JP2003516967A - 1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用 - Google Patents
1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用Info
- Publication number
- JP2003516967A JP2003516967A JP2001544683A JP2001544683A JP2003516967A JP 2003516967 A JP2003516967 A JP 2003516967A JP 2001544683 A JP2001544683 A JP 2001544683A JP 2001544683 A JP2001544683 A JP 2001544683A JP 2003516967 A JP2003516967 A JP 2003516967A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- compound
- formulation
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17113999P | 1999-12-16 | 1999-12-16 | |
| US60/171,139 | 1999-12-16 | ||
| PCT/US2000/034504 WO2001044193A1 (en) | 1999-12-16 | 2000-12-18 | 1,3,4-substituted piperidine analogs and uses thereof in treating addictions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003516967A true JP2003516967A (ja) | 2003-05-20 |
| JP2003516967A5 JP2003516967A5 (enExample) | 2008-02-21 |
Family
ID=22622694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001544683A Pending JP2003516967A (ja) | 1999-12-16 | 2000-12-18 | 1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20020025967A1 (enExample) |
| EP (1) | EP1248770A1 (enExample) |
| JP (1) | JP2003516967A (enExample) |
| CA (1) | CA2395075A1 (enExample) |
| WO (1) | WO2001044193A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| RS20060035A (sr) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Derivati diaril i arilheteroaril uree kao modulatori receptora 5-ht2a serotonina korisni u profilaksi i lečenju poremećaja u vezi sa njima |
| CN101163477A (zh) * | 2005-02-23 | 2008-04-16 | 普雷萨药品公司 | 多介质多巴胺转运抑制剂,以及其相关应用 |
| EP2338881A1 (en) | 2005-02-23 | 2011-06-29 | Prexa Pharmaceuticals, Inc. | Dopamine transporter inhibitors for use in treatment of movement disorders and other CNS indications |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物 |
| EP2190844B3 (en) | 2007-08-15 | 2013-07-17 | Arena Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| RS57110B1 (sr) | 2008-10-28 | 2018-06-29 | Arena Pharm Inc | Sastavi modulatora 5-ht2a serotoninskog receptora korisni za tretiranje poremećaja povezanih sa njim |
| CN104662015B (zh) | 2012-06-20 | 2017-03-29 | 诺华股份有限公司 | 补体途径调节剂及其用途 |
| WO2016019312A2 (en) * | 2014-07-31 | 2016-02-04 | Oregon Health & Science University | Vmat inhibitory compounds |
| DK3212637T3 (da) | 2014-10-31 | 2021-07-12 | Indivior Uk Ltd | Dopamin-d3-receptorantagonistforbindelser |
| AU2016276966A1 (en) | 2015-06-12 | 2018-01-18 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of REM sleep behavior disorder |
| EP3322415A4 (en) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE1058058B (de) * | 1954-02-27 | 1959-05-27 | Basf Ag | Verfahren zur Herstellung von Alkylpyridinen |
| GB850417A (en) * | 1957-05-31 | 1960-10-05 | Merck & Co Inc | Process for the preparation of 1-(p-nitrophenyl)-4-carboalkoxy-4-phenyl-piperidines |
| JP2002526528A (ja) * | 1998-10-07 | 2002-08-20 | ジョージタウン ユニヴァーシティー | 単量体およびニ量体の複素環、ならびにその治療的使用 |
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| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| DE3441927A1 (de) * | 1984-11-16 | 1986-05-28 | Basf Ag, 6700 Ludwigshafen | Am stickstoff substituierte 4-(p-tert.butyl-phenyl)-3-methyl-piperidine, dessen quartaere salze sowie deren anwendung als fungizide |
| US5620993A (en) * | 1995-06-07 | 1997-04-15 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| ES2329739T3 (es) * | 1997-04-07 | 2009-11-30 | Georgetown University | Analogos de cocaina. |
-
2000
- 2000-12-18 EP EP00989325A patent/EP1248770A1/en not_active Withdrawn
- 2000-12-18 JP JP2001544683A patent/JP2003516967A/ja active Pending
- 2000-12-18 US US09/739,184 patent/US20020025967A1/en not_active Abandoned
- 2000-12-18 CA CA002395075A patent/CA2395075A1/en not_active Abandoned
- 2000-12-18 WO PCT/US2000/034504 patent/WO2001044193A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1058058B (de) * | 1954-02-27 | 1959-05-27 | Basf Ag | Verfahren zur Herstellung von Alkylpyridinen |
| GB850417A (en) * | 1957-05-31 | 1960-10-05 | Merck & Co Inc | Process for the preparation of 1-(p-nitrophenyl)-4-carboalkoxy-4-phenyl-piperidines |
| JP2002526528A (ja) * | 1998-10-07 | 2002-08-20 | ジョージタウン ユニヴァーシティー | 単量体およびニ量体の複素環、ならびにその治療的使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20020025967A1 (en) | 2002-02-28 |
| WO2001044193A1 (en) | 2001-06-21 |
| EP1248770A1 (en) | 2002-10-16 |
| CA2395075A1 (en) | 2001-06-21 |
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