CN101595217B - 具有快速皮肤穿透速度的带正电荷的水溶性的1H-咪唑并[4,5-c]喹啉-4-胺类及其相关化合物的前药 - Google Patents
具有快速皮肤穿透速度的带正电荷的水溶性的1H-咪唑并[4,5-c]喹啉-4-胺类及其相关化合物的前药 Download PDFInfo
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- CN101595217B CN101595217B CN200780050660.9A CN200780050660A CN101595217B CN 101595217 B CN101595217 B CN 101595217B CN 200780050660 A CN200780050660 A CN 200780050660A CN 101595217 B CN101595217 B CN 101595217B
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- imidazo
- quinolin
- quinoline
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- alkyl
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Abstract
Description
Claims (18)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610481539.2A CN106432226B (zh) | 2007-01-31 | 2007-01-31 | 1H-咪唑并[4,5-c]喹啉-4-胺类及其相关化合物的前药 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2007/050322 WO2008093173A1 (en) | 2007-01-31 | 2007-01-31 | Positively charged water-soluble prodrugs of 1h-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610481539.2A Division CN106432226B (zh) | 2007-01-31 | 2007-01-31 | 1H-咪唑并[4,5-c]喹啉-4-胺类及其相关化合物的前药 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101595217A CN101595217A (zh) | 2009-12-02 |
CN101595217B true CN101595217B (zh) | 2016-06-08 |
Family
ID=39673699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN200780050660.9A Active CN101595217B (zh) | 2007-01-31 | 2007-01-31 | 具有快速皮肤穿透速度的带正电荷的水溶性的1H-咪唑并[4,5-c]喹啉-4-胺类及其相关化合物的前药 |
Country Status (10)
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US (2) | US8349866B2 (zh) |
EP (2) | EP2115140B8 (zh) |
JP (1) | JP5389668B2 (zh) |
CN (1) | CN101595217B (zh) |
AU (3) | AU2007345952C1 (zh) |
CA (1) | CA2675845C (zh) |
ES (1) | ES2607901T3 (zh) |
HU (1) | HUE031307T2 (zh) |
PL (1) | PL2115140T3 (zh) |
WO (1) | WO2008093173A1 (zh) |
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EP2091914A4 (en) | 2006-11-08 | 2010-12-29 | Chongxi Yu | TRANSDERMAL ADMINISTRATION SYSTEMS FOR PEPTIDES AND RELATED CONNECTIONS |
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PL2125697T3 (pl) | 2007-01-15 | 2017-01-31 | Yu | Dodatnio naładowane, rozpuszczalne w wodzie proleki retinoidów i związków podobnych do retinoidów o bardzo wysokich współczynnikach przenikania przez skórę |
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-
2007
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- 2007-01-31 PL PL07705747T patent/PL2115140T3/pl unknown
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Also Published As
Publication number | Publication date |
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CA2675845A1 (en) | 2008-08-07 |
HUE031307T2 (hu) | 2017-07-28 |
US8349866B2 (en) | 2013-01-08 |
AU2014224111B2 (en) | 2016-12-15 |
US9567329B2 (en) | 2017-02-14 |
PL2115140T3 (pl) | 2017-03-31 |
CA2675845C (en) | 2019-03-05 |
CN101595217A (zh) | 2009-12-02 |
AU2007345952A1 (en) | 2008-08-07 |
AU2007345952C1 (en) | 2017-06-08 |
US20130131100A1 (en) | 2013-05-23 |
ES2607901T3 (es) | 2017-04-04 |
EP2115140A1 (en) | 2009-11-11 |
EP2115140A4 (en) | 2011-01-05 |
JP2010516802A (ja) | 2010-05-20 |
WO2008093173A1 (en) | 2008-08-07 |
EP2115140B8 (en) | 2017-01-25 |
AU2007345952B2 (en) | 2014-06-12 |
EP3176169A1 (en) | 2017-06-07 |
EP2115140B1 (en) | 2016-11-30 |
AU2014224111A1 (en) | 2014-10-02 |
AU2017201728A1 (en) | 2017-03-30 |
JP5389668B2 (ja) | 2014-01-15 |
US20100021394A1 (en) | 2010-01-28 |
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