JP2003521914A - トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター - Google Patents

トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター

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Publication number
JP2003521914A
JP2003521914A JP2001557910A JP2001557910A JP2003521914A JP 2003521914 A JP2003521914 A JP 2003521914A JP 2001557910 A JP2001557910 A JP 2001557910A JP 2001557910 A JP2001557910 A JP 2001557910A JP 2003521914 A JP2003521914 A JP 2003521914A
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JP
Japan
Prior art keywords
inhibitor
human
milk
mammal
human mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001557910A
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English (en)
Japanese (ja)
Other versions
JP2003521914A5 (enExample
Inventor
ヨハネス ヘンリクス ノイエンス,
フェーン, ヘンリクス アントニウス ファン
フランク エール. ピーピル,
ヨリス ヤン ヒュース,
Original Assignee
ファーミング インテレクチュアル プロパティー ベー.フェー.
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Application filed by ファーミング インテレクチュアル プロパティー ベー.フェー. filed Critical ファーミング インテレクチュアル プロパティー ベー.フェー.
Publication of JP2003521914A publication Critical patent/JP2003521914A/ja
Publication of JP2003521914A5 publication Critical patent/JP2003521914A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/107Rabbit
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C2230/00Aspects relating to animal feed or genotype
    • A23C2230/05Milk or milk products from transgenic animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Animal Husbandry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
JP2001557910A 2000-01-31 2001-01-31 トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター Withdrawn JP2003521914A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US17931000P 2000-01-31 2000-01-31
EP00200320.0 2000-01-31
US60/179,310 2000-01-31
EP00200320 2000-01-31
US18758000P 2000-03-07 2000-03-07
EP00200810 2000-03-07
US60/187,580 2000-03-07
EP00200810.0 2000-03-07
PCT/NL2001/000068 WO2001057079A2 (en) 2000-01-31 2001-01-31 C1 inhibitor produced in the milk of transgenic mammals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011270236A Division JP2012050465A (ja) 2000-01-31 2011-12-09 トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター

Publications (2)

Publication Number Publication Date
JP2003521914A true JP2003521914A (ja) 2003-07-22
JP2003521914A5 JP2003521914A5 (enExample) 2008-02-28

Family

ID=56290105

Family Applications (1)

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JP2001557910A Withdrawn JP2003521914A (ja) 2000-01-31 2001-01-31 トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター

Country Status (9)

Country Link
EP (1) EP1252184B1 (enExample)
JP (1) JP2003521914A (enExample)
AT (1) ATE382635T1 (enExample)
CA (1) CA2398707C (enExample)
DE (2) DE122011000002I1 (enExample)
DK (1) DK1252184T3 (enExample)
ES (1) ES2299473T3 (enExample)
PT (1) PT1252184E (enExample)
WO (1) WO2001057079A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009520815A (ja) * 2005-12-21 2009-05-28 ファーミング インテレクチュアル プロパティ ビー.ブイ. 虚血再灌流障害を予防するためのc1インヒビターの使用
JP2011526495A (ja) * 2008-06-30 2011-10-13 チョ−エー・ファーム・カンパニー・リミテッド 豚のαS1カゼイン遺伝子、そのプロモーター、及びその用途
JP2012050465A (ja) * 2000-01-31 2012-03-15 Pharming Intellectual Pty Bv トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター
JP2016511394A (ja) * 2013-01-20 2016-04-14 ダイアックス コーポレーション pKal関連疾病の評価、アッセイおよび治療
JP2021515757A (ja) * 2018-02-28 2021-06-24 ファーミング・インテレクチュアル・プロパティー・ビー.ブイ. 子癇前症の治療及び予防
US11754570B2 (en) 2019-04-16 2023-09-12 Takeda Pharmaceutical Company Limited Methods for quantitation of functional C1 esterase inhibitor (FC1-INH)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112617A1 (de) * 2001-03-14 2002-10-02 Aventis Behring Gmbh Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren
PL376318A1 (en) * 2002-10-17 2005-12-27 Pharming Intellectual Property B.V. Protein modification
EP1947116B1 (en) 2003-02-10 2017-06-21 2-BBB Medicines B.V. Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions
HUE052154T2 (hu) * 2003-05-16 2021-04-28 Pharming Intellectual Property B V Rövid felezési idejû C1 inhibitor tranziens kezeléshez
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
EP3028716B1 (en) 2006-10-10 2020-09-16 Regenesance B.V. Complement inhibition for improved nerve regeneration
WO2010087702A1 (en) 2009-01-30 2010-08-05 Stichting Katholieke Universiteit TET2 gene as a marker for diagnosing a myelodysuplastic syndrome (MDS) or an acute myeloid leukemia (AML) and determining the prognosis in a subject
WO2011034421A1 (en) 2009-09-16 2011-03-24 Stichting Het Nederlands Kanker Instituut Fra-1 target genes as drug targets for treating cancer
EP2305717A1 (en) 2009-09-21 2011-04-06 Koninklijke Nederlandse Akademie van Wetenschappen Inhibiting TNIK for treating colon cancer
EP2354244A1 (en) 2010-02-04 2011-08-10 Stichting Top Institute Food and Nutrition MBL2 as a marker of liver-specific insulin resistance
EP2354245A1 (en) 2010-02-04 2011-08-10 Stichting Top Institute Food and Nutrition MBL2 as a marker of hepatic PPAR- activity
WO2012026820A2 (en) 2010-08-27 2012-03-01 Pantarhei Bioscience B.V. Immunotherapeutic method for treating prostate cancer
EP2465928A1 (en) 2010-12-16 2012-06-20 Academisch Medisch Centrum bij de Universiteit van Amsterdam Treatment of Th17-mediated diseases
EP2866826B1 (en) 2012-06-27 2025-08-06 Meiragtx UK II Limited Combination for treating an inflammatory disorder
EP2912065A4 (en) 2012-10-25 2016-10-19 True North Therapeutics Inc ANTI COMPLEMENT C1S ANTIBODIES AND USES THEREOF
RS63212B1 (sr) 2012-11-02 2022-06-30 Bioverativ Usa Inc Antikomplementna c1s antitela i njihove primene
SI2968434T1 (sl) 2013-03-15 2017-11-30 Shire Viropharma Incorporated, C1-INH sestavki za uporabo pri preprečevanju in zdravljenju hereditarnega angioedema (HAE)
US10758550B2 (en) 2013-10-04 2020-09-01 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
WO2016080830A2 (en) 2014-11-18 2016-05-26 Pantarhei Bioscience B.V. Immunotherapeutic method for treating pancreatic cancer
BR112017021289A2 (en) 2015-04-06 2018-06-26 Bioverativ Usa Inc. humanized anti-c1s antibodies and methods of use
WO2017087882A1 (en) * 2015-11-19 2017-05-26 Shire Human Genetic Therapies, Inc. Recombinant human c1 esterase inhibitor and uses thereof
EP3525583B8 (en) 2016-10-12 2025-09-10 Bioverativ USA Inc. Anti-c1s antibodies and methods of use thereof
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
EP3895726A1 (en) 2020-04-17 2021-10-20 Pharming Intellectual Property BV Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress
CA3225079A1 (en) 2021-07-09 2023-01-12 Bruno Giannetti Using c1 esterase inhibitor to treat viral infection-related symptoms

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10504715A (ja) * 1994-07-27 1998-05-12 ファーミング ビー.ブイ. トランスジェニック哺乳動物の乳汁におけるコラーゲンの産生
WO1999051724A1 (en) * 1998-04-07 1999-10-14 Pharming Intellectual Property B.V. PURIFICATION OF HUMAN ACID α-GLUCOSIDASE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601034B1 (fr) * 1986-07-03 1989-11-17 Pasteur Institut Inhibiteur de l'activite de la c1-esterase plasmatique (c1-inhibiteur) et d'autres enzymes proteolytiques du groupe des proteases a serine, son procede de preparation, acides nucleiques codant pour cet inhibiteur, methodes de detection d'affections correlees aux defauts dudit inhibiteur a l'aide d'anticorps ou de sondes nucleotidiques et medicaments contenant ledit inhibiteur de synthese
JPH05503001A (ja) * 1989-10-27 1993-05-27 スティッチング セントラール ラボラトリウム ファン デ ブルートトランスフュジエディエンスト ファン ヘット ネデールランツェ ローデ クルイス C1インヒビターミューティンおよびその利用
WO1992022320A1 (en) * 1991-06-14 1992-12-23 Genentech, Inc. C1 inhibitor variants and treating inflammatory response with c1 inhibitor
DE4227762A1 (de) * 1992-08-24 1994-03-03 Behringwerke Ag Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10504715A (ja) * 1994-07-27 1998-05-12 ファーミング ビー.ブイ. トランスジェニック哺乳動物の乳汁におけるコラーゲンの産生
WO1999051724A1 (en) * 1998-04-07 1999-10-14 Pharming Intellectual Property B.V. PURIFICATION OF HUMAN ACID α-GLUCOSIDASE

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6009021425; J. Mammary Gland Biol. Neoplasia 3(3)(1998), p.337-350 *
JPN6010067861; Lab. Invest. 65(4), p.381-388 *
JPN6010067863; J. Biol. Chem. 253(24)(1988), p.11776-11779 *
JPN6012012290; 'Journal of Clinical Investigation' 1989, Vol.84, p.443-450

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012050465A (ja) * 2000-01-31 2012-03-15 Pharming Intellectual Pty Bv トランスジェニック哺乳動物の乳汁に産生されるc1インヒビター
JP2009520815A (ja) * 2005-12-21 2009-05-28 ファーミング インテレクチュアル プロパティ ビー.ブイ. 虚血再灌流障害を予防するためのc1インヒビターの使用
JP2011526495A (ja) * 2008-06-30 2011-10-13 チョ−エー・ファーム・カンパニー・リミテッド 豚のαS1カゼイン遺伝子、そのプロモーター、及びその用途
US9738694B2 (en) 2008-06-30 2017-08-22 Cho-A Pharm. Co., Ltd. Gene of porcine alpha-s1 casein, a promoter of the same and use thereof
JP2016511394A (ja) * 2013-01-20 2016-04-14 ダイアックス コーポレーション pKal関連疾病の評価、アッセイおよび治療
US10690670B2 (en) 2013-01-20 2020-06-23 Dyax Corp. Assays for determining levels of plasma protease C1 inhibitor
US11892450B2 (en) 2013-01-20 2024-02-06 Takeda Pharmaceutical Company Limited Evaluation, assays and treatment of pKal-mediated disorders
JP2021515757A (ja) * 2018-02-28 2021-06-24 ファーミング・インテレクチュアル・プロパティー・ビー.ブイ. 子癇前症の治療及び予防
US11754570B2 (en) 2019-04-16 2023-09-12 Takeda Pharmaceutical Company Limited Methods for quantitation of functional C1 esterase inhibitor (FC1-INH)

Also Published As

Publication number Publication date
CA2398707A1 (en) 2001-08-09
EP1252184B1 (en) 2008-01-02
EP1252184A2 (en) 2002-10-30
DK1252184T3 (da) 2008-02-04
CA2398707C (en) 2010-10-26
ATE382635T1 (de) 2008-01-15
DE60132169D1 (de) 2008-02-14
WO2001057079A2 (en) 2001-08-09
ES2299473T3 (es) 2008-06-01
WO2001057079A3 (en) 2002-08-15
DE60132169T2 (de) 2008-12-11
DE122011000002I1 (de) 2011-05-05
PT1252184E (pt) 2008-04-15

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Effective date: 20120124

A912 Re-examination (zenchi) completed and case transferred to appeal board

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Effective date: 20120309

A761 Written withdrawal of application

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Effective date: 20140423