JP2003523336A5 - - Google Patents
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- JP2003523336A5 JP2003523336A5 JP2001560192A JP2001560192A JP2003523336A5 JP 2003523336 A5 JP2003523336 A5 JP 2003523336A5 JP 2001560192 A JP2001560192 A JP 2001560192A JP 2001560192 A JP2001560192 A JP 2001560192A JP 2003523336 A5 JP2003523336 A5 JP 2003523336A5
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- JP
- Japan
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- group
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 description 48
- 125000003342 alkenyl group Chemical group 0.000 description 27
- 125000000304 alkynyl group Chemical group 0.000 description 27
- 239000008194 pharmaceutical composition Substances 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 21
- 125000003118 aryl group Chemical group 0.000 description 15
- 229910052799 carbon Inorganic materials 0.000 description 15
- 125000001153 fluoro group Chemical group F* 0.000 description 15
- 125000000623 heterocyclic group Chemical group 0.000 description 15
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 12
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- 229910052739 hydrogen Inorganic materials 0.000 description 11
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- 229910052757 nitrogen Inorganic materials 0.000 description 6
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 4
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- LALFOYNTGMUKGG-BGRFNVSISA-L rosuvastatin calcium Chemical compound [Ca+2].CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O.CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O LALFOYNTGMUKGG-BGRFNVSISA-L 0.000 description 4
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| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| RU2756946C2 (ru) | 2001-01-26 | 2021-10-07 | Мерк Шарп И Доум Корп. | Применение замещенных азетидинонов для лечения ситостеролемии |
| AU2002247019C1 (en) | 2001-01-26 | 2017-05-11 | Organon Llc | Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| CA2437118A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| MXPA04002179A (es) | 2001-09-08 | 2004-06-29 | Astrazeneca Ab | Derivados de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte del acido ileal biliar (ibat) para tratar hiperlipidemia. |
| BR0212512A (pt) | 2001-09-14 | 2004-10-26 | Tularik Inc | Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta |
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| JP7696898B2 (ja) | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN114761018B (zh) | 2019-12-04 | 2025-12-02 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
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| EP4243831A1 (en) | 2020-11-12 | 2023-09-20 | Albireo AB | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| CA3198216A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
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|---|---|---|---|---|
| US4728662A (en) * | 1977-11-21 | 1988-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | 1,2-benzisoxazoloxyacetic acids and related compounds |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
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2001
- 2001-02-14 CA CA002400021A patent/CA2400021A1/en not_active Abandoned
- 2001-02-14 AU AU38214/01A patent/AU784722B2/en not_active Ceased
- 2001-02-14 EP EP01910624A patent/EP1259494A4/en not_active Withdrawn
- 2001-02-14 JP JP2001560192A patent/JP2003523336A/ja not_active Withdrawn
- 2001-02-14 WO PCT/US2001/004636 patent/WO2001060807A1/en not_active Ceased
- 2001-02-15 CO CO01011989A patent/CO5261629A1/es not_active Application Discontinuation
- 2001-02-16 PE PE2001000178A patent/PE20011056A1/es not_active Application Discontinuation
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