JP2003518138A5 - - Google Patents
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- JP2003518138A5 JP2003518138A5 JP2001547554A JP2001547554A JP2003518138A5 JP 2003518138 A5 JP2003518138 A5 JP 2003518138A5 JP 2001547554 A JP2001547554 A JP 2001547554A JP 2001547554 A JP2001547554 A JP 2001547554A JP 2003518138 A5 JP2003518138 A5 JP 2003518138A5
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- JP
- Japan
- Prior art keywords
- ligand
- cells
- receptor
- domain
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 description 75
- 210000004027 cell Anatomy 0.000 description 62
- 238000000034 method Methods 0.000 description 41
- 102000037865 fusion proteins Human genes 0.000 description 34
- 108020001507 fusion proteins Proteins 0.000 description 34
- 102000005962 receptors Human genes 0.000 description 32
- 108020003175 receptors Proteins 0.000 description 32
- 239000000758 substrate Substances 0.000 description 13
- 238000012512 characterization method Methods 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 12
- 230000003993 interaction Effects 0.000 description 7
- 238000012744 immunostaining Methods 0.000 description 5
- 102000016978 Orphan receptors Human genes 0.000 description 4
- 108070000031 Orphan receptors Proteins 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000009410 Chemokine receptor Human genes 0.000 description 3
- 108050000299 Chemokine receptor Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000012190 activator Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 210000001179 synovial fluid Anatomy 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 102000003675 cytokine receptors Human genes 0.000 description 1
- 108010057085 cytokine receptors Proteins 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17297999P | 1999-12-20 | 1999-12-20 | |
| US60/172,979 | 1999-12-20 | ||
| US18662600P | 2000-03-03 | 2000-03-03 | |
| US60/186,626 | 2000-03-03 | ||
| US09/721,908 | 2000-11-24 | ||
| US09/721,908 US6699677B1 (en) | 1999-12-20 | 2000-11-24 | Tethered ligands and methods of use |
| PCT/US2000/034503 WO2001046698A2 (en) | 1999-12-20 | 2000-12-18 | Tethered ligands and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003518138A JP2003518138A (ja) | 2003-06-03 |
| JP2003518138A5 true JP2003518138A5 (enExample) | 2008-02-28 |
| JP4777570B2 JP4777570B2 (ja) | 2011-09-21 |
Family
ID=27390216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001547554A Expired - Fee Related JP4777570B2 (ja) | 1999-12-20 | 2000-12-18 | テザード・リガンド及び使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6699677B1 (enExample) |
| EP (1) | EP1247103B1 (enExample) |
| JP (1) | JP4777570B2 (enExample) |
| AT (1) | ATE405838T1 (enExample) |
| AU (1) | AU2440001A (enExample) |
| CA (1) | CA2390690C (enExample) |
| DE (1) | DE60040019D1 (enExample) |
| ES (1) | ES2311485T3 (enExample) |
| WO (1) | WO2001046698A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6998239B1 (en) * | 1999-10-12 | 2006-02-14 | Chemocentryx, Inc. | Method for identifying a modulator of the binding of CCX CKR polypeptide to a chemokine |
| USRE39849E1 (en) | 1999-10-12 | 2007-09-18 | Chemocentryx, Inc. | Methods for identifying modulators of CCX CKR activity |
| US6780602B2 (en) * | 2001-11-01 | 2004-08-24 | Microbiosystems, Limited Partnership | Taxonomic identification of pathogenic microorganisms and their toxic proteins |
| US7413866B2 (en) * | 2001-11-30 | 2008-08-19 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7504364B2 (en) | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| US20060160076A1 (en) * | 2002-06-10 | 2006-07-20 | Meatabolex, Inc. | Methods of treating and diagnosing diabetes with cx3cr1 modulators |
| US7469076B2 (en) | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| US20040115634A1 (en) | 2002-12-11 | 2004-06-17 | Isis Pharmaceuticals, Inc. | Modulation of stat 6 expression |
| US7981694B2 (en) * | 2003-01-28 | 2011-07-19 | The Regents Of The University Of California | Solid phase isolation of proteins, nucleic acids and other macromolecules |
| GB0306428D0 (en) * | 2003-03-20 | 2003-04-23 | Oxagen Ltd | Receptor proteins |
| EP1613737A4 (en) | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
| EP1656092B1 (en) * | 2003-08-12 | 2008-07-23 | Philips Intellectual Property & Standards GmbH | Closure device for a container |
| DK2211183T3 (da) * | 2003-11-19 | 2013-05-13 | Satoris Inc | Fremgangsmåde til diagnosticering og overvågning af Alzheimer's sygdom |
| US20060094064A1 (en) * | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
| US7884052B2 (en) | 2004-09-03 | 2011-02-08 | Receptors Llc | Combinatorial artificial receptors including tether building blocks on scaffolds |
| EP1789792A2 (en) | 2004-09-11 | 2007-05-30 | Receptors LLC | Combinatorial artificial receptors including peptide building blocks |
| US7585968B2 (en) | 2005-03-28 | 2009-09-08 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to thymus and activation-regulated chemokine (TARC) |
| US20060258610A1 (en) | 2005-05-12 | 2006-11-16 | Isis Pharmaceuticals, Inc. | Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness |
| WO2007005715A2 (en) * | 2005-07-01 | 2007-01-11 | Inhibtex, Inc. | Staphylococcal antibodies which cross-react with fungal antigens |
| CA2673085C (en) | 2006-12-12 | 2013-10-15 | Biorexis Pharmaceutical Corporation | Transferrin fusion protein libraries |
| WO2009124295A2 (en) * | 2008-04-04 | 2009-10-08 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity |
| US20110202284A1 (en) * | 2010-02-10 | 2011-08-18 | Mcreynolds Cristopher | Novel groups of biomarkers for diagnosing alzheimer's disease |
| US9163094B2 (en) | 2011-09-27 | 2015-10-20 | Massachusetts Institute Of Technology | Light-activated fusion proteins and uses therefor |
| US9718887B2 (en) | 2012-09-06 | 2017-08-01 | Adelaide Research & Innovation Pty Ltd | Methods and products for preventing and/or treating metastatic cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08507602A (ja) | 1993-02-19 | 1996-08-13 | アリス・ファーマスーティカル・コーポレイション | リガンドを構成しかつ提示するための薄膜ｈｐｍｐマトリックス系および方法 |
| JPH07147987A (ja) | 1993-05-28 | 1995-06-13 | Wisconsin Alumni Res Found | ユビキチン接合性酵素（ｅ２）融合タンパク質 |
| US5763199A (en) | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
| US5817527A (en) | 1995-11-06 | 1998-10-06 | Chiron Diagnostics Corporation | Conjugation of ligand to immobilized protein in organic solvent |
| EP0876487B1 (en) | 1996-01-24 | 2008-03-12 | Schering Corporation | Mammalian cx3c chemokine genes |
| WO1998049557A1 (en) | 1997-04-28 | 1998-11-05 | B-E Safe, Inc. | Taxonomic identification of microorganisms, proteins and peptides involved in vertebrate disease states |
-
2000
- 2000-11-24 US US09/721,908 patent/US6699677B1/en not_active Expired - Lifetime
- 2000-12-18 CA CA2390690A patent/CA2390690C/en not_active Expired - Fee Related
- 2000-12-18 DE DE60040019T patent/DE60040019D1/de not_active Expired - Lifetime
- 2000-12-18 AU AU24400/01A patent/AU2440001A/en not_active Abandoned
- 2000-12-18 WO PCT/US2000/034503 patent/WO2001046698A2/en not_active Ceased
- 2000-12-18 AT AT00988164T patent/ATE405838T1/de not_active IP Right Cessation
- 2000-12-18 EP EP00988164A patent/EP1247103B1/en not_active Expired - Lifetime
- 2000-12-18 ES ES00988164T patent/ES2311485T3/es not_active Expired - Lifetime
- 2000-12-18 JP JP2001547554A patent/JP4777570B2/ja not_active Expired - Fee Related
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