DE60040019D1 - Gebundene ligande und deren verwendung - Google Patents
Gebundene ligande und deren verwendungInfo
- Publication number
- DE60040019D1 DE60040019D1 DE60040019T DE60040019T DE60040019D1 DE 60040019 D1 DE60040019 D1 DE 60040019D1 DE 60040019 T DE60040019 T DE 60040019T DE 60040019 T DE60040019 T DE 60040019T DE 60040019 D1 DE60040019 D1 DE 60040019D1
- Authority
- DE
- Germany
- Prior art keywords
- domain
- ligand
- bonded ligands
- receptor
- reagents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17297999P | 1999-12-20 | 1999-12-20 | |
US18662600P | 2000-03-03 | 2000-03-03 | |
US09/721,908 US6699677B1 (en) | 1999-12-20 | 2000-11-24 | Tethered ligands and methods of use |
PCT/US2000/034503 WO2001046698A2 (en) | 1999-12-20 | 2000-12-18 | Tethered ligands and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60040019D1 true DE60040019D1 (de) | 2008-10-02 |
Family
ID=27390216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60040019T Expired - Lifetime DE60040019D1 (de) | 1999-12-20 | 2000-12-18 | Gebundene ligande und deren verwendung |
Country Status (9)
Country | Link |
---|---|
US (1) | US6699677B1 (de) |
EP (1) | EP1247103B1 (de) |
JP (1) | JP4777570B2 (de) |
AT (1) | ATE405838T1 (de) |
AU (1) | AU2440001A (de) |
CA (1) | CA2390690C (de) |
DE (1) | DE60040019D1 (de) |
ES (1) | ES2311485T3 (de) |
WO (1) | WO2001046698A2 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE39849E1 (en) | 1999-10-12 | 2007-09-18 | Chemocentryx, Inc. | Methods for identifying modulators of CCX CKR activity |
US6998239B1 (en) * | 1999-10-12 | 2006-02-14 | Chemocentryx, Inc. | Method for identifying a modulator of the binding of CCX CKR polypeptide to a chemokine |
US6780602B2 (en) * | 2001-11-01 | 2004-08-24 | Microbiosystems, Limited Partnership | Taxonomic identification of pathogenic microorganisms and their toxic proteins |
US7413866B2 (en) * | 2001-11-30 | 2008-08-19 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
US7504364B2 (en) | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
CA2487438A1 (en) * | 2002-06-10 | 2003-12-18 | Metabolex, Inc. | Methods of treating and diagnosing diabetes with cx3cr1 modulators |
US7469076B2 (en) | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
US20040115634A1 (en) | 2002-12-11 | 2004-06-17 | Isis Pharmaceuticals, Inc. | Modulation of stat 6 expression |
US7981694B2 (en) * | 2003-01-28 | 2011-07-19 | The Regents Of The University Of California | Solid phase isolation of proteins, nucleic acids and other macromolecules |
GB0306428D0 (en) * | 2003-03-20 | 2003-04-23 | Oxagen Ltd | Receptor proteins |
EP1613737A4 (de) | 2003-03-28 | 2008-12-03 | Receptors Llc | Reversibel immobilisierte bausteine beinhaltend künstliche rezeptoren und verfahren |
WO2005013883A1 (en) * | 2003-08-12 | 2005-02-17 | Philips Intellectual Property & Standards Gmbh | Closure device for a container |
US20060094064A1 (en) * | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
JP2007513337A (ja) * | 2003-11-19 | 2007-05-24 | サトリス, インコーポレイテッド | アルツハイマー病の診断方法、層化方法およびモニタリング方法 |
EP1789797A1 (de) | 2004-09-03 | 2007-05-30 | Receptors LLC | Kombinatorische künstliche rezeptoren mit anbindungsbausteinen |
EP1789792A2 (de) | 2004-09-11 | 2007-05-30 | Receptors LLC | Kombinatorische künstliche rezeptoren mit peptidbausteinen |
US7585968B2 (en) * | 2005-03-28 | 2009-09-08 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to thymus and activation-regulated chemokine (TARC) |
US20060258610A1 (en) * | 2005-05-12 | 2006-11-16 | Isis Pharmaceuticals, Inc. | Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness |
WO2007005715A2 (en) * | 2005-07-01 | 2007-01-11 | Inhibtex, Inc. | Staphylococcal antibodies which cross-react with fungal antigens |
EP2114999A2 (de) * | 2006-12-12 | 2009-11-11 | Biorexis Pharmaceutical Corporation | Transferrin-fusionsproteinbibliotheken |
US8846639B2 (en) * | 2008-04-04 | 2014-09-30 | Isis Pharmaceutical, Inc. | Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity |
US20110202284A1 (en) * | 2010-02-10 | 2011-08-18 | Mcreynolds Cristopher | Novel groups of biomarkers for diagnosing alzheimer's disease |
US9163094B2 (en) | 2011-09-27 | 2015-10-20 | Massachusetts Institute Of Technology | Light-activated fusion proteins and uses therefor |
CN104884087B (zh) | 2012-09-06 | 2019-07-30 | 阿德莱德研究创新有限公司 | 预防和/或治疗转移性癌症的产品和方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6393994A (en) | 1993-02-19 | 1994-09-14 | Arris Pharmaceutical Corporation | Thin film hpmp matrix systems and methods for constructing and displaying ligands |
JPH07147987A (ja) | 1993-05-28 | 1995-06-13 | Wisconsin Alumni Res Found | ユビキチン接合性酵素(e2)融合タンパク質 |
US5763199A (en) | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
US5817527A (en) | 1995-11-06 | 1998-10-06 | Chiron Diagnostics Corporation | Conjugation of ligand to immobilized protein in organic solvent |
WO1997027299A1 (en) | 1996-01-24 | 1997-07-31 | Schering Corporation | Mammalian cx3c chemokine genes |
WO1998049557A1 (en) | 1997-04-28 | 1998-11-05 | B-E Safe, Inc. | Taxonomic identification of microorganisms, proteins and peptides involved in vertebrate disease states |
-
2000
- 2000-11-24 US US09/721,908 patent/US6699677B1/en not_active Expired - Lifetime
- 2000-12-18 WO PCT/US2000/034503 patent/WO2001046698A2/en active Application Filing
- 2000-12-18 DE DE60040019T patent/DE60040019D1/de not_active Expired - Lifetime
- 2000-12-18 ES ES00988164T patent/ES2311485T3/es not_active Expired - Lifetime
- 2000-12-18 AU AU24400/01A patent/AU2440001A/en not_active Abandoned
- 2000-12-18 AT AT00988164T patent/ATE405838T1/de not_active IP Right Cessation
- 2000-12-18 EP EP00988164A patent/EP1247103B1/de not_active Expired - Lifetime
- 2000-12-18 JP JP2001547554A patent/JP4777570B2/ja not_active Expired - Fee Related
- 2000-12-18 CA CA2390690A patent/CA2390690C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2440001A (en) | 2001-07-03 |
CA2390690C (en) | 2010-08-10 |
US6699677B1 (en) | 2004-03-02 |
WO2001046698A2 (en) | 2001-06-28 |
EP1247103A2 (de) | 2002-10-09 |
ATE405838T1 (de) | 2008-09-15 |
EP1247103B1 (de) | 2008-08-20 |
JP4777570B2 (ja) | 2011-09-21 |
ES2311485T3 (es) | 2009-02-16 |
CA2390690A1 (en) | 2001-06-28 |
JP2003518138A (ja) | 2003-06-03 |
WO2001046698A3 (en) | 2002-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60040019D1 (de) | Gebundene ligande und deren verwendung | |
Stern et al. | Label-free electronic detection of the antigen-specific T-cell immune response | |
BR0313033A (pt) | anticorpos, anticorpos monoclonais, linhagens de células de hibridoma, anticorpos receptores de anti-taci isolados, anticorpos anti -taci, métodos de modulação da atividade biológica | |
HK1082296A1 (en) | Adhered membranes retaining porosity and biological activity in assay device for measuring serum cholesterol associated with high-density lipoproteins | |
US20060076249A1 (en) | Measuring device and measuring method for detecting analytes | |
WO2001042786A3 (en) | System for cell based screening : cell spreading | |
TW200514979A (en) | Biosensor | |
ATE449963T1 (de) | Immunoassays unter verwendung von sers (surface enhanced raman scattering) | |
DE69940198D1 (de) | Mikrovorrichtung zum screening von biomolekülen | |
AU6834700A (en) | Device and method for determining multiple analytes | |
GB2347223A (en) | Method of electrochemical analysis of an analyte | |
AU2002365421A1 (en) | Methods and compositions for detecting the activation state of the multiple proteins in single cells | |
ATE527543T1 (de) | Testvorrichtung zur schnelldiagnose | |
WO2004057341A3 (en) | Cvd assay | |
US7828949B2 (en) | Biomolecule detection device, mobile phone for biomolecule detection, and biomolecule detection method | |
GB0618496D0 (en) | Blood typing | |
Bennett et al. | B‐cell chronic lymphocytic leukaemia cells show specific changes in membrane protein expression during different stages of cell cycle | |
ATE395363T1 (de) | Monoklonale antikörper gegen das protein g3bp und deren verwendungen | |
CA2366514A1 (en) | Diagnostic and therapeutic use of antibodies against the urokinase receptor | |
NZ511217A (en) | Method for measuring cellular adhesion | |
WO2001042503A3 (en) | Apparatus and methods for drug screening based on nucleic acid analysis | |
CY1106349T1 (el) | Συστηματα ανιχνευσης ανοσοπροσδιορισμου ιικου αντιγονου ηπατιτιδας c | |
WO2002071061A3 (en) | Quantitative detection of the conformation changes of p-glycoprotein | |
DE69523492T2 (de) | Immunoassay-Reagenzien, Testsätze und Verfahren | |
DE3785175T2 (de) | A-assoziierte h-antigene, spezifische monoklonale antikoerper und methoden zu deren verwendung zur blutgruppenbestimmung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |