JP2003520606A5 - - Google Patents
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- JP2003520606A5 JP2003520606A5 JP2001554422A JP2001554422A JP2003520606A5 JP 2003520606 A5 JP2003520606 A5 JP 2003520606A5 JP 2001554422 A JP2001554422 A JP 2001554422A JP 2001554422 A JP2001554422 A JP 2001554422A JP 2003520606 A5 JP2003520606 A5 JP 2003520606A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- hla
- seq
- restricted
- eso
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001744 T-lymphocyte Anatomy 0.000 description 55
- 206010028980 Neoplasm Diseases 0.000 description 36
- 201000011510 cancer Diseases 0.000 description 35
- 238000000034 method Methods 0.000 description 35
- 239000002253 acid Substances 0.000 description 28
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 27
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 27
- 108090000765 processed proteins & peptides Proteins 0.000 description 27
- 241000700605 Viruses Species 0.000 description 21
- 239000000427 antigen Substances 0.000 description 18
- 102000036639 antigens Human genes 0.000 description 18
- 108091007433 antigens Proteins 0.000 description 18
- 239000003814 drug Substances 0.000 description 17
- 150000001413 amino acids Chemical class 0.000 description 16
- 108010010378 HLA-DP Antigens Proteins 0.000 description 15
- 102000015789 HLA-DP Antigens Human genes 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 14
- 239000013604 expression vector Substances 0.000 description 14
- 102000043131 MHC class II family Human genes 0.000 description 13
- 108091054438 MHC class II family Proteins 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 13
- 230000003308 immunostimulating effect Effects 0.000 description 11
- 239000008194 pharmaceutical composition Substances 0.000 description 11
- 241000124008 Mammalia Species 0.000 description 10
- 108020004999 messenger RNA Proteins 0.000 description 10
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 102000043129 MHC class I family Human genes 0.000 description 8
- 108091054437 MHC class I family Proteins 0.000 description 8
- 239000012472 biological sample Substances 0.000 description 8
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- 239000000523 sample Substances 0.000 description 8
- 230000002163 immunogen Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 201000009030 Carcinoma Diseases 0.000 description 6
- 102000006354 HLA-DR Antigens Human genes 0.000 description 6
- 108010058597 HLA-DR Antigens Proteins 0.000 description 6
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- 101100005713 Homo sapiens CD4 gene Proteins 0.000 description 5
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- 102000014914 Carrier Proteins Human genes 0.000 description 3
- 108010078791 Carrier Proteins Proteins 0.000 description 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
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- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 2
- 108010084313 CD58 Antigens Proteins 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- -1 GP-100 Proteins 0.000 description 2
- 102100031618 HLA class II histocompatibility antigen, DP beta 1 chain Human genes 0.000 description 2
- 108010045483 HLA-DPB1 antigen Proteins 0.000 description 2
- 102100022339 Integrin alpha-L Human genes 0.000 description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 2
- 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 description 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 description 2
- 101710093778 L-dopachrome tautomerase Proteins 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
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- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940023146 nucleic acid vaccine Drugs 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241000701447 unidentified baculovirus Species 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000000666 Fowlpox Diseases 0.000 description 1
- 241000700662 Fowlpox virus Species 0.000 description 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 description 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 208000008732 thymoma Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17900400P | 2000-01-28 | 2000-01-28 | |
| US60/179,004 | 2000-01-28 | ||
| US23710700P | 2000-09-29 | 2000-09-29 | |
| US60/237,107 | 2000-09-29 | ||
| PCT/US2001/002765 WO2001055393A2 (en) | 2000-01-28 | 2001-01-26 | Mhc class ii restricted t cell epitopes from the cancer antigen ny-eso-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011002419A Division JP5588363B2 (ja) | 2000-01-28 | 2011-01-07 | 癌抗原ｎｙｅｓｏ−１由来の新規ｍｈｃクラスｉｉ拘束ｔ細胞エピトープ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520606A JP2003520606A (ja) | 2003-07-08 |
| JP2003520606A5 true JP2003520606A5 (enExample) | 2008-03-13 |
| JP4776852B2 JP4776852B2 (ja) | 2011-09-21 |
Family
ID=26874905
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001554422A Expired - Fee Related JP4776852B2 (ja) | 2000-01-28 | 2001-01-26 | 癌抗原ｎｙｅｓｏ−１由来の新規ｍｈｃクラスｉｉ拘束ｔ細胞エピトープ |
| JP2011002419A Expired - Lifetime JP5588363B2 (ja) | 2000-01-28 | 2011-01-07 | 癌抗原ｎｙｅｓｏ−１由来の新規ｍｈｃクラスｉｉ拘束ｔ細胞エピトープ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011002419A Expired - Lifetime JP5588363B2 (ja) | 2000-01-28 | 2011-01-07 | 癌抗原ｎｙｅｓｏ−１由来の新規ｍｈｃクラスｉｉ拘束ｔ細胞エピトープ |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7619057B2 (enExample) |
| EP (4) | EP2333065B1 (enExample) |
| JP (2) | JP4776852B2 (enExample) |
| AU (1) | AU785151B2 (enExample) |
| CA (1) | CA2398743C (enExample) |
| WO (1) | WO2001055393A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2333065B1 (en) | 2000-01-28 | 2017-03-15 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | MHC class II restricted T cell epitopes from the cancer antigen NY ESO-1 |
| FR2830940B1 (fr) * | 2001-10-17 | 2007-06-15 | Commissariat Energie Atomique | Procede de selection de ligands d'hla-dp4 et ses applications |
| CN101024842A (zh) | 2001-11-07 | 2007-08-29 | 曼康公司 | 编码靶相关抗原表位的表达载体及其设计方法 |
| EP1536021A1 (en) * | 2003-11-27 | 2005-06-01 | Consortium National de Recherche en Genomique (CNRG) | Method for HLA typing |
| US7632506B2 (en) * | 2004-09-09 | 2009-12-15 | Ludwig Institute For Cancer Research | Identification of new NY-ESO-1 epitopes recognized by CD4+ T-cells |
| WO2006133497A1 (en) * | 2005-06-15 | 2006-12-21 | Adelaide Research & Innovation Pty Ltd | Combination treatment |
| PT2476435T (pt) | 2006-08-11 | 2018-03-05 | Life Sciences Res Partners Vzw | Péptidos imunogénicos e a sua utilização em distúrbios imunitários |
| JP4305547B2 (ja) * | 2006-10-27 | 2009-07-29 | エプソンイメージングデバイス株式会社 | 実装構造体、電気光学装置、電子機器及び実装構造体の製造方法 |
| US7893533B2 (en) * | 2006-10-25 | 2011-02-22 | Epson Imaging Devices Corporation | Semiconductor device, mounting structure, electro-optical apparatus, electronic system, and method for manufacturing electronic component |
| US8999346B2 (en) | 2008-02-14 | 2015-04-07 | Life Sciences Research Partners Vzw | Immunogenic control of tumours and tumour cells |
| CN107252489A (zh) | 2009-04-13 | 2017-10-17 | 法国健康和医学研究院 | Hpv颗粒及其用途 |
| WO2011140284A2 (en) * | 2010-05-04 | 2011-11-10 | Fred Hutchinson Cancer Research Center | Conditional superagonist ctl ligands for the promotion of tumor-specific ctl responses |
| EP2618835B1 (en) * | 2010-09-20 | 2017-07-05 | BioNTech Cell & Gene Therapies GmbH | Antigen-specific t cell receptors and t cell epitopes |
| RU2615460C2 (ru) | 2010-11-25 | 2017-04-04 | Имнейт Сарл | Иммуногенные пептиды для применения в профилактике и/или лечении инфекционных заболеваний, аутоиммунных заболеваний, иммунных ответов на аллогенные факторы, аллергических заболеваний, опухолей, отторжения трансплантата и иммунных ответов против вирусных векторов. используемых для генной терапии или генной вакцинации |
| GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
| CA2906587C (en) * | 2013-03-13 | 2023-02-14 | Health Research, Inc. | Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| CA2953747A1 (en) * | 2013-06-28 | 2014-12-31 | Auckland Uniservices Limited | Amino acid and peptide conjugates and conjugation process |
| US10898555B2 (en) * | 2013-07-02 | 2021-01-26 | Japanese Foundation For Cancer Research | Cellular immunity inducing vaccine |
| GB201315946D0 (en) * | 2013-09-06 | 2013-10-23 | Immune Targeting Systems Its Ltd | Oncology vaccine |
| MX385842B (es) | 2013-09-18 | 2025-03-18 | Aura Biosciences Inc | Conjugados de partículas de tipo virus y uso de las mismas. |
| WO2016014725A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
| USD761957S1 (en) | 2014-11-11 | 2016-07-19 | Nuvasive, Inc. | Combined intradiscal insertion tool and intradiscal shim |
| JP2018505152A (ja) | 2014-12-23 | 2018-02-22 | アン ブリンブル マーガレット | アミノ酸複合体及びペプチド複合体ならびにそれらの使用 |
| WO2016128060A1 (en) * | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| EP3067366A1 (en) * | 2015-03-13 | 2016-09-14 | Max-Delbrück-Centrum Für Molekulare Medizin | Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1 |
| US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
| GB2557123B (en) | 2015-07-31 | 2021-11-03 | Univ Minnesota | Modified cells and methods of therapy |
| US11623001B2 (en) * | 2015-10-12 | 2023-04-11 | Nantomics, Llc | Compositions and methods for viral cancer neoepitopes |
| AU2016343722A1 (en) * | 2015-10-30 | 2018-05-24 | Aleta Biotherapeutics, Inc. | Targeted cancer therapy |
| WO2017145097A2 (en) | 2016-02-26 | 2017-08-31 | Auckland Uniservices Limited | Amino acid and peptide conjugates and conjugation process |
| US20190167722A1 (en) * | 2016-08-02 | 2019-06-06 | Nant Holdings Ip, Llc | Transfection of dendritic cells and methods therefor |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| CA3062591A1 (en) | 2017-05-08 | 2018-11-15 | Gritstone Oncology, Inc. | Alphavirus neoantigen vectors |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| CA3099644A1 (en) * | 2018-05-23 | 2019-11-28 | Gritstone Oncology, Inc. | Shared antigens |
| SG11202108691TA (en) * | 2019-03-12 | 2021-09-29 | BioNTech SE | Therapeutic rna for prostate cancer |
| EP3947640A4 (en) | 2019-04-02 | 2022-12-14 | The Brigham & Women's Hospital, Inc. | PROCEDURE FOR DETERMINING THE PROGRESSION OF PRIMARY MELANOMA |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| CA3187258A1 (en) | 2020-08-06 | 2022-02-10 | Karin Jooss | Multiepitope vaccine cassettes |
| CN116732078A (zh) * | 2023-07-21 | 2023-09-12 | 中国人民解放军海军军医大学 | 以pET28a作为载体制备肿瘤相关抗原NY-ESO-1的方法及应用 |
| US20250232833A1 (en) * | 2024-01-13 | 2025-07-17 | Noergaard Anders Kaare | Cyclin D1 Based Cancer Vaccine |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4738846A (en) | 1984-08-30 | 1988-04-19 | The Salk Institute For Biological Studies | Vaccine for vesicular stomatitis virus |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5175385A (en) | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
| US6723832B1 (en) * | 1996-10-03 | 2004-04-20 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof |
| AU4058489A (en) | 1988-08-08 | 1990-03-05 | Michael A. Iffiu | Collapsible recumbent bicycle with streamlined three-part folding canopy |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| US5174986A (en) | 1989-07-05 | 1992-12-29 | Genpharm International, Inc. | Method for determining oncogenic potential of a chemical compound |
| US5840839A (en) * | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US6287756B1 (en) * | 1997-05-05 | 2001-09-11 | Ludwig Institute For Cancer Research | Methods for determining presence of cancer in a sample by determining expression of an SSX gene |
| EP1021535B1 (en) * | 1997-10-08 | 2007-03-07 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Human cancer antigen ny eso-1/cag-3 and gene encoding same |
| EP1064354A4 (en) * | 1998-03-20 | 2002-06-12 | Genzyme Corp | COMPOSITIONS AND METHODS FOR CAUSING T CELL RESPONSE WITH GENE-BASED VACCINES |
| US6800730B1 (en) * | 1998-10-02 | 2004-10-05 | Ludwig Institute For Cancer Research | Isolated peptides which bind to MHC class II molecules, and uses thereof |
| JP4615805B2 (ja) * | 1999-11-15 | 2011-01-19 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｎｙ−ｅｓｏ−１ペプチド誘導体およびその使用 |
| EP2333065B1 (en) | 2000-01-28 | 2017-03-15 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | MHC class II restricted T cell epitopes from the cancer antigen NY ESO-1 |
-
2001
- 2001-01-26 EP EP10010354.8A patent/EP2333065B1/en not_active Expired - Lifetime
- 2001-01-26 EP EP01905152A patent/EP1252309A2/en not_active Withdrawn
- 2001-01-26 JP JP2001554422A patent/JP4776852B2/ja not_active Expired - Fee Related
- 2001-01-26 EP EP10010353A patent/EP2311950A1/en not_active Withdrawn
- 2001-01-26 US US10/182,506 patent/US7619057B2/en not_active Expired - Fee Related
- 2001-01-26 AU AU33062/01A patent/AU785151B2/en not_active Expired
- 2001-01-26 WO PCT/US2001/002765 patent/WO2001055393A2/en not_active Ceased
- 2001-01-26 CA CA2398743A patent/CA2398743C/en not_active Expired - Lifetime
- 2001-01-26 EP EP10010389A patent/EP2311951A1/en not_active Withdrawn
-
2009
- 2009-09-28 US US12/568,134 patent/US8754046B2/en not_active Expired - Fee Related
-
2011
- 2011-01-07 JP JP2011002419A patent/JP5588363B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-22 US US14/284,971 patent/US9447144B2/en not_active Expired - Fee Related
-
2016
- 2016-08-19 US US15/241,996 patent/US10251912B2/en not_active Expired - Fee Related
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