JP2003519655A - リンパ増殖症候群の緩和および阻害のためのｏ−メチル化ラパマイシン誘導体 - Google Patents
リンパ増殖症候群の緩和および阻害のためのｏ−メチル化ラパマイシン誘導体Info
- Publication number
- JP2003519655A JP2003519655A JP2001551473A JP2001551473A JP2003519655A JP 2003519655 A JP2003519655 A JP 2003519655A JP 2001551473 A JP2001551473 A JP 2001551473A JP 2001551473 A JP2001551473 A JP 2001551473A JP 2003519655 A JP2003519655 A JP 2003519655A
- Authority
- JP
- Japan
- Prior art keywords
- rapamycin
- ethyl
- hydroxy
- tumor
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17608600P | 2000-01-14 | 2000-01-14 | |
| US60/176,086 | 2000-01-14 | ||
| PCT/US2001/001537 WO2001051049A1 (en) | 2000-01-14 | 2001-01-12 | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008000081A Division JP5184894B2 (ja) | 2000-01-14 | 2008-01-04 | リンパ増殖症候群の緩和および阻害のためのｏ−メチル化ラパマイシン誘導体 |
| JP2009269988A Division JP5180177B2 (ja) | 2000-01-14 | 2009-11-27 | リンパ増殖症候群の緩和および阻害のためのｏ−メチル化ラパマイシン誘導体 |
Publications (2)
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| JP2009269988A Expired - Lifetime JP5180177B2 (ja) | 2000-01-14 | 2009-11-27 | リンパ増殖症候群の緩和および阻害のためのｏ−メチル化ラパマイシン誘導体 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016117431A1 (ja) * | 2015-01-19 | 2016-07-28 | 学校法人慶應義塾 | 内耳性難聴治療薬 |
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| US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
| EP2298299A3 (en) * | 2000-01-14 | 2012-02-29 | The Trustees Of The University Of Pennsylvania | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders |
| PL409579A1 (pl) * | 2001-02-19 | 2015-03-02 | Novartis Ag | Leczenie raka |
| AU2011226833B9 (en) * | 2001-02-19 | 2014-07-03 | Novartis Ag | Cancer treatment |
| US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US20040024450A1 (en) * | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US7169404B2 (en) * | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
| US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
| US8067055B2 (en) * | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
| US20080103584A1 (en) * | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
| KR100930167B1 (ko) * | 2007-09-19 | 2009-12-07 | 삼성전기주식회사 | 초광각 광학계 |
| US20110098241A1 (en) * | 2008-04-14 | 2011-04-28 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| EP2365802B1 (en) | 2008-11-11 | 2017-08-02 | The Board of Regents,The University of Texas System | Microcapsules of rapamycin and use for treating cancer |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US20170079962A1 (en) | 2009-11-11 | 2017-03-23 | Rapamycin Holdings, Llc | Oral Rapamycin Preparation and Use for Stomatitus |
| CN102268015B (zh) * | 2011-08-30 | 2013-08-28 | 成都摩尔生物医药有限公司 | 一种依维莫司的合成方法 |
| US20150290176A1 (en) | 2012-10-12 | 2015-10-15 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
| EP2968281B1 (en) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| AU2014373683B2 (en) | 2013-12-31 | 2020-05-07 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| CN105254646A (zh) * | 2014-05-28 | 2016-01-20 | 上海博邦医药科技有限公司 | 一种制备依维莫司的方法 |
| JP2020507632A (ja) * | 2017-02-10 | 2020-03-12 | マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. | ラパマイシン類似体 |
| EP3848065B1 (en) | 2017-05-15 | 2023-07-26 | C. R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
| EP3880266B1 (en) | 2018-11-14 | 2025-05-07 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
| CN109776571B (zh) * | 2019-01-31 | 2021-06-11 | 哈药慈航制药股份有限公司 | 一种雷帕霉素类似物及其制备方法和应用 |
| WO2020209828A1 (en) | 2019-04-08 | 2020-10-15 | Bard Peripheral Vascular, Inc. | Medical device with drug-eluting coating on modified device surface |
| CN110917194A (zh) * | 2019-11-07 | 2020-03-27 | 福建省微生物研究所 | 雷帕霉素噻唑类衍生物在制备抗阿尔茨海默症药物中的应用 |
| CN113653305B (zh) * | 2021-09-07 | 2024-11-05 | 中国五冶集团有限公司 | 一种电动顶升操作平台 |
| CN115323915B (zh) * | 2022-10-17 | 2023-01-06 | 广州市市政工程试验检测有限公司 | 一种桥梁索杆检测与修复机器人 |
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| US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| US4699783A (en) * | 1983-03-11 | 1987-10-13 | Terman David S | Products and methods for treatment of cancer |
| ATE135583T1 (de) * | 1991-06-18 | 1996-04-15 | American Home Prod | Verwendung von rapamycin zur behandlung von t- zellen lymphom/leukämie bei erwachsenen |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| US5525610A (en) * | 1994-03-31 | 1996-06-11 | American Home Products Corporation | 42-Epi-rapamycin and pharmaceutical compositions thereof |
| ATE233098T1 (de) * | 1996-06-11 | 2003-03-15 | Novartis Ag | Kombination eines somatostatin analogs und eines rapamycins |
| JP3352411B2 (ja) * | 1998-03-05 | 2002-12-03 | 株式会社東芝 | 制御システム、電力系統保護制御システムおよびプログラムを記憶した記憶媒体 |
| JP2002544167A (ja) | 1999-05-10 | 2002-12-24 | ノバルティス アクチエンゲゼルシャフト | 有機化合物 |
| EP2298299A3 (en) * | 2000-01-14 | 2012-02-29 | The Trustees Of The University Of Pennsylvania | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders |
| EP1319008B1 (en) * | 2000-09-19 | 2008-10-15 | Wyeth | Water soluble rapamycin esters |
| US6399625B1 (en) * | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
| US6440991B1 (en) * | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
| US6399626B1 (en) * | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
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- 2001-01-12 WO PCT/US2001/001537 patent/WO2001051049A1/en not_active Ceased
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- 2001-01-12 AT AT01903095T patent/ATE475418T1/de not_active IP Right Cessation
- 2001-01-12 JP JP2001551473A patent/JP2003519655A/ja not_active Withdrawn
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016117431A1 (ja) * | 2015-01-19 | 2016-07-28 | 学校法人慶應義塾 | 内耳性難聴治療薬 |
| US11013725B2 (en) | 2015-01-19 | 2021-05-25 | Keio University | Therapeutic agents for inner ear hearing impairment |
| US11058669B2 (en) | 2015-01-19 | 2021-07-13 | Keio University | Therapeutic agents for inner ear hearing impairment |
Also Published As
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| EP1250135B1 (en) | 2010-07-28 |
| ATE475418T1 (de) | 2010-08-15 |
| US20100305151A1 (en) | 2010-12-02 |
| CA2397354C (en) | 2011-07-19 |
| US20080125457A1 (en) | 2008-05-29 |
| US7754734B2 (en) | 2010-07-13 |
| US20080182867A9 (en) | 2008-07-31 |
| US20040010002A1 (en) | 2004-01-15 |
| US20110104304A1 (en) | 2011-05-05 |
| US7781447B2 (en) | 2010-08-24 |
| JP2010090131A (ja) | 2010-04-22 |
| EP1250135A1 (en) | 2002-10-23 |
| US8759370B2 (en) | 2014-06-24 |
| WO2001051049A1 (en) | 2001-07-19 |
| AU2001230956B2 (en) | 2005-08-18 |
| EP2298299A3 (en) | 2012-02-29 |
| US8778961B2 (en) | 2014-07-15 |
| JP5180177B2 (ja) | 2013-04-10 |
| WO2001051049A9 (en) | 2003-01-16 |
| EP1250135A4 (en) | 2006-06-07 |
| HK1050145A1 (en) | 2003-06-13 |
| US8569332B2 (en) | 2013-10-29 |
| EP2298299A2 (en) | 2011-03-23 |
| ES2349458T3 (es) | 2011-01-03 |
| CA2397354A1 (en) | 2001-07-19 |
| JP5184894B2 (ja) | 2013-04-17 |
| DE60142677D1 (de) | 2010-09-09 |
| JP2008106074A (ja) | 2008-05-08 |
| AU3095601A (en) | 2001-07-24 |
| US20100290994A1 (en) | 2010-11-18 |
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