JP2003519666A5 - - Google Patents

Info

Publication number

JP2003519666A5

JP2003519666A5 JP2001551497A JP2001551497A JP2003519666A5 JP 2003519666 A5 JP2003519666 A5 JP 2003519666A5 JP 2001551497 A JP2001551497 A JP 2001551497A JP 2001551497 A JP2001551497 A JP 2001551497A JP 2003519666 A5 JP2003519666 A5 JP 2003519666A5

Authority

JP

Japan

Prior art keywords

composition

botulinum toxin

neurotoxin

pancreatic

type

Prior art date

2000-06-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 description 30
• 238000000034 method Methods 0.000 description 24
• 239000002581 neurotoxin Substances 0.000 description 16
• 101710138657 Neurotoxin Proteins 0.000 description 15
• 231100000618 neurotoxin Toxicity 0.000 description 15
• 108030001720 Bontoxilysin Proteins 0.000 description 12
• 229940053031 botulinum toxin Drugs 0.000 description 12
• 108010057266 Type A Botulinum Toxins Proteins 0.000 description 8
• 229940094657 botulinum toxin type a Drugs 0.000 description 8
• 210000004923 pancreatic tissue Anatomy 0.000 description 8
• 208000016222 Pancreatic disease Diseases 0.000 description 7
• 239000008194 pharmaceutical composition Substances 0.000 description 7
• 230000028327 secretion Effects 0.000 description 6
• 208000024691 pancreas disease Diseases 0.000 description 5
• 230000001713 cholinergic effect Effects 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 3
• 241000894006 Bacteria Species 0.000 description 2
• 241000193403 Clostridium Species 0.000 description 2
• 102000051325 Glucagon Human genes 0.000 description 2
• 108060003199 Glucagon Proteins 0.000 description 2
• 206010033645 Pancreatitis Diseases 0.000 description 2
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 2
• 229960004666 glucagon Drugs 0.000 description 2
• 230000003345 hyperglycaemic effect Effects 0.000 description 2
• 201000008980 hyperinsulinism Diseases 0.000 description 2
• 230000002218 hypoglycaemic effect Effects 0.000 description 2
• 238000002347 injection Methods 0.000 description 2
• 239000007924 injection Substances 0.000 description 2
• 241000193155 Clostridium botulinum Species 0.000 description 1
• 241000193171 Clostridium butyricum Species 0.000 description 1
• 206010060378 Hyperinsulinaemia Diseases 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 210000003020 exocrine pancreas Anatomy 0.000 description 1
• 239000012634 fragment Substances 0.000 description 1
• 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
• 230000003914 insulin secretion Effects 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 230000009996 pancreatic endocrine effect Effects 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1