifetime
- 2001-03-28 RU RU2002129579/15A patent/RU2251422C2/ru not_active IP Right Cessation
- 2001-03-28 WO PCT/EP2001/003536 patent/WO2001072288A2/en not_active Ceased
- 2001-03-28 CA CA002402707A patent/CA2402707C/en not_active Expired - Fee Related
- 2001-03-28 US US10/240,159 patent/US6894032B2/en not_active Expired - Lifetime
-
2002
- 2002-08-08 ZA ZA200206349A patent/ZA200206349B/en unknown
- 2002-08-09 IL IL151163A patent/IL151163A/en not_active IP Right Cessation
- 2002-09-24 NO NO20024574A patent/NO329766B1/no not_active IP Right Cessation
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