JP2003522193A5 - - Google Patents
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- Publication number
- JP2003522193A5 JP2003522193A5 JP2001558059A JP2001558059A JP2003522193A5 JP 2003522193 A5 JP2003522193 A5 JP 2003522193A5 JP 2001558059 A JP2001558059 A JP 2001558059A JP 2001558059 A JP2001558059 A JP 2001558059A JP 2003522193 A5 JP2003522193 A5 JP 2003522193A5
- Authority
- JP
- Japan
- Prior art keywords
- drug delivery
- delivery system
- poly
- integer
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 description 36
- 150000002632 lipids Chemical class 0.000 description 26
- 239000008186 active pharmaceutical agent Substances 0.000 description 12
- 229940088679 drug related substance Drugs 0.000 description 11
- 229920000954 Polyglycolide Polymers 0.000 description 10
- 229920000747 poly(lactic acid) Polymers 0.000 description 10
- 125000001931 aliphatic group Chemical group 0.000 description 9
- 125000000962 organic group Chemical group 0.000 description 9
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 7
- 102000015439 Phospholipases Human genes 0.000 description 7
- 108010064785 Phospholipases Proteins 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229940002612 prodrug Drugs 0.000 description 7
- 239000000651 prodrug Substances 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 229920006187 aquazol Polymers 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 150000008103 phosphatidic acids Chemical class 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- -1 polymethoxazoline Polymers 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 4
- 229930186217 Glycolipid Natural products 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 201000009030 Carcinoma Diseases 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 3
- 150000001408 amides Chemical group 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 230000004968 inflammatory condition Effects 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 125000005641 methacryl group Chemical group 0.000 description 3
- 125000004430 oxygen atom Chemical group O* 0.000 description 3
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 108020002496 Lysophospholipase Proteins 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229940126523 co-drug Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 150000007524 organic acids Chemical group 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200000211 | 2000-02-10 | ||
| DKPA200000211 | 2000-02-10 | ||
| DKPA200000616 | 2000-04-12 | ||
| DK200000616 | 2000-04-12 | ||
| PCT/DK2001/000092 WO2001058910A2 (en) | 2000-02-10 | 2001-02-09 | Lipid-based drug delivery systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522193A JP2003522193A (ja) | 2003-07-22 |
| JP2003522193A5 true JP2003522193A5 (enExample) | 2008-04-03 |
Family
ID=26068763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558059A Pending JP2003522193A (ja) | 2000-02-10 | 2001-02-09 | ホスホリパーゼａ２で分解可能な脂質誘導体を含有する脂質をベースとした薬物送達系、および治療におけるその使用 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1254143B1 (enExample) |
| JP (1) | JP2003522193A (enExample) |
| AT (1) | ATE277935T1 (enExample) |
| AU (1) | AU778659B2 (enExample) |
| CA (1) | CA2399821A1 (enExample) |
| DE (1) | DE60105977T2 (enExample) |
| ES (1) | ES2230268T3 (enExample) |
| PT (1) | PT1254143E (enExample) |
| WO (1) | WO2001058910A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003028696A2 (en) * | 2001-10-03 | 2003-04-10 | Celator Technologies Inc. | Compositions for delivery of drug combinations |
| CA2383259A1 (en) | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| JP2008518886A (ja) * | 2004-11-03 | 2008-06-05 | リプラサム ファーマ アー／エス | 非天然ホスホリパーゼａ２分解性脂質誘導体を含有する脂質ベースの薬剤送達系およびその治療的使用 |
| WO2006086992A2 (en) * | 2005-02-18 | 2006-08-24 | Liplasome Pharma A/S | Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands |
| US8137693B2 (en) | 2005-09-30 | 2012-03-20 | Auburn University | Drug delivery nanocarriers targeted by landscape phage |
| AU2007229160A1 (en) * | 2006-03-23 | 2007-09-27 | Liplasome Pharma A/S | Lipid based drug delivery systems comprising phospholipase A2 degradable lipids that perform an intramolecular cyclization reaction upon hydrolysis |
| EP2123258A1 (en) * | 2008-05-23 | 2009-11-25 | Liplasome Pharma A/S | Liposomes for drug delivery |
| DK177532B1 (en) | 2009-09-17 | 2013-09-08 | Bio Bedst Aps | Medical use of sPLA2 hydrolysable liposomes |
| DK177529B1 (en) * | 2009-10-23 | 2013-09-08 | Bio Bedst Aps | Liposomes with improved storage stability |
| EP2343310A1 (en) | 2010-01-08 | 2011-07-13 | Novozymes A/S | Serine hydrolase formulation |
| WO2011098578A2 (en) | 2010-02-12 | 2011-08-18 | Bioneer A/S | Liposome system for ocular administration |
| CZ308596B6 (cs) * | 2017-04-03 | 2020-12-23 | Ústav molekulární genetiky AV ČR, v. v. i. | Deriváty fosfolipidů a jejich použití jako léčiva |
| EP3530266A1 (en) * | 2018-02-27 | 2019-08-28 | LipoCoat B.V. | A lipid-based coating composition, and an object having a lipid-based coating |
| EP3530265A1 (en) * | 2018-02-27 | 2019-08-28 | LipoCoat B.V. | Universal method for the preparation of lipid-based coatings |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622392A (en) * | 1984-06-21 | 1986-11-11 | Health Research Inc. (Roswell Park Division) | Thiophospholipid conjugates of antitumor agents |
| US5153000A (en) * | 1988-11-22 | 1992-10-06 | Kao Corporation | Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome |
| JPH07126166A (ja) * | 1993-10-29 | 1995-05-16 | Sagami Chem Res Center | ホスホリパ−ゼａ２阻害剤 |
| JP3498336B2 (ja) * | 1993-12-06 | 2004-02-16 | 日本油脂株式会社 | リン脂質誘導体 |
| JP3620059B2 (ja) * | 1994-03-04 | 2005-02-16 | 日本油脂株式会社 | 反応性小胞体、形成剤および機能性物質固定化小胞体 |
| DE4408011C1 (de) * | 1994-03-10 | 1995-11-02 | Max Delbrueck Centrum | Pharmazeutisches Mittel zur Tumortherapie |
| US5817856A (en) * | 1995-12-11 | 1998-10-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiation-protective phospholipid and method |
| JP3778528B2 (ja) * | 1996-11-08 | 2006-05-24 | 三菱化学株式会社 | ミセルに組み込まれた水溶性高分子物質の分析方法 |
| US5827836A (en) * | 1996-11-15 | 1998-10-27 | Clarion Pharmaceuticals Inc. | Retinoid glycerol phospholipid conjugates |
| US6200598B1 (en) * | 1998-06-18 | 2001-03-13 | Duke University | Temperature-sensitive liposomal formulation |
-
2001
- 2001-02-09 EP EP01903609A patent/EP1254143B1/en not_active Expired - Lifetime
- 2001-02-09 EP EP04015791A patent/EP1484332A3/en not_active Withdrawn
- 2001-02-09 PT PT01903609T patent/PT1254143E/pt unknown
- 2001-02-09 ES ES01903609T patent/ES2230268T3/es not_active Expired - Lifetime
- 2001-02-09 AT AT01903609T patent/ATE277935T1/de not_active IP Right Cessation
- 2001-02-09 WO PCT/DK2001/000092 patent/WO2001058910A2/en not_active Ceased
- 2001-02-09 AU AU31533/01A patent/AU778659B2/en not_active Ceased
- 2001-02-09 JP JP2001558059A patent/JP2003522193A/ja active Pending
- 2001-02-09 CA CA002399821A patent/CA2399821A1/en not_active Abandoned
- 2001-02-09 DE DE60105977T patent/DE60105977T2/de not_active Expired - Lifetime
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