JP2003517011A5 - - Google Patents
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- Publication number
- JP2003517011A5 JP2003517011A5 JP2001544880A JP2001544880A JP2003517011A5 JP 2003517011 A5 JP2003517011 A5 JP 2003517011A5 JP 2001544880 A JP2001544880 A JP 2001544880A JP 2001544880 A JP2001544880 A JP 2001544880A JP 2003517011 A5 JP2003517011 A5 JP 2003517011A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17122899P | 1999-12-16 | 1999-12-16 | |
| US17123799P | 1999-12-16 | 1999-12-16 | |
| US60/171,237 | 1999-12-16 | ||
| US60/171,228 | 1999-12-16 | ||
| US18264700P | 2000-02-15 | 2000-02-15 | |
| US60/182,647 | 2000-02-15 | ||
| US20241600P | 2000-05-08 | 2000-05-08 | |
| US60/202,416 | 2000-05-08 | ||
| PCT/US2000/033866 WO2001043742A1 (en) | 1999-12-16 | 2000-12-14 | Novel processes for making- and a new crystalline form of- leflunomide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003517011A JP2003517011A (ja) | 2003-05-20 |
| JP2003517011A5 true JP2003517011A5 (https=) | 2005-12-22 |
Family
ID=27496942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001544880A Pending JP2003517011A (ja) | 1999-12-16 | 2000-12-14 | レフルノミドの新規な製法及び新しい結晶形態 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6610718B2 (https=) |
| EP (1) | EP1242077A4 (https=) |
| JP (1) | JP2003517011A (https=) |
| KR (1) | KR20020067545A (https=) |
| CN (1) | CN1411373A (https=) |
| AU (1) | AU779931B2 (https=) |
| CA (1) | CA2397601A1 (https=) |
| CZ (1) | CZ20022000A3 (https=) |
| HR (2) | HRP20020521A2 (https=) |
| HU (1) | HUP0204069A3 (https=) |
| IL (1) | IL149792A0 (https=) |
| PL (1) | PL356243A1 (https=) |
| SK (1) | SK8332002A3 (https=) |
| WO (1) | WO2001043742A1 (https=) |
| YU (1) | YU45102A (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0903345B1 (de) * | 1997-08-08 | 2000-10-04 | Aventis Pharma Deutschland GmbH | Kristallform von 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)-anilid |
| CN1411373A (zh) * | 1999-12-16 | 2003-04-16 | 特瓦制药工业有限公司 | 制备来氟米特的新方法和新晶形的来氟米特 |
| WO2001051089A1 (de) * | 2000-01-13 | 2001-07-19 | Merck Patent Gmbh | Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler |
| ES2237553T3 (es) * | 2000-02-15 | 2005-08-01 | Teva Pharmaceutical Industries Ltd. | Procedimiento para la sintesis de leflunomida. |
| US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
| WO2006103506A1 (en) * | 2005-03-31 | 2006-10-05 | Ranbaxy Laboratories Limited | Sertraline-containing pharmaceutical compositions and a process for preparation thereof |
| CN101563082A (zh) * | 2006-09-05 | 2009-10-21 | 窦德献 | 治疗免疫介导性皮肤病的组合物和方法 |
| CN101143834B (zh) * | 2006-09-15 | 2010-09-08 | 欣凯医药化工中间体（上海）有限公司 | N-(4-三氟甲基苯)-2-氰基-3-羟基丁烯酰胺钠盐的多晶型及其制备方法 |
| US8664390B2 (en) | 2007-06-29 | 2014-03-04 | Generics (Uk) Limited | Process for the introduction of hydroxyethoxy side chain in bosentan |
| NZ585438A (en) | 2007-10-24 | 2012-09-28 | Generics Uk Ltd | Novel crystalline forms of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yI]-benzenesulfonamide |
| CA2712860C (en) | 2008-02-08 | 2014-11-18 | Abhay Gaitonde | Process for preparing bosentan |
| CA2741928A1 (en) | 2008-11-03 | 2010-06-03 | Generics [Uk] Limited | Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers |
| CN101817797B (zh) * | 2009-02-26 | 2013-04-10 | 江苏亚邦爱普森药业有限公司 | 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法 |
| MY180626A (en) | 2013-11-15 | 2020-12-03 | Akebia Therapeutics Inc | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| US11801232B2 (en) * | 2019-11-27 | 2023-10-31 | Yale University | Targeting of ARID1A-deficient cancers by inhibiting de novo pyrimidine synthesis pathway |
| CN112898215B (zh) * | 2021-02-04 | 2022-11-08 | 美罗药业股份有限公司 | 一种来氟米特晶型i的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| US5268382A (en) * | 1985-09-27 | 1993-12-07 | Hoechst Aktiengesellschaft | Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus |
| DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| ES2102367T3 (es) * | 1990-05-18 | 1997-08-01 | Hoechst Ag | Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion. |
| US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| DE19610955A1 (de) * | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| DE19711800A1 (de) * | 1997-03-21 | 1998-09-24 | Hoechst Ag | Verlängerung der Expression von transgenen Proteinen durch immunmodulierende Behandlung |
| EP0903345B1 (de) | 1997-08-08 | 2000-10-04 | Aventis Pharma Deutschland GmbH | Kristallform von 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)-anilid |
| EP0933633A1 (en) * | 1997-12-11 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Process for obtaining L-dihydroorotic acid and use thereof |
| US7691890B2 (en) * | 1998-03-11 | 2010-04-06 | James W. Williams | Anti-viral uses of leflunomide products |
| US6303652B1 (en) * | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| DE19908527C2 (de) * | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
| ATE248835T1 (de) * | 1999-06-25 | 2003-09-15 | Vertex Pharma | Prodrugs von impdh-inhibierenden carbamaten |
| CN1411373A (zh) * | 1999-12-16 | 2003-04-16 | 特瓦制药工业有限公司 | 制备来氟米特的新方法和新晶形的来氟米特 |
| ES2237553T3 (es) * | 2000-02-15 | 2005-08-01 | Teva Pharmaceutical Industries Ltd. | Procedimiento para la sintesis de leflunomida. |
| US6548527B2 (en) * | 2000-03-27 | 2003-04-15 | The General Hospital Corporation | Treatments for immune-mediated ear disorders |
| WO2002013822A1 (en) * | 2000-08-14 | 2002-02-21 | Teva Pharmaceutical Industries Ltd. | Micronized leflunomide |
| DE60137728D1 (de) * | 2000-08-24 | 2009-04-02 | Univ Tennessee Res Foundation | Selektive Modulatoren des Androgenrezeptors und Methoden zu deren Verwendung |
| JP4212278B2 (ja) * | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
| US20040229849A1 (en) * | 2002-09-24 | 2004-11-18 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| CA2535345A1 (en) * | 2003-08-13 | 2005-03-03 | Medtronic, Inc. | Active agent delivery systems including a miscible polymer blend, medical devices, and methods |
| US20050064038A1 (en) * | 2003-08-13 | 2005-03-24 | Dinh Thomas Q. | Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods |
| US20050053600A1 (en) * | 2003-09-09 | 2005-03-10 | Lane Thomas E. | Methods for treating rheumatoid arthritis |
-
2000
- 2000-12-14 CN CN00817283A patent/CN1411373A/zh active Pending
- 2000-12-14 CA CA002397601A patent/CA2397601A1/en not_active Abandoned
- 2000-12-14 KR KR1020027007575A patent/KR20020067545A/ko not_active Ceased
- 2000-12-14 AU AU25788/01A patent/AU779931B2/en not_active Ceased
- 2000-12-14 HR HR20020521A patent/HRP20020521A2/hr not_active Application Discontinuation
- 2000-12-14 CZ CZ20022000A patent/CZ20022000A3/cs unknown
- 2000-12-14 HR HR20050176A patent/HRP20050176A2/xx not_active Application Discontinuation
- 2000-12-14 SK SK833-2002A patent/SK8332002A3/sk unknown
- 2000-12-14 US US09/736,727 patent/US6610718B2/en not_active Expired - Fee Related
- 2000-12-14 EP EP00989253A patent/EP1242077A4/en not_active Withdrawn
- 2000-12-14 PL PL00356243A patent/PL356243A1/xx not_active Application Discontinuation
- 2000-12-14 WO PCT/US2000/033866 patent/WO2001043742A1/en not_active Ceased
- 2000-12-14 IL IL14979200A patent/IL149792A0/xx unknown
- 2000-12-14 HU HU0204069A patent/HUP0204069A3/hu unknown
- 2000-12-14 JP JP2001544880A patent/JP2003517011A/ja active Pending
- 2000-12-14 YU YU45102A patent/YU45102A/sh unknown
-
2003
- 2003-04-08 US US10/410,493 patent/US6806373B2/en not_active Expired - Fee Related
-
2004
- 2004-07-22 US US10/897,778 patent/US20050004191A1/en not_active Abandoned