JP2003520573A5 - - Google Patents
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- JP2003520573A5 JP2003520573A5 JP2001509537A JP2001509537A JP2003520573A5 JP 2003520573 A5 JP2003520573 A5 JP 2003520573A5 JP 2001509537 A JP2001509537 A JP 2001509537A JP 2001509537 A JP2001509537 A JP 2001509537A JP 2003520573 A5 JP2003520573 A5 JP 2003520573A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- cells
- cell
- produced
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 description 48
- 238000000034 method Methods 0.000 description 42
- 210000004027 cell Anatomy 0.000 description 32
- 239000002245 particle Substances 0.000 description 20
- 108091034135 Vault RNA Proteins 0.000 description 13
- 208000015181 infectious disease Diseases 0.000 description 12
- 239000013604 expression vector Substances 0.000 description 9
- 229960005486 vaccine Drugs 0.000 description 9
- 230000002458 infectious effect Effects 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- 108060004795 Methyltransferase Proteins 0.000 description 4
- 102000007999 Nuclear Proteins Human genes 0.000 description 4
- 108010089610 Nuclear Proteins Proteins 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 210000002845 virion Anatomy 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 241000701109 Human adenovirus 2 Species 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 210000004748 cultured cell Anatomy 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 210000003501 vero cell Anatomy 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000001638 lipofection Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14364599P | 1999-07-14 | 1999-07-14 | |
| US60/143,645 | 1999-07-14 | ||
| GBGB9916794.2A GB9916794D0 (en) | 1999-07-16 | 1999-07-16 | In vitro virus reconstitution |
| GB9916794.2 | 1999-07-16 | ||
| PCT/GB2000/002710 WO2001004333A1 (en) | 1999-07-14 | 2000-07-14 | In vitro reconstitution of segmented negative-strand rna viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520573A JP2003520573A (ja) | 2003-07-08 |
| JP2003520573A5 true JP2003520573A5 (https=) | 2008-06-05 |
| JP4850375B2 JP4850375B2 (ja) | 2012-01-11 |
Family
ID=10857427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001509537A Expired - Lifetime JP4850375B2 (ja) | 1999-07-14 | 2000-07-14 | 分節化した（−）鎖ＲＮＡウイルスのｉｎｖｉｔｒｏ再構築 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4850375B2 (https=) |
| DE (1) | DE122011100041I1 (https=) |
| GB (1) | GB9916794D0 (https=) |
| PT (1) | PT1194580E (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| ES2496315T3 (es) * | 2005-10-19 | 2014-09-18 | University Of Florida Research Foundation, Incorporated | Materiales para el control de la enfermedad respiratoria en caninos |
| WO2011012999A1 (en) * | 2009-07-31 | 2011-02-03 | Novartis Ag | Reverse genetics systems |
| CN102741399A (zh) * | 2009-10-20 | 2012-10-17 | 诺华有限公司 | 用于病毒拯救的改良反向遗传方法 |
| US9982240B2 (en) * | 2012-08-03 | 2018-05-29 | Sanofi Pasteur | Production of infectious influenza viruses |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1820853B1 (en) * | 1999-04-06 | 2011-09-21 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
-
1999
- 1999-07-16 GB GBGB9916794.2A patent/GB9916794D0/en not_active Ceased
-
2000
- 2000-07-14 PT PT00946097T patent/PT1194580E/pt unknown
- 2000-07-14 JP JP2001509537A patent/JP4850375B2/ja not_active Expired - Lifetime
- 2000-07-14 DE DE201112100041 patent/DE122011100041I1/de active Pending
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