JP2003520868A5 - - Google Patents
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- JP2003520868A5 JP2003520868A5 JP2001553766A JP2001553766A JP2003520868A5 JP 2003520868 A5 JP2003520868 A5 JP 2003520868A5 JP 2001553766 A JP2001553766 A JP 2001553766A JP 2001553766 A JP2001553766 A JP 2001553766A JP 2003520868 A5 JP2003520868 A5 JP 2003520868A5
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- JP
- Japan
- Prior art keywords
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- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 description 21
- 229910052739 hydrogen Inorganic materials 0.000 description 20
- 239000001257 hydrogen Substances 0.000 description 19
- 125000003118 aryl group Chemical group 0.000 description 16
- 239000000975 dye Substances 0.000 description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 9
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 150000002431 hydrogen Chemical class 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 125000004008 6 membered carbocyclic group Chemical group 0.000 description 3
- 125000001960 7 membered carbocyclic group Chemical group 0.000 description 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 125000004434 sulfur atom Chemical group 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 125000001054 5 membered carbocyclic group Chemical group 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 208000003788 Neoplasm Micrometastasis Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000002586 coronary angiography Methods 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000002428 photodynamic therapy Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/484,322 US6395257B1 (en) | 2000-01-18 | 2000-01-18 | Dendrimer precursor dyes for imaging |
| US09/484,322 | 2000-01-18 | ||
| PCT/US2001/001407 WO2001053292A1 (en) | 2000-01-18 | 2001-01-17 | Dendrimer precursor dyes for imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003520868A JP2003520868A (ja) | 2003-07-08 |
| JP2003520868A5 true JP2003520868A5 (https=) | 2008-03-06 |
Family
ID=23923665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001553766A Withdrawn JP2003520868A (ja) | 2000-01-18 | 2001-01-17 | 造影用のデンドリマー前駆体染料 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6395257B1 (https=) |
| EP (1) | EP1250333A4 (https=) |
| JP (1) | JP2003520868A (https=) |
| AU (1) | AU2001229513A1 (https=) |
| WO (1) | WO2001053292A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60029944T2 (de) * | 1999-04-30 | 2007-04-05 | Cellgate, Inc., Redwood City | Polyamine und ihre therapeutische verwendung |
| US7312244B2 (en) * | 1999-04-30 | 2007-12-25 | Cellgate, Inc. | Polyamine analog-amino acid conjugates useful as anticancer agents |
| US20080233050A1 (en) * | 2000-01-18 | 2008-09-25 | Mallinckrodt Inc. | Diagnostic and therapeutic optical agents |
| US7198778B2 (en) * | 2000-01-18 | 2007-04-03 | Mallinckrodt Inc. | Tumor-targeted optical contrast agents |
| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US6939532B2 (en) * | 2000-01-18 | 2005-09-06 | Mallinckrodt, Inc. | Versatile hydrophilic dyes |
| US6395257B1 (en) * | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US7351807B2 (en) * | 2000-01-18 | 2008-04-01 | Mallinckrodt Inc. | Cyanine-sulfenates for dual phototherapy |
| WO2001072215A1 (en) * | 2000-03-28 | 2001-10-04 | Board Of Regents, The University Of Texas System | Enhancing contrast in biological imaging |
| US6733744B1 (en) * | 2000-10-16 | 2004-05-11 | Mallinckrodt Inc. | Indole compounds as minimally invasive physiological function monitoring agents |
| US7556797B2 (en) | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
| US6656451B1 (en) * | 2000-10-16 | 2003-12-02 | Mallinckrodt, Inc. | Indole compounds as novel dyes for organ function monitoring |
| AU2002252459A1 (en) * | 2001-03-22 | 2002-10-08 | Minerva Biotechnologies Corporation | Customized therapeutics and in situ diagnostics |
| US20030105299A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications |
| US6761878B2 (en) | 2001-10-17 | 2004-07-13 | Mallinckrodt, Inc. | Pathological tissue detection and treatment employing targeted benzoindole optical agents |
| US20030105300A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Tumor targeted photodiagnostic-phototherapeutic agents |
| JP2003261464A (ja) * | 2002-03-07 | 2003-09-16 | Fuji Photo Film Co Ltd | 近赤外蛍光造影剤および蛍光造影法 |
| EP1515973A1 (en) | 2002-06-26 | 2005-03-23 | Cellgate Inc. | Porphyrin-polyamine conjugates for cancer therapy |
| AU2003256038A1 (en) * | 2002-08-30 | 2004-03-19 | Ramot At Tel Aviv University Ltd. | Self-immolative dendrimers releasing many active moieties upon a single activating event |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| ES2431520T3 (es) * | 2003-01-25 | 2013-11-26 | Seno Medical Instruments, Inc. | Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas |
| CA2523605A1 (en) * | 2003-03-10 | 2004-09-23 | Charles W. Spangler | Targeted agents for both photodiagnosis and photodynamic therapy |
| WO2006102167A2 (en) * | 2005-03-18 | 2006-09-28 | Stanford University | Compounds for tissue imaging and methods of use thereof |
| US20060269480A1 (en) * | 2005-05-31 | 2006-11-30 | Ramot At Tel Aviv University Ltd. | Multi-triggered self-immolative dendritic compounds |
| US20100022449A1 (en) * | 2006-03-09 | 2010-01-28 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US8221721B2 (en) * | 2007-02-09 | 2012-07-17 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| US20080282480A1 (en) * | 2007-05-15 | 2008-11-20 | The Hong Kong Polytechnic University | Multifunction Finishing Liquids Containing Dendrimers and the Application of the Liquids in Textile Finishing |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| WO2010129258A2 (en) | 2009-04-27 | 2010-11-11 | Mallinckrodt Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| GB201010878D0 (en) * | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| WO2012054784A1 (en) | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
| US9138492B2 (en) * | 2012-02-23 | 2015-09-22 | Canon Kabushiki Kaisha | Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle |
| US10806804B2 (en) * | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| CN111592482B (zh) * | 2020-05-15 | 2021-06-25 | 江南大学 | 一种pH可逆激活型光热/光动力/荧光一体化探针分子 |
| CN117777751B (zh) * | 2023-12-21 | 2026-03-13 | 中国科学技术大学 | 一种花菁类染料及其应用 |
| CN119101100B (zh) * | 2024-11-07 | 2025-01-24 | 四川大学华西医院 | 一种放射性核素药物及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59192595A (ja) * | 1983-04-16 | 1984-10-31 | Tdk Corp | 光記録媒体 |
| JPH0729496B2 (ja) * | 1986-03-07 | 1995-04-05 | 三菱レイヨン株式会社 | 光情報記録媒体 |
| JP3023726B2 (ja) * | 1991-04-16 | 2000-03-21 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
| JP3354975B2 (ja) * | 1992-10-06 | 2002-12-09 | イビデン株式会社 | 蛍光標識試薬および蛍光免疫測定法 |
| US5453505A (en) * | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US5732104A (en) | 1994-12-14 | 1998-03-24 | Motorola, Inc. | Signalling techniques and device for high speed data transmission over voiceband channels |
| US5672333A (en) * | 1996-05-13 | 1997-09-30 | Mallinckrodt Medical, Inc. | Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging |
| US5709845A (en) | 1996-05-13 | 1998-01-20 | Rajagopalan; Raghavan | Tricyclic functional dyes for contrast enhancement in optical imaging |
| US5723104A (en) * | 1996-05-13 | 1998-03-03 | Fung; Ella Y. | Monocyclic functional dyes for contrast enhancement in optical imaging |
| DE19649971A1 (de) | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| AUPO598797A0 (en) | 1997-04-04 | 1997-05-01 | Decor Corporation Pty Ltd, The | Mops |
| GB9707133D0 (en) | 1997-04-08 | 1997-05-28 | Identalink Corp | Identity systems |
| WO1998048838A1 (en) * | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Compounds |
| JP2001526650A (ja) * | 1997-04-29 | 2001-12-18 | ニユコメド・イメージング・アクシエセルカペト | 光画像造影剤 |
| US6190641B1 (en) | 2000-01-18 | 2001-02-20 | Mallinckrodt Inc. | Indocyanine dyes |
| US6183726B1 (en) | 2000-01-18 | 2001-02-06 | Mallinckrodt Inc. | Versatile hydrophilic dyes |
| US6395257B1 (en) * | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US6180085B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Dyes |
| US6180086B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
| US6180087B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Tunable indocyanine dyes for biomedical applications |
-
2000
- 2000-01-18 US US09/484,322 patent/US6395257B1/en not_active Expired - Lifetime
-
2001
- 2001-01-17 AU AU2001229513A patent/AU2001229513A1/en not_active Abandoned
- 2001-01-17 JP JP2001553766A patent/JP2003520868A/ja not_active Withdrawn
- 2001-01-17 EP EP01942624A patent/EP1250333A4/en not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001407 patent/WO2001053292A1/en not_active Ceased
- 2001-05-23 US US09/864,011 patent/US6706254B2/en not_active Expired - Fee Related
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