AU785151B2 - Novel MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1 - Google Patents
Novel MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1 Download PDFInfo
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- AU785151B2 AU785151B2 AU33062/01A AU3306201A AU785151B2 AU 785151 B2 AU785151 B2 AU 785151B2 AU 33062/01 A AU33062/01 A AU 33062/01A AU 3306201 A AU3306201 A AU 3306201A AU 785151 B2 AU785151 B2 AU 785151B2
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| PCT/US2001/002765 WO2001055393A2 (en) | 2000-01-28 | 2001-01-26 | Mhc class ii restricted t cell epitopes from the cancer antigen ny-eso-1 |
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| WO2016014725A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
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| CN107250103A (zh) | 2014-12-23 | 2017-10-13 | 玛格丽特·安妮·布林布尔 | 氨基酸缀合物和肽缀合物以及其用途 |
| WO2016128060A1 (en) * | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
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| GB2592821B (en) | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
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| AU2019275072A1 (en) * | 2018-05-23 | 2021-01-21 | Seattle Project Corp. | Shared antigens |
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| EP3947640A4 (en) * | 2019-04-02 | 2022-12-14 | The Brigham & Women's Hospital, Inc. | PROCEDURE FOR DETERMINING THE PROGRESSION OF PRIMARY MELANOMA |
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| IL300026A (en) | 2020-08-06 | 2023-03-01 | Gritstone Bio Inc | Multiepitope vaccine cassettes |
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| US20250232833A1 (en) * | 2024-01-13 | 2025-07-17 | Noergaard Anders Kaare | Cyclin D1 Based Cancer Vaccine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999018206A2 (en) * | 1997-10-08 | 1999-04-15 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Human cancer antigen ny eso-1/cag-3 and gene encoding same |
| WO1999053938A1 (en) * | 1998-04-17 | 1999-10-28 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of ny-eso-1, wherein bind to mhc class i and mhc class ii molecules, and uses thereof |
| WO2001023560A2 (en) * | 1999-09-29 | 2001-04-05 | Ludwig Institute For Cancer Research | Isolated peptides which bind to mhc class ii molecules, and uses thereof |
| WO2001036453A2 (en) * | 1999-11-15 | 2001-05-25 | Ludwig Institute For Cancer Research | Ny-eso-1 nanopeptide derivatives, and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4738846A (en) | 1984-08-30 | 1988-04-19 | The Salk Institute For Biological Studies | Vaccine for vesicular stomatitis virus |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5175385A (en) | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
| WO1990001443A1 (de) | 1988-08-08 | 1990-02-22 | Iffiu Michael A | Klappbares sesselrad mit stromlinienförmiger, in drei geteilter und faltbarer verkleidung |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| US5174986A (en) | 1989-07-05 | 1992-12-29 | Genpharm International, Inc. | Method for determining oncogenic potential of a chemical compound |
| US5840839A (en) * | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US6287756B1 (en) * | 1997-05-05 | 2001-09-11 | Ludwig Institute For Cancer Research | Methods for determining presence of cancer in a sample by determining expression of an SSX gene |
| JP2002506633A (ja) | 1998-03-20 | 2002-03-05 | ジェンザイム・コーポレーション | Ｔ細胞応答を誘発するための遺伝子に基づくワクチンの組成物および使用法 |
| EP1252309A2 (en) | 2000-01-28 | 2002-10-30 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Mhc class ii restricted t cell epitopes from the cancer antigen ny-eso-1 |
-
2001
- 2001-01-26 EP EP01905152A patent/EP1252309A2/en not_active Withdrawn
- 2001-01-26 EP EP10010353A patent/EP2311950A1/en not_active Withdrawn
- 2001-01-26 AU AU33062/01A patent/AU785151B2/en not_active Expired
- 2001-01-26 JP JP2001554422A patent/JP4776852B2/ja not_active Expired - Fee Related
- 2001-01-26 WO PCT/US2001/002765 patent/WO2001055393A2/en not_active Ceased
- 2001-01-26 EP EP10010389A patent/EP2311951A1/en not_active Withdrawn
- 2001-01-26 EP EP10010354.8A patent/EP2333065B1/en not_active Expired - Lifetime
- 2001-01-26 US US10/182,506 patent/US7619057B2/en not_active Expired - Fee Related
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-
2009
- 2009-09-28 US US12/568,134 patent/US8754046B2/en not_active Expired - Fee Related
-
2011
- 2011-01-07 JP JP2011002419A patent/JP5588363B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-22 US US14/284,971 patent/US9447144B2/en not_active Expired - Fee Related
-
2016
- 2016-08-19 US US15/241,996 patent/US10251912B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999018206A2 (en) * | 1997-10-08 | 1999-04-15 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Human cancer antigen ny eso-1/cag-3 and gene encoding same |
| WO1999053938A1 (en) * | 1998-04-17 | 1999-10-28 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of ny-eso-1, wherein bind to mhc class i and mhc class ii molecules, and uses thereof |
| WO2001023560A2 (en) * | 1999-09-29 | 2001-04-05 | Ludwig Institute For Cancer Research | Isolated peptides which bind to mhc class ii molecules, and uses thereof |
| WO2001036453A2 (en) * | 1999-11-15 | 2001-05-25 | Ludwig Institute For Cancer Research | Ny-eso-1 nanopeptide derivatives, and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| J. EXP MED 187, 265-70 * |
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| EP2333065A1 (en) | 2011-06-15 |
| CA2398743A1 (en) | 2001-08-02 |
| JP2011135874A (ja) | 2011-07-14 |
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| US20160354409A1 (en) | 2016-12-08 |
| US8754046B2 (en) | 2014-06-17 |
| US10251912B2 (en) | 2019-04-09 |
| US20100021468A1 (en) | 2010-01-28 |
| JP4776852B2 (ja) | 2011-09-21 |
| JP2003520606A (ja) | 2003-07-08 |
| EP2311950A1 (en) | 2011-04-20 |
| US20050136402A1 (en) | 2005-06-23 |
| EP1252309A2 (en) | 2002-10-30 |
| EP2333065B1 (en) | 2017-03-15 |
| WO2001055393A2 (en) | 2001-08-02 |
| EP2311951A1 (en) | 2011-04-20 |
| US20140335053A1 (en) | 2014-11-13 |
| US7619057B2 (en) | 2009-11-17 |
| JP5588363B2 (ja) | 2014-09-10 |
| WO2001055393A9 (en) | 2003-03-06 |
| AU3306201A (en) | 2001-08-07 |
| US9447144B2 (en) | 2016-09-20 |
| CA2398743C (en) | 2015-06-23 |
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