JP2003521914A5 - - Google Patents
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- Publication number
- JP2003521914A5 JP2003521914A5 JP2001557910A JP2001557910A JP2003521914A5 JP 2003521914 A5 JP2003521914 A5 JP 2003521914A5 JP 2001557910 A JP2001557910 A JP 2001557910A JP 2001557910 A JP2001557910 A JP 2001557910A JP 2003521914 A5 JP2003521914 A5 JP 2003521914A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- human
- mammal
- exchange column
- human mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000055157 Complement C1 Inhibitor Human genes 0.000 description 20
- 108700040183 Complement C1 Inhibitor Proteins 0.000 description 20
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 description 15
- 102000044507 human SERPING1 Human genes 0.000 description 15
- 238000000034 method Methods 0.000 description 11
- 239000008267 milk Substances 0.000 description 8
- 210000004080 milk Anatomy 0.000 description 8
- 235000013336 milk Nutrition 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 201000007120 C1 inhibitor deficiency Diseases 0.000 description 4
- 206010019860 Hereditary angioedema Diseases 0.000 description 4
- 108010076504 Protein Sorting Signals Proteins 0.000 description 4
- 238000005342 ion exchange Methods 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 102000003839 Human Proteins Human genes 0.000 description 3
- 108090000144 Human Proteins Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- 238000005349 anion exchange Methods 0.000 description 3
- 238000005341 cation exchange Methods 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 210000004216 mammary stem cell Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17931000P | 2000-01-31 | 2000-01-31 | |
| US60/179,310 | 2000-01-31 | ||
| EP00200320.0 | 2000-01-31 | ||
| EP00200320 | 2000-01-31 | ||
| US18758000P | 2000-03-07 | 2000-03-07 | |
| US60/187,580 | 2000-03-07 | ||
| EP00200810.0 | 2000-03-07 | ||
| EP00200810 | 2000-03-07 | ||
| PCT/NL2001/000068 WO2001057079A2 (en) | 2000-01-31 | 2001-01-31 | C1 inhibitor produced in the milk of transgenic mammals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011270236A Division JP2012050465A (ja) | 2000-01-31 | 2011-12-09 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003521914A JP2003521914A (ja) | 2003-07-22 |
| JP2003521914A5 true JP2003521914A5 (https=) | 2008-02-28 |
Family
ID=56290105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557910A Withdrawn JP2003521914A (ja) | 2000-01-31 | 2001-01-31 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1252184B1 (https=) |
| JP (1) | JP2003521914A (https=) |
| AT (1) | ATE382635T1 (https=) |
| CA (1) | CA2398707C (https=) |
| DE (2) | DE60132169T2 (https=) |
| DK (1) | DK1252184T3 (https=) |
| ES (1) | ES2299473T3 (https=) |
| PT (1) | PT1252184E (https=) |
| WO (1) | WO2001057079A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10690670B2 (en) | 2013-01-20 | 2020-06-23 | Dyax Corp. | Assays for determining levels of plasma protease C1 inhibitor |
| US11754570B2 (en) | 2019-04-16 | 2023-09-12 | Takeda Pharmaceutical Company Limited | Methods for quantitation of functional C1 esterase inhibitor (FC1-INH) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067713B2 (en) * | 2000-01-31 | 2006-06-27 | Pharming Intellectual Property B.V. | C1 Inhibitor produced in the milk of transgenic non-human mammals |
| DE10112617A1 (de) * | 2001-03-14 | 2002-10-02 | Aventis Behring Gmbh | Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren |
| CA2502539A1 (en) * | 2002-10-17 | 2004-04-29 | Pharming Intellectual Property B.V. | Protein modification |
| EP1947116B1 (en) | 2003-02-10 | 2017-06-21 | 2-BBB Medicines B.V. | Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions |
| EP1626736B1 (en) | 2003-05-16 | 2020-09-16 | Pharming Intellectual Property B.V. | C1 inhibitor with short half-life for transient treatment |
| AU2006327989B2 (en) | 2005-12-21 | 2012-06-07 | Pharming Intellectual Property Bv | Use of C1 inhibitor for the prevention of ischemia-reperfusion injury |
| FR2901707B1 (fr) | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
| FR2901796A1 (fr) * | 2006-05-31 | 2007-12-07 | Lab Francais Du Fractionnement | Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait |
| LT3028716T (lt) | 2006-10-10 | 2020-12-10 | Regenesance B.V. | Komplemento slopinimas nervų regeneracijos pagerinimui |
| KR101033818B1 (ko) | 2008-06-30 | 2011-05-13 | 조아제약주식회사 | 돼지의 알파에스 1 카제인 유전자, 그 프로모터 및 그의 용도 |
| WO2010087702A1 (en) | 2009-01-30 | 2010-08-05 | Stichting Katholieke Universiteit | TET2 gene as a marker for diagnosing a myelodysuplastic syndrome (MDS) or an acute myeloid leukemia (AML) and determining the prognosis in a subject |
| JP2013505232A (ja) | 2009-09-16 | 2013-02-14 | スティヒティング ヘット ネーデルラント カンカー インスティテュート | 癌治療のための薬剤標的としてのＦｒａ−１標的遺伝子 |
| EP2305717A1 (en) | 2009-09-21 | 2011-04-06 | Koninklijke Nederlandse Akademie van Wetenschappen | Inhibiting TNIK for treating colon cancer |
| EP2354244A1 (en) | 2010-02-04 | 2011-08-10 | Stichting Top Institute Food and Nutrition | MBL2 as a marker of liver-specific insulin resistance |
| EP2354245A1 (en) | 2010-02-04 | 2011-08-10 | Stichting Top Institute Food and Nutrition | MBL2 as a marker of hepatic PPAR- activity |
| EP2608802B1 (en) | 2010-08-27 | 2017-02-22 | Pantarhei Bioscience B.V. | Immunotherapeutic method for treating prostate cancer |
| EP2465928A1 (en) | 2010-12-16 | 2012-06-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Treatment of Th17-mediated diseases |
| AU2013281328B2 (en) | 2012-06-27 | 2017-11-23 | MeiraGTx Gene Regulation Limited | Combination for treating an inflammatory disorder |
| CN104870475B (zh) | 2012-10-25 | 2019-11-08 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
| DK2914291T3 (da) | 2012-11-02 | 2022-05-16 | Bioverativ Usa Inc | Anti-komplement-c1s-antistoffer og anvendelser deraf |
| BR112015023207A8 (pt) | 2013-03-15 | 2018-01-23 | Shire Viropharma Inc | composições de ci-inh e métodos para prevenção e tratamento de desordens associadas à deficiência de inibidor de c1 esterase. |
| US10758550B2 (en) | 2013-10-04 | 2020-09-01 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
| WO2016080830A2 (en) | 2014-11-18 | 2016-05-26 | Pantarhei Bioscience B.V. | Immunotherapeutic method for treating pancreatic cancer |
| WO2016164358A1 (en) | 2015-04-06 | 2016-10-13 | True North Therapeutics, Inc. | Humanized anti-c1s antibodies and methods of use thereof |
| CA3005906A1 (en) * | 2015-11-19 | 2017-05-26 | Shire Human Genetic Therapies, Inc. | Recombinant human c1 esterase inhibitor and uses thereof |
| HUE073475T2 (hu) | 2016-10-12 | 2026-01-28 | Bioverativ Usa Inc | C1s elleni antitestek és alkalmazási eljárásaik |
| WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| PL3758739T3 (pl) * | 2018-02-28 | 2024-09-16 | Pharming Intellectual Property B.V. | Leczenie i zapobieganie stanowi przedrzucawkowemu |
| EP3895726A1 (en) | 2020-04-17 | 2021-10-20 | Pharming Intellectual Property BV | Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress |
| JP2024525084A (ja) | 2021-07-09 | 2024-07-09 | ファーミング・インテレクチュアル・プロパティー・ビー．ブイ． | Ｃ１エステラーゼ阻害剤によるウイルス感染関連症状の治療 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601034B1 (fr) * | 1986-07-03 | 1989-11-17 | Pasteur Institut | Inhibiteur de l'activite de la c1-esterase plasmatique (c1-inhibiteur) et d'autres enzymes proteolytiques du groupe des proteases a serine, son procede de preparation, acides nucleiques codant pour cet inhibiteur, methodes de detection d'affections correlees aux defauts dudit inhibiteur a l'aide d'anticorps ou de sondes nucleotidiques et medicaments contenant ledit inhibiteur de synthese |
| EP0497833A1 (en) * | 1989-10-27 | 1992-08-12 | Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis | C1 inhibitor muteins and uses thereof |
| WO1992022320A1 (en) * | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
| DE4227762A1 (de) * | 1992-08-24 | 1994-03-03 | Behringwerke Ag | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
| US6713662B1 (en) * | 1994-07-27 | 2004-03-30 | Pharming Intellectual Property B.V. | Production of collagen in the milk of transgenic mammals |
| GB9807464D0 (en) * | 1998-04-07 | 1998-06-10 | Pharming Bv | Purification of human acid µ-glucosidase |
-
2001
- 2001-01-31 ES ES01906428T patent/ES2299473T3/es not_active Expired - Lifetime
- 2001-01-31 CA CA2398707A patent/CA2398707C/en not_active Expired - Lifetime
- 2001-01-31 PT PT01906428T patent/PT1252184E/pt unknown
- 2001-01-31 JP JP2001557910A patent/JP2003521914A/ja not_active Withdrawn
- 2001-01-31 WO PCT/NL2001/000068 patent/WO2001057079A2/en not_active Ceased
- 2001-01-31 DE DE60132169T patent/DE60132169T2/de not_active Expired - Lifetime
- 2001-01-31 EP EP01906428A patent/EP1252184B1/en not_active Expired - Lifetime
- 2001-01-31 AT AT01906428T patent/ATE382635T1/de active
- 2001-01-31 DE DE122011000002C patent/DE122011000002I1/de active Pending
- 2001-01-31 DK DK01906428T patent/DK1252184T3/da active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10690670B2 (en) | 2013-01-20 | 2020-06-23 | Dyax Corp. | Assays for determining levels of plasma protease C1 inhibitor |
| US11892450B2 (en) | 2013-01-20 | 2024-02-06 | Takeda Pharmaceutical Company Limited | Evaluation, assays and treatment of pKal-mediated disorders |
| US11754570B2 (en) | 2019-04-16 | 2023-09-12 | Takeda Pharmaceutical Company Limited | Methods for quantitation of functional C1 esterase inhibitor (FC1-INH) |
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