ES2170649B1 - Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica. - Google Patents
Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica.Info
- Publication number
- ES2170649B1 ES2170649B1 ES200000765A ES200000765A ES2170649B1 ES 2170649 B1 ES2170649 B1 ES 2170649B1 ES 200000765 A ES200000765 A ES 200000765A ES 200000765 A ES200000765 A ES 200000765A ES 2170649 B1 ES2170649 B1 ES 2170649B1
- Authority
- ES
- Spain
- Prior art keywords
- cdp
- treatment
- hill
- abstinence
- alcoholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001476 alcoholic effect Effects 0.000 title 1
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 abstract 2
- 206010053164 Alcohol withdrawal syndrome Diseases 0.000 abstract 1
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Addiction (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200000765A ES2170649B1 (es) | 2000-03-29 | 2000-03-29 | Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica. |
| AT01936147T ATE281172T1 (de) | 2000-03-29 | 2001-03-28 | Verwendung von cdp-choline zur behandlung des alkoholentzugsyndroms |
| US10/240,159 US6894032B2 (en) | 2000-03-29 | 2001-03-28 | Use of CDP-choline for the treatment of alcohol withdrawal syndrome |
| EP01936147A EP1267892B1 (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
| IL15116301A IL151163A0 (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
| JP2001570249A JP4724348B2 (ja) | 2000-03-29 | 2001-03-28 | アルコール禁断症状を治療するためのcdp−コリンの使用 |
| PT01936147T PT1267892E (pt) | 2000-03-29 | 2001-03-28 | Utilizacao de cdp-colina para o tratamento do sindrome de abstinencia de alcool |
| PL363177A PL199291B1 (pl) | 2000-03-29 | 2001-03-28 | Zastosowanie CDP-choliny do leczenia zespołu odstawienia alkoholu |
| NZ520825A NZ520825A (en) | 2000-03-29 | 2001-03-28 | CDP-choline (cytidine diphosphate choline, citicoline) for the treatment of alcohol withdrawal syndrome |
| DE60106890T DE60106890T2 (de) | 2000-03-29 | 2001-03-28 | Verwendung von cdp-cholin zur behandlung des alkoholentzugsyndroms |
| KR1020027012966A KR100794891B1 (ko) | 2000-03-29 | 2001-03-28 | 씨디피-콜린 또는 그의 약학적으로 수용 가능한 염을 포함하는 알코올 금단 증후군의 치료용 약제 및 치료 방법 |
| CZ20023245A CZ298933B6 (cs) | 2000-03-29 | 2001-03-28 | Farmaceutický prostredek |
| CA002402707A CA2402707C (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
| MXPA02009442A MXPA02009442A (es) | 2000-03-29 | 2001-03-28 | Uso de la cdp-colina en el tratamento del sindrome de la abstinencia alcoholica. |
| AU6214101A AU6214101A (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
| AU2001262141A AU2001262141B2 (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
| RU2002129579/15A RU2251422C2 (ru) | 2000-03-29 | 2001-03-28 | Cdp-холин-средство для лечения синдрома алкогольной абстиненции и способ лечения с его использованием |
| DK01936147T DK1267892T3 (da) | 2000-03-29 | 2001-03-28 | Anvendelse af CDP-cholin til behandling af alkoholabstinenssyndrom |
| BR0109477-7A BR0109477A (pt) | 2000-03-29 | 2001-03-28 | Uso de cdp-colina para o tratamento da sìndrome da supressão do álcool |
| PCT/EP2001/003536 WO2001072288A2 (en) | 2000-03-29 | 2001-03-28 | Use of cdp-choline for the treatment of alcohol withdrawal syndrome |
| ZA200206349A ZA200206349B (en) | 2000-03-29 | 2002-08-08 | Use of CDP-Choline for the treatment of alcohol withdrawal syndrome. |
| IL151163A IL151163A (en) | 2000-03-29 | 2002-08-09 | Use of cdp-choline for the preparation of a medicament for treating alcohol withdrawal syndrome |
| NO20024574A NO329766B1 (no) | 2000-03-29 | 2002-09-24 | Anvendelse av CDP-kolin for fremstilling av medikament for behandling av alkoholabstinens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200000765A ES2170649B1 (es) | 2000-03-29 | 2000-03-29 | Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2170649A1 ES2170649A1 (es) | 2002-08-01 |
| ES2170649B1 true ES2170649B1 (es) | 2003-06-16 |
Family
ID=8492914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200000765A Expired - Fee Related ES2170649B1 (es) | 2000-03-29 | 2000-03-29 | Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6894032B2 (enExample) |
| EP (1) | EP1267892B1 (enExample) |
| JP (1) | JP4724348B2 (enExample) |
| KR (1) | KR100794891B1 (enExample) |
| AT (1) | ATE281172T1 (enExample) |
| AU (2) | AU2001262141B2 (enExample) |
| BR (1) | BR0109477A (enExample) |
| CA (1) | CA2402707C (enExample) |
| CZ (1) | CZ298933B6 (enExample) |
| DE (1) | DE60106890T2 (enExample) |
| DK (1) | DK1267892T3 (enExample) |
| ES (1) | ES2170649B1 (enExample) |
| IL (2) | IL151163A0 (enExample) |
| MX (1) | MXPA02009442A (enExample) |
| NO (1) | NO329766B1 (enExample) |
| NZ (1) | NZ520825A (enExample) |
| PL (1) | PL199291B1 (enExample) |
| PT (1) | PT1267892E (enExample) |
| RU (1) | RU2251422C2 (enExample) |
| WO (1) | WO2001072288A2 (enExample) |
| ZA (1) | ZA200206349B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030294B2 (en) | 2000-03-16 | 2011-10-04 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
| EP1541154A1 (en) * | 2002-07-11 | 2005-06-15 | Yamasa Corporation | Medicinal composition for drug-induced neuropathy |
| CN100430066C (zh) | 2002-11-08 | 2008-11-05 | 麦克莱恩医院 | 用于烟草依赖性和戒断治疗的化合物 |
| AU2003299715A1 (en) * | 2002-12-20 | 2004-07-22 | The Mclean Hospital Corporation | Compounds for the normalization of the sleep/wake cycle |
| US20050129710A1 (en) * | 2003-10-08 | 2005-06-16 | Renshaw Perry F. | Methods of treating psychiatric substance abuse, and other disorders using combinations containing omega-3 fatty acids |
| EP1765075A4 (en) | 2004-06-10 | 2010-11-10 | Mclean Hospital Corp | PYRIMIDINES, AS FORM. uridine; IN THE TREATMENT OF PATIENTS WITH MANIC-DEPRESSIVE PSYCHOSIS |
| WO2006020703A1 (en) | 2004-08-11 | 2006-02-23 | The Mclean Hospital Corporation | Compounds for the treatment of marihuana dependence, withdrawal, and usage |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308627A (en) * | 1990-08-07 | 1994-05-03 | Umbdenstock Jr Anthony J | Nutritional supplement for optimizing cellular health |
| RU2072239C1 (ru) * | 1991-01-11 | 1997-01-27 | Институт биохимии СО РАМН | Способ коррекции метаболической зависимости от алкоголя и средство л.е.панина для его осуществления |
| DE4342173A1 (de) * | 1993-12-10 | 1995-06-14 | Lohmann Therapie Syst Lts | Pharmazeutische Formulierung zur Prophylaxe bzw. Vorbehandlung einer Vergiftung durch phosphororganische Cholinesterasehemmer |
| CA2193967C (en) * | 1994-07-01 | 2007-09-11 | Reid W. Von Borstel | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
| KR100217488B1 (ko) * | 1997-06-03 | 1999-09-01 | 맹섭 | 골프채의 헤드커버 |
| RU2127589C1 (ru) * | 1997-06-03 | 1999-03-20 | Порембский Ярослав Олегович | Способ лечения стрессорных поражений нервной системы |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| US8030294B2 (en) | 2000-03-16 | 2011-10-04 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
-
2000
- 2000-03-29 ES ES200000765A patent/ES2170649B1/es not_active Expired - Fee Related
-
2001
- 2001-03-28 RU RU2002129579/15A patent/RU2251422C2/ru not_active IP Right Cessation
- 2001-03-28 JP JP2001570249A patent/JP4724348B2/ja not_active Expired - Fee Related
- 2001-03-28 PL PL363177A patent/PL199291B1/pl unknown
- 2001-03-28 BR BR0109477-7A patent/BR0109477A/pt not_active Application Discontinuation
- 2001-03-28 IL IL15116301A patent/IL151163A0/xx active IP Right Grant
- 2001-03-28 CZ CZ20023245A patent/CZ298933B6/cs not_active IP Right Cessation
- 2001-03-28 AU AU2001262141A patent/AU2001262141B2/en not_active Ceased
- 2001-03-28 CA CA002402707A patent/CA2402707C/en not_active Expired - Fee Related
- 2001-03-28 MX MXPA02009442A patent/MXPA02009442A/es active IP Right Grant
- 2001-03-28 NZ NZ520825A patent/NZ520825A/en not_active IP Right Cessation
- 2001-03-28 WO PCT/EP2001/003536 patent/WO2001072288A2/en not_active Ceased
- 2001-03-28 AU AU6214101A patent/AU6214101A/xx active Pending
- 2001-03-28 PT PT01936147T patent/PT1267892E/pt unknown
- 2001-03-28 DE DE60106890T patent/DE60106890T2/de not_active Expired - Lifetime
- 2001-03-28 US US10/240,159 patent/US6894032B2/en not_active Expired - Lifetime
- 2001-03-28 KR KR1020027012966A patent/KR100794891B1/ko not_active Expired - Fee Related
- 2001-03-28 AT AT01936147T patent/ATE281172T1/de active
- 2001-03-28 DK DK01936147T patent/DK1267892T3/da active
- 2001-03-28 EP EP01936147A patent/EP1267892B1/en not_active Expired - Lifetime
-
2002
- 2002-08-08 ZA ZA200206349A patent/ZA200206349B/en unknown
- 2002-08-09 IL IL151163A patent/IL151163A/en not_active IP Right Cessation
- 2002-09-24 NO NO20024574A patent/NO329766B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20020801 Kind code of ref document: A1 Effective date: 20020801 |
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| FG2A | Definitive protection |
Ref document number: 2170649B1 Country of ref document: ES |
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| FD2A | Announcement of lapse in spain |
Effective date: 20211122 |